Nice study! :)
from (Perez et al., 2024) A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment [nature communications] https://doi.org/10.1038/s41467-024-49608-z
Their provided dfs have the uniprot accession from mice. So mapped those to the mouse_ref (uniprot df), to get gene names which were then mapped to the rat gene gene names (where uniprot infor was pulled) to get rat proteins & other details.
NOTE: some exported randomly have Q6LED0 Histone H3.1 in the exported sheets? not sure why? look into?
Code is a bit of a mess (maybe clean up later in a new version).
library(tidyverse)
## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ──
## ✔ dplyr 1.1.4 ✔ readr 2.1.5
## ✔ forcats 1.0.1 ✔ stringr 1.5.2
## ✔ ggplot2 4.0.0 ✔ tibble 3.3.0
## ✔ lubridate 1.9.4 ✔ tidyr 1.3.1
## ✔ purrr 1.1.0
## ── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ──
## ✖ purrr::%||%() masks base::%||%()
## ✖ dplyr::filter() masks stats::filter()
## ✖ dplyr::lag() masks stats::lag()
## ℹ Use the conflicted package (<http://conflicted.r-lib.org/>) to force all conflicts to become errors
library(readxl)
library(writexl)
library(ggrepel) # for geom_text_repel()
library(gt)
library(ggh4x) # facet_nested
prot_df_EEall <- read_excel("input/Perez_2024_EE_age_proteomics_sds20_41467_2024_49608_MOESM23_ESM.xlsx",
sheet = "EEall")
prot_df_EEyng <- read_excel("input/Perez_2024_EE_age_proteomics_sds20_41467_2024_49608_MOESM23_ESM.xlsx",
sheet = "EEyng")
prot_df_EEold <- read_excel("input/Perez_2024_EE_age_proteomics_sds20_41467_2024_49608_MOESM23_ESM.xlsx",
sheet = "EEold")
prot_df <- bind_rows(list(all = prot_df_EEall,
young = prot_df_EEyng,
old = prot_df_EEold),
.id = "proteomics_id")
# load in uniprot df
load(file = "input/mouse_ref_proteome_2025_12_13_54864x295.rda")
load(file = "input/rat_ref_proteome_2025_12_13_51872x295.rda")
load(file = "input/rat_other_proteome_2025_12_15_39538x295.rda")
# cols I want from uniprot
#colnames(mouse_ref_proteome_2025_12_13)
my_cols <- c("Entry", "Entry.Name", "Protein.names", "Gene.Names..primary.",
"Gene.Names", "Gene.Names..synonym.", "Annotation", "Reviewed",
"Protein.existence", "Protein.families", "Length", "Organism",
"Keywords", "Keyword.ID", "Function..CC.", "Miscellaneous..CC.", "Pathway",
"GeneID", "Ensembl",
"Gene.Ontology..GO.", "Gene.Ontology..cellular.component.",
"Gene.Ontology..molecular.function.", "Gene.Ontology..biological.process.",
"Gene.Ontology.IDs", "KEGG", "Reactome", "STRING",
"Entry.version", "Date.of.creation", "Date.of.last.modification",
"Date.of.last.sequence.modification"
)
The code below adds additional metrics to the uniprot dataframe including a calculation score for protein existence ranked from highest (evidence at the protein level) & and occupied metric that measures the number of NA values per row. These scoring metrics are useful to break ties when there are multiple instances of a mapping (see later …).
Stepwise process includes…
Selecting desired columns (based on the
my_cols list above)
Make a Protein.existence
column with assigned rankings. For example,
Protein.existence == "Evidence at protein level" ~ 5 will
allow it to try to keep the highest scoring observation when using
slice_max() down the line (see https://www.uniprot.org/help/protein_existence for more
info).
Calculating NAs per row. this metric will allow keeping the row with the most info (is partially covered by the existing annotation column that is supplied by uniprot but still useful to break further ties at the end).
Note: some blank entries have
NA but some are "" (just blank) (which makes
them automatically chr class btw), to convert them to all
NA without disturbing other columns use
na_if() from dplyr (https://dplyr.tidyverse.org/reference/na_if.html) &
then mutate across where is.character (see below).
Afterwards then the next computed column occupied will correctly count the NA across the row using baseR rowSums
# https://www.uniprot.org/help/protein_existence - see rankings
unique(rat_ref_proteome_2025_12_13$Protein.existence)
## [1] "Evidence at protein level" "Evidence at transcript level"
## [3] "Inferred from homology" "Uncertain"
## [5] "Predicted"
# MOUSE REF PROTEOME
mouse_ref <- mouse_ref_proteome_2025_12_13 %>%
dplyr::select(all_of(my_cols)) %>%
mutate(existence_ranking = case_when( # ranking level of evidence
Protein.existence == "Evidence at protein level" ~ 5,
Protein.existence == "Evidence at transcript level" ~ 4,
Protein.existence == "Inferred from homology" ~ 3,
Protein.existence == "Predicted" ~ 2,
Protein.existence == "Uncertain" ~ 1
), .after = Protein.existence) %>%
mutate(across(where(is.character), ~ na_if(.x, "")))
# need to run in separate line as mouse ref is input (otheriwise object not found )
mouse_ref <- mouse_ref %>%
mutate(occupied = rowSums(!is.na(mouse_ref)))
# 2025_12_15 - NOTE DID NOT GET MOUSE OTHER PROTEOME FROM UNIPROT BECAUSE IT SAYS CONTAIMINATED!
# RAT REF PROTEOME
rat_ref <- rat_ref_proteome_2025_12_13 %>%
dplyr::select(all_of(my_cols)) %>%
mutate(existence_ranking = case_when( # ranking level of evidence
Protein.existence == "Evidence at protein level" ~ 5,
Protein.existence == "Evidence at transcript level" ~ 4,
Protein.existence == "Inferred from homology" ~ 3,
Protein.existence == "Predicted" ~ 2,
Protein.existence == "Uncertain" ~ 1
), .after = Protein.existence) %>%
mutate(across(where(is.character), ~ na_if(.x, "")))
rat_ref <- rat_ref %>%
mutate(occupied = rowSums(!is.na(rat_ref)))
# RAT OTHER PROTEOME
rat_other <- other_rat_proteome_2025_12_15 %>%
dplyr::select(all_of(my_cols)) %>%
mutate(existence_ranking = case_when( # ranking level of evidence
Protein.existence == "Evidence at protein level" ~ 5,
Protein.existence == "Evidence at transcript level" ~ 4,
Protein.existence == "Inferred from homology" ~ 3,
Protein.existence == "Predicted" ~ 2,
Protein.existence == "Uncertain" ~ 1
), .after = Protein.existence) %>%
mutate(across(where(is.character), ~ na_if(.x, "")))
rat_other <- rat_other %>%
mutate(occupied = rowSums(!is.na(rat_other)))
,Map uniprot accessions provided by perez to uniprot mice df to get primary gene names etc
Note: occasionally some uniprot ids are 2 in 1 row, sep by ; must unnest. So need to mutate a new column by string_split to recognize the ; when multiple entires are in one Perez’s UNIPROT column. Then use tidyr unnest() to split & expand.
Side note: just unnest UNIPROT (ignore UNIPROT_DB since the other df
has this info anyway.) otherwise Error in tidyr::unnest():
! In row 279, can’t recycle input of size 3 to size 2.
Join join provided df to uniprot mouse df (left_join keeps all of x (original df))
# String split & unnest to deal with 2 in 1 accessions in cells
prot_df_unnested <- prot_df %>%
mutate(split_UNIPROT = str_split(UNIPROT, ";"),
.after = UNIPROT) %>%
tidyr::unnest(split_UNIPROT) # goes from 6750 to 6849 rows
# Join Perez df to mouse_ref by uniprot accession.
prot_df_mouse <- left_join(prot_df_unnested, mouse_ref,
by = join_by(UNIPROT == Entry))
sum(is.na(prot_df_mouse$Entry.Name)) # check unmapped | 291 of 6558 unmapped
## [1] 291
#sum(!(is.na(prot_df_mouse$Entry.Name))) # 6558
Now with the mapped mouse df. Use the prot_df_mouse, select cols of interest, rename those that will duplicate (to avoid .x at the end when joining, & then join.
Probably could have just mutated .x to .m, but oh well.
#colnames(prot_df_mouse)
prot_df_map_rat_1 <- prot_df_mouse %>%
dplyr::select(proteomics_id:Gene.Names, Annotation:Protein.existence,
Protein.families:Length, GeneID:Ensembl) %>% # 24 cols
rename(entry.name.m = Entry.Name, # new = old
protein.names.m = Protein.names,
gene.names.primary.m = Gene.Names..primary.,
gene.names.m = Gene.Names,
annotation.m = Annotation,
reviewed.m = Reviewed,
protein.existence.m = Protein.existence,
protein.families.m = Protein.families,
length.m = Length,
GeneID.m = GeneID,
Ensembl.m = Ensembl) %>%
# group_by(proteomics_id) %>%
left_join(rat_ref, # many to many warning
by = join_by(gene.names.primary.m == Gene.Names..primary.))
## Warning in left_join(., rat_ref, by = join_by(gene.names.primary.m == Gene.Names..primary.)): Detected an unexpected many-to-many relationship between `x` and `y`.
## ℹ Row 1 of `x` matches multiple rows in `y`.
## ℹ Row 923 of `y` matches multiple rows in `x`.
## ℹ If a many-to-many relationship is expected, set `relationship =
## "many-to-many"` to silence this warning.
# gives many to many warning (fine?) but why 337629 (prev 24513)
# unique entries are the same though
Make sure to group by proteomics_id so it doesn’t delete adjacent groups! (e.g. EEold).
Takes prot_df_map_rat_1 then filters out any NAs enties (so unable to map by primary gene name), then groups by proteomics_id (so EEyoung, EEold, EEall), then gene names & then UNIPROT id (provided by Perez) (this is to deal with any gene ids that get dealt to multiple unique uniprot accession entries). Afterwards, the filtering begins - swissprot reviewed > best annotation score > existence ranking > occupied (least NAs).
# informs grouping.
length(unique(prot_df_map_rat_1$proteomics_id)) # 3
## [1] 3
length(unique(prot_df_map_rat_1$gene.names.primary.m)) # 2186
## [1] 2186
length(unique(prot_df_map_rat_1$split_UNIPROT)) # 8040
## [1] 2283
length(unique(prot_df_map_rat_1$Entry)) # 8040
## [1] 8040
# take non empty entries & then group & filter any with multiples
# based on reviewed > annotation score > protein existence
prot_df_map_rat_2 <- prot_df_map_rat_1 %>% #24513 | 337629
group_by(proteomics_id, gene.names.primary.m, split_UNIPROT) %>% # group by
# 1 - remove NAs
filter(!(is.na(Entry))) %>% #24117 | 337524
# 2 - keep reviewed/swissprot entries
# or maybe group by just proteomics_id, gene - since rat map is based on gene???
filter(if(any(Reviewed == "reviewed", na.rm = TRUE)) {
Reviewed == "reviewed" # if reviewed = keep,
} else {TRUE}) %>% #10278|44907 - if none, keep unreviewed ones, & filter below
# 3
slice_max(Annotation, n = 1) %>% #8445|10773
# 4 # keep entry with least NAs
slice_max(existence_ranking, n = 1) %>% #7905|9942
# 5 - keep entry with least NAs
slice_max(occupied, n = 1) %>% # |7017
# still 216 with duplicate entries
# 6 - final
mutate(id_priority = case_when(
!is.na(GeneID) & !is.na(Ensembl) & !is.na(KEGG) ~ 6, # has geneID & ensembl & KEGG!
!is.na(GeneID) & !is.na(Ensembl) ~ 5, # has both geneID & ensembl!
!is.na(GeneID) ~ 4, # has only gene ID
!is.na(Ensembl) ~ 3, # has only Ensembl
!is.na(KEGG) ~ 2, # has only KEGG
TRUE ~ 0 # all others (if all above were FALSE, then TRUE - so it writes 0)
)) %>%
slice_max(id_priority, n = 1, with_ties = FALSE) %>%
dplyr::select(-id_priority) %>%
ungroup() # good practice?
# 1st 6849 (geneID & ensembl - still has duplicates -> 153)
# 2nd 6924? (geneID & ensembl & kegg - still has duplicates -> 129)
# note varying combos of Gene.ID.m, Ensembl.m, Reactome, STRING,
# also tried go_id_count - did not resolve - seems to be isoforms? i think
# # 216 with duplicate entries | after (GeneID & Ensembl trim) = 153
# # 129 KEGG,GeneID& Ensembl| 0 eeny meeny miny moe then with_ties
#
# # for checking duplicate entries trimming (see case_when in the chunk above)
# prot_df_map_rat_2_dups <- prot_df_map_rat_2 %>%
# count(gene.names.primary.m) %>%
# filter(n > 1)
#
# prot_df_maps_rat_2_inspect <- prot_df_map_rat_2 %>%
# filter(gene.names.primary.m %in% prot_df_map_rat_2_dups$gene.names.primary.m)
# dropped a bit due to removing the NA values ?
length(unique(prot_df_map_rat_2$gene.names.primary.m)) # 2151
## [1] 2151
length(unique(prot_df_map_rat_2$split_UNIPROT)) # 2248
## [1] 2248
length(unique(prot_df_map_rat_2$Entry)) # 2151
## [1] 2151
Filter NA Entries (no rat accession), then select & peel back columns (to avoid duplicating in subsequent join), then filter out non NAs in the gene.names.primary.m col otherwise remaps & results in >3mil cols
prot_df_map_rat_1_na <- prot_df_map_rat_1 %>%
filter(is.na(Entry)) %>% #396|105 obs?
dplyr::select(proteomics_id:Ensembl.m) %>% # peel back to 24 cols
filter(!is.na(gene.names.primary.m)) # filter out non NAs otherwise maps >3 mil below
# Prep rat_ref_split df
rat_ref_split <- rat_ref %>% #51872 to 55829
mutate(split_synonyms = str_split(Gene.Names..synonym., " ")) %>% #sep split by space
tidyr::unnest(split_synonyms)
Recovered Sh3bgrl, Tceal3, Mtco2, Mtnd1, Mtnd5, Eif2s3x (gene synonyms that match mouse primary). No duplicates here so no need to rank.
# note filtered NAs in gene.names.primary.m (otherwise maps 3 million as NA to NA)
# results in 18 of 105 recovered (or 6 proteins (since 3 groups))
prot_df_map_rat_3 <- left_join(prot_df_map_rat_1_na, rat_ref_split,
by = join_by(gene.names.primary.m == split_synonyms))
sum(is.na(prot_df_map_rat_3$Entry)) # still 87 NA
## [1] 87
# many of those NAs see either too specific or too general or non reference prote.
# e.g. Histone H3, RIKEN cDNA 2900026A02 gene, etc unmapped
prot_df_map_rat_3_filtered <- prot_df_map_rat_3 %>%
filter(!is.na(Entry))
prot_df_map_rat_3_na <- prot_df_map_rat_3 %>%
filter(is.na(Entry)) %>% #|87
dplyr::select(proteomics_id:Ensembl.m) %>% # peel back to 24 cols
filter(!is.na(gene.names.primary.m)) # filter out non NAs otherwise maps >3 mil below
prot_df_map_rat_4 <- left_join(prot_df_map_rat_3_na, rat_other,
by = join_by(
gene.names.primary.m == Gene.Names..primary.)) %>%
# recovered Grcc10, Timm8a1, H3f3a, Phpt1, Vbp1
group_by(proteomics_id, gene.names.primary.m, split_UNIPROT) %>%
filter(if(any(Reviewed == "reviewed", na.rm = TRUE)) {
Reviewed == "reviewed"
} else {TRUE}) %>%
slice_max(Annotation, n = 1) %>%
slice_max(existence_ranking, n = 1) %>%
slice_max(occupied, n = 1) %>% # from 90 entries to 87 - only drops dup of Grcc10
ungroup() # good practice?
## Warning in left_join(prot_df_map_rat_3_na, rat_other, by = join_by(gene.names.primary.m == : Detected an unexpected many-to-many relationship between `x` and `y`.
## ℹ Row 14 of `x` matches multiple rows in `y`.
## ℹ Row 14754 of `y` matches multiple rows in `x`.
## ℹ If a many-to-many relationship is expected, set `relationship =
## "many-to-many"` to silence this warning.
sum(is.na(prot_df_map_rat_4$Entry)) # still 72 NA (or 24 missing?)
## [1] 72
# Note: deleted rat_other_split with synonyms as it did not further recover any IDs.
# hence combining this chunk
# note the join has 90 entries & follow up filter drops it to 3 (so only removes the 3)
prot_df_map_rat_combined <- bind_rows(list(
by_ref_primary_gene = prot_df_map_rat_2,
by_ref_synonym = prot_df_map_rat_3_filtered,
by_other_primary_gene = prot_df_map_rat_4),
.id = "map_method_df") %>%
arrange(proteomics_id, desc(dir), gene.names.primary.m)
dim(prot_df_map_rat_combined) # 6849 x 58 | still some duplicates?
## [1] 6849 58
# # export
# write_excel_csv(prot_df_map_rat_combined,
# "output/2025_12_16_Perez_2024_proteomics_map_rat_combined_v1.csv")
# # export | with ungroup() added ? not sure if it matters -> check
# write_excel_csv(prot_df_map_rat_combined,
# "output/2025_12_27_Perez_2024_proteomics_map_rat_combined_v1.csv")
plot(prot_df_map_rat_combined$logFC)
# for lit review table | Note - duplicates have not been removed - to do manually
lit_review_proteomics <- prot_df_map_rat_combined %>%
mutate(
Year = 2024,
Author = 'Perez',
Animal = 'Mice',
Condition = proteomics_id,
Region = 'Hippocampus',
Whole = 'Yes',
Exp_type = 'Protein',
Method = 'PROTEOMICS_LCMS_LFQ_DIA_OS',
Used_name = SYMBOL,
Mod = " ",
Mod_type = " ",
Gene_name = `gene.names.primary.m`, # genename used to map mouse 1° to rat gene
Comparison = 2,
In_EE = dir,
Fold_change = logFC, # prob the same as log2FC?
Arrows = case_when( # dplyr case when, instead of ifelse
logFC > 2.5 ~ '+++',
logFC > 1 ~ '++',
logFC > .05 ~ '+',
logFC > -.05 ~ '=',
logFC > -1 ~ '-',
logFC > -2.5 ~ '--',
logFC <= -2.5 ~ '---',
),
Significant = ifelse(adj.P.Val <= 0.05, 'yes', 'no'),
pvalue = adj.P.Val,
N_tested = ' ',
Stats_adj = 'adjusted',
Note = ' ',
Full_name = Protein.names,
Uniprot_rat_accession = Entry,
Uniprot_entry_name = Entry.Name,
Uniprot_link = ifelse(!is.na(Entry),
paste0('https://www.uniprot.org/uniprotkb/', Entry,'/entry'),
' '),
Wikipedia_link = ifelse(!is.na(Entry),
paste0('https://en.wikipedia.org/wiki/',
`gene.names.primary.m`), ' '),
Curation_method = case_when(
Reviewed == "reviewed" & map_method_df == "by_ref_primary_gene"
~ "auto - ref & reviewed (primary gene name)",
Reviewed == "unreviewed" & map_method_df == "by_ref_primary_gene"
~ "auto - ref & unreviewed (primary gene name)",
Reviewed == "reviewed" & map_method_df == "by_ref_synonym"
~ "auto - ref & reviewed (synonym)",
Reviewed == "unreviewed" & map_method_df == "by_ref_synonym"
~ "auto - ref proteome (synonym)",
Reviewed == "reviewed" & map_method_df == "by_other_primary_gene"
~ "auto - other & reviewed (primary gene name)",
is.na(Entry.Name)
~ "manual - na"),
Class_group = ' ',
Other_link = ' ',
Other_comments = 'misc shows combined gene_uniprot_ensembl info from their df',
misc = paste0(SYMBOL, '_', UNIPROT, '_', GENEID)
)
Write excel
https://r4ds.hadley.nz/spreadsheets.html#sec-writing-to-excel
# results in 3 x [2283 x 89] df
split_prot_df_map_rat <- split(lit_review_proteomics,
lit_review_proteomics$proteomics_id)
# then add the combined one at the end
split_prot_df_map_rat$combined <- lit_review_proteomics
# #writes out by sheet (using writexl package)
# write_xlsx(split_prot_df_map_rat,
# path = "output/2025_12_16_Perez_2024_proteomics_lit_review_all_v1.xlsx")
# #writes out by sheet (using writexl package) | with ungroup?
# write_xlsx(split_prot_df_map_rat,
# path = "output/2025_12_27_Perez_2024_proteomics_lit_review_all_v1.xlsx")
Significant Only
lit_review_proteomics_sig <- lit_review_proteomics %>%
filter(adj.P.Val <= 0.05) #6936 to 2015
split_prot_df_map_rat_sig <- split(lit_review_proteomics_sig,
lit_review_proteomics_sig$proteomics_id)
split_prot_df_map_rat_sig$combined <- lit_review_proteomics_sig
# write_xlsx(split_prot_df_map_rat_sig,
# path = "output/2025_12_16_Perez_2024_proteomics_lit_review_sig_v1.xlsx")
prot_df_map_rat_sig <- prot_df_map_rat_combined %>%
filter(adj.P.Val <= 0.05) # 2097 entries!
# color coding doesn't work!?!?
volcano_pv <- lit_review_proteomics_sig %>%
ungroup() %>%
ggplot(aes(x = logFC, y = -log2(adj.P.Val),
label = Gene_name)) +
geom_point(aes(color = case_when(
adj.P.Val < 0.05 & logFC > 0.05 ~ "Upregulated (adj.p<0.05)",
adj.P.Val < 0.05 & logFC < -0.05 ~ "Downregulated (adj.p<0.05)",
TRUE ~ "Not Significant")),
alpha = 1, size = 1, shape = 1) +
# xlim(-8,12) +
geom_vline(xintercept = 0, linetype = "dashed",
color = "grey40", linewidth = .5) +
scale_color_manual(values = c("firebrick3",
"royalblue4",
"grey80"),
breaks = c("Upregulated (adj.p<0.05)",
"Downregulated (adj.p<0.05)",
"Not Significant"),
labels = c("Upregulated Proteins (p<0.05)",
"Downregulated Proteins (p<0.05)",
"Not Significant")) +
geom_text_repel(label.size = .1) +
facet_wrap(~proteomics_id, ncol = 1,
scales = "free_y") +
labs(
title = "Perez 2024 - Proteomics - Hippocampus (Mice) - Aging x EE (2025_12_16/17)",
subtitle = "lit_review_proteomics_sig df - map up mouse (provided) 2 up mouse gene 2 up rat gene",
x = "Log2 Signal",
y = "-Log2(adj.p-value)",
color = "mRNA Regulation") +
theme_bw() +
theme(legend.position = "bottom",
strip.text = element_text(size = 12))
## Warning in geom_text_repel(label.size = 0.1): Ignoring unknown parameters:
## `label.size`
volcano_pv
## Warning: Removed 59 rows containing missing values or values outside the scale range
## (`geom_text_repel()`).
## Warning: ggrepel: 872 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
## Warning: ggrepel: 498 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
## Warning: ggrepel: 410 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
ignore
NA Q6LED0 H31_RAT Histone H3.1
# EE VS SH (ALL)
# gt 1 - by fold change direction & pvalue
lit_review_proteomics_sig |>
dplyr::ungroup() |>
dplyr:: filter(Condition == "all") %>%
#dplyr::select(-(c(`Av. Ratio`, ))) |>
dplyr::select(c(Condition, In_EE, Gene_name, Entry, Entry.Name,
Protein.names, Fold_change, adj.P.Val)) |>
dplyr::arrange(desc(In_EE), adj.P.Val, Fold_change) |>
gt(
groupname_col = "Condition",
rowname_col = "In_EE"
) |>
fmt_number(decimals = 3) |>
tab_header(
title = "All - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only)",
subtitle = "2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by all)"
) |>
tab_options(table.font.size=11.5,
stub.font.weight = "bold",
row_group.font.weight = "bold",
row_group.font.size = 12.5,
column_labels.font.size = 12.5,
column_labels.font.weight = "bold")
| All - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only) | ||||||
| 2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by all) | ||||||
| Gene_name | Entry | Entry.Name | Protein.names | Fold_change | adj.P.Val | |
|---|---|---|---|---|---|---|
| all | ||||||
| up | Slc9a1 | P26431 | SL9A1_RAT | Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | 0.908 | 0.001 |
| up | H1-0 | P43278 | H10_RAT | Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] | 0.972 | 0.001 |
| up | Map6 | Q63560 | MAP6_RAT | Microtubule-associated protein 6 (MAP-6) (145-kDa STOP) (STOP145) (Stable tubule-only polypeptide) (STOP) | 0.997 | 0.001 |
| up | Tsr2 | A0A8I5ZLR7 | A0A8I5ZLR7_RAT | Pre-rRNA-processing protein TSR2 homolog | 1.030 | 0.001 |
| up | Ptprn2 | Q63475 | PTPR2_RAT | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (PTP NE-6) (PTPNE6) (Phogrin) [Cleaved into: IA-2beta60] | 1.138 | 0.001 |
| up | Psip1 | Q812D1 | PSIP1_RAT | PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) | 1.197 | 0.001 |
| up | Txn | P11232 | THIO_RAT | Thioredoxin (Trx) | 1.212 | 0.001 |
| up | Chchd4 | Q5BJN5 | MIA40_RAT | Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) | 1.224 | 0.001 |
| up | Wasl | O08816 | WASL_RAT | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | 1.248 | 0.001 |
| up | Tceal5 | A0ABK0KXI7 | A0ABK0KXI7_RAT | Transcription elongation factor A like 5 | 1.311 | 0.001 |
| up | Sod1 | P07632 | SODC_RAT | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) | 1.346 | 0.001 |
| up | Hdgfl3 | Q923W4 | HDGR3_RAT | Hepatoma-derived growth factor-related protein 3 (HRP-3) | 1.349 | 0.001 |
| up | Bag3 | A6IA08 | A6IA08_RAT | BAG family molecular chaperone regulator 3 (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) | 1.379 | 0.001 |
| up | Atp5pf | P21571 | ATP5J_RAT | ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) | 1.447 | 0.001 |
| up | Rph3a | P47709 | RP3A_RAT | Rabphilin-3A (Exophilin-1) | 0.899 | 0.001 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.929 | 0.001 |
| up | Akap12 | Q5QD51 | AKA12_RAT | A-kinase anchor protein 12 (AKAP-12) | 1.071 | 0.001 |
| up | Cdkn1b | O08769 | O08769_RAT | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | 0.859 | 0.001 |
| up | Basp1 | Q05175 | BASP1_RAT | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | 0.921 | 0.001 |
| up | Slc32a1 | O35458 | VIAAT_RAT | Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (rGVAT) (rat UNC-47 homolog) (RUNC-47) | 1.017 | 0.001 |
| up | Ythdf3 | A0A8I6ACC2 | A0A8I6ACC2_RAT | YTH domain-containing family protein | 1.135 | 0.001 |
| up | Nfu1 | D3ZA85 | D3ZA85_RAT | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5) | 1.257 | 0.001 |
| up | Cltb | P08082 | CLCB_RAT | Clathrin light chain B (Lcb) | 1.272 | 0.001 |
| up | Bsn | O88778 | BSN_RAT | Protein bassoon | 0.853 | 0.001 |
| up | Fabp3 | P07483 | FABPH_RAT | Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) | 0.864 | 0.001 |
| up | Vgf | P20156 | VGF_RAT | Neurosecretory protein VGF (VGF8a protein) [Cleaved into: VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-11; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-30; VGF-derived peptide TLQP-62; VGF-derived peptide HFHH-10; VGF-derived peptide AQEE-30; VGF-derived peptide LQEQ-19] | 1.213 | 0.001 |
| up | Clta | P08081 | CLCA_RAT | Clathrin light chain A (Lca) | 1.052 | 0.001 |
| up | Amph | O08838 | AMPH_RAT | Amphiphysin | 1.055 | 0.001 |
| up | Ppp1r11 | Q6MFY6 | PP1RB_RAT | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Protein phosphatase 1 regulatory subunit 11) | 1.157 | 0.001 |
| up | Map1a | P34926 | MAP1A_RAT | Microtubule-associated protein 1A (MAP-1A) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | 1.106 | 0.001 |
| up | Ppp1r1b | Q6J4I0 | PPR1B_RAT | Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) | 1.160 | 0.001 |
| up | Pclo | Q9JKS6 | PCLO_RAT | Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) | 1.048 | 0.001 |
| up | Bod1 | Q6AYJ2 | BOD1_RAT | Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) | 1.122 | 0.001 |
| up | Gap43 | P07936 | NEUM_RAT | Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Protein F1) | 1.128 | 0.002 |
| up | Rbmx | Q4V898 | RBMX_RAT | RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) (RNA-binding motif protein, X chromosome retrogene) (RNA-binding motif protein, X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | 0.805 | 0.002 |
| up | Gfer | Q63042 | ALR_RAT | FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) | 1.158 | 0.002 |
| up | Efhd2 | Q4FZY0 | EFHD2_RAT | EF-hand domain-containing protein D2 (Swiprosin-1) | 1.592 | 0.002 |
| up | Fam169a | D3ZKX8 | D3ZKX8_RAT | Family with sequence similarity 169, member A | 0.796 | 0.002 |
| up | Sarnp | Q498U4 | SARNP_RAT | SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1) | 1.043 | 0.002 |
| up | Tppp3 | Q5PPN5 | TPPP3_RAT | Tubulin polymerization-promoting protein family member 3 | 1.141 | 0.002 |
| up | Hspe1 | P26772 | CH10_RAT | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) | 1.325 | 0.002 |
| up | Tsc22d1 | P62501 | T22D1_RAT | TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | 1.303 | 0.002 |
| up | Eif4b | A0ABK0LP36 | A0ABK0LP36_RAT | Eukaryotic translation initiation factor 4B | 0.942 | 0.002 |
| up | Zfp428 | A0A0G2K1B1 | A0A0G2K1B1_RAT | Zinc finger protein 428 | 1.316 | 0.002 |
| up | Gprin1 | A0A8I6AJM0 | A0A8I6AJM0_RAT | G protein-regulated inducer of neurite outgrowth 1 | 1.456 | 0.002 |
| up | Wipf3 | Q9Z0G8 | WIPF3_RAT | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16) | 1.002 | 0.002 |
| up | Glrx5 | D4ADD7 | D4ADD7_RAT | Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5) | 0.867 | 0.002 |
| up | Polr2m | Q91XQ4 | GRL1A_RAT | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | 1.209 | 0.002 |
| up | Fkbp3 | G3V6L9 | G3V6L9_RAT | peptidylprolyl isomerase (EC 5.2.1.8) | 0.635 | 0.002 |
| up | Naca | M0R9L0 | M0R9L0_RAT | Nascent polypeptide associated complex subunit alpha | 0.898 | 0.002 |
| up | Tmpo | Q62733 | LAP2_RAT | Lamina-associated polypeptide 2, isoform beta (Thymopoietin isoform beta) (TP beta) | 0.985 | 0.002 |
| up | Rgs10 | P49806 | RGS10_RAT | Regulator of G-protein signaling 10 (RGS10) | 1.180 | 0.002 |
| up | Marcks | P30009 | MARCS_RAT | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein) | 1.210 | 0.002 |
| up | Atp6v1g1 | A0A8I6B3N3 | A0A8I6B3N3_RAT | V-type proton ATPase subunit G | 0.696 | 0.002 |
| up | Pdap1 | Q62785 | HAP28_RAT | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | 1.085 | 0.002 |
| up | Rad23b | Q4KMA2 | RD23B_RAT | UV excision repair protein RAD23 homolog B | 1.217 | 0.002 |
| up | Chgb | O35314 | SCG1_RAT | Secretogranin-1 (Chromogranin-B) (CgB) (Glucagonoma peptide) (Secretogranin-I) (SgI) [Cleaved into: PE-11; CCB peptide short form; CCB peptide long form] | 1.230 | 0.002 |
| up | Zdhhc5 | Q2THW7 | ZDHC5_RAT | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) | 1.668 | 0.002 |
| up | Lmtk3 | F1LSB5 | F1LSB5_RAT | non-specific serine/threonine protein kinase (EC 2.7.11.1) | 0.871 | 0.002 |
| up | Slc39a10 | A0A1W2Q626 | A0A1W2Q626_RAT | Solute carrier family 39 member 10 | 1.073 | 0.002 |
| up | Nherf1 | Q9JJ19 | NHRF1_RAT | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | 1.157 | 0.002 |
| up | Cplx2 | P84087 | CPLX2_RAT | Complexin-2 (Complexin II) (CPX II) (Synaphin-1) | 0.920 | 0.002 |
| up | Habp4 | A1L1K8 | HABP4_RAT | Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) | 0.595 | 0.002 |
| up | Bola1 | Q06C60 | Q06C60_RAT | BolA-like protein 1 | 0.760 | 0.002 |
| up | Atp5if1 | Q03344 | ATIF1_RAT | ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) | 1.143 | 0.002 |
| up | Cttn | Q66HL2 | SRC8_RAT | Src substrate cortactin | 0.835 | 0.002 |
| up | Nsfl1c | O35987 | NSF1C_RAT | NSFL1 cofactor p47 (XY body-associated protein XY40) (p97 cofactor p47) | 0.873 | 0.003 |
| up | Ensa | P60841 | ENSA_RAT | Alpha-endosulfine (ARPP-19e) | 1.225 | 0.003 |
| up | Ndufv3 | Q6PCU8 | NDUV3_RAT | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) | 1.120 | 0.003 |
| up | Ubap2l | A0A8I5ZUK2 | A0A8I5ZUK2_RAT | Ubiquitin associated protein 2-like | 0.950 | 0.003 |
| up | Abl2 | F1M0N1 | F1M0N1_RAT | Tyrosine-protein kinase (EC 2.7.10.2) | 1.060 | 0.003 |
| up | Serbp1 | Q6AXS5 | SERB1_RAT | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) (RDA288) | 0.869 | 0.003 |
| up | Map1b | P15205 | MAP1B_RAT | Microtubule-associated protein 1B (MAP-1B) (Neuraxin) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | 0.926 | 0.003 |
| up | Smap | NA | NA | NA | 1.591 | 0.003 |
| up | 2900026A02Rik | NA | NA | NA | 0.612 | 0.003 |
| up | Eif3j1 | NA | NA | NA | 0.811 | 0.003 |
| up | Rplp2 | P02401 | RLA2_RAT | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) | 1.473 | 0.003 |
| up | Txndc17 | A0ABK0M2Q2 | A0ABK0M2Q2_RAT | Thioredoxin domain containing 17 | 2.030 | 0.003 |
| up | Scg2 | P10362 | SCG2_RAT | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | 1.071 | 0.003 |
| up | Gm2a | A0A8I6A5G9 | A0A8I6A5G9_RAT | Ganglioside GM2 activator | 1.107 | 0.003 |
| up | Ubqln1 | Q9JJP9 | UBQL1_RAT | Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) | 1.142 | 0.003 |
| up | Stmn1 | P13668 | STMN1_RAT | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Pr22 protein) (Prosolin) (pp17) | 1.681 | 0.003 |
| up | Ndufab1 | D3ZF13 | D3ZF13_RAT | Acyl carrier protein | 1.190 | 0.003 |
| up | Prrt2 | D3ZFB6 | PRRT2_RAT | Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3) | 1.310 | 0.003 |
| up | Srrm2 | A0A8I6A2Y2 | A0A8I6A2Y2_RAT | Serine/arginine repetitive matrix 2 | 1.060 | 0.003 |
| up | Ybx1 | P62961 | YBOX1_RAT | Y-box-binding protein 1 (YB-1) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | 1.303 | 0.003 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.706 | 0.004 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.706 | 0.004 |
| up | Snca | P37377 | SYUA_RAT | Alpha-synuclein | 0.909 | 0.004 |
| up | Dek | Q6AXS3 | DEK_RAT | Protein DEK | 0.683 | 0.004 |
| up | Lbh | A0ABK0L5J9 | A0ABK0L5J9_RAT | LBH regulator of WNT signaling pathway | 1.557 | 0.004 |
| up | Psmd9 | Q9WTV5 | PSMD9_RAT | 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) (Transactivating protein Bridge-1) | 0.716 | 0.004 |
| up | Oxsr1 | A0A8I5ZNK2 | OXSR1_RAT | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | 0.722 | 0.004 |
| up | Sf1 | F1LM37 | F1LM37_RAT | Splicing factor 1 | 0.934 | 0.004 |
| up | Tpm1 | P04692 | TPM1_RAT | Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) | 1.189 | 0.004 |
| up | Mical3 | D3ZGN7 | D3ZGN7_RAT | F-actin monooxygenase (EC 1.14.13.225) | 0.857 | 0.004 |
| up | Fkbp2 | A0A8I6GH88 | A0A8I6GH88_RAT | peptidylprolyl isomerase (EC 5.2.1.8) | 0.707 | 0.004 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.849 | 0.004 |
| up | Hdgfl2 | Q925G1 | HDGR2_RAT | Hepatoma-derived growth factor-related protein 2 (HRP-2) (Hepatoma-derived growth factor 3) (HDGF-3) | 0.720 | 0.004 |
| up | Calb2 | P47728 | CALB2_RAT | Calretinin (CR) | 0.981 | 0.004 |
| up | Ptpn23 | O88902 | PTN23_RAT | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | 0.982 | 0.004 |
| up | Cnpy3 | A0A8I6A0W3 | A0A8I6A0W3_RAT | Protein canopy homolog 3 | 0.978 | 0.004 |
| up | Washc2 | Q80X08 | WASC2_RAT | WASH complex subunit 2 | 0.669 | 0.004 |
| up | Lrpap1 | Q99068 | AMRP_RAT | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Gp330-binding 45 kDa protein) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | 0.796 | 0.004 |
| up | Cfdp1 | Q75UQ2 | CFDP1_RAT | Craniofacial development protein 1 (Bucentaur) | 0.911 | 0.004 |
| up | Fabp7 | P55051 | FABP7_RAT | Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) | 1.535 | 0.004 |
| up | Tppp | D3ZQL7 | TPPP_RAT | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p25-alpha) | 0.557 | 0.004 |
| up | Drap1 | A0JPP1 | NC2A_RAT | Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) | 0.781 | 0.004 |
| up | Tpm4 | P09495 | TPM4_RAT | Tropomyosin alpha-4 chain (Tropomyosin-4) (TM-4) | 0.837 | 0.004 |
| up | Pcnp | Q7TP40 | PCNP_RAT | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) (Liver regeneration-related protein LRRG084) | 1.118 | 0.005 |
| up | Rims1 | Q9JIR4 | RIMS1_RAT | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) | 0.541 | 0.005 |
| up | Prrt3 | D3ZWQ0 | D3ZWQ0_RAT | Proline-rich transmembrane protein 3 | 0.799 | 0.005 |
| up | Gcsh | Q5I0P2 | GCSH_RAT | Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein) | 1.190 | 0.005 |
| up | Sdc4 | P34901 | SDC4_RAT | Syndecan-4 (SYND4) (Ryudocan core protein) | 0.995 | 0.005 |
| up | Endod1 | D3ZIP8 | D3ZIP8_RAT | Endonuclease domain containing 1 | 0.610 | 0.005 |
| up | Larp1 | A0A8I6GJC3 | A0A8I6GJC3_RAT | La ribonucleoprotein 1, translational regulator | 0.977 | 0.005 |
| up | Alb | P02770 | ALBU_RAT | Albumin | 0.979 | 0.005 |
| up | Mapre1 | Q66HR2 | MARE1_RAT | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | 0.590 | 0.005 |
| up | Scp2 | P11915 | SCP2_RAT | Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (Sterol carrier protein X) (SCP-X) | 0.596 | 0.005 |
| up | Hcn1 | Q9JKB0 | HCN1_RAT | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 0.777 | 0.005 |
| up | Prkcsh | A0A8I6G8K5 | A0A8I6G8K5_RAT | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) | 0.647 | 0.005 |
| up | Hgs | Q9JJ50 | HGS_RAT | Hepatocyte growth factor-regulated tyrosine kinase substrate (SNAP-25-interacting protein Hrs-2) | 0.680 | 0.005 |
| up | Lasp1 | Q99MZ8 | LASP1_RAT | LIM and SH3 domain protein 1 (LASP-1) | 0.748 | 0.005 |
| up | Rabl6 | D3ZKQ4 | D3ZKQ4_RAT | Rab-like protein 6 (GTP-binding protein Parf) (Rab-like protein 1) | 1.159 | 0.005 |
| up | Bcas1 | Q3ZB98 | BCAS1_RAT | Breast carcinoma-amplified sequence 1 homolog (Protein whose mRNA is enriched in synaptosomes 2) (Pmes-2) | 0.796 | 0.005 |
| up | Prrc2c | A0A8I5Y7A0 | A0A8I5Y7A0_RAT | Proline-rich coiled-coil 2C | 0.873 | 0.005 |
| up | Chmp5 | Q4QQV8 | CHMP5_RAT | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) | 1.164 | 0.005 |
| up | Cstf2 | B4F7F1 | B4F7F1_RAT | Cleavage stimulation factor subunit 2 (Cstf2 protein) | 0.827 | 0.005 |
| up | Stip1 | O35814 | STIP1_RAT | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) | 0.625 | 0.005 |
| up | Cd99l2 | Q8R1R5 | C99L2_RAT | CD99 antigen-like protein 2 (MIC2-like protein 1) (Rhombencephalic expression protein 40 kDa) (Protein rhombex-40) (CD antigen CD99) | 0.751 | 0.005 |
| up | Hmgn5 | B4F777 | HMGN5_RAT | High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1) | 0.960 | 0.005 |
| up | H1-4 | P15865 | H14_RAT | Histone H1.4 (H1d) | 1.005 | 0.005 |
| up | Pcsk1n | Q9QXU9 | PCS1N_RAT | ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; PEN-20; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] | 1.525 | 0.005 |
| up | Zbed5 | D3ZTR5 | D3ZTR5_RAT | Zinc finger BED-type containing 5 | 1.107 | 0.006 |
| up | Acin1 | E9PST5 | E9PST5_RAT | Apoptotic chromatin condensation inducer in the nucleus | 0.870 | 0.006 |
| up | Btf3 | F7EZE5 | F7EZE5_RAT | Transcription factor BTF3 | 0.830 | 0.006 |
| up | Vsnl1 | P62762 | VISL1_RAT | Visinin-like protein 1 (VILIP) (21 kDa CABP) (Neural visinin-like protein 1) (NVL-1) (NVP-1) | 0.847 | 0.006 |
| up | Ermn | Q5RJL0 | ERMIN_RAT | Ermin (Juxtanodin) (JN) | 1.067 | 0.006 |
| up | Mrpl12 | D3ZXF9 | D3ZXF9_RAT | Large ribosomal subunit protein bL12m (39S ribosomal protein L12, mitochondrial) | 1.353 | 0.007 |
| up | Fgf12 | P61150 | FGF12_RAT | Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) | 0.746 | 0.007 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.766 | 0.007 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.766 | 0.007 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.766 | 0.007 |
| up | Cst3 | P14841 | CYTC_RAT | Cystatin-C (Cystatin-3) | 0.559 | 0.007 |
| up | Lin7a | Q9Z250 | LIN7A_RAT | Protein lin-7 homolog A (Lin-7A) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1) | 0.581 | 0.007 |
| up | C1qbp | O35796 | C1QBP_RAT | Complement component 1 Q subcomponent-binding protein, mitochondrial (GC1q-R protein) (Glycoprotein gC1qBP) (C1qBP) | 0.797 | 0.007 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.196 | 0.007 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.196 | 0.007 |
| up | Snap25 | P60881 | SNP25_RAT | Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) | 0.570 | 0.008 |
| up | Rbm3 | Q925G0 | RBM3_RAT | RNA-binding protein 3 (RNA-binding motif protein 3) | 0.663 | 0.008 |
| up | Myl6 | Q64119 | MYL6_RAT | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | 0.629 | 0.008 |
| up | Fkbp1a | Q62658 | FKB1A_RAT | Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) | 0.547 | 0.008 |
| up | Scg3 | P47868 | SCG3_RAT | Secretogranin-3 (1B1075) (Secretogranin III) (SgIII) | 0.727 | 0.008 |
| up | Timm8a1 | A6IVF6 | A6IVF6_RAT | Mitochondrial import inner membrane translocase subunit | 1.052 | 0.008 |
| up | Tfg | Q4R1A4 | Q4R1A4_RAT | TRK-fused gene protein (Trafficking from ER to golgi regulator) | 0.466 | 0.008 |
| up | Tcea1 | Q4KLL0 | TCEA1_RAT | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) | 0.623 | 0.008 |
| up | Ndufs8 | A0A8I6AL00 | A0A8I6AL00_RAT | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) | 0.641 | 0.008 |
| up | Npc2 | A0A8I6AWS0 | A0A8I6AWS0_RAT | NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) | 0.728 | 0.008 |
| up | Tbc1d10b | D3ZSY8 | D3ZSY8_RAT | TBC1 domain family, member 10b | 0.587 | 0.009 |
| up | Uqcrh | Q5M9I5 | QCR6_RAT | Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) | 0.722 | 0.009 |
| up | Fubp1 | Q32PX7 | FUBP1_RAT | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) | 1.121 | 0.009 |
| up | Sparcl1 | P24054 | SPRL1_RAT | SPARC-like protein 1 (Matrix glycoprotein Sc1) | 0.740 | 0.009 |
| up | Mrrf | Q5RKI9 | RRFM_RAT | Ribosome-recycling factor, mitochondrial (RRF) (Ribosome-releasing factor, mitochondrial) | 0.799 | 0.009 |
| up | Epn1 | O88339 | EPN1_RAT | Epsin-1 (EPS-15-interacting protein 1) | 0.518 | 0.009 |
| up | Syn3 | O70441 | SYN3_RAT | Synapsin-3 (Synapsin III) | 0.688 | 0.010 |
| up | Tceal3 | M0RBL8 | M0RBL8_RAT | Transcription elongation factor A like 3 (Transcription elongation factor A like 6) | 0.896 | 0.010 |
| up | Pafah1b2 | O35264 | PA1B2_RAT | Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) (Platelet-activating factor acetylhydrolase alpha 2 subunit) (PAF-AH alpha 2) | 0.898 | 0.010 |
| up | Pnpo | O88794 | PNPO_RAT | Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) | 0.419 | 0.010 |
| up | Dctn2 | Q6AYH5 | DCTN2_RAT | Dynactin subunit 2 | 0.409 | 0.010 |
| up | Chmp1a | A0A8I6GLB8 | A0A8I6GLB8_RAT | Charged multivesicular body protein 1A | 0.790 | 0.010 |
| up | Dbi | P11030 | ACBP_RAT | Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) [Cleaved into: Triakontatetraneuropeptide (TTN); Octadecaneuropeptide (ODN)] | 1.549 | 0.011 |
| up | Apoe | P02650 | APOE_RAT | Apolipoprotein E (Apo-E) | 0.736 | 0.011 |
| up | Elob | P62870 | ELOB_RAT | Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) | 0.430 | 0.011 |
| up | Dnajc5 | P60905 | DNJC5_RAT | DnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP) | 0.564 | 0.011 |
| up | Gpc1 | P35053 | GPC1_RAT | Glypican-1 (HSPG M12) [Cleaved into: Secreted glypican-1] | 0.523 | 0.011 |
| up | Camk2n1 | Q9JI15 | CK2N1_RAT | Calcium/calmodulin-dependent protein kinase II inhibitor 1 (calcium/calmodulin-dependent protein kinase II inhibitor alpha) (CaM-KIINalpha) (CaMKIINalpha) | 0.923 | 0.011 |
| up | Khdrbs3 | Q9JLP1 | KHDR3_RAT | KH domain-containing, RNA-binding, signal transduction-associated protein 3 (Sam68-like mammalian protein 2) (SLM-2) (rSLM-2) | 0.581 | 0.011 |
| up | Cnst | A0A8I5ZKG8 | A0A8I5ZKG8_RAT | Consortin, connexin sorting protein | 0.907 | 0.011 |
| up | Mbp | P02688 | MBP_RAT | Myelin basic protein (MBP) | 0.758 | 0.011 |
| up | Rida | P52759 | RIDA_RAT | 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Liver perchloric acid-soluble protein) (L-PSP) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (UK114 antigen homolog) (rp14.5) | 0.593 | 0.012 |
| up | Zyx | A0A8I6AV84 | A0A8I6AV84_RAT | Zyxin | 1.211 | 0.012 |
| up | Set | Q63945 | SET_RAT | Protein SET (Liver regeneration-related protein LRRGR00002) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | 1.030 | 0.012 |
| up | Ndel1 | Q78PB6 | NDEL1_RAT | Nuclear distribution protein nudE-like 1 (Protein Nudel) | 1.070 | 0.012 |
| up | Lgals1 | P11762 | LEG1_RAT | Galectin-1 (Gal-1) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (RL 14.5) (S-Lac lectin 1) | 0.765 | 0.012 |
| up | Ppp1r2 | P50411 | IPP2_RAT | Protein phosphatase inhibitor 2 (IPP-2) | 0.862 | 0.012 |
| up | Trmt112 | B2RYS9 | B2RYS9_RAT | Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) | 0.545 | 0.012 |
| up | Tom1l2 | A0A8I5ZP70 | A0A8I5ZP70_RAT | Target of myb1 like 2 membrane trafficking protein | 0.522 | 0.013 |
| up | Epb41l2 | A0A0G2K162 | A0A0G2K162_RAT | Erythrocyte membrane protein band 4.1-like 2 | 0.621 | 0.013 |
| up | Lsm3 | D4A7U6 | D4A7U6_RAT | U6 snRNA-associated Sm-like protein LSm3 | 0.555 | 0.013 |
| up | Homer3 | Q9Z2X5 | HOME3_RAT | Homer protein homolog 3 (Homer-3) (VASP/Ena-related gene up-regulated during seizure and LTP 3) (Vesl-3) | 0.469 | 0.013 |
| up | Rps18-ps6 | NA | NA | NA | 0.511 | 0.013 |
| up | Omg | F7EYB9 | F7EYB9_RAT | Oligodendrocyte-myelin glycoprotein | 0.576 | 0.013 |
| up | Hnrnpab | A6HE59 | A6HE59_RAT | Heterogeneous nuclear ribonucleoprotein A/B | 0.993 | 0.013 |
| up | Rps25 | P62853 | RS25_RAT | Small ribosomal subunit protein eS25 (40S ribosomal protein S25) | 0.841 | 0.013 |
| up | Pex14 | Q642G4 | PEX14_RAT | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | 1.005 | 0.013 |
| up | Cdv3 | Q5XIM5 | CDV3_RAT | Protein CDV3 homolog | 1.017 | 0.013 |
| up | Pgrmc1 | P70580 | PGRC1_RAT | Membrane-associated progesterone receptor component 1 (mPR) (25-DX) (Acidic 25 kDa protein) (Ventral midline antigen) (VEMA) | 0.627 | 0.013 |
| up | Bnip3l | A6K6N6 | A6K6N6_RAT | BCL2 interacting protein 3 like (BCL2/adenovirus E1B interacting protein 3-like) | 1.187 | 0.013 |
| up | Gpr158 | D4A6L0 | MGLYR_RAT | Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158) | 0.581 | 0.013 |
| up | Ahnak | A0A0G2JUA5 | A0A0G2JUA5_RAT | AHNAK nucleoprotein | 0.865 | 0.013 |
| up | Shfl | Q5RJN4 | SHFL_RAT | Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog (SHFL) (Repressor of yield of DENV protein homolog) (RyDEN) | 0.692 | 0.013 |
| up | Nebl | D4A164 | D4A164_RAT | Nebulette | 0.618 | 0.014 |
| up | Cul4b | D3ZK73 | D3ZK73_RAT | Cullin-4B | 0.906 | 0.014 |
| up | Abraxas2 | D4A415 | D4A415_RAT | Abraxas 2, BRISC complex subunit | 1.196 | 0.014 |
| up | Eif4h | Q5XI72 | IF4H_RAT | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein homolog) | 0.964 | 0.014 |
| up | Atxn2l | A0A0G2JYE0 | A0A0G2JYE0_RAT | Ataxin 2-like | 0.770 | 0.014 |
| up | Reps1 | A0A0G2JZY3 | A0A0G2JZY3_RAT | RALBP1 associated Eps domain containing 1 | 0.788 | 0.014 |
| up | Alyref | M0RBB1 | M0RBB1_RAT | Aly/REF export factor | 0.458 | 0.014 |
| up | Marcksl1 | Q9EPH2 | MRP_RAT | MARCKS-related protein (Brain protein F52) (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | 1.472 | 0.014 |
| up | Rad23a | F7FJT3 | F7FJT3_RAT | UV excision repair protein RAD23 | 0.757 | 0.014 |
| up | Negr1 | Q9Z0J8 | NEGR1_RAT | Neuronal growth regulator 1 (Kindred of IgLON) (Kilon) | 0.422 | 0.014 |
| up | Evl | O08719 | EVL_RAT | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | 1.174 | 0.015 |
| up | Ube2n | Q9EQX9 | UBE2N_RAT | Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) | 0.365 | 0.015 |
| up | Dtd1 | A0A8I6A4Q0 | A0A8I6A4Q0_RAT | D-aminoacyl-tRNA deacylase (EC 3.1.1.96) | 0.624 | 0.015 |
| up | Dbndd2 | A0ABK0LCG8 | A0ABK0LCG8_RAT | Uncharacterized protein | 0.897 | 0.015 |
| up | Cnot3 | D3ZUV9 | D3ZUV9_RAT | CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) | 0.927 | 0.015 |
| up | Ndufs4 | Q5XIF3 | NDUS4_RAT | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (NADH-ubiquinone oxidoreductase 18 kDa subunit) | 0.442 | 0.015 |
| up | Caprin1 | Q5M9G3 | CAPR1_RAT | Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (RNA granule protein 105) | 0.663 | 0.015 |
| up | Atp6v1f | P50408 | VATF_RAT | V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F) | 0.525 | 0.015 |
| up | Ppp1r12a | Q10728 | MYPT1_RAT | Protein phosphatase 1 regulatory subunit 12A (MBSP) (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) (Protein phosphatase subunit 1M) (PP-1M) (Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110) | 0.578 | 0.015 |
| up | Tpd52l2 | Q6PCT3 | TPD54_RAT | Tumor protein D54 (Tumor protein D52-like 2) | 0.515 | 0.015 |
| up | Sgtb | Q80W98 | SGTB_RAT | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | 0.559 | 0.015 |
| up | Cacna1b | Q02294 | CAC1B_RAT | Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) | 0.656 | 0.016 |
| up | Clip2 | O55156 | CLIP2_RAT | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) | 0.581 | 0.016 |
| up | Tjp1 | A0A0G2K2P5 | ZO1_RAT | Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) | 0.741 | 0.016 |
| up | Carmil2 | D3ZC15 | D3ZC15_RAT | Capping protein regulator and myosin 1 linker 2 | 0.464 | 0.016 |
| up | Tpm3-rs7 | NA | NA | NA | 1.875 | 0.016 |
| up | Tpm3 | Q63610 | TPM3_RAT | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) | 1.110 | 0.016 |
| up | Chchd6 | D4A7N1 | MIC25_RAT | MICOS complex subunit Mic25 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) | 0.650 | 0.016 |
| up | Cbx1 | A0A8I5ZM96 | A0A8I5ZM96_RAT | Chromobox 1 | 0.936 | 0.017 |
| up | Znf207 | NA | NA | NA | 1.004 | 0.019 |
| up | Sh3bgrl3 | B2RZ27 | SH3L3_RAT | SH3 domain-binding glutamic acid-rich-like protein 3 (TNF inhibitory protein B1) (TIP-B1) | 1.155 | 0.019 |
| up | Map1s | P0C5W1 | MAP1S_RAT | Microtubule-associated protein 1S (MAP-1S) [Cleaved into: MAP1S heavy chain; MAP1S light chain] | 0.847 | 0.019 |
| up | Lnpk | A0JN29 | A0JN29_RAT | Endoplasmic reticulum junction formation protein lunapark | 0.418 | 0.019 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.435 | 0.019 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.435 | 0.019 |
| up | Ogfrl1 | Q4KLH3 | OGRL1_RAT | Opioid growth factor receptor-like protein 1 | 0.696 | 0.020 |
| up | Ubqln2 | D4AA63 | D4AA63_RAT | Ubiquilin 2 | 0.899 | 0.020 |
| up | Lrrc59 | Q5RJR8 | LRC59_RAT | Leucine-rich repeat-containing protein 59 (Protein p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] | 0.459 | 0.020 |
| up | Khsrp | Q99PF5 | FUBP2_RAT | Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (MAP2 RNA trans-acting protein 1) (MARTA1) | 0.381 | 0.020 |
| up | Fam131b | Q568Z1 | F131B_RAT | Protein FAM131B | 0.720 | 0.020 |
| up | Isca2 | D4A4L5 | D4A4L5_RAT | Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1) | 0.539 | 0.020 |
| up | Pacsin1 | Q9Z0W5 | PACN1_RAT | Protein kinase C and casein kinase substrate in neurons protein 1 (Dynamin proline-rich domain-interacting protein) (Dynamin PRD-interacting protein) (Synaptic, dynamin-associated protein I) (Syndapin-1) (Syndapin-I) (SdpI) | 0.452 | 0.020 |
| up | Bag4 | A0ABZ3NN99 | A0ABZ3NN99_RAT | BAG cochaperone 4 | 0.481 | 0.020 |
| up | Trp53bp1 | NA | NA | NA | 0.513 | 0.021 |
| up | Mast1 | Q810W7 | MAST1_RAT | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | 0.949 | 0.021 |
| up | Fgf1 | P61149 | FGF1_RAT | Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Heparin-binding growth factor 1) (HBGF-1) | 0.377 | 0.021 |
| up | Safb | O88453 | SAFB1_RAT | Scaffold attachment factor B1 (SAF-B) (SAF-B1) | 0.404 | 0.021 |
| up | Zc3h4 | D3ZVW3 | D3ZVW3_RAT | Zinc finger CCCH domain-containing protein 4 | 1.322 | 0.022 |
| up | Sgta | O70593 | SGTA_RAT | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 1) | 0.416 | 0.022 |
| up | Atp5f1d | P35434 | ATPD_RAT | ATP synthase F(1) complex subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit) | 1.219 | 0.022 |
| up | Cyb5a | P00173 | CYB5_RAT | Cytochrome b5 | 0.734 | 0.022 |
| up | 4833439L19Rik | NA | NA | NA | 0.778 | 0.022 |
| up | Tpr | F1MA98 | TPR_RAT | Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) | 0.655 | 0.023 |
| up | Pym1 | A0A8I6GKW1 | A0A8I6GKW1_RAT | PYM homolog 1, exon junction complex associated factor | 1.022 | 0.023 |
| up | Wipf2 | D3ZUD3 | D3ZUD3_RAT | WAS/WASL interacting protein family, member 2 | 0.645 | 0.023 |
| up | Pea15 | Q5U318 | PEA15_RAT | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) | 0.591 | 0.023 |
| up | Shank2 | Q9QX74 | SHAN2_RAT | SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3) | 0.417 | 0.024 |
| up | Coa7 | D4AC65 | D4AC65_RAT | Cytochrome c oxidase assembly factor 7 | 1.009 | 0.024 |
| up | Asap1 | Q1AAU6 | ASAP1_RAT | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | 0.884 | 0.024 |
| up | Nenf | Q6IUR5 | NENF_RAT | Neudesin (Neuron-derived neurotrophic factor) (SCIRP10-related protein) (Spinal cord injury-related protein 10) | 0.969 | 0.024 |
| up | Hyou1 | Q63617 | HYOU1_RAT | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) | 0.524 | 0.024 |
| up | Srsf1 | D4A9L2 | D4A9L2_RAT | Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1) | 0.429 | 0.024 |
| up | Map7 | A0A0G2KB52 | A0A0G2KB52_RAT | Microtubule-associated protein 7 | 0.583 | 0.024 |
| up | Pebp1 | P31044 | PEBP1_RAT | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (23 kDa morphine-binding protein) (HCNPpp) (P23K) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | 0.350 | 0.025 |
| up | Dmtn | A0A8I5ZXT2 | A0A8I5ZXT2_RAT | Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) | 0.355 | 0.025 |
| up | Cspg5 | Q9ERQ6 | CSPG5_RAT | Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C) | 0.377 | 0.025 |
| up | Uqcrb | B2RYS2 | B2RYS2_RAT | Cytochrome b-c1 complex subunit 7 | 0.808 | 0.025 |
| up | Rbm8a | Q27W01 | RBM8A_RAT | RNA-binding protein 8A (RNA-binding motif protein 8A) (Ribonucleoprotein RBM8A) | 0.983 | 0.026 |
| up | Pde4a | P54748 | PDE4A_RAT | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (cAMP-specific phosphodiesterase 4A) | 0.761 | 0.026 |
| up | Sumo2 | P61959 | SUMO2_RAT | Small ubiquitin-related modifier 2 (SUMO-2) (SMT3 homolog 2) (Sentrin-2) (Ubiquitin-like protein SMT3A) (Smt3A) | 1.260 | 0.026 |
| up | Arpin | D4A1B2 | D4A1B2_RAT | Arpin | 0.984 | 0.027 |
| up | Saa1 | NA | NA | NA | 1.485 | 0.027 |
| up | Ptms | P04550 | PTMS_RAT | Parathymosin (Zinc-binding 11.5 kDa protein) | 1.186 | 0.027 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.565 | 0.028 |
| up | Ppp4r2 | D4A8H5 | D4A8H5_RAT | Protein phosphatase 4, regulatory subunit 2 | 0.955 | 0.029 |
| up | Fxn | D3ZYW7 | FRDA_RAT | Frataxin, mitochondrial (Fxn) (EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form; Extramitochondrial frataxin] | 0.906 | 0.029 |
| up | Rps19 | P17074 | RS19_RAT | Small ribosomal subunit protein eS19 (40S ribosomal protein S19) | 1.091 | 0.031 |
| up | Lysmd2 | A0A0G2K146 | A0A0G2K146_RAT | LysM domain containing 2 | 0.690 | 0.031 |
| up | Map7d2 | D4A4L4 | MA7D2_RAT | MAP7 domain-containing protein 2 (Brain-enriched E-MAP-115-like protein) | 0.822 | 0.031 |
| up | Csnk1a1 | P97633 | KC1A_RAT | Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) | 1.128 | 0.032 |
| up | Ndufa7 | A9UMV9 | A9UMV9_RAT | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a) | 0.342 | 0.032 |
| up | Arfgap1 | Q62848 | ARFG1_RAT | ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) | 0.343 | 0.033 |
| up | Ap1m1 | Q32Q06 | AP1M1_RAT | AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) | 0.657 | 0.033 |
| up | Apod | P23593 | APOD_RAT | Apolipoprotein D (Apo-D) (ApoD) | 0.747 | 0.034 |
| up | Nol3 | Q62881 | NOL3_RAT | Nucleolar protein 3 (Apoptosis repressor with CARD) | 0.774 | 0.034 |
| up | Coq8a | Q5BJQ0 | COQ8A_RAT | Atypical kinase COQ8A, mitochondrial (EC 2.7.-.-) (Chaperone activity of bc1 complex-like) (Chaperone-ABC1-like) (Coenzyme Q protein 8A) (aarF domain-containing protein kinase 3) | 0.420 | 0.034 |
| up | Ggt7 | Q99MZ4 | GGT7_RAT | Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain] | 0.422 | 0.036 |
| up | Cbx3 | Q5RJK5 | Q5RJK5_RAT | Chromobox 3 (Chromobox homolog 3 (HP1 gamma homolog, Drosophila)) | 0.534 | 0.036 |
| up | Bcam | Q9ESS6 | BCAM_RAT | Basal cell adhesion molecule (B-CAM cell surface glycoprotein) (Lutheran antigen) (CD antigen CD239) | 0.576 | 0.037 |
| up | Psap | P10960 | SAP_RAT | Prosaposin (Sulfated glycoprotein 1) (SGP-1) [Cleaved into: Saposin-A; Saposin-B-Val; Saposin-B; Saposin-C; Saposin-D] | 0.944 | 0.037 |
| up | Plcl2 | F1M324 | F1M324_RAT | Phosphoinositide phospholipase C (EC 3.1.4.11) | 0.519 | 0.038 |
| up | Cx3cl1 | O55145 | X3CL1_RAT | Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine] | 0.618 | 0.038 |
| up | Cmpk1 | Q4KM73 | KCY_RAT | UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) | 0.760 | 0.038 |
| up | Rwdd1 | Q99ND9 | RWDD1_RAT | RWD domain-containing protein 1 (Small androgen receptor-interacting protein) | 0.919 | 0.038 |
| up | Baiap2 | Q6GMN2 | BAIP2_RAT | BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53) | 0.317 | 0.038 |
| up | Spock2 | A0A8I5ZQG2 | A0A8I5ZQG2_RAT | Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2) | 0.817 | 0.038 |
| up | Thrap3 | Q5M7V8 | TR150_RAT | Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | 0.458 | 0.038 |
| up | Mtdh | Q9Z1W6 | LYRIC_RAT | Protein LYRIC (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | 0.564 | 0.040 |
| up | Lbhd2 | D3ZC31 | D3ZC31_RAT | LBH domain containing 2 | 1.151 | 0.041 |
| up | Ubqln4 | D4A3P1 | D4A3P1_RAT | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) | 0.689 | 0.041 |
| up | Hnrnpd | Q9JJ54 | HNRPD_RAT | Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) | 0.709 | 0.041 |
| up | Itgb1 | P49134 | ITB1_RAT | Integrin beta-1 (Beta oligodendroglia) (Beta OL) (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) | 0.498 | 0.042 |
| up | Akt1s1 | A0A8I5ZRQ9 | A0A8I5ZRQ9_RAT | AKT1 substrate 1 | 1.384 | 0.042 |
| up | Hmgb3 | F7EWK1 | F7EWK1_RAT | High mobility group protein B3 (High mobility group protein 2a) (High mobility group protein 4) | 1.039 | 0.042 |
| up | Acyp2 | P35745 | ACYP2_RAT | Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2) | 0.359 | 0.043 |
| up | Ndufb3 | A0A8I5Y9A4 | A0A8I5Y9A4_RAT | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (NADH-ubiquinone oxidoreductase B12 subunit) | 0.404 | 0.044 |
| up | Hopx | Q78ZR5 | HOP_RAT | Homeodomain-only protein (Global ischemia-induced gene 15B protein) (GIIg15b) (Odd homeobox protein 1) | 0.742 | 0.044 |
| up | Fam219a | D4AAI7 | D4AAI7_RAT | Family with sequence similarity 219, member A | 0.875 | 0.044 |
| up | Fus | Q5PQK2 | Q5PQK2_RAT | RNA-binding protein FUS | 0.425 | 0.044 |
| up | Cnpy2 | A0JN30 | A0JN30_RAT | Canopy FGF signaling regulator 2 | 0.468 | 0.044 |
| up | Slc39a6 | Q4V887 | S39A6_RAT | Zinc transporter ZIP6 (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) | 0.614 | 0.045 |
| up | Ppib | P24368 | PPIB_RAT | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | 0.299 | 0.045 |
| up | Akap5 | P24587 | AKAP5_RAT | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 150 kDa) (AKAP 150) (P150) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | 0.446 | 0.045 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.293 | 0.046 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.293 | 0.046 |
| up | Opcml | P32736 | OPCM_RAT | Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) | 0.372 | 0.046 |
| up | Clu | P05371 | CLUS_RAT | Clusterin (Dimeric acid glycoprotein) (DAG) (Sulfated glycoprotein 2) (SGP-2) (Testosterone repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain; Clusterin alpha chain] | 0.316 | 0.047 |
| up | Nudc | Q63525 | NUDC_RAT | Nuclear migration protein nudC (Nuclear distribution protein C homolog) (c15) | 0.465 | 0.047 |
| up | Rpl23a | P62752 | RL23A_RAT | Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) | 0.383 | 0.048 |
| up | U2af2 | F2Z3T9 | F2Z3T9_RAT | Splicing factor U2AF subunit (U2 snRNP auxiliary factor large subunit) | 1.428 | 0.048 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.820 | 0.048 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.820 | 0.048 |
| up | Mtpn | P62775 | MTPN_RAT | Myotrophin (Granule cell differentiation protein) (Protein V-1) | 0.734 | 0.049 |
| up | Wnk2 | A0A0G2KAS8 | A0A0G2KAS8_RAT | non-specific serine/threonine protein kinase (EC 2.7.11.1) | 0.758 | 0.049 |
| up | Snrpa | Q5U214 | Q5U214_RAT | U1 small nuclear ribonucleoprotein A | 0.557 | 0.049 |
| up | Kalrn | P97924 | KALRN_RAT | Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (PAM COOH-terminal interactor protein 10) (P-CIP10) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) | 0.632 | 0.049 |
| up | Wnk1 | Q9JIH7 | WNK1_RAT | Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) | 0.521 | 0.050 |
| up | Gng2 | A0ABK0LUW9 | A0ABK0LUW9_RAT | G protein subunit gamma 2 | 0.402 | 0.050 |
| down | Drg2 | A0A8I5ZWK0 | A0A8I5ZWK0_RAT | Developmentally-regulated GTP-binding protein 2 (Translation factor GTPase DRG2) | −1.045 | 0.001 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.893 | 0.001 |
| down | Cyb5r1 | Q5EB81 | NB5R1_RAT | NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) | −1.195 | 0.001 |
| down | Unc13a | Q62768 | UN13A_RAT | Protein unc-13 homolog A (Munc13-1) | −1.345 | 0.001 |
| down | Shisa6 | D4A4M0 | D4A4M0_RAT | Shisa family member 6 | −0.812 | 0.001 |
| down | Acadl | P15650 | ACADL_RAT | Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8) | −0.798 | 0.001 |
| down | Rab3a | P63012 | RAB3A_RAT | Ras-related protein Rab-3A (EC 3.6.5.2) | −0.699 | 0.002 |
| down | Ap1b1 | P52303 | AP1B1_RAT | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | −0.818 | 0.002 |
| down | Eipr1 | Q5PPK9 | EIPR1_RAT | EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) | −0.894 | 0.002 |
| down | Dlg3 | Q62936 | DLG3_RAT | Disks large homolog 3 (PSD-95/SAP90-related protein 1) (Synapse-associated protein 102) (SAP-102) (SAP102) | −0.872 | 0.002 |
| down | Rab6a | Q9WVB1 | RAB6A_RAT | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | −1.234 | 0.002 |
| down | Xpo7 | F1LQM9 | F1LQM9_RAT | Exportin 7 | −1.164 | 0.002 |
| down | Actr3b | A0A8I6GL35 | A0A8I6GL35_RAT | Actin related protein 3B | −1.012 | 0.002 |
| down | Ppp1cb | P62142 | PP1B_RAT | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53) | −0.780 | 0.002 |
| down | Kctd12 | A0A8I5Y7I2 | A0A8I5Y7I2_RAT | Potassium channel tetramerization domain containing 12 | −0.706 | 0.002 |
| down | C1qb | P31721 | C1QB_RAT | Complement C1q subcomponent subunit B | −1.236 | 0.002 |
| down | Padi2 | P20717 | PADI2_RAT | Protein-arginine deiminase type-2 (EC 3.5.3.15) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) | −0.818 | 0.002 |
| down | Grin2a | Q00959 | NMDE1_RAT | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) | −1.375 | 0.002 |
| down | Sptbn2 | Q9QWN8 | SPTN2_RAT | Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41) | −0.808 | 0.002 |
| down | Prkcg | P63319 | KPCG_RAT | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | −0.735 | 0.002 |
| down | Ptk2b | P70600 | FAK2_RAT | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) | −0.628 | 0.002 |
| down | Ddx5 | Q6AYI1 | Q6AYI1_RAT | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) | −0.628 | 0.002 |
| down | Twf1 | Q5RJR2 | TWF1_RAT | Twinfilin-1 | −0.851 | 0.002 |
| down | Crym | Q9QYU4 | CRYM_RAT | Ketimine reductase mu-crystallin (EC 1.5.1.25) (1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase) (P2C/Pyr2C reductase) (EC 1.5.1.1) (CDK108) (NADP-regulated thyroid-hormone-binding protein) | −0.591 | 0.002 |
| down | Hsp90aa1 | P82995 | HS90A_RAT | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) | −0.857 | 0.003 |
| down | Camk2b | P08413 | KCC2B_RAT | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | −1.046 | 0.003 |
| down | Agap3 | A0A0G2K2D4 | A0A0G2K2D4_RAT | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (CRAM-associated GTPase) (Centaurin-gamma-3) (MR1-interacting protein) | −0.718 | 0.003 |
| down | Pdk3 | A6IPZ9 | A6IPZ9_RAT | Protein-serine/threonine kinase (EC 2.7.11.-) | −0.593 | 0.003 |
| down | Ganab | D3ZAN3 | D3ZAN3_RAT | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | −0.910 | 0.003 |
| down | Opa3 | A0A8I6AQX4 | A0A8I6AQX4_RAT | Outer mitochondrial membrane lipid metabolism regulator OPA3 | −0.900 | 0.003 |
| down | Actr2 | Q5M7U6 | ARP2_RAT | Actin-related protein 2 (Actin-like protein 2) | −0.583 | 0.003 |
| down | Gnb1 | P54311 | GBB1_RAT | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) | −0.674 | 0.003 |
| down | Slc2a1 | P11167 | GTR1_RAT | Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) | −0.663 | 0.003 |
| down | Lgi1 | Q8K4Y5 | LGI1_RAT | Leucine-rich glioma-inactivated protein 1 | −0.601 | 0.003 |
| down | Sfxn5 | Q8CFD0 | SFXN5_RAT | Sideroflexin-5 (Tricarboxylate carrier BBG-TCC) | −0.541 | 0.003 |
| down | Rps16 | P62250 | RS16_RAT | Small ribosomal subunit protein uS9 (40S ribosomal protein S16) | −0.716 | 0.003 |
| down | Atp6v1c1 | Q5FVI6 | VATC1_RAT | V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) | −0.745 | 0.003 |
| down | Ckap5 | F1M949 | F1M949_RAT | Cytoskeleton-associated protein 5 | −0.869 | 0.003 |
| down | Igsf8 | A0A8I6ANQ3 | A0A8I6ANQ3_RAT | Immunoglobulin superfamily member 8 (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (Prostaglandin regulatory-like protein) | −0.675 | 0.003 |
| down | Prep | O70196 | PPCE_RAT | Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) (rPop) | −0.667 | 0.003 |
| down | Atp5f1c | P35435 | ATPG_RAT | ATP synthase F(1) complex subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit) | −1.185 | 0.004 |
| down | Pfkp | P47860 | PFKAP_RAT | ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) | −0.872 | 0.004 |
| down | Hnrnpl | F1LQ48 | HNRPL_RAT | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | −0.652 | 0.004 |
| down | Phyhip | Q568Z9 | PHYIP_RAT | Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1) | −1.075 | 0.004 |
| down | Dpysl4 | Q62951 | DPYL4_RAT | Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) | −0.590 | 0.004 |
| down | Tspan7 | B0BNE7 | B0BNE7_RAT | Tetraspanin | −1.073 | 0.004 |
| down | Prepl | Q5HZA6 | PPCEL_RAT | Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) | −0.795 | 0.004 |
| down | Adss2 | D4AEP0 | D4AEP0_RAT | Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) | −0.624 | 0.004 |
| down | Dars1 | P15178 | SYDC_RAT | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) | −0.693 | 0.004 |
| down | Gria1 | P19490 | GRIA1_RAT | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) | −0.717 | 0.004 |
| down | Hspa2 | P14659 | HSP72_RAT | Heat shock-related 70 kDa protein 2 (Heat shock protein 70.2) (Testis-specific heat shock protein-related) (HST) | −0.646 | 0.004 |
| down | Cct7 | A0A8I6AR12 | A0A8I6AR12_RAT | T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) | −0.582 | 0.004 |
| down | Rgs14 | O08773 | RGS14_RAT | Regulator of G-protein signaling 14 (RGS14) | −0.499 | 0.004 |
| down | Bdh1 | P29147 | BDH_RAT | D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) | −0.921 | 0.004 |
| down | Mapk10 | P49187 | MK10_RAT | Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta) | −0.540 | 0.004 |
| down | Rab5b | A1L1J8 | A1L1J8_RAT | small monomeric GTPase (EC 3.6.5.2) | −0.909 | 0.004 |
| down | Slc6a7 | P28573 | SC6A7_RAT | Sodium-dependent proline transporter (Solute carrier family 6 member 7) | −0.717 | 0.004 |
| down | Pfkl | P30835 | PFKAL_RAT | ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase) | −0.686 | 0.004 |
| down | Hspa4l | P83581 | HS74L_RAT | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) | −0.546 | 0.004 |
| down | Ahcyl1 | B5DFN2 | SAHH2_RAT | S-adenosylhomocysteine hydrolase-like protein 1 (IP3R-binding protein released with inositol 1,4,5-trisphosphate) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | −0.641 | 0.004 |
| down | Anks1b | P0C6S7 | ANS1B_RAT | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) | −0.615 | 0.004 |
| down | Septin8 | B0BNF1 | SEPT8_RAT | Septin-8 | −0.953 | 0.004 |
| down | Pspc1 | Q4KLH4 | PSPC1_RAT | Paraspeckle component 1 | −0.828 | 0.004 |
| down | Exoc4 | Q62824 | EXOC4_RAT | Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8) | −0.658 | 0.004 |
| down | Stum | A0ABK0LZH3 | A0ABK0LZH3_RAT | Uncharacterized protein | −1.157 | 0.004 |
| down | Inpp4a | Q62784 | INP4A_RAT | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | −0.754 | 0.004 |
| down | Ppfia3 | Q91Z79 | LIPA3_RAT | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | −0.610 | 0.004 |
| down | Rheb | Q62639 | RHEB_RAT | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | −0.821 | 0.004 |
| down | Ca4 | P48284 | CAH4_RAT | Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV) | −1.558 | 0.005 |
| down | Prkce | P09216 | KPCE_RAT | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | −0.564 | 0.005 |
| down | Dlgap1 | P97836 | DLGP1_RAT | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (rGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | −1.628 | 0.005 |
| down | Etfa | P13803 | ETFA_RAT | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | −0.704 | 0.005 |
| down | Pygm | P09812 | PYGM_RAT | Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) | −0.732 | 0.005 |
| down | Gapdh | P04797 | G3P_RAT | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | −0.498 | 0.005 |
| down | Fkbp8 | Q3B7U9 | FKBP8_RAT | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (FK506-binding protein 8) (FKBP-8) (Rotamase) | −1.771 | 0.005 |
| down | Cdipt | P70500 | CDIPT_RAT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase) | −0.717 | 0.005 |
| down | Ap2m1 | P84092 | AP2M1_RAT | AP-2 complex subunit mu (AP-2 mu chain) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) | −0.647 | 0.005 |
| down | Pdha1 | P26284 | ODPA_RAT | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | −0.697 | 0.005 |
| down | Aifm1 | Q9JM53 | AIFM1_RAT | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | −0.671 | 0.005 |
| down | Cops4 | Q68FS2 | CSN4_RAT | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | −0.643 | 0.005 |
| down | Dhx9 | A0A8I6ABZ7 | A0A8I6ABZ7_RAT | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) | −0.710 | 0.005 |
| down | Mpp2 | D3ZAA9 | MPP2_RAT | MAGUK p55 subfamily member 2 (Protein MPP2) | −0.730 | 0.005 |
| down | Glul | P09606 | GLNA_RAT | Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) | −0.714 | 0.005 |
| down | Strap | Q5XIG8 | STRAP_RAT | Serine-threonine kinase receptor-associated protein (UNR-interacting protein) | −0.508 | 0.005 |
| down | Rab14 | P61107 | RAB14_RAT | Ras-related protein Rab-14 (EC 3.6.5.2) | −0.765 | 0.005 |
| down | Rps11 | P62282 | RS11_RAT | Small ribosomal subunit protein uS17 (40S ribosomal protein S11) | −0.690 | 0.005 |
| down | Pcx | NA | NA | NA | −0.542 | 0.005 |
| down | Prpsap1 | Q63468 | KPRA_RAT | Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) | −1.264 | 0.005 |
| down | Trim2 | D3ZQG6 | TRIM2_RAT | Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2) | −0.591 | 0.005 |
| down | Syngap1 | Q9QUH6 | SYGP1_RAT | Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (p135 SynGAP) | −0.599 | 0.005 |
| down | Cct6a | F7ELS2 | F7ELS2_RAT | T-complex protein 1 subunit zeta | −0.637 | 0.005 |
| down | Actr3 | Q4V7C7 | ARP3_RAT | Actin-related protein 3 (Actin-like protein 3) | −0.515 | 0.005 |
| down | Rpl11 | P62914 | RL11_RAT | Large ribosomal subunit protein uL5 (60S ribosomal protein L11) | −1.979 | 0.005 |
| down | Scrn3 | A0A8I6A9K3 | A0A8I6A9K3_RAT | Secernin 3 | −1.929 | 0.005 |
| down | Prmt1 | Q63009 | ANM1_RAT | Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) | −1.109 | 0.005 |
| down | Gsk3b | P18266 | GSK3B_RAT | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | −0.649 | 0.005 |
| down | Atp6v1a | D4A133 | D4A133_RAT | V-type proton ATPase catalytic subunit A (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha) | −0.537 | 0.005 |
| down | Arpc1a | Q99PD4 | ARC1A_RAT | Actin-related protein 2/3 complex subunit 1A | −0.546 | 0.005 |
| down | Mtmr1 | A0A0G2JUZ0 | A0A0G2JUZ0_RAT | phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) | −0.791 | 0.005 |
| down | Actr1a | P85515 | ACTZ_RAT | Alpha-centractin (Centractin) | −0.769 | 0.005 |
| down | Acadvl | P45953 | ACADV_RAT | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | −0.612 | 0.005 |
| down | Rab18 | Q5EB77 | RAB18_RAT | Ras-related protein Rab-18 (EC 3.6.5.2) | −0.600 | 0.005 |
| down | Ddx1 | Q641Y8 | DDX1_RAT | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) | −1.343 | 0.006 |
| down | Grin1 | P35439 | NMDZ1_RAT | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) | −0.701 | 0.006 |
| down | Cpne6 | D4ACG7 | D4ACG7_RAT | Copine-6 (Copine VI) | −0.606 | 0.006 |
| down | Fasn | P12785 | FAS_RAT | Fatty acid synthase (EC 2.3.1.85) (Type I FAS) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | −0.663 | 0.006 |
| down | Tnr | Q05546 | TENR_RAT | Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) | −0.494 | 0.006 |
| down | Cpne4 | F1M0Z3 | F1M0Z3_RAT | Copine-4 (Copine IV) | −1.066 | 0.006 |
| down | Rps3 | P62909 | RS3_RAT | Small ribosomal subunit protein uS3 (EC 4.2.99.18) (40S ribosomal protein S3) | −0.546 | 0.006 |
| down | Tmx3 | M0R402 | M0R402_RAT | Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) | −0.940 | 0.006 |
| down | Rab3c | P62824 | RAB3C_RAT | Ras-related protein Rab-3C (EC 3.6.5.2) | −0.645 | 0.006 |
| down | Wdr7 | Q9ERH3 | WDR7_RAT | WD repeat-containing protein 7 (TGF-beta resistance-associated protein TRAG) | −0.648 | 0.006 |
| down | Dync1h1 | P38650 | DYHC1_RAT | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) (MAP 1C) | −0.683 | 0.006 |
| down | Eif3b | Q4G061 | EIF3B_RAT | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta) | −0.671 | 0.006 |
| down | Rps8 | P62243 | RS8_RAT | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | −0.732 | 0.006 |
| down | Svop | Q9Z2I7 | SVOP_RAT | Synaptic vesicle 2-related protein (SV2-related protein) | −1.279 | 0.006 |
| down | Atp2b2 | P11506 | AT2B2_RAT | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | −0.561 | 0.006 |
| down | Rock2 | Q62868 | ROCK2_RAT | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (RhoA-binding kinase 2) (p150 ROK-alpha) (ROKalpha) (p164 ROCK-2) | −0.636 | 0.006 |
| down | Hnrnpm | Q62826 | HNRPM_RAT | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) (M4 protein) | −0.559 | 0.006 |
| down | Ewsr1 | A0A0G2K850 | A0A0G2K850_RAT | RNA-binding protein EWS | −1.258 | 0.006 |
| down | Rab7a | P09527 | RAB7A_RAT | Ras-related protein Rab-7a (EC 3.6.5.2) (Ras-related protein BRL-RAS) (Ras-related protein p23) | −0.629 | 0.006 |
| down | Gdap1l1 | B4F774 | B4F774_RAT | Ganglioside-induced differentiation-associated protein 1-like 1 | −0.620 | 0.006 |
| down | Eef2 | P05197 | EF2_RAT | Elongation factor 2 (EF-2) (EC 3.6.5.-) | −0.492 | 0.006 |
| down | Nckap1 | P55161 | NCKP1_RAT | Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) | −0.746 | 0.006 |
| down | Gmps | Q4V7C6 | GUAA_RAT | GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) | −0.570 | 0.006 |
| down | Srr | Q76EQ0 | SRR_RAT | Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) | −0.483 | 0.006 |
| down | Ogt | P56558 | OGT1_RAT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) | −0.636 | 0.007 |
| down | Cct3 | Q6P502 | TCPG_RAT | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) | −0.518 | 0.007 |
| down | Cltc | P11442 | CLH1_RAT | Clathrin heavy chain 1 | −0.637 | 0.007 |
| down | Xpnpep1 | O54975 | XPP1_RAT | Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) | −0.553 | 0.007 |
| down | Septin9 | Q9QZR6 | SEPT9_RAT | Septin-9 (Eighth septin) (Eseptin) (Septin-like protein) (SLP) | −0.536 | 0.007 |
| down | Ugp2 | Q4V8I9 | Q4V8I9_RAT | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | −0.553 | 0.007 |
| down | Slc8a2 | P48768 | NAC2_RAT | Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) | −0.534 | 0.007 |
| down | Hnrnpul2 | D4ABT8 | D4ABT8_RAT | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | −0.483 | 0.007 |
| down | Naxd | D4AAT7 | NNRD_RAT | ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase) | −0.622 | 0.007 |
| down | Madd | O08873 | MADD_RAT | MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (RabGEP) | −0.601 | 0.007 |
| down | Phyhipl | Q6AYN4 | PHIPL_RAT | Phytanoyl-CoA hydroxylase-interacting protein-like | −0.449 | 0.007 |
| down | Slc6a1 | P23978 | SC6A1_RAT | Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) | −0.634 | 0.007 |
| down | Got2 | P00507 | AATM_RAT | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | −0.529 | 0.007 |
| down | Tpp2 | Q64560 | TPP2_RAT | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | −0.841 | 0.007 |
| down | Pde2a | Q01062 | PDE2A_RAT | cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) | −0.719 | 0.007 |
| down | Stxbp1 | P61765 | STXB1_RAT | Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) (rbSec1) | −0.534 | 0.007 |
| down | Sbf1 | M0RAP5 | M0RAP5_RAT | SET binding factor 1 | −0.540 | 0.007 |
| down | Auh | F1LU71 | AUHM_RAT | Methylglutaconyl-CoA hydratase, mitochondrial (3-MG-CoA hydratase) (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (Itaconyl-CoA hydratase) (EC 4.2.1.56) | −0.519 | 0.007 |
| down | Get3 | G3V9T7 | GET3_RAT | ATPase Get3 (EC 3.6.4.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) | −0.481 | 0.007 |
| down | Kcnma1 | Q62976 | KCMA1_RAT | Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) | −1.533 | 0.007 |
| down | Ctsb | P00787 | CATB_RAT | Cathepsin B (EC 3.4.22.1) (Cathepsin B1) (RSG-2) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | −1.054 | 0.007 |
| down | Gnb2 | P54313 | GBB2_RAT | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | −0.906 | 0.007 |
| down | Itpka | P17105 | IP3KA_RAT | Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A) | −0.553 | 0.007 |
| down | Pls3 | Q63598 | PLST_RAT | Plastin-3 (T-plastin) | −0.539 | 0.007 |
| down | Ppm1h | Q5M821 | PPM1H_RAT | Protein phosphatase 1H (EC 3.1.3.16) | −0.814 | 0.007 |
| down | Ap2a2 | P18484 | AP2A2_RAT | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | −0.608 | 0.007 |
| down | Psma6 | P60901 | PSA6_RAT | Proteasome subunit alpha type-6 (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1) | −0.783 | 0.007 |
| down | Acly | P16638 | ACLY_RAT | ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) | −0.655 | 0.007 |
| down | Ndufv1 | Q5XIH3 | Q5XIH3_RAT | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 7.1.1.2) | −0.603 | 0.007 |
| down | Lrrc57 | Q5FVI3 | LRC57_RAT | Leucine-rich repeat-containing protein 57 | −0.939 | 0.007 |
| down | Hnrnpr | Q566E4 | Q566E4_RAT | Heterogeneous nuclear ribonucleoprotein Q (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | −1.408 | 0.007 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.163 | 0.007 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.163 | 0.007 |
| down | Mapk3 | P21708 | MK03_RAT | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1) | −0.598 | 0.007 |
| down | Ppp3cb | P20651 | PP2BB_RAT | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) | −0.534 | 0.007 |
| down | Adam23 | A0A8I6A4T9 | A0A8I6A4T9_RAT | ADAM metallopeptidase domain 23 | −1.254 | 0.008 |
| down | Arcn1 | Q66H80 | COPD_RAT | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | −0.613 | 0.008 |
| down | Gdi1 | P50398 | GDIA_RAT | Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) | −0.471 | 0.008 |
| down | Pfn2 | Q9EPC6 | PROF2_RAT | Profilin-2 (Profilin II) | −0.559 | 0.008 |
| down | Ogdh | Q5XI78 | ODO1_RAT | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | −0.837 | 0.008 |
| down | Add3 | Q62847 | ADDG_RAT | Gamma-adducin (Adducin-like protein 70) (Protein kinase C-binding protein 35H) | −0.438 | 0.008 |
| down | Slc24a2 | O54701 | NCKX2_RAT | Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2) | −0.741 | 0.008 |
| down | Exoc8 | O54924 | EXOC8_RAT | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | −0.489 | 0.008 |
| down | Ctnna2 | A0A0G2JYF7 | A0A0G2JYF7_RAT | Catenin alpha-2 (Alpha N-catenin) | −0.486 | 0.008 |
| down | Braf | A0A8I6ATH0 | A0A8I6ATH0_RAT | non-specific serine/threonine protein kinase (EC 2.7.11.1) | −0.546 | 0.008 |
| down | Mlc1 | D4ABB2 | D4ABB2_RAT | Modulator of VRAC current 1 | −1.162 | 0.008 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.705 | 0.008 |
| down | Gabbr1 | Q9Z0U4 | GABR1_RAT | Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) | −1.504 | 0.008 |
| down | Sirt2 | Q5RJQ4 | SIR2_RAT | NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | −0.431 | 0.008 |
| down | Sfxn3 | Q9JHY2 | SFXN3_RAT | Sideroflexin-3 | −0.572 | 0.008 |
| down | Lrrc47 | F1LT49 | F1LT49_RAT | Leucine-rich repeat-containing protein 47 | −0.684 | 0.008 |
| down | Tardbp | A6IU83 | A6IU83_RAT | TAR DNA-binding protein 43 | −0.605 | 0.008 |
| down | Naxe | B0BNM1 | NNRE_RAT | NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) | −0.655 | 0.008 |
| down | Ppp3ca | P63329 | PP2BA_RAT | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) | −0.422 | 0.008 |
| down | Prmt5 | A0A8I5ZP89 | A0A8I5ZP89_RAT | Protein arginine N-methyltransferase 5 (EC 2.1.1.320) | −1.024 | 0.008 |
| down | Bpnt1 | Q9Z1N4 | BPNT1_RAT | 3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57) (RnPIP) (scHAL2 analogous 3) | −0.727 | 0.008 |
| down | Atp5f1a | P15999 | ATPA_RAT | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | −0.415 | 0.008 |
| down | Rab11b | O35509 | RB11B_RAT | Ras-related protein Rab-11B (EC 3.6.5.2) | −0.596 | 0.008 |
| down | Prkca | P05696 | KPCA_RAT | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | −0.675 | 0.009 |
| down | Mpst | P97532 | THTM_RAT | 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) | −0.689 | 0.009 |
| down | Aco2 | Q9ER34 | ACON_RAT | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | −0.478 | 0.009 |
| down | Cand1 | P97536 | CAND1_RAT | Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) | −0.483 | 0.009 |
| down | Vars1 | Q04462 | SYVC_RAT | Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) | −0.614 | 0.009 |
| down | Atp1b2 | P13638 | AT1B2_RAT | Sodium/potassium-transporting ATPase subunit beta-2 (Sodium/potassium-dependent ATPase subunit beta-2) | −1.031 | 0.009 |
| down | Nae1 | Q9Z1A5 | ULA1_RAT | NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) | −0.499 | 0.009 |
| down | Slc25a12 | F1LX07 | S2512_RAT | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Solute carrier family 25 member 12) | −0.497 | 0.009 |
| down | Prrt1 | Q6MG82 | PRRT1_RAT | Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4) | −0.708 | 0.009 |
| down | Ivd | P12007 | IVD_RAT | Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4) (Butyryl-CoA dehydrogenase) (EC 1.3.8.1) | −0.487 | 0.009 |
| down | Maoa | P21396 | AOFA_RAT | Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) | −0.509 | 0.009 |
| down | Mfn2 | Q8R500 | MFN2_RAT | Mitofusin-2 (EC 3.6.5.-) (Mitochondrial transmembrane GTPase FZO1A) (Protein HSG) (Transmembrane GTPase MFN2) | −1.596 | 0.009 |
| down | Coro2b | F1LMV9 | F1LMV9_RAT | Coronin | −0.606 | 0.009 |
| down | Gnao1 | P59215 | GNAO_RAT | Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) | −0.393 | 0.009 |
| down | Rab1a | A0A8I6AJ88 | A0A8I6AJ88_RAT | small monomeric GTPase (EC 3.6.5.2) | −0.479 | 0.009 |
| down | Nsf | Q9QUL6 | NSF_RAT | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | −0.471 | 0.009 |
| down | Rap1gap | F1LV89 | F1LV89_RAT | Rap1 GTPase-activating protein | −0.661 | 0.009 |
| down | Rhot1 | A1L1L6 | MIRO1_RAT | Mitochondrial Rho GTPase (MIRO-1) (EC 3.6.5.-) (Ras homolog gene family member T1) | −0.736 | 0.009 |
| down | Adam11 | A0A1W2Q6C2 | A0A1W2Q6C2_RAT | ADAM metallopeptidase domain 11 | −0.714 | 0.009 |
| down | Mcu | A0A0G2K059 | A0A0G2K059_RAT | Calcium uniporter protein | −0.647 | 0.009 |
| down | Cyfip2 | A0A8I6AHL8 | A0A8I6AHL8_RAT | Cytoplasmic FMR1-interacting protein | −0.556 | 0.009 |
| down | Tst | P24329 | THTR_RAT | Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) | −0.521 | 0.009 |
| down | Kif2a | Q9WV63 | KIF2A_RAT | Kinesin-like protein KIF2A (Kinesin-2) | −0.518 | 0.009 |
| down | Uba1 | Q5U300 | UBA1_RAT | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) | −0.506 | 0.009 |
| down | Rac1 | Q6RUV5 | RAC1_RAT | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1) | −0.489 | 0.009 |
| down | Mtfp1 | A6IKE5 | A6IKE5_RAT | Mitochondrial fission process protein 1 (Mitochondrial 18 kDa protein) | −1.170 | 0.010 |
| down | Dpp10 | Q6Q629 | DPP10_RAT | Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase X) (DPP X) (Kv4 potassium channel auxiliary subunit) | −0.911 | 0.010 |
| down | Cntnap2 | A0A8I6GH02 | A0A8I6GH02_RAT | Contactin associated protein 2 | −0.869 | 0.010 |
| down | Nomo1 | D3ZSA9 | D3ZSA9_RAT | Nodal modulator 1 | −0.601 | 0.010 |
| down | Sar1a | Q6AY18 | Q6AY18_RAT | small monomeric GTPase (EC 3.6.5.2) | −0.546 | 0.010 |
| down | Diras2 | A0A8I5ZKR8 | A0A8I5ZKR8_RAT | DIRAS family GTPase 2 | −1.286 | 0.010 |
| down | Pip4k2b | O88377 | PI42B_RAT | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (Phosphatidylinositol-phosphate kinase IIgamma) (PIPKIIgamma) (PtdIns(5)P-4-kinase isoform 2-beta) | −0.845 | 0.010 |
| down | Mdh2 | P04636 | MDHM_RAT | Malate dehydrogenase, mitochondrial (EC 1.1.1.37) | −0.586 | 0.010 |
| down | Akr7a2 | Q8CG45 | ARK72_RAT | Aflatoxin B1 aldehyde reductase member 2 (rAFAR2) (EC 1.1.1.n11) (Succinic semialdehyde reductase) (SSA reductase) | −0.831 | 0.010 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.791 | 0.010 |
| down | Pfas | D4AB17 | D4AB17_RAT | Phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (Formylglycinamide ribotide amidotransferase) | −0.560 | 0.010 |
| down | Adh5 | P12711 | ADHX_RAT | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase B2) (ADH-B2) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | −0.524 | 0.010 |
| down | Cdk5 | Q03114 | CDK5_RAT | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | −0.491 | 0.010 |
| down | Otub1 | B2RYG6 | OTUB1_RAT | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (Ubiquitin-specific-processing protease OTUB1) | −0.475 | 0.010 |
| down | Slc12a5 | Q63633 | S12A5_RAT | Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Furosemide-sensitive K-Cl cotransporter) (K-Cl cotransporter 2) (rKCC2) (Neuronal K-Cl cotransporter) | −0.491 | 0.010 |
| down | Aldh6a1 | Q02253 | MMSA_RAT | Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) | −0.603 | 0.010 |
| down | Pdhb | P49432 | ODPB_RAT | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) | −0.420 | 0.010 |
| down | Vdac2 | P81155 | VDAC2_RAT | Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (B36-VDAC) (Outer mitochondrial membrane protein porin 2) | −0.717 | 0.010 |
| down | Fscn1 | P85845 | FSCN1_RAT | Fascin | −0.694 | 0.010 |
| down | Nptn | P97546 | NPTN_RAT | Neuroplastin (Glycoprotein 55/65) (gp55/65) (Stromal cell-derived receptor 1) (SDR-1) | −0.412 | 0.010 |
| down | Acat1 | P17764 | THIL_RAT | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) | −0.630 | 0.010 |
| down | Sec13 | Q5XFW8 | SEC13_RAT | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) | −1.638 | 0.010 |
| down | Nf1 | P97526 | NF1_RAT | Neurofibromin (Neurofibromatosis-related protein NF-1) | −1.069 | 0.010 |
| down | Nfs1 | Q99P39 | NFS1_RAT | Cysteine desulfurase (EC 2.8.1.7) | −0.659 | 0.010 |
| down | Cct8 | A0A8I6AAR4 | A0A8I6AAR4_RAT | T-complex protein 1 subunit theta (CCT-theta) | −0.504 | 0.010 |
| down | Gnb5 | P62882 | GNB5_RAT | Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) | −1.416 | 0.010 |
| down | Ndufs1 | Q66HF1 | NDUS1_RAT | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 7.1.1.2) | −0.517 | 0.010 |
| down | Lxn | Q64361 | LXN_RAT | Latexin (Endogenous carboxypeptidase inhibitor) (ECI) (Tissue carboxypeptidase inhibitor) (TCI) | −0.814 | 0.011 |
| down | Grin2b | Q00960 | NMDE2_RAT | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) | −0.776 | 0.011 |
| down | Hnrnph1 | Q8VHV7 | HNRH1_RAT | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) (Ratsg1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | −0.508 | 0.011 |
| down | Slc25a18 | Q505J6 | GHC2_RAT | Mitochondrial glutamate carrier 2 (GC-2) (Glutamate/H(+) symporter 2) (Solute carrier family 25 member 18) | −0.600 | 0.011 |
| down | Psmd3 | A6HIT6 | A6HIT6_RAT | 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) | −0.465 | 0.011 |
| down | Ppp2r5a | D3ZDI7 | D3ZDI7_RAT | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit | −0.620 | 0.011 |
| down | Syncrip | Q7TP47 | HNRPQ_RAT | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Liver regeneration-related protein LRRG077) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | −0.625 | 0.011 |
| down | Dpysl2 | P47942 | DPYL2_RAT | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (Turned on after division 64 kDa protein) (TOAD-64) | −0.392 | 0.011 |
| down | Gclc | P19468 | GSH1_RAT | Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) | −0.500 | 0.011 |
| down | Cul3 | B5DF89 | CUL3_RAT | Cullin-3 | −0.751 | 0.011 |
| down | Pgm2l1 | D3Z955 | D3Z955_RAT | Phosphoglucomutase 2-like 1 | −0.403 | 0.011 |
| down | Pip4k2c | O88370 | PI42C_RAT | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | −0.540 | 0.011 |
| down | Eif3a | Q1JU68 | EIF3A_RAT | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) | −0.657 | 0.011 |
| down | Rapgef2 | F1M386 | RPGF2_RAT | Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) | −0.508 | 0.011 |
| down | Atic | O35567 | PUR9_RAT | Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] | −0.560 | 0.012 |
| down | Arf6 | P62332 | ARF6_RAT | ADP-ribosylation factor 6 (EC 3.6.5.2) | −0.458 | 0.012 |
| down | Septin6 | B5DFG5 | B5DFG5_RAT | Septin | −0.606 | 0.012 |
| down | Nbea | A0A8I6AB61 | A0A8I6AB61_RAT | Neurobeachin (Lysosomal-trafficking regulator 2) | −0.531 | 0.012 |
| down | Faah | P97612 | FAAH1_RAT | Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidase) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1) | −1.519 | 0.012 |
| down | Rnpep | O09175 | AMPB_RAT | Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) (Cytosol aminopeptidase IV) | −1.086 | 0.012 |
| down | Snx15 | Q4V896 | SNX15_RAT | Sorting nexin-15 | −0.764 | 0.012 |
| down | Adam22 | F1M542 | F1M542_RAT | ADAM metallopeptidase domain 22 | −0.592 | 0.012 |
| down | Psmc2 | Q63347 | PRS7_RAT | 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) | −0.521 | 0.012 |
| down | Git1 | Q9Z272 | GIT1_RAT | ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (GRK-interactor 1) | −0.467 | 0.012 |
| down | Dnm3 | Q08877 | DYN3_RAT | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) | −0.720 | 0.012 |
| down | Gsr | P70619 | GSHR_RAT | Glutathione reductase (GR) (GRase) (EC 1.8.1.7) | −0.637 | 0.012 |
| down | Ogdhl | D3ZQD3 | OGDHL_RAT | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | −0.489 | 0.012 |
| down | Dgkg | P49620 | DGKG_RAT | Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (88 kDa diacylglycerol kinase) (DGK-III) (Diglyceride kinase gamma) (DGK-gamma) | −0.762 | 0.012 |
| down | Uqcrc2 | P32551 | QCR2_RAT | Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) | −0.384 | 0.012 |
| down | Hacd3 | D4ABI7 | D4ABI7_RAT | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) | −1.096 | 0.012 |
| down | Rps10 | P63326 | RS10_RAT | Small ribosomal subunit protein eS10 (40S ribosomal protein S10) | −1.254 | 0.012 |
| down | Dmxl2 | F1M3W5 | F1M3W5_RAT | Dmx-like 2 | −0.674 | 0.012 |
| down | Tkt | P50137 | TKT_RAT | Transketolase (TK) (EC 2.2.1.1) | −0.386 | 0.012 |
| down | Dpp6 | P46101 | DPP6_RAT | A-type potassium channel modulatory protein DPP6 (DPPX) (Dipeptidyl aminopeptidase-like protein 6) (Dipeptidyl aminopeptidase-related protein) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl peptidase VI) (DPP VI) | −0.518 | 0.012 |
| down | Ap1g1 | A0A8I6ARE9 | A0A8I6ARE9_RAT | AP-1 complex subunit gamma | −0.678 | 0.013 |
| down | Micu3 | A0A8I6A2H6 | MICU3_RAT | Calcium uptake protein 3, mitochondrial | −0.790 | 0.013 |
| down | Idh3g | P41565 | IDHG1_RAT | Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) | −0.769 | 0.013 |
| down | Cct5 | Q68FQ0 | TCPE_RAT | T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) | −0.674 | 0.013 |
| down | Tollip | A2RUW1 | TOLIP_RAT | Toll-interacting protein | −0.540 | 0.013 |
| down | Rab2a | P05712 | RAB2A_RAT | Ras-related protein Rab-2A (EC 3.6.5.2) | −0.520 | 0.013 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.158 | 0.013 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.158 | 0.013 |
| down | Acad9 | B1WC61 | ACAD9_RAT | Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) | −0.727 | 0.013 |
| down | Flot1 | Q9Z1E1 | FLOT1_RAT | Flotillin-1 (Reggie-2) (REG-2) | −0.683 | 0.013 |
| down | Pygb | P53534 | PYGB_RAT | Glycogen phosphorylase, brain form (EC 2.4.1.1) | −0.442 | 0.013 |
| down | Atp6v1h | A0A8I6ACJ2 | A0A8I6ACJ2_RAT | V-type proton ATPase subunit H | −0.700 | 0.013 |
| down | Wars1 | Q6P7B0 | SYWC_RAT | Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS] | −0.646 | 0.013 |
| down | Cntnap1 | P97846 | CNTP1_RAT | Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (Paranodin) (p190) | −0.573 | 0.013 |
| down | Slc25a3 | P16036 | S25A3_RAT | Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP) | −0.428 | 0.013 |
| down | Echdc1 | Q6AYG5 | ECHD1_RAT | Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) | −0.777 | 0.013 |
| down | Rab1b | P10536 | RAB1B_RAT | Ras-related protein Rab-1B (EC 3.6.5.2) | −0.570 | 0.013 |
| down | Rab21 | Q6AXT5 | RAB21_RAT | Ras-related protein Rab-21 (EC 3.6.5.2) | −0.512 | 0.013 |
| down | Hspa12a | D3ZC55 | D3ZC55_RAT | Heat shock 70 kDa protein 12A | −0.443 | 0.013 |
| down | Gabrb3 | P63079 | GBRB3_RAT | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3) | −0.686 | 0.013 |
| down | Gnaq | P82471 | GNAQ_RAT | Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) | −0.622 | 0.013 |
| down | Rack1 | P63245 | RACK1_RAT | Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) (Receptor of activated protein kinase C 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Receptor of activated protein C kinase 1, N-terminally processed)] | −0.601 | 0.013 |
| down | Rpn2 | P25235 | RPN2_RAT | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2) | −0.593 | 0.013 |
| down | Ndufa11 | Q80W89 | NDUAB_RAT | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7) | −0.474 | 0.013 |
| down | Atp2b3 | Q64568 | AT2B3_RAT | Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) | −0.469 | 0.013 |
| down | Psma5 | P34064 | PSA5_RAT | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | −0.442 | 0.013 |
| down | Cntn1 | Q63198 | CNTN1_RAT | Contactin-1 (Neural cell surface protein F3) | −0.436 | 0.013 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.412 | 0.013 |
| down | Park7 | O88767 | PARK7_RAT | Parkinson disease protein 7 homolog (Contraception-associated protein 1) (Protein CAP1) (Fertility protein SP22) (Maillard deglycase) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) | −0.356 | 0.013 |
| down | Aldh7a1 | Q64057 | AL7A1_RAT | Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) | −0.776 | 0.013 |
| down | Farp1 | F1LYQ8 | FARP1_RAT | FERM, ARHGEF and pleckstrin domain-containing protein 1 (FERM, RhoGEF and pleckstrin domain-containing protein 1) | −0.624 | 0.013 |
| down | Capza2 | Q3T1K5 | CAZA2_RAT | F-actin-capping protein subunit alpha-2 (CapZ alpha-2) | −0.550 | 0.013 |
| down | Tmed10 | Q63584 | TMEDA_RAT | Transmembrane emp24 domain-containing protein 10 (Protein Tmed10) (21 kDa transmembrane-trafficking protein) (Transmembrane protein Tmp21) (p24 family protein delta-1) (p24delta1) | −1.135 | 0.013 |
| down | Tuba4a | Q5XIF6 | TBA4A_RAT | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 4) (Tubulin alpha-4 chain) | −0.743 | 0.013 |
| down | Sdcbp | Q9JI92 | SDCB1_RAT | Syntenin-1 (Syndecan-binding protein 1) | −0.563 | 0.013 |
| down | Rpn1 | P07153 | RPN1_RAT | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | −0.534 | 0.013 |
| down | Uso1 | P41542 | USO1_RAT | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | −0.599 | 0.013 |
| down | Gnai2 | P04897 | GNAI2_RAT | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | −0.673 | 0.013 |
| down | Pfn1 | P62963 | PROF1_RAT | Profilin-1 (Profilin I) | −0.926 | 0.014 |
| down | Atp1a3 | P06687 | AT1A3_RAT | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | −0.439 | 0.014 |
| down | Mtch1 | B0BN30 | B0BN30_RAT | Mitochondrial carrier homolog 1 | −0.938 | 0.014 |
| down | Ruvbl1 | P60123 | RUVB1_RAT | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (DNA helicase p50) (Pontin 52) (TIP49a) | −0.540 | 0.014 |
| down | Pfkm | P47858 | PFKAM_RAT | ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) | −0.534 | 0.014 |
| down | Mif | P30904 | MIF_RAT | Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glutathione-binding 13 kDa protein) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) | −0.478 | 0.014 |
| down | Psmb1 | P18421 | PSB1_RAT | Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) | −0.525 | 0.014 |
| down | Dctn6 | A0A8I5Y4I3 | A0A8I5Y4I3_RAT | Dynactin subunit 6 (Dynactin subunit p27) | −1.145 | 0.014 |
| down | Cnksr2 | Q9Z1T4 | CNKR2_RAT | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) (Membrane-associated guanylate kinase-interacting protein) (Maguin) | −0.663 | 0.014 |
| down | Iars2 | A0A0G2K261 | A0A0G2K261_RAT | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) | −0.588 | 0.014 |
| down | Vcp | P46462 | TERA_RAT | Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) | −0.366 | 0.014 |
| down | Slc7a14 | A0A0G2K1G8 | A0A0G2K1G8_RAT | Solute carrier family 7, member 14 | −0.876 | 0.014 |
| down | Dusp3 | A0A8I6AF61 | A0A8I6AF61_RAT | Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) | −0.507 | 0.014 |
| down | Psmc3 | Q63569 | PRS6A_RAT | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA) (Tat-binding protein 1) (TBP-1) | −0.388 | 0.014 |
| down | Septin7 | Q9WVC0 | SEPT7_RAT | Septin-7 (CDC10 protein homolog) | −0.388 | 0.014 |
| down | Ndufa9 | Q5BK63 | NDUA9_RAT | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (Sperm flagella protein 3) | −0.995 | 0.014 |
| down | Ppp2ca | P63331 | PP2AA_RAT | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) | −0.506 | 0.014 |
| down | Nceh1 | B2GV54 | NCEH1_RAT | Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1) | −1.029 | 0.014 |
| down | Ap2a1 | A0A8I6A4J2 | A0A8I6A4J2_RAT | AP-2 complex subunit alpha | −0.532 | 0.014 |
| down | Tufm | P85834 | EFTU_RAT | Elongation factor Tu, mitochondrial (EC 3.6.5.3) | −0.375 | 0.014 |
| down | Ahsa1 | B0BN63 | B0BN63_RAT | Activator of 90 kDa heat shock protein ATPase homolog 1 | −0.467 | 0.014 |
| down | Psma3 | P18422 | PSA3_RAT | Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit K) (Proteasome subunit alpha-7) (alpha-7) | −0.524 | 0.014 |
| down | Epha4 | D3ZZK3 | D3ZZK3_RAT | receptor protein-tyrosine kinase (EC 2.7.10.1) | −0.623 | 0.014 |
| down | Ablim1 | A0A8I5Y6A1 | A0A8I5Y6A1_RAT | Actin-binding LIM protein 1 | −0.445 | 0.014 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.689 | 0.014 |
| down | Ablim2 | Q6KC51 | ABLM2_RAT | Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) | −0.671 | 0.014 |
| down | Slc1a3 | P24942 | EAA1_RAT | Excitatory amino acid transporter 1 (Glial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST) (GLAST-1) (Solute carrier family 1 member 3) | −0.563 | 0.014 |
| down | Slc25a22 | A0A0G2K5L2 | GHC1_RAT | Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) | −0.388 | 0.014 |
| down | Oxct1 | B2GV06 | SCOT1_RAT | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase) | −0.441 | 0.014 |
| down | Tecr | Q64232 | TECR_RAT | Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER) | −0.721 | 0.014 |
| down | Mthfd1l | B2GUZ3 | B2GUZ3_RAT | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | −0.709 | 0.015 |
| down | Icam5 | D4A435 | D4A435_RAT | Intercellular adhesion molecule 5 (Telencephalin) | −0.440 | 0.015 |
| down | Adcy9 | M0R5U4 | M0R5U4_RAT | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (Adenylyl cyclase 9) | −0.971 | 0.015 |
| down | Smap1 | A0A8I5ZQ30 | A0A8I5ZQ30_RAT | Small ArfGAP 1 | −0.522 | 0.015 |
| down | Aldh2 | P11884 | ALDH2_RAT | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDH1) | −0.793 | 0.015 |
| down | Hadha | Q64428 | ECHA_RAT | Trifunctional enzyme subunit alpha, mitochondrial (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] | −0.994 | 0.015 |
| down | Kif5c | P56536 | KIF5C_RAT | Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) | −0.336 | 0.015 |
| down | Eef1g | Q68FR6 | EF1G_RAT | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | −0.781 | 0.015 |
| down | Gk | Q63060 | GLPK_RAT | Glycerol kinase (Glycerokinase) (EC 2.7.1.30) (ATP-stimulated glucocorticoid-receptor translocation promoter) (ASTP) (ATP:glycerol 3-phosphotransferase) | −0.851 | 0.015 |
| down | Flot2 | Q9Z2S9 | FLOT2_RAT | Flotillin-2 (Reggie-1) (REG-1) | −0.988 | 0.015 |
| down | Cct2 | Q5XIM9 | TCPB_RAT | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) | −0.685 | 0.015 |
| down | Coro1c | A0A8I6GLR9 | A0A8I6GLR9_RAT | Coronin | −0.495 | 0.015 |
| down | Akr1b1 | P07943 | ALDR_RAT | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) | −0.468 | 0.015 |
| down | Atp8a1 | F1LUT4 | F1LUT4_RAT | Phospholipid-transporting ATPase (EC 7.6.2.1) | −0.856 | 0.016 |
| down | Cd82 | O70352 | CD82_RAT | CD82 antigen (Metastasis suppressor Kangai-1 homolog) (CD antigen CD82) | −0.403 | 0.016 |
| down | Mthfd1 | P27653 | C1TC_RAT | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | −0.492 | 0.016 |
| down | Sdha | Q920L2 | SDHA_RAT | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp) (Malate dehydrogenase [quinone] flavoprotein subunit) (EC 1.1.5.-) | −0.442 | 0.016 |
| down | Gabbr2 | O88871 | GABR2_RAT | Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) | −0.514 | 0.016 |
| down | Acot13 | D3ZA93 | D3ZA93_RAT | Acyl-coenzyme A thioesterase 13 (EC 3.1.2.2) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (Thioesterase superfamily member 2) | −0.352 | 0.016 |
| down | Dlg4 | P31016 | DLG4_RAT | Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) | −0.495 | 0.016 |
| down | Glud1 | P10860 | DHE3_RAT | Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) (Memory-related gene 2 protein) (MRG-2) | −0.440 | 0.016 |
| down | Aldh1b1 | Q66HF8 | AL1B1_RAT | Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase family 1 member B1) | −0.636 | 0.016 |
| down | Acot7 | Q64559 | BACH_RAT | Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (ACH1) (ACT) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-IIb) (CTE-II) (LACH1) (Long chain acyl-CoA thioester hydrolase) (MTE-II) | −0.529 | 0.016 |
| down | Syngr3 | D4ABK1 | D4ABK1_RAT | Synaptogyrin 3 | −0.490 | 0.017 |
| down | Mpp3 | O88954 | MPP3_RAT | MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) | −0.855 | 0.017 |
| down | Ccdc22 | P86182 | CCD22_RAT | Coiled-coil domain-containing protein 22 | −1.363 | 0.017 |
| down | Arl15 | A0A8I5ZSX7 | A0A8I5ZSX7_RAT | ADP-ribosylation factor-like protein 15 | −0.679 | 0.017 |
| down | Prkar2a | P12368 | KAP2_RAT | cAMP-dependent protein kinase type II-alpha regulatory subunit | −0.585 | 0.017 |
| down | Uba2 | A0A8I6A3Z5 | A0A8I6A3Z5_RAT | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) | −0.508 | 0.017 |
| down | Abat | P50554 | GABT_RAT | 4-aminobutyrate aminotransferase, mitochondrial (beta-AlaAT I) (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT) [Cleaved into: 4-aminobutyrate aminotransferase, brain isoform; 4-aminobutyrate aminotransferase, liver isoform] | −0.504 | 0.017 |
| down | Sucla2 | F1LM47 | F1LM47_RAT | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) | −0.345 | 0.017 |
| down | Pafah1b1 | P63004 | LIS1_RAT | Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | −0.583 | 0.017 |
| down | Nedd4 | Q62940 | NEDD4_RAT | E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) | −0.705 | 0.017 |
| down | Prkcb | P68403 | KPCB_RAT | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | −0.436 | 0.017 |
| down | Ptprs | Q64605 | PTPRS_RAT | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) | −0.744 | 0.017 |
| down | Ezr | P31977 | EZRI_RAT | Ezrin (Cytovillin) (Villin-2) (p81) | −0.744 | 0.018 |
| down | Dnm1 | P21575 | DYN1_RAT | Dynamin-1 (EC 3.6.5.5) (B-dynamin) (D100) (Dynamin I) (Dynamin, brain) | −0.652 | 0.018 |
| down | Ap3m2 | P53678 | AP3M2_RAT | AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) | −0.550 | 0.018 |
| down | Rps4x | P62703 | RS4X_RAT | Small ribosomal subunit protein eS4 (40S ribosomal protein S4, X isoform) | −0.528 | 0.018 |
| down | Pdk1 | Q63065 | PDK1_RAT | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (PDK p48) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | −0.827 | 0.018 |
| down | Actr1b | F7F067 | F7F067_RAT | Actin related protein 1B | −0.504 | 0.018 |
| down | Ndufa12 | F1LXA0 | F1LXA0_RAT | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | −0.597 | 0.018 |
| down | Camk4 | P13234 | KCC4_RAT | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) (Calspermin) | −0.594 | 0.018 |
| down | Kcnd2 | Q63881 | KCND2_RAT | A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2) | −0.818 | 0.018 |
| down | Dynll1 | P63170 | DYL1_RAT | Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) | −0.332 | 0.018 |
| down | Rgs7 | P49803 | RGS7_RAT | Regulator of G-protein signaling 7 (RGS7) | −0.915 | 0.018 |
| down | Idh3b | A0A8I6AMM2 | A0A8I6AMM2_RAT | Isocitrate dehydrogenase [NAD] subunit, mitochondrial | −0.435 | 0.018 |
| down | Syp | P07825 | SYPH_RAT | Synaptophysin (Major synaptic vesicle protein p38) | −0.385 | 0.018 |
| down | Rpl12 | P23358 | RL12_RAT | Large ribosomal subunit protein uL11 (60S ribosomal protein L12) | −0.304 | 0.018 |
| down | Acot2 | O55171 | ACOT2_RAT | Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (ARTISt/p43) (Acyl coenzyme A thioester hydrolase) (MTE-I) (Very-long-chain acyl-CoA thioesterase) | −0.475 | 0.019 |
| down | Ap3b2 | A0ABK0LE23 | A0ABK0LE23_RAT | Adaptor related protein complex 3 subunit beta 2 | −0.457 | 0.019 |
| down | Stxbp5l | D3ZU84 | D3ZU84_RAT | Syntaxin binding protein 5L | −0.839 | 0.019 |
| down | Ptges3 | P83868 | TEBP_RAT | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | −0.714 | 0.019 |
| down | Uqcrc1 | Q68FY0 | QCR1_RAT | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | −0.525 | 0.019 |
| down | Rogdi | Q4V7D2 | ROGDI_RAT | Protein rogdi homolog | −0.334 | 0.019 |
| down | Ctbp1 | Q9Z2F5 | CTBP1_RAT | C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) (50 kDa BFA-dependent ADP-ribosylation substrate) (BARS-50) (C-terminal-binding protein 3) (CtBP3) | −0.656 | 0.019 |
| down | Atp1a1 | P06685 | AT1A1_RAT | Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) | −0.373 | 0.019 |
| down | Gsk3a | P18265 | GSK3A_RAT | Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) | −0.688 | 0.019 |
| down | Pgk1 | P16617 | PGK1_RAT | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) | −0.407 | 0.019 |
| down | Cacna1e | Q07652 | CAC1E_RAT | Voltage-dependent R-type calcium channel subunit alpha-1E (BII) (Brain calcium channel II) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (RBE-II) (RBE2) (Voltage-gated calcium channel subunit alpha Cav2.3) | −0.721 | 0.019 |
| down | Syn2 | Q63537 | SYN2_RAT | Synapsin-2 (Synapsin II) | −0.676 | 0.019 |
| down | Slc2a3 | Q07647 | GTR3_RAT | Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) | −0.465 | 0.019 |
| down | Psat1 | A0A0G2K931 | A0A0G2K931_RAT | Phosphoserine aminotransferase (EC 2.6.1.52) | −0.453 | 0.019 |
| down | Plppr2 | Q6W5G4 | PLPR2_RAT | Phospholipid phosphatase-related protein type 2 (Inactive phospholipid phosphatase PLPPR2) (Lipid phosphate phosphatase-related protein type 2) (Plasticity-related gene 4 protein) (PRG-4) | −1.275 | 0.019 |
| down | Prpf8 | G3V6H2 | G3V6H2_RAT | Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) | −0.565 | 0.019 |
| down | Usp5 | D3ZVQ0 | D3ZVQ0_RAT | Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) | −0.407 | 0.019 |
| down | Gpd2 | P35571 | GPDM_RAT | Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) | −0.667 | 0.020 |
| down | Cops2 | P61203 | CSN2_RAT | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | −0.594 | 0.020 |
| down | Slc4a7 | Q9R1N3 | S4A7_RAT | Sodium bicarbonate cotransporter 3 (Electroneutral sodium bicarbonate cotransporter 1) (NBC-like protein) (Solute carrier family 4 member 7) | −1.337 | 0.020 |
| down | Hadhb | Q60587 | ECHB_RAT | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] | −0.434 | 0.020 |
| down | Rps2 | P27952 | RS2_RAT | Small ribosomal subunit protein uS5 (40S ribosomal protein S2) | −0.404 | 0.020 |
| down | Twf2 | B0BMY7 | B0BMY7_RAT | Twinfilin actin-binding protein 2 | −0.989 | 0.020 |
| down | Dclk1 | O08875 | DCLK1_RAT | Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) | −0.593 | 0.020 |
| down | Agap2 | Q8CGU4 | AGAP2_RAT | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE) | −0.653 | 0.020 |
| down | Lap3 | Q68FS4 | AMPL_RAT | Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (LAP) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) | −0.413 | 0.020 |
| down | Tubb3 | Q4QRB4 | TBB3_RAT | Tubulin beta-3 chain (Neuron-specific class III beta-tubulin) | −1.201 | 0.020 |
| down | Msra | Q923M1 | MSRA_RAT | Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR) | −0.455 | 0.020 |
| down | Cyrib | A0A0G2JXI6 | A0A0G2JXI6_RAT | CYFIP related Rac1 interactor B | −0.364 | 0.020 |
| down | Tcp1 | P28480 | TCPA_RAT | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) | −0.341 | 0.020 |
| down | Slc4a4 | Q9JI66 | S4A4_RAT | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (NBC-like protein) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) | −0.438 | 0.020 |
| down | Ppp2r1a | Q5XI34 | Q5XI34_RAT | Protein phosphatase 2 scaffold subunit A alpha | −0.549 | 0.021 |
| down | Bcat1 | P54690 | BCAT1_RAT | Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) | −0.425 | 0.021 |
| down | Pcbp2 | Q6AYU2 | Q6AYU2_RAT | Poly(rC) binding protein 2 | −0.366 | 0.021 |
| down | Acat2 | Q5XI22 | THIC_RAT | Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase) | −0.773 | 0.021 |
| down | Ap2s1 | P62744 | AP2S1_RAT | AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma-adaptin 3b) (Sigma2-adaptin) | −0.350 | 0.021 |
| down | Hnrnph2 | Q6AY09 | HNRH2_RAT | Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] | −1.444 | 0.021 |
| down | Cmas | P69060 | NEUA_RAT | N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) | −0.661 | 0.021 |
| down | Arpc2 | P85970 | ARPC2_RAT | Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) | −0.398 | 0.021 |
| down | Mlf2 | A0A0G2K8Z8 | A0A0G2K8Z8_RAT | Myeloid leukemia factor 2 | −0.457 | 0.021 |
| down | Oat | P04182 | OAT_RAT | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine--oxo-acid aminotransferase) | −0.638 | 0.021 |
| down | Chordc1 | D4A4T9 | CHRD1_RAT | Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHP-1) (Morgana) | −0.478 | 0.021 |
| down | Cyb5r3 | P20070 | NB5R3_RAT | NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) | −0.594 | 0.021 |
| down | Sdhc | Q641Z9 | Q641Z9_RAT | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (Malate dehydrogenase [quinone] cytochrome b560 subunit) (QPs-1) | −0.533 | 0.021 |
| down | Fbxl16 | Q5MJ12 | FXL16_RAT | F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) (Spinal cord injury and regeneration-related protein 1) | −0.510 | 0.022 |
| down | Rap1gap2 | A0A0G2K0S7 | A0A0G2K0S7_RAT | RAP1 GTPase activating protein 2 | −1.482 | 0.022 |
| down | Ola1 | A0JPJ7 | OLA1_RAT | Obg-like ATPase 1 | −0.473 | 0.022 |
| down | Cbr4 | Q7TS56 | CBR4_RAT | 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) | −1.124 | 0.022 |
| down | Syt1 | P21707 | SYT1_RAT | Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) | −0.359 | 0.022 |
| down | Slc25a25 | Q8K3P6 | SCMC2_RAT | Mitochondrial adenyl nucleotide antiporter SLC25A25 (Mitochondrial calcium-dependent solute carrier) (Short calcium-binding mitochondrial carrier protein 2) (SCaMC-2) (Solute carrier family 25 member 25) | −0.910 | 0.022 |
| down | Nras | Q04970 | RASN_RAT | GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras) | −0.324 | 0.022 |
| down | Hsp90ab1 | P34058 | HS90B_RAT | Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84) | −1.065 | 0.022 |
| down | Idh2 | P56574 | IDHP_RAT | Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | −0.433 | 0.023 |
| down | Paics | P51583 | PUR6_RAT | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] | −0.649 | 0.023 |
| down | Npepps | F1M9V7 | F1M9V7_RAT | Aminopeptidase (EC 3.4.11.-) | −0.430 | 0.023 |
| down | Gda | Q9WTT6 | GUAD_RAT | Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) | −0.415 | 0.023 |
| down | Bri3bp | A0A8I6AHD0 | A0A8I6AHD0_RAT | Bri3 binding protein | −1.253 | 0.023 |
| down | Myo5a | Q9QYF3 | MYO5A_RAT | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) | −0.415 | 0.023 |
| down | Ndufs7 | F7ELE5 | F7ELE5_RAT | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 7.1.1.2) (Complex I-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) | −1.548 | 0.023 |
| down | Acsl6 | P33124 | ACSL6_RAT | Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6) (Long-chain-fatty-acid--CoA ligase, brain isozyme) | −1.003 | 0.023 |
| down | Nrxn1 | Q63372 | NRX1A_RAT | Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) | −0.407 | 0.023 |
| down | Ppm1e | Q80Z30 | PPM1E_RAT | Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA) | −0.369 | 0.023 |
| down | Rps9 | P29314 | RS9_RAT | Small ribosomal subunit protein uS4 (40S ribosomal protein S9) | −0.415 | 0.023 |
| down | Ap2b1 | P62944 | AP2B1_RAT | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | −0.632 | 0.023 |
| down | Ncdn | O35095 | NCDN_RAT | Neurochondrin (Neurite outgrowth-related protein from the rat brain) (Norbin) | −0.441 | 0.023 |
| down | Vdac1 | Q9Z2L0 | VDAC1_RAT | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (rVDAC1) | −0.507 | 0.023 |
| down | Adap1 | O88768 | O88768_RAT | ArfGAP with dual PH domains 1 (IP4/PIP3 binding protein) | −1.194 | 0.023 |
| down | Cdc42 | Q8CFN2 | CDC42_RAT | Cell division control protein 42 homolog (EC 3.6.5.2) | −0.427 | 0.023 |
| down | Napa | P54921 | SNAA_RAT | Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) | −0.417 | 0.024 |
| down | Mal2 | Q7TPB7 | Q7TPB7_RAT | MAL2A (Mal, T-cell differentiation protein 2) | −0.396 | 0.024 |
| down | Gnai1 | P10824 | GNAI1_RAT | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | −0.333 | 0.024 |
| down | Grk2 | P26817 | ARBK1_RAT | Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein-coupled receptor kinase 2) | −0.518 | 0.024 |
| down | Ndufs2 | Q641Y2 | NDUS2_RAT | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit) | −0.433 | 0.024 |
| down | Cs | Q8VHF5 | CISY_RAT | Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) | −0.428 | 0.024 |
| down | Eif3d | Q6AYK8 | EIF3D_RAT | Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) | −0.950 | 0.024 |
| down | Mtch2 | A0A8I6AK45 | A0A8I6AK45_RAT | Mitochondrial carrier homolog 2 | −0.511 | 0.024 |
| down | Tubb4a | A6KQR9 | A6KQR9_RAT | Tubulin beta chain | −1.041 | 0.024 |
| down | Rasal1 | D3ZHY9 | D3ZHY9_RAT | RAS protein activator like 1 | −0.525 | 0.024 |
| down | Gak | P97874 | GAK_RAT | Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) | −0.689 | 0.025 |
| down | Rap2b | P61227 | RAP2B_RAT | Ras-related protein Rap-2b (EC 3.6.5.2) | −0.663 | 0.025 |
| down | Gpi | Q6P6V0 | G6PI_RAT | Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) | −0.412 | 0.025 |
| down | Mtnd1 | P03889 | NU1M_RAT | NADH-ubiquinone oxidoreductase chain 1 (EC 7.1.1.2) (NADH dehydrogenase subunit 1) | −0.753 | 0.025 |
| down | Phb1 | P67779 | PHB1_RAT | Prohibitin 1 | −0.348 | 0.025 |
| down | Dnaja3 | G3V6I5 | G3V6I5_RAT | DnaJ heat shock protein family (Hsp40) member A3 | −0.445 | 0.025 |
| down | Agk | D3Z9L0 | D3Z9L0_RAT | Acylglycerol kinase, mitochondrial (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) | −0.741 | 0.025 |
| down | Pcyt2 | O88637 | PCY2_RAT | Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) | −0.703 | 0.025 |
| down | Prxl2a | Q6AXX6 | PXL2A_RAT | Peroxiredoxin-like 2A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) (Redox-regulatory protein FAM213A) (Sperm head protein 1) | −0.873 | 0.025 |
| down | Cds2 | Q91XU8 | CDS2_RAT | Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) | −0.376 | 0.025 |
| down | Rpl23 | P62832 | RL23_RAT | Large ribosomal subunit protein uL14 (60S ribosomal protein L23) | −0.934 | 0.025 |
| down | Gars1 | Q5I0G4 | GARS_RAT | Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) | −0.466 | 0.025 |
| down | Diras1 | D4A304 | D4A304_RAT | DIRAS family GTPase 1 | −0.960 | 0.025 |
| down | Alg2 | G3V6U3 | G3V6U3_RAT | Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) | −0.672 | 0.025 |
| down | L2hgdh | D3ZVS2 | D3ZVS2_RAT | L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2) | −0.567 | 0.025 |
| down | Esd | B0BNE5 | ESTD_RAT | S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) | −0.463 | 0.025 |
| down | Sars1 | Q6P799 | SYSC_RAT | Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) | −0.456 | 0.025 |
| down | Sod2 | P07895 | SODM_RAT | Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) | −0.391 | 0.025 |
| down | Dcps | Q8K4F7 | DCPS_RAT | m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) | −0.804 | 0.026 |
| down | Suclg1 | P13086 | SUCA_RAT | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) | −1.586 | 0.026 |
| down | Lta4h | P30349 | LKHA4_RAT | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) | −0.384 | 0.026 |
| down | Ubxn6 | A0A0G2K012 | A0A0G2K012_RAT | UBX domain-containing protein 6 (UBX domain-containing protein 1) | −0.448 | 0.026 |
| down | Pcyox1 | Q99ML5 | PCYOX_RAT | Prenylcysteine oxidase 1 (EC 1.8.3.5) (Chloride ion pump-associated 55 kDa protein) | −0.605 | 0.026 |
| down | Mpc2 | P38718 | MPC2_RAT | Mitochondrial pyruvate carrier 2 (Brain protein 44) (Protein 0-44) | −0.318 | 0.026 |
| down | Capn2 | Q07009 | CAN2_RAT | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | −0.669 | 0.026 |
| down | Nrxn3 | Q07310 | NRX3A_RAT | Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha) | −0.438 | 0.027 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.530 | 0.027 |
| down | Decr1 | Q64591 | DECR_RAT | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) | −0.602 | 0.027 |
| down | Ldha | P04642 | LDHA_RAT | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (LDH muscle subunit) (LDH-M) | −0.311 | 0.027 |
| down | Atl1 | Q6PST4 | ATLA1_RAT | Atlastin-1 (EC 3.6.5.-) (Spastic paraplegia 3A homolog) | −0.509 | 0.027 |
| down | Arf5 | P84083 | ARF5_RAT | ADP-ribosylation factor 5 | −0.691 | 0.028 |
| down | Psma4 | P21670 | PSA4_RAT | Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) | −0.473 | 0.028 |
| down | Yars1 | Q4KM49 | SYYC_RAT | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | −0.356 | 0.028 |
| down | Rap1b | Q62636 | RAP1B_RAT | Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B) | −0.789 | 0.029 |
| down | Hsd17b10 | O70351 | HCD2_RAT | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | −0.394 | 0.029 |
| down | Dld | Q6P6R2 | DLDH_RAT | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) | −0.557 | 0.029 |
| down | Gpx4 | P36970 | GPX4_RAT | Phospholipid hydroperoxide glutathione peroxidase (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) (EC 1.11.1.9) | −0.527 | 0.029 |
| down | Plxna4 | D3ZES7 | D3ZES7_RAT | Plexin-A4 | −0.956 | 0.030 |
| down | Dync1i2 | Q62871 | DC1I2_RAT | Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) | −0.505 | 0.031 |
| down | Spr | P18297 | SPRE_RAT | Sepiapterin reductase (SPR) (EC 1.1.1.153) | −0.265 | 0.031 |
| down | Gnaz | P19627 | GNAZ_RAT | Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) | −0.504 | 0.031 |
| down | Exoc6b | A0A0G2JYR1 | A0A0G2JYR1_RAT | Exocyst complex component | −1.215 | 0.031 |
| down | Acaa2 | P13437 | THIM_RAT | 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) | −0.843 | 0.031 |
| down | Nudt3 | Q566C7 | NUDT3_RAT | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59) | −1.062 | 0.031 |
| down | Abr | A0A0G2JTR4 | ABR_RAT | Active breakpoint cluster region-related protein | −0.584 | 0.031 |
| down | Ddx39b | Q63413 | DX39B_RAT | Spliceosome RNA helicase Ddx39b (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein Uap56) | −0.529 | 0.031 |
| down | Psmc4 | Q63570 | PRS6B_RAT | 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (Proteasome 26S subunit ATPase 4) (S6 ATPase) (Tat-binding protein 7) (TBP-7) | −0.362 | 0.031 |
| down | Mtco2 | P00406 | COX2_RAT | Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II) | −0.382 | 0.032 |
| down | Hspa8 | P63018 | HSP7C_RAT | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) | −0.323 | 0.032 |
| down | Kctd16 | A0ABK0M5I7 | A0ABK0M5I7_RAT | Potassium channel tetramerization domain containing 16 | −0.833 | 0.033 |
| down | Rpl18 | P12001 | RL18_RAT | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | −0.446 | 0.033 |
| down | Map2k4 | S4VP54 | S4VP54_RAT | Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (SAPK/ERK kinase 1) | −0.360 | 0.033 |
| down | Gga1 | A0A8I6GLY6 | A0A8I6GLY6_RAT | Golgi associated, gamma adaptin ear containing, ARF binding protein 1 | −0.900 | 0.033 |
| down | Samm50 | Q6AXV4 | SAM50_RAT | Sorting and assembly machinery component 50 homolog | −0.670 | 0.033 |
| down | Cnn3 | P37397 | CNN3_RAT | Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform) | −0.578 | 0.033 |
| down | Actn1 | Q9Z1P2 | ACTN1_RAT | Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) | −0.370 | 0.033 |
| down | Rps15a | P62246 | RS15A_RAT | Small ribosomal subunit protein uS8 (40S ribosomal protein S15a) | −0.378 | 0.034 |
| down | Dnajc11 | A6IUF7 | A6IUF7_RAT | DnaJ homolog subfamily C member 11 | −0.946 | 0.034 |
| down | Babam2 | Q6P7Q1 | BABA2_RAT | BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) | −1.145 | 0.034 |
| down | Kyat3 | Q58FK9 | KAT3_RAT | Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) | −0.742 | 0.034 |
| down | Slc17a7 | Q62634 | VGLU1_RAT | Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7) | −0.373 | 0.034 |
| down | Dlg2 | Q63622 | DLG2_RAT | Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) | −0.366 | 0.034 |
| down | Celf2 | Q792H5 | CELF2_RAT | CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Protein ETR-R3) (Neuroblastoma apoptosis-related RNA-binding protein) (rNapor) (RNA-binding protein BRUNOL-3) | −0.335 | 0.034 |
| down | Eprs1 | Q6TXE9 | Q6TXE9_RAT | Bifunctional glutamate/proline--tRNA ligase (EC 6.1.1.15) (Bifunctional aminoacyl-tRNA synthetase) | −0.670 | 0.034 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.716 | 0.034 |
| down | Rhob | P62747 | RHOB_RAT | Rho-related GTP-binding protein RhoB | −0.300 | 0.034 |
| down | Cnp | P13233 | CN37_RAT | 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) | −0.314 | 0.034 |
| down | Anxa11 | A0A8I6A5R0 | A0A8I6A5R0_RAT | Annexin | −0.581 | 0.034 |
| down | Alcam | O35112 | CD166_RAT | CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166) | −0.453 | 0.034 |
| down | Vps35 | G3V8A5 | G3V8A5_RAT | Vacuolar protein sorting-associated protein 35 | −0.452 | 0.034 |
| down | Txnrd1 | O89049 | TRXR1_RAT | Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (NADPH-dependent thioredoxin reductase) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1) | −0.532 | 0.035 |
| down | Grm3 | P31422 | GRM3_RAT | Metabotropic glutamate receptor 3 (mGluR3) | −0.708 | 0.035 |
| down | Myh10 | Q9JLT0 | MYH10_RAT | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | −0.424 | 0.035 |
| down | Gnas | P63095 | GNAS2_RAT | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (G-alpha-8) | −0.361 | 0.035 |
| down | Rpl4 | P50878 | RL4_RAT | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | −0.461 | 0.035 |
| down | Arhgef2 | Q5FVC2 | ARHG2_RAT | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) | −0.423 | 0.035 |
| down | Cbx5 | B2RYU7 | B2RYU7_RAT | Cbx5 protein (Chromobox 5) (Chromobox homolog 5 (HP1 alpha homolog, Drosophila)) | −0.877 | 0.036 |
| down | Gls | P13264 | GLSK_RAT | Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain] | −0.370 | 0.036 |
| down | Rras2 | Q5BJU0 | Q5BJU0_RAT | RAS related 2 | −0.790 | 0.036 |
| down | Crmp1 | Q62950 | DPYL1_RAT | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) | −0.675 | 0.036 |
| down | Sec23a | B5DFC3 | B5DFC3_RAT | Protein transport protein SEC23 | −1.244 | 0.036 |
| down | Atp6v0d1 | A0A8I6AMP1 | A0A8I6AMP1_RAT | V-type proton ATPase subunit | −0.358 | 0.036 |
| down | Hapln1 | P03994 | HPLN1_RAT | Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein) | −0.315 | 0.037 |
| down | Ttyh1 | P0C5X8 | TTYH1_RAT | Protein tweety homolog 1 (Volume-regulated anion channel subunit Ttyh1) | −0.511 | 0.037 |
| down | Eef1a1 | P62630 | EF1A1_RAT | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) | −1.125 | 0.038 |
| down | Afg3l2 | F1LN92 | F1LN92_RAT | AFG3 like matrix AAA peptidase subunit 2 | −0.498 | 0.038 |
| down | Hycc2 | Q4V7D4 | Q4V7D4_RAT | Family with sequence similarity 126, member B (Hyccin PI4KA lipid kinase complex subunit 2) | −0.392 | 0.038 |
| down | Rap2a | A0ABK0M907 | A0ABK0M907_RAT | Uncharacterized protein | −0.362 | 0.038 |
| down | Acsbg1 | Q924N5 | ACBG1_RAT | Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (Gonadotropin-regulated long chain acyl CoA synthetase) (GR-LACS) | −0.350 | 0.038 |
| down | Gstp1 | P04906 | GSTP1_RAT | Glutathione S-transferase P (EC 2.5.1.18) (Chain 7) (GST 7-7) (GST class-pi) | −0.335 | 0.038 |
| down | Eif3c | B5DFC8 | EIF3C_RAT | Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) | −0.451 | 0.039 |
| down | Opa1 | Q2TA68 | OPA1_RAT | Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1 homolog) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)] | −0.340 | 0.039 |
| down | Pgd | P85968 | 6PGD_RAT | 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) | −0.366 | 0.039 |
| down | Fkbp4 | Q9QVC8 | FKBP4_RAT | Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] | −0.322 | 0.039 |
| down | Ilf2 | Q7TP98 | ILF2_RAT | Interleukin enhancer-binding factor 2 (Liver regeneration-related protein LRRG031) | −0.486 | 0.040 |
| down | Gstm5 | Q9Z1B2 | GSTM5_RAT | Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) | −0.371 | 0.040 |
| down | Camk2g | P11730 | KCC2G_RAT | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) | −0.695 | 0.041 |
| down | Ddb1 | Q9ESW0 | DDB1_RAT | DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) | −0.469 | 0.041 |
| down | Aars1 | P50475 | SYAC_RAT | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) | −0.403 | 0.041 |
| down | Tspan2 | Q9JJW1 | TSN2_RAT | Tetraspanin-2 (Tspan-2) | −1.581 | 0.041 |
| down | Usp14 | A0A8I5ZY29 | A0A8I5ZY29_RAT | Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) | −0.479 | 0.041 |
| down | Sipa1l3 | F1LYG2 | F1LYG2_RAT | Signal-induced proliferation-associated 1 like 3 | −0.493 | 0.041 |
| down | Srm | Q99MI5 | Q99MI5_RAT | Spermidine synthase (EC 2.5.1.16) (Putrescine aminopropyltransferase) | −0.441 | 0.042 |
| down | Nars1 | F1LPV0 | F1LPV0_RAT | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (Asparaginyl-tRNA synthetase 1) | −0.517 | 0.042 |
| down | Htt | P51111 | HD_RAT | Huntingtin (Huntington disease protein homolog) (HD protein homolog) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | −0.691 | 0.042 |
| down | Src | Q9WUD9 | SRC_RAT | Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) | −0.806 | 0.042 |
| down | Plpbp | A0A8I6AQ45 | A0A8I6AQ45_RAT | Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) (Proline synthase co-transcribed bacterial homolog protein) | −1.392 | 0.042 |
| down | Inpp1 | A6INV6 | A6INV6_RAT | Inositol polyphosphate 1-phosphatase (EC 3.1.3.57) | −0.913 | 0.043 |
| down | Lancl2 | Q68FQ9 | Q68FQ9_RAT | LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) | −0.490 | 0.043 |
| down | Srgap3 | F1M5M9 | F1M5M9_RAT | SLIT-ROBO Rho GTPase-activating protein 3 (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) | −0.395 | 0.043 |
| down | Slc25a5 | Q09073 | ADT2_RAT | ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed] | −1.492 | 0.043 |
| down | Rab5a | M0RC99 | RAB5A_RAT | Ras-related protein Rab-5A (EC 3.6.5.2) (Small GTP-binding protein rab5) | −0.302 | 0.043 |
| down | Epb41l1 | Q9WTP0 | E41L1_RAT | Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) | −0.330 | 0.044 |
| down | Rhog | Q32PX6 | Q32PX6_RAT | Rho-related GTP-binding protein RhoG | −0.530 | 0.044 |
| down | Pi4ka | O08662 | PI4KA_RAT | Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) | −0.438 | 0.044 |
| down | Slc25a11 | P97700 | M2OM_RAT | Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) | −0.383 | 0.044 |
| down | Rab3b | Q63941 | RAB3B_RAT | Ras-related protein Rab-3B (EC 3.6.5.2) | −0.697 | 0.044 |
| down | Vps26a | Q6AY86 | VP26A_RAT | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) | −0.413 | 0.044 |
| down | Snrpd1 | A6KNE7 | A6KNE7_RAT | Small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) | −0.807 | 0.044 |
| down | Aldh1l1 | P28037 | AL1L1_RAT | Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1) (FBP-CI) | −0.549 | 0.044 |
| down | Napb | P85969 | SNAB_RAT | Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta) | −0.334 | 0.045 |
| down | Kpnb1 | P52296 | IMB1_RAT | Importin subunit beta-1 (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | −0.322 | 0.045 |
| down | Klc1 | P37285 | KLC1_RAT | Kinesin light chain 1 (KLC 1) | −0.279 | 0.045 |
| down | Mat2a | P18298 | METK2_RAT | S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) | −0.745 | 0.045 |
| down | Cap2 | P52481 | CAP2_RAT | Adenylyl cyclase-associated protein 2 (CAP 2) | −0.295 | 0.045 |
| down | Pdxp | Q8VD52 | PLPP_RAT | Chronophin (EC 3.1.3.16) (EC 3.1.3.74) (Pyridoxal phosphate phosphatase) (PLP phosphatase) (Reg I-binding protein 1) | −0.308 | 0.045 |
| down | Ndufa10 | Q561S0 | NDUAA_RAT | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) | −0.319 | 0.046 |
| down | Myadm | Q6VBQ5 | MYADM_RAT | Myeloid-associated differentiation marker (Myeloid up-regulated protein) | −1.469 | 0.046 |
| down | Septin4 | A0A096MJN4 | SEPT4_RAT | Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (Arts) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2) | −0.434 | 0.046 |
| down | Ppa1 | A0A8I6AI23 | A0A8I6AI23_RAT | inorganic diphosphatase (EC 3.6.1.1) | −0.311 | 0.046 |
| down | Slc6a17 | P31662 | S6A17_RAT | Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) | −0.621 | 0.047 |
| down | Ndufa4 | A6IDY9 | A6IDY9_RAT | Cytochrome c oxidase subunit NDUFA4 | −0.261 | 0.047 |
| down | Snap47 | Q6P6S0 | SNP47_RAT | Synaptosomal-associated protein 47 (SNAP-47) (Synaptosomal-associated 47 kDa protein) | −0.429 | 0.047 |
| down | Nudcd2 | Q5M823 | NUDC2_RAT | NudC domain-containing protein 2 | −0.710 | 0.047 |
| down | Rpl6 | P21533 | RL6_RAT | Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) | −0.423 | 0.048 |
| down | Pmm1 | A6HT35 | A6HT35_RAT | Phosphomannomutase (EC 5.4.2.8) | −0.591 | 0.048 |
| down | Trim9 | Q91ZY8 | TRIM9_RAT | E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM9) (SNAP-25-interacting RING finger protein) (Tripartite motif-containing protein 9) | −0.474 | 0.048 |
| down | Rpl7a | P62425 | RL7A_RAT | Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) | −0.416 | 0.049 |
| down | S1pr1 | P48303 | S1PR1_RAT | Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) | −1.402 | 0.049 |
| down | Tomm70 | Q75Q39 | TOM70_RAT | Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) | −0.509 | 0.049 |
| down | Slc7a5 | Q63016 | LAT1_RAT | Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (Integral membrane protein E16) (Protein TA1) (L-type amino acid transporter 1) (LAT-1) (Solute carrier family 7 member 5) | −0.349 | 0.050 |
# EE VS SH (Young)
# gt 2 - by fold change direction & pvalue
lit_review_proteomics_sig |>
dplyr::ungroup() |>
dplyr:: filter(Condition == "young") %>%
#dplyr::select(-(c(`Av. Ratio`, ))) |>
dplyr::select(c(Condition, In_EE, Gene_name, Entry, Entry.Name,
Protein.names, Fold_change, adj.P.Val)) |>
dplyr::arrange(desc(In_EE), adj.P.Val, Fold_change) |>
gt(
groupname_col = "Condition",
rowname_col = "In_EE"
) |>
fmt_number(decimals = 3) |>
tab_header(
title = "Young - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only)",
subtitle = "2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by young)"
) |>
tab_options(table.font.size=11.5,
stub.font.weight = "bold",
row_group.font.weight = "bold",
row_group.font.size = 12.5,
column_labels.font.size = 12.5,
column_labels.font.weight = "bold")
| Young - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only) | ||||||
| 2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by young) | ||||||
| Gene_name | Entry | Entry.Name | Protein.names | Fold_change | adj.P.Val | |
|---|---|---|---|---|---|---|
| young | ||||||
| up | H1-0 | P43278 | H10_RAT | Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] | 1.078 | 0.007 |
| up | Wasl | O08816 | WASL_RAT | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | 1.423 | 0.007 |
| up | Basp1 | Q05175 | BASP1_RAT | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | 1.038 | 0.010 |
| up | H1-4 | P15865 | H14_RAT | Histone H1.4 (H1d) | 1.450 | 0.010 |
| up | Slc9a1 | P26431 | SL9A1_RAT | Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | 0.866 | 0.010 |
| up | Rph3a | P47709 | RP3A_RAT | Rabphilin-3A (Exophilin-1) | 0.968 | 0.010 |
| up | Map6 | Q63560 | MAP6_RAT | Microtubule-associated protein 6 (MAP-6) (145-kDa STOP) (STOP145) (Stable tubule-only polypeptide) (STOP) | 1.026 | 0.010 |
| up | Ptprn2 | Q63475 | PTPR2_RAT | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (PTP NE-6) (PTPNE6) (Phogrin) [Cleaved into: IA-2beta60] | 1.095 | 0.010 |
| up | Txn | P11232 | THIO_RAT | Thioredoxin (Trx) | 1.157 | 0.010 |
| up | Atp5pf | P21571 | ATP5J_RAT | ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) | 1.203 | 0.010 |
| up | Hdgfl3 | Q923W4 | HDGR3_RAT | Hepatoma-derived growth factor-related protein 3 (HRP-3) | 1.401 | 0.010 |
| up | Hgs | Q9JJ50 | HGS_RAT | Hepatocyte growth factor-regulated tyrosine kinase substrate (SNAP-25-interacting protein Hrs-2) | 0.942 | 0.010 |
| up | Sod1 | P07632 | SODC_RAT | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) | 1.305 | 0.011 |
| up | Dtd1 | A0A8I6A4Q0 | A0A8I6A4Q0_RAT | D-aminoacyl-tRNA deacylase (EC 3.1.1.96) | 1.002 | 0.012 |
| up | Syn3 | O70441 | SYN3_RAT | Synapsin-3 (Synapsin III) | 1.028 | 0.012 |
| up | Rgs10 | P49806 | RGS10_RAT | Regulator of G-protein signaling 10 (RGS10) | 1.417 | 0.012 |
| up | Chchd4 | Q5BJN5 | MIA40_RAT | Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) | 1.101 | 0.012 |
| up | Tsr2 | A0A8I5ZLR7 | A0A8I5ZLR7_RAT | Pre-rRNA-processing protein TSR2 homolog | 0.975 | 0.012 |
| up | Bag3 | A6IA08 | A6IA08_RAT | BAG family molecular chaperone regulator 3 (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) | 1.289 | 0.012 |
| up | Slc32a1 | O35458 | VIAAT_RAT | Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (rGVAT) (rat UNC-47 homolog) (RUNC-47) | 1.053 | 0.012 |
| up | Mical3 | D3ZGN7 | D3ZGN7_RAT | F-actin monooxygenase (EC 1.14.13.225) | 1.092 | 0.013 |
| up | Psip1 | Q812D1 | PSIP1_RAT | PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) | 1.100 | 0.013 |
| up | Tceal5 | A0ABK0KXI7 | A0ABK0KXI7_RAT | Transcription elongation factor A like 5 | 1.222 | 0.013 |
| up | Scg3 | P47868 | SCG3_RAT | Secretogranin-3 (1B1075) (Secretogranin III) (SgIII) | 1.035 | 0.013 |
| up | Mbp | P02688 | MBP_RAT | Myelin basic protein (MBP) | 1.132 | 0.014 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.786 | 0.014 |
| up | Rbmx | Q4V898 | RBMX_RAT | RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) (RNA-binding motif protein, X chromosome retrogene) (RNA-binding motif protein, X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | 0.843 | 0.015 |
| up | Bod1 | Q6AYJ2 | BOD1_RAT | Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) | 1.156 | 0.015 |
| up | Rims1 | Q9JIR4 | RIMS1_RAT | Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) | 0.683 | 0.016 |
| up | Nfu1 | D3ZA85 | D3ZA85_RAT | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5) | 0.842 | 0.016 |
| up | Cdkn1b | O08769 | O08769_RAT | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | 0.679 | 0.017 |
| up | Fam169a | D3ZKX8 | D3ZKX8_RAT | Family with sequence similarity 169, member A | 0.803 | 0.017 |
| up | Akap12 | Q5QD51 | AKA12_RAT | A-kinase anchor protein 12 (AKAP-12) | 0.869 | 0.017 |
| up | Cltb | P08082 | CLCB_RAT | Clathrin light chain B (Lcb) | 1.159 | 0.017 |
| up | Txndc17 | A0ABK0M2Q2 | A0ABK0M2Q2_RAT | Thioredoxin domain containing 17 | 2.379 | 0.017 |
| up | Vgf | P20156 | VGF_RAT | Neurosecretory protein VGF (VGF8a protein) [Cleaved into: VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-11; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-30; VGF-derived peptide TLQP-62; VGF-derived peptide HFHH-10; VGF-derived peptide AQEE-30; VGF-derived peptide LQEQ-19] | 1.099 | 0.017 |
| up | Gap43 | P07936 | NEUM_RAT | Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Protein F1) | 1.110 | 0.018 |
| up | Ythdf3 | A0A8I6ACC2 | A0A8I6ACC2_RAT | YTH domain-containing family protein | 0.965 | 0.018 |
| up | Fabp3 | P07483 | FABPH_RAT | Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) | 0.758 | 0.019 |
| up | Map1a | P34926 | MAP1A_RAT | Microtubule-associated protein 1A (MAP-1A) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | 1.046 | 0.019 |
| up | Bsn | O88778 | BSN_RAT | Protein bassoon | 0.728 | 0.019 |
| up | Pclo | Q9JKS6 | PCLO_RAT | Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) | 0.991 | 0.019 |
| up | Hcn1 | Q9JKB0 | HCN1_RAT | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 0.955 | 0.020 |
| up | Shroom2 | Q7TP36 | SHRM2_RAT | Protein Shroom2 (Liver regeneration-related protein LRRG167) (Protein Apxl) | 1.044 | 0.020 |
| up | Lmtk3 | F1LSB5 | F1LSB5_RAT | non-specific serine/threonine protein kinase (EC 2.7.11.1) | 0.922 | 0.021 |
| up | Ube2v2 | Q7M767 | UB2V2_RAT | Ubiquitin-conjugating enzyme E2 variant 2 (Ubiquitin-conjugating enzyme variant MMS2) | 2.170 | 0.021 |
| up | Snap25 | P60881 | SNP25_RAT | Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) | 0.743 | 0.021 |
| up | Ubap2l | A0A8I5ZUK2 | A0A8I5ZUK2_RAT | Ubiquitin associated protein 2-like | 1.031 | 0.021 |
| up | Tsc22d1 | P62501 | T22D1_RAT | TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | 1.260 | 0.021 |
| up | Clta | P08081 | CLCA_RAT | Clathrin light chain A (Lca) | 0.859 | 0.022 |
| up | Glg1 | Q62638 | GSLG1_RAT | Golgi apparatus protein 1 (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) | 0.598 | 0.023 |
| up | Prrc2c | A0A8I5Y7A0 | A0A8I5Y7A0_RAT | Proline-rich coiled-coil 2C | 1.062 | 0.023 |
| up | Amph | O08838 | AMPH_RAT | Amphiphysin | 0.876 | 0.024 |
| up | Ppp1r1b | Q6J4I0 | PPR1B_RAT | Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) | 0.972 | 0.024 |
| up | Ppp1r11 | Q6MFY6 | PP1RB_RAT | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Protein phosphatase 1 regulatory subunit 11) | 0.911 | 0.025 |
| up | Spock2 | A0A8I5ZQG2 | A0A8I5ZQG2_RAT | Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2) | 1.379 | 0.025 |
| up | Tppp | D3ZQL7 | TPPP_RAT | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p25-alpha) | 0.631 | 0.025 |
| up | Sarnp | Q498U4 | SARNP_RAT | SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1) | 0.938 | 0.025 |
| up | Efhd2 | Q4FZY0 | EFHD2_RAT | EF-hand domain-containing protein D2 (Swiprosin-1) | 1.061 | 0.025 |
| up | Sorbs2 | O35413 | SRBS2_RAT | Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Neural ArgBP2) (nArgBP2) (Sorbin) | 1.470 | 0.025 |
| up | Ldah | Q5HZX7 | LDAH_RAT | Lipid droplet-associated hydrolase (EC 3.1.1.13) (Lipid droplet-associated serine hydrolase) | 1.742 | 0.025 |
| up | Ppp1r12a | Q10728 | MYPT1_RAT | Protein phosphatase 1 regulatory subunit 12A (MBSP) (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) (Protein phosphatase subunit 1M) (PP-1M) (Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110) | 0.831 | 0.025 |
| up | Gfer | Q63042 | ALR_RAT | FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) | 0.968 | 0.026 |
| up | Bnip3l | A6K6N6 | A6K6N6_RAT | BCL2 interacting protein 3 like (BCL2/adenovirus E1B interacting protein 3-like) | 1.662 | 0.026 |
| up | Pdap1 | Q62785 | HAP28_RAT | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | 1.066 | 0.026 |
| up | Spart | E9PT90 | E9PT90_RAT | Spartin | 1.712 | 0.026 |
| up | Tppp3 | Q5PPN5 | TPPP3_RAT | Tubulin polymerization-promoting protein family member 3 | 0.985 | 0.026 |
| up | Gprin1 | A0A8I6AJM0 | A0A8I6AJM0_RAT | G protein-regulated inducer of neurite outgrowth 1 | 1.333 | 0.026 |
| up | Oxsr1 | A0A8I5ZNK2 | OXSR1_RAT | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | 0.777 | 0.027 |
| up | Wipf3 | Q9Z0G8 | WIPF3_RAT | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16) | 0.901 | 0.028 |
| up | Prrt3 | D3ZWQ0 | D3ZWQ0_RAT | Proline-rich transmembrane protein 3 | 0.901 | 0.028 |
| up | Zdhhc5 | Q2THW7 | ZDHC5_RAT | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) | 1.603 | 0.028 |
| up | Ahnak | A0A0G2JUA5 | A0A0G2JUA5_RAT | AHNAK nucleoprotein | 1.184 | 0.030 |
| up | Hspe1 | P26772 | CH10_RAT | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) | 0.974 | 0.030 |
| up | Fkbp3 | G3V6L9 | G3V6L9_RAT | peptidylprolyl isomerase (EC 5.2.1.8) | 0.553 | 0.032 |
| up | 2900026A02Rik | NA | NA | NA | 0.601 | 0.032 |
| up | Marcks | P30009 | MARCS_RAT | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein) | 1.097 | 0.032 |
| up | Pacsin2 | Q9QY17 | PACN2_RAT | Protein kinase C and casein kinase substrate in neurons 2 protein (Synaptic dynamin-associated protein II) (Syndapin-2) (Syndapin-II) (SdpII) | 0.549 | 0.032 |
| up | Habp4 | A1L1K8 | HABP4_RAT | Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) | 0.537 | 0.033 |
| up | Atp6v1g1 | A0A8I6B3N3 | A0A8I6B3N3_RAT | V-type proton ATPase subunit G | 0.608 | 0.033 |
| up | Shank2 | Q9QX74 | SHAN2_RAT | SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3) | 0.613 | 0.033 |
| up | Eif4b | A0ABK0LP36 | A0ABK0LP36_RAT | Eukaryotic translation initiation factor 4B | 0.732 | 0.033 |
| up | Naca | M0R9L0 | M0R9L0_RAT | Nascent polypeptide associated complex subunit alpha | 0.779 | 0.033 |
| up | Eif3j1 | NA | NA | NA | 0.796 | 0.033 |
| up | Cacna1b | Q02294 | CAC1B_RAT | Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) | 0.904 | 0.033 |
| up | Polr2m | Q91XQ4 | GRL1A_RAT | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | 1.024 | 0.033 |
| up | Zfp428 | A0A0G2K1B1 | A0A0G2K1B1_RAT | Zinc finger protein 428 | 1.009 | 0.033 |
| up | Sf1 | F1LM37 | F1LM37_RAT | Splicing factor 1 | 0.945 | 0.034 |
| up | Scg2 | P10362 | SCG2_RAT | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | 1.048 | 0.034 |
| up | Necab2 | F1LQY6 | NECA2_RAT | N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) | 0.539 | 0.035 |
| up | Glrx5 | D4ADD7 | D4ADD7_RAT | Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5) | 0.665 | 0.035 |
| up | Sdc4 | P34901 | SDC4_RAT | Syndecan-4 (SYND4) (Ryudocan core protein) | 1.065 | 0.035 |
| up | Ybx1 | P62961 | YBOX1_RAT | Y-box-binding protein 1 (YB-1) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | 1.284 | 0.035 |
| up | Evl | O08719 | EVL_RAT | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | 1.579 | 0.035 |
| up | Cnst | A0A8I5ZKG8 | A0A8I5ZKG8_RAT | Consortin, connexin sorting protein | 1.146 | 0.035 |
| up | Bcas1 | Q3ZB98 | BCAS1_RAT | Breast carcinoma-amplified sequence 1 homolog (Protein whose mRNA is enriched in synaptosomes 2) (Pmes-2) | 0.863 | 0.036 |
| up | Slc39a10 | A0A1W2Q626 | A0A1W2Q626_RAT | Solute carrier family 39 member 10 | 0.923 | 0.036 |
| up | Dnajc5 | P60905 | DNJC5_RAT | DnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP) | 0.702 | 0.036 |
| up | Reps1 | A0A0G2JZY3 | A0A0G2JZY3_RAT | RALBP1 associated Eps domain containing 1 | 1.044 | 0.036 |
| up | Rabl6 | D3ZKQ4 | D3ZKQ4_RAT | Rab-like protein 6 (GTP-binding protein Parf) (Rab-like protein 1) | 1.250 | 0.036 |
| up | Tmpo | Q62733 | LAP2_RAT | Lamina-associated polypeptide 2, isoform beta (Thymopoietin isoform beta) (TP beta) | 0.613 | 0.037 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.673 | 0.037 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.673 | 0.037 |
| up | Psmd9 | Q9WTV5 | PSMD9_RAT | 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) (Transactivating protein Bridge-1) | 0.685 | 0.037 |
| up | Cplx2 | P84087 | CPLX2_RAT | Complexin-2 (Complexin II) (CPX II) (Synaphin-1) | 0.773 | 0.037 |
| up | Abl2 | F1M0N1 | F1M0N1_RAT | Tyrosine-protein kinase (EC 2.7.10.2) | 0.953 | 0.037 |
| up | Larp1 | A0A8I6GJC3 | A0A8I6GJC3_RAT | La ribonucleoprotein 1, translational regulator | 1.022 | 0.037 |
| up | Smap | NA | NA | NA | 1.454 | 0.037 |
| up | Fabp7 | P55051 | FABP7_RAT | Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) | 1.544 | 0.037 |
| up | Saa1 | NA | NA | NA | 2.197 | 0.037 |
| up | Pkig | A6JX44 | A6JX44_RAT | cAMP-dependent protein kinase inhibitor | 2.399 | 0.037 |
| up | Endod1 | D3ZIP8 | D3ZIP8_RAT | Endonuclease domain containing 1 | 0.621 | 0.037 |
| up | Cstf2 | B4F7F1 | B4F7F1_RAT | Cleavage stimulation factor subunit 2 (Cstf2 protein) | 0.879 | 0.037 |
| up | Khdrbs3 | Q9JLP1 | KHDR3_RAT | KH domain-containing, RNA-binding, signal transduction-associated protein 3 (Sam68-like mammalian protein 2) (SLM-2) (rSLM-2) | 0.709 | 0.038 |
| up | Ktn1 | A0A8I6A4W2 | A0A8I6A4W2_RAT | Kinectin 1 | 1.889 | 0.038 |
| up | Chgb | O35314 | SCG1_RAT | Secretogranin-1 (Chromogranin-B) (CgB) (Glucagonoma peptide) (Secretogranin-I) (SgI) [Cleaved into: PE-11; CCB peptide short form; CCB peptide long form] | 0.939 | 0.038 |
| up | Inf2 | E9PT22 | E9PT22_RAT | Inverted formin-2 | 1.166 | 0.038 |
| up | Shfl | Q5RJN4 | SHFL_RAT | Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog (SHFL) (Repressor of yield of DENV protein homolog) (RyDEN) | 0.880 | 0.039 |
| up | Dek | Q6AXS3 | DEK_RAT | Protein DEK | 0.631 | 0.039 |
| up | Omg | F7EYB9 | F7EYB9_RAT | Oligodendrocyte-myelin glycoprotein | 0.719 | 0.039 |
| up | Rad23b | Q4KMA2 | RD23B_RAT | UV excision repair protein RAD23 homolog B | 0.758 | 0.039 |
| up | Gm2a | A0A8I6A5G9 | A0A8I6A5G9_RAT | Ganglioside GM2 activator | 1.001 | 0.039 |
| up | Ppp6r3 | F1MAH5 | F1MAH5_RAT | Protein phosphatase 6, regulatory subunit 3 | 1.094 | 0.039 |
| up | Nsfl1c | O35987 | NSF1C_RAT | NSFL1 cofactor p47 (XY body-associated protein XY40) (p97 cofactor p47) | 0.699 | 0.039 |
| up | Cttn | Q66HL2 | SRC8_RAT | Src substrate cortactin | 0.653 | 0.040 |
| up | Bola1 | Q06C60 | Q06C60_RAT | BolA-like protein 1 | 0.567 | 0.040 |
| up | Thrap3 | Q5M7V8 | TR150_RAT | Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) | 0.696 | 0.041 |
| up | Nherf1 | Q9JJ19 | NHRF1_RAT | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | 0.858 | 0.041 |
| up | Mast1 | Q810W7 | MAST1_RAT | Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) | 1.300 | 0.041 |
| up | Serbp1 | Q6AXS5 | SERB1_RAT | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) (RDA288) | 0.717 | 0.041 |
| up | Rpl23a | P62752 | RL23A_RAT | Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) | 0.601 | 0.042 |
| up | Map1b | P15205 | MAP1B_RAT | Microtubule-associated protein 1B (MAP-1B) (Neuraxin) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | 0.757 | 0.042 |
| up | Atp5if1 | Q03344 | ATIF1_RAT | ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) | 0.819 | 0.042 |
| up | Caskin1 | Q8VHK2 | CSKI1_RAT | Caskin-1 (CASK-interacting protein 1) | 0.570 | 0.043 |
| up | Ogfrl1 | Q4KLH3 | OGRL1_RAT | Opioid growth factor receptor-like protein 1 | 0.920 | 0.044 |
| up | Atxn2l | A0A0G2JYE0 | A0A0G2JYE0_RAT | Ataxin 2-like | 0.953 | 0.045 |
| up | Zfand2b | Q4KLG9 | ZFN2B_RAT | AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein) | 0.693 | 0.045 |
| up | Ensa | P60841 | ENSA_RAT | Alpha-endosulfine (ARPP-19e) | 0.894 | 0.045 |
| up | Ndufv3 | Q6PCU8 | NDUV3_RAT | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) | 0.791 | 0.047 |
| up | Plppr3 | Q7TMB0 | PLPR3_RAT | Phospholipid phosphatase-related protein type 3 (Inactive phospholipid phosphatase PLPPR3) (Lipid phosphate phosphatase-related protein type 3) (Plasticity-related gene 2 protein) (PRG-2) | 1.250 | 0.047 |
| up | Nebl | D4A164 | D4A164_RAT | Nebulette | 0.748 | 0.047 |
| up | Ptpn23 | O88902 | PTN23_RAT | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | 0.869 | 0.047 |
| down | Reep2 | A0A0G2K1L5 | A0A0G2K1L5_RAT | Receptor expression-enhancing protein | −3.433 | 0.000 |
| down | Tubb3 | Q4QRB4 | TBB3_RAT | Tubulin beta-3 chain (Neuron-specific class III beta-tubulin) | −2.267 | 0.001 |
| down | Tubb4a | A6KQR9 | A6KQR9_RAT | Tubulin beta chain | −2.005 | 0.001 |
| down | Eef1a1 | P62630 | EF1A1_RAT | Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) | −2.248 | 0.006 |
| down | Lxn | Q64361 | LXN_RAT | Latexin (Endogenous carboxypeptidase inhibitor) (ECI) (Tissue carboxypeptidase inhibitor) (TCI) | −1.356 | 0.007 |
| down | Msn | O35763 | MOES_RAT | Moesin (Membrane-organizing extension spike protein) | −3.434 | 0.007 |
| down | Ddx1 | Q641Y8 | DDX1_RAT | ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) | −2.035 | 0.007 |
| down | Adcy9 | M0R5U4 | M0R5U4_RAT | Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (Adenylyl cyclase 9) | −1.651 | 0.007 |
| down | Rab6a | Q9WVB1 | RAB6A_RAT | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | −1.627 | 0.007 |
| down | Cyb5b | P04166 | CYB5B_RAT | Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform) | −1.627 | 0.007 |
| down | Ckap5 | F1M949 | F1M949_RAT | Cytoskeleton-associated protein 5 | −1.202 | 0.007 |
| down | Drg2 | A0A8I5ZWK0 | A0A8I5ZWK0_RAT | Developmentally-regulated GTP-binding protein 2 (Translation factor GTPase DRG2) | −1.196 | 0.007 |
| down | Hsp90aa1 | P82995 | HS90A_RAT | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) | −1.151 | 0.007 |
| down | Dtna | D4A772 | D4A772_RAT | Dystrobrevin | −1.088 | 0.007 |
| down | Grin2a | Q00959 | NMDE1_RAT | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) | −1.786 | 0.009 |
| down | Twf1 | Q5RJR2 | TWF1_RAT | Twinfilin-1 | −1.112 | 0.009 |
| down | Tspan7 | B0BNE7 | B0BNE7_RAT | Tetraspanin | −1.473 | 0.009 |
| down | Actr3b | A0A8I6GL35 | A0A8I6GL35_RAT | Actin related protein 3B | −1.280 | 0.009 |
| down | Dnm1 | P21575 | DYN1_RAT | Dynamin-1 (EC 3.6.5.5) (B-dynamin) (D100) (Dynamin I) (Dynamin, brain) | −1.121 | 0.009 |
| down | Arl3 | P37996 | ARL3_RAT | ADP-ribosylation factor-like protein 3 (ARD3) | −0.929 | 0.009 |
| down | Tmed2 | Q63524 | TMED2_RAT | Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (Membrane protein p24A) (RNP21.4) (p24 family protein beta-1) (p24beta1) | −1.981 | 0.010 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.940 | 0.010 |
| down | Smap1 | A0A8I5ZQ30 | A0A8I5ZQ30_RAT | Small ArfGAP 1 | −0.866 | 0.010 |
| down | Hsp90ab1 | P34058 | HS90B_RAT | Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84) | −1.850 | 0.010 |
| down | Sh3gl3 | O35180 | SH3G3_RAT | Endophilin-A3 (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) (SH3p13) | −1.751 | 0.010 |
| down | Rab14 | P61107 | RAB14_RAT | Ras-related protein Rab-14 (EC 3.6.5.2) | −1.071 | 0.010 |
| down | Eif3i | B0BNA7 | EIF3I_RAT | Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (eIF-3-beta) (eIF3 p36) | −1.053 | 0.010 |
| down | Padi2 | P20717 | PADI2_RAT | Protein-arginine deiminase type-2 (EC 3.5.3.15) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) | −1.022 | 0.010 |
| down | Ppp2r1a | Q5XI34 | Q5XI34_RAT | Protein phosphatase 2 scaffold subunit A alpha | −0.940 | 0.010 |
| down | Shisa6 | D4A4M0 | D4A4M0_RAT | Shisa family member 6 | −0.904 | 0.010 |
| down | Dlg3 | Q62936 | DLG3_RAT | Disks large homolog 3 (PSD-95/SAP90-related protein 1) (Synapse-associated protein 102) (SAP-102) (SAP102) | −1.036 | 0.010 |
| down | Ca4 | P48284 | CAH4_RAT | Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV) | −2.132 | 0.011 |
| down | Them4 | Q566R0 | THEM4_RAT | Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Thioesterase superfamily member 4) | −2.182 | 0.012 |
| down | Dynlrb1 | P62628 | DLRB1_RAT | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (robl/LC7-like protein) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) | −1.733 | 0.012 |
| down | Pfkp | P47860 | PFKAP_RAT | ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) | −1.137 | 0.012 |
| down | Gtf2i | Q5U2Y1 | GTF2I_RAT | General transcription factor II-I (GTFII-I) (TFII-I) | −2.330 | 0.012 |
| down | Tspan2 | Q9JJW1 | TSN2_RAT | Tetraspanin-2 (Tspan-2) | −2.958 | 0.012 |
| down | Rps7 | P62083 | RS7_RAT | Small ribosomal subunit protein eS7 (40S ribosomal protein S7) (S8) | −2.384 | 0.012 |
| down | Atp1b2 | P13638 | AT1B2_RAT | Sodium/potassium-transporting ATPase subunit beta-2 (Sodium/potassium-dependent ATPase subunit beta-2) | −1.530 | 0.012 |
| down | Atp5f1c | P35435 | ATPG_RAT | ATP synthase F(1) complex subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit) | −1.525 | 0.012 |
| down | Rab3a | P63012 | RAB3A_RAT | Ras-related protein Rab-3A (EC 3.6.5.2) | −0.787 | 0.012 |
| down | Serpina3k | P05545 | SPA3K_RAT | Serine protease inhibitor A3K (Serpin A3K) (CPI-21) (Contrapsin-like protease inhibitor 1) (GHR-P63) (Growth hormone-regulated proteinase inhibitor) (Kallikrein-binding protein) (KBP) (SPI-2.3) (Serine protease inhibitor 2) (SPI-2) (Thyroid hormone-regulated protein) | −0.898 | 0.012 |
| down | Arpc5l | A1L108 | ARP5L_RAT | Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) | −1.128 | 0.012 |
| down | Lrrc47 | F1LT49 | F1LT49_RAT | Leucine-rich repeat-containing protein 47 | −0.991 | 0.012 |
| down | Rab11b | O35509 | RB11B_RAT | Ras-related protein Rab-11B (EC 3.6.5.2) | −0.868 | 0.012 |
| down | Slc2a1 | P11167 | GTR1_RAT | Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) | −0.820 | 0.012 |
| down | Rras2 | Q5BJU0 | Q5BJU0_RAT | RAS related 2 | −1.435 | 0.012 |
| down | Hadha | Q64428 | ECHA_RAT | Trifunctional enzyme subunit alpha, mitochondrial (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] | −1.584 | 0.012 |
| down | Alcam | O35112 | CD166_RAT | CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166) | −0.814 | 0.012 |
| down | Adss1 | M0R629 | M0R629_RAT | Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (IMP--aspartate ligase 1) | −2.156 | 0.012 |
| down | Mapk3 | P21708 | MK03_RAT | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1) | −0.847 | 0.013 |
| down | Gpd2 | P35571 | GPDM_RAT | Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) | −1.098 | 0.013 |
| down | Pitpnc1 | A0A8I5ZSD8 | A0A8I5ZSD8_RAT | Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (Retinal degeneration B homolog beta) | −2.762 | 0.013 |
| down | Armc10 | B1WBW4 | ARM10_RAT | Armadillo repeat-containing protein 10 | −1.457 | 0.013 |
| down | Cyb5r1 | Q5EB81 | NB5R1_RAT | NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) | −1.154 | 0.013 |
| down | Acadl | P15650 | ACADL_RAT | Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8) | −0.834 | 0.013 |
| down | Purb | Q68A21 | PURB_RAT | Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) | −1.079 | 0.014 |
| down | Gnai2 | P04897 | GNAI2_RAT | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | −1.034 | 0.014 |
| down | Hint1 | P62959 | HINT1_RAT | Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (17 kDa inhibitor of protein kinase C) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) | −1.702 | 0.014 |
| down | Idh3g | P41565 | IDHG1_RAT | Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) | −1.160 | 0.014 |
| down | Dnm3 | Q08877 | DYN3_RAT | Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) | −1.082 | 0.014 |
| down | Gng3 | G3V8K2 | G3V8K2_RAT | Guanine nucleotide-binding protein subunit gamma | −0.945 | 0.014 |
| down | Atp6v1c1 | Q5FVI6 | VATC1_RAT | V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) | −0.900 | 0.014 |
| down | Pfkl | P30835 | PFKAL_RAT | ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase) | −0.873 | 0.014 |
| down | Septin8 | B0BNF1 | SEPT8_RAT | Septin-8 | −1.214 | 0.014 |
| down | Pdk3 | A6IPZ9 | A6IPZ9_RAT | Protein-serine/threonine kinase (EC 2.7.11.-) | −0.690 | 0.014 |
| down | Ndufv1 | Q5XIH3 | Q5XIH3_RAT | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 7.1.1.2) | −0.832 | 0.015 |
| down | Rgs7 | P49803 | RGS7_RAT | Regulator of G-protein signaling 7 (RGS7) | −1.461 | 0.015 |
| down | Kctd12 | A0A8I5Y7I2 | A0A8I5Y7I2_RAT | Potassium channel tetramerization domain containing 12 | −0.777 | 0.015 |
| down | Naxe | B0BNM1 | NNRE_RAT | NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) | −0.919 | 0.015 |
| down | Rdx | E9PT65 | E9PT65_RAT | Radixin | −1.792 | 0.016 |
| down | Igsf8 | A0A8I6ANQ3 | A0A8I6ANQ3_RAT | Immunoglobulin superfamily member 8 (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (Prostaglandin regulatory-like protein) | −0.806 | 0.016 |
| down | Sfxn3 | Q9JHY2 | SFXN3_RAT | Sideroflexin-3 | −0.793 | 0.016 |
| down | Mpp3 | O88954 | MPP3_RAT | MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) | −1.336 | 0.016 |
| down | Fkbp8 | Q3B7U9 | FKBP8_RAT | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (FK506-binding protein 8) (FKBP-8) (Rotamase) | −2.262 | 0.017 |
| down | Cct2 | Q5XIM9 | TCPB_RAT | T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) | −1.053 | 0.017 |
| down | Map1lc3b | Q62625 | MLP3B_RAT | Microtubule-associated protein 1 light chain 3 beta (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (Microtubule-associated proteins 1A/1B light chain 3B) (MAP1A/MAP1B LC3 B) (MAP1A/MAP1B light chain 3 B) | −1.734 | 0.017 |
| down | Mapk1 | P63086 | MK01_RAT | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | −1.404 | 0.017 |
| down | Opa3 | A0A8I6AQX4 | A0A8I6AQX4_RAT | Outer mitochondrial membrane lipid metabolism regulator OPA3 | −1.032 | 0.017 |
| down | Gnaq | P82471 | GNAQ_RAT | Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) | −0.925 | 0.017 |
| down | Sar1a | Q6AY18 | Q6AY18_RAT | small monomeric GTPase (EC 3.6.5.2) | −0.773 | 0.017 |
| down | Stxbp1 | P61765 | STXB1_RAT | Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) (rbSec1) | −0.715 | 0.017 |
| down | Ctsb | P00787 | CATB_RAT | Cathepsin B (EC 3.4.22.1) (Cathepsin B1) (RSG-2) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | −1.419 | 0.017 |
| down | Ptges3 | P83868 | TEBP_RAT | Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) | −1.122 | 0.017 |
| down | Eipr1 | Q5PPK9 | EIPR1_RAT | EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) | −0.918 | 0.017 |
| down | Aifm1 | Q9JM53 | AIFM1_RAT | Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) | −0.844 | 0.017 |
| down | Ppp1cb | P62142 | PP1B_RAT | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53) | −0.831 | 0.017 |
| down | Atp6v1h | A0A8I6ACJ2 | A0A8I6ACJ2_RAT | V-type proton ATPase subunit H | −1.029 | 0.018 |
| down | Unc13a | Q62768 | UN13A_RAT | Protein unc-13 homolog A (Munc13-1) | −1.157 | 0.018 |
| down | Hnrnpk | P61980 | HNRPK_RAT | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (dC stretch-binding protein) (CSBP) | −3.831 | 0.019 |
| down | Gdi2 | P50399 | GDIB_RAT | Rab GDP dissociation inhibitor beta (Rab GDI beta) (GDI-3) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) | −0.764 | 0.019 |
| down | Syncrip | Q7TP47 | HNRPQ_RAT | Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Liver regeneration-related protein LRRG077) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | −0.887 | 0.019 |
| down | Dgke | A0A096UWG9 | A0A096UWG9_RAT | Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) | −2.713 | 0.019 |
| down | Pgk1 | P16617 | PGK1_RAT | Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) | −0.628 | 0.019 |
| down | Dld | Q6P6R2 | DLDH_RAT | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) | −0.926 | 0.019 |
| down | Ndufa9 | Q5BK63 | NDUA9_RAT | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (Sperm flagella protein 3) | −1.473 | 0.019 |
| down | Ap1b1 | P52303 | AP1B1_RAT | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | −0.799 | 0.020 |
| down | Tollip | A2RUW1 | TOLIP_RAT | Toll-interacting protein | −0.777 | 0.020 |
| down | Mllt11 | Q5M971 | AF1Q_RAT | Protein AF1q | −1.998 | 0.020 |
| down | Pygm | P09812 | PYGM_RAT | Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) | −0.892 | 0.020 |
| down | Tst | P24329 | THTR_RAT | Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) | −0.711 | 0.020 |
| down | Acat2 | Q5XI22 | THIC_RAT | Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase) | −1.208 | 0.020 |
| down | Dusp3 | A0A8I6AF61 | A0A8I6AF61_RAT | Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) | −0.738 | 0.021 |
| down | Pfn1 | P62963 | PROF1_RAT | Profilin-1 (Profilin I) | −1.346 | 0.021 |
| down | Mlc1 | D4ABB2 | D4ABB2_RAT | Modulator of VRAC current 1 | −1.544 | 0.021 |
| down | Tuba4a | Q5XIF6 | TBA4A_RAT | Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 4) (Tubulin alpha-4 chain) | −1.071 | 0.021 |
| down | Rab7a | P09527 | RAB7A_RAT | Ras-related protein Rab-7a (EC 3.6.5.2) (Ras-related protein BRL-RAS) (Ras-related protein p23) | −0.798 | 0.021 |
| down | Xpo7 | F1LQM9 | F1LQM9_RAT | Exportin 7 | −1.171 | 0.022 |
| down | Cacna1e | Q07652 | CAC1E_RAT | Voltage-dependent R-type calcium channel subunit alpha-1E (BII) (Brain calcium channel II) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (RBE-II) (RBE2) (Voltage-gated calcium channel subunit alpha Cav2.3) | −1.100 | 0.022 |
| down | Atxn10 | Q9ER24 | ATX10_RAT | Ataxin-10 (Neuronal beta-catenin-like protein) (Spinocerebellar ataxia type 10 protein homolog) | −1.675 | 0.023 |
| down | Rab2a | P05712 | RAB2A_RAT | Ras-related protein Rab-2A (EC 3.6.5.2) | −0.732 | 0.023 |
| down | Adam23 | A0A8I6A4T9 | A0A8I6A4T9_RAT | ADAM metallopeptidase domain 23 | −1.626 | 0.023 |
| down | Uba2 | A0A8I6A3Z5 | A0A8I6A3Z5_RAT | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) | −0.755 | 0.023 |
| down | Gnb1 | P54311 | GBB1_RAT | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) | −0.714 | 0.024 |
| down | Hnrnpl | F1LQ48 | HNRPL_RAT | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | −0.724 | 0.024 |
| down | Pip4k2c | O88370 | PI42C_RAT | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) | −0.740 | 0.024 |
| down | Nf1 | P97526 | NF1_RAT | Neurofibromin (Neurofibromatosis-related protein NF-1) | −1.453 | 0.024 |
| down | Cops4 | Q68FS2 | CSN4_RAT | COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) | −0.759 | 0.025 |
| down | Gnb2 | P54313 | GBB2_RAT | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) | −1.151 | 0.025 |
| down | Suclg1 | P13086 | SUCA_RAT | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) | −2.515 | 0.025 |
| down | Kcnma1 | Q62976 | KCMA1_RAT | Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) | −1.939 | 0.025 |
| down | Gm49948 | NA | NA | NA | −1.447 | 0.025 |
| down | Dlgap2 | P97837 | DLGP2_RAT | Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2) | −1.328 | 0.025 |
| down | Aldh1a1 | P51647 | AL1A1_RAT | Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) | −1.218 | 0.025 |
| down | Mpp2 | D3ZAA9 | MPP2_RAT | MAGUK p55 subfamily member 2 (Protein MPP2) | −0.860 | 0.025 |
| down | Eef2 | P05197 | EF2_RAT | Elongation factor 2 (EF-2) (EC 3.6.5.-) | −0.601 | 0.025 |
| down | Zmym3 | E9PTE5 | E9PTE5_RAT | Zinc finger MYM-type containing 3 | −1.819 | 0.025 |
| down | Dgkg | P49620 | DGKG_RAT | Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (88 kDa diacylglycerol kinase) (DGK-III) (Diglyceride kinase gamma) (DGK-gamma) | −1.051 | 0.025 |
| down | Nmt1 | Q8K1Q0 | NMT1_RAT | Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) | −1.260 | 0.025 |
| down | Fscn1 | P85845 | FSCN1_RAT | Fascin | −0.921 | 0.026 |
| down | Ctnna2 | A0A0G2JYF7 | A0A0G2JYF7_RAT | Catenin alpha-2 (Alpha N-catenin) | −0.614 | 0.026 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.602 | 0.026 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.602 | 0.026 |
| down | Ddx39b | Q63413 | DX39B_RAT | Spliceosome RNA helicase Ddx39b (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein Uap56) | −0.851 | 0.026 |
| down | Inpp4a | Q62784 | INP4A_RAT | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | −0.852 | 0.027 |
| down | Tpi1 | P48500 | TPIS_RAT | Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) | −0.732 | 0.027 |
| down | Tstd3 | A0A8I6GJH7 | A0A8I6GJH7_RAT | Thiosulfate sulfurtransferase like domain containing 3 | −1.895 | 0.027 |
| down | Dpp10 | Q6Q629 | DPP10_RAT | Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase X) (DPP X) (Kv4 potassium channel auxiliary subunit) | −1.189 | 0.027 |
| down | Babam2 | Q6P7Q1 | BABA2_RAT | BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) | −1.854 | 0.028 |
| down | Cpne4 | F1M0Z3 | F1M0Z3_RAT | Copine-4 (Copine IV) | −1.269 | 0.028 |
| down | Eci1 | P23965 | ECI1_RAT | Enoyl-CoA delta isomerase 1, mitochondrial (MECI) (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) | −0.774 | 0.028 |
| down | Rps16 | P62250 | RS16_RAT | Small ribosomal subunit protein uS9 (40S ribosomal protein S16) | −0.738 | 0.028 |
| down | Prep | O70196 | PPCE_RAT | Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) (rPop) | −0.698 | 0.028 |
| down | Ddx5 | Q6AYI1 | Q6AYI1_RAT | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) | −0.588 | 0.028 |
| down | Anxa6 | P48037 | ANXA6_RAT | Annexin A6 (Annexin VI) (Annexin-6) (Calcium-binding protein 65/67) (CBP 65/67) | −0.622 | 0.028 |
| down | Ptk2b | P70600 | FAK2_RAT | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) | −0.588 | 0.028 |
| down | Ezr | P31977 | EZRI_RAT | Ezrin (Cytovillin) (Villin-2) (p81) | −1.077 | 0.028 |
| down | Rab21 | Q6AXT5 | RAB21_RAT | Ras-related protein Rab-21 (EC 3.6.5.2) | −0.697 | 0.028 |
| down | Crym | Q9QYU4 | CRYM_RAT | Ketimine reductase mu-crystallin (EC 1.5.1.25) (1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase) (P2C/Pyr2C reductase) (EC 1.5.1.1) (CDK108) (NADP-regulated thyroid-hormone-binding protein) | −0.558 | 0.028 |
| down | Prkar2a | P12368 | KAP2_RAT | cAMP-dependent protein kinase type II-alpha regulatory subunit | −0.839 | 0.028 |
| down | Uqcrc1 | Q68FY0 | QCR1_RAT | Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) | −0.761 | 0.029 |
| down | Dstn | Q7M0E3 | DEST_RAT | Destrin (Actin-depolymerizing factor) (ADF) | −4.283 | 0.030 |
| down | Serpina1e | NA | NA | NA | −1.628 | 0.030 |
| down | Nisch | Q4G017 | NISCH_RAT | Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline-1 receptor) (I1R) | −1.750 | 0.030 |
| down | Camkk1 | P97756 | KKCC1_RAT | Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) | −1.121 | 0.032 |
| down | Tmed9 | Q5I0E7 | TMED9_RAT | Transmembrane emp24 domain-containing protein 9 (p24 family protein alpha-2) (p24alpha2) | −0.656 | 0.032 |
| down | Ipo5 | D4A781 | D4A781_RAT | Importin-5 (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) | −1.646 | 0.032 |
| down | Nars1 | F1LPV0 | F1LPV0_RAT | Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (Asparaginyl-tRNA synthetase 1) | −0.850 | 0.032 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.012 | 0.032 |
| down | Rab1a | A0A8I6AJ88 | A0A8I6AJ88_RAT | small monomeric GTPase (EC 3.6.5.2) | −0.598 | 0.032 |
| down | Mtfr1l | Q5XII9 | MFR1L_RAT | Mitochondrial fission regulator 1-like | −1.770 | 0.033 |
| down | Kcna2 | P63142 | KCNA2_RAT | Potassium voltage-gated channel subfamily A member 2 (RAK) (RBK2) (RCK5) (Voltage-gated potassium channel subunit Kv1.2) | −1.713 | 0.033 |
| down | Sez6l | D4AD89 | D4AD89_RAT | Seizure 6-like protein | −1.130 | 0.033 |
| down | Crmp1 | Q62950 | DPYL1_RAT | Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) | −1.080 | 0.033 |
| down | Ndufa12 | F1LXA0 | F1LXA0_RAT | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | −0.845 | 0.033 |
| down | Prepl | Q5HZA6 | PPCEL_RAT | Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) | −0.826 | 0.033 |
| down | Arcn1 | Q66H80 | COPD_RAT | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | −0.739 | 0.033 |
| down | Ppa1 | A0A8I6AI23 | A0A8I6AI23_RAT | inorganic diphosphatase (EC 3.6.1.1) | −0.516 | 0.033 |
| down | Faah | P97612 | FAAH1_RAT | Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidase) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1) | −1.995 | 0.033 |
| down | Ccdc22 | P86182 | CCD22_RAT | Coiled-coil domain-containing protein 22 | −1.911 | 0.033 |
| down | Diras2 | A0A8I5ZKR8 | A0A8I5ZKR8_RAT | DIRAS family GTPase 2 | −1.623 | 0.033 |
| down | Dctn6 | A0A8I5Y4I3 | A0A8I5Y4I3_RAT | Dynactin subunit 6 (Dynactin subunit p27) | −1.546 | 0.033 |
| down | Rap2b | P61227 | RAP2B_RAT | Ras-related protein Rap-2b (EC 3.6.5.2) | −0.989 | 0.033 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.911 | 0.033 |
| down | Cnn3 | P37397 | CNN3_RAT | Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform) | −0.908 | 0.033 |
| down | Bpnt1 | Q9Z1N4 | BPNT1_RAT | 3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57) (RnPIP) (scHAL2 analogous 3) | −0.888 | 0.033 |
| down | Pspc1 | Q4KLH4 | PSPC1_RAT | Paraspeckle component 1 | −0.884 | 0.033 |
| down | Rps8 | P62243 | RS8_RAT | Small ribosomal subunit protein eS8 (40S ribosomal protein S8) | −0.842 | 0.033 |
| down | Rack1 | P63245 | RACK1_RAT | Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) (Receptor of activated protein kinase C 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Receptor of activated protein C kinase 1, N-terminally processed)] | −0.800 | 0.033 |
| down | Aldh6a1 | Q02253 | MMSA_RAT | Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) | −0.760 | 0.033 |
| down | Sirt2 | Q5RJQ4 | SIR2_RAT | NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | −0.516 | 0.033 |
| down | Akr7a2 | Q8CG45 | ARK72_RAT | Aflatoxin B1 aldehyde reductase member 2 (rAFAR2) (EC 1.1.1.n11) (Succinic semialdehyde reductase) (SSA reductase) | −1.048 | 0.033 |
| down | Gdap1l1 | B4F774 | B4F774_RAT | Ganglioside-induced differentiation-associated protein 1-like 1 | −0.711 | 0.033 |
| down | Dnaja3 | G3V6I5 | G3V6I5_RAT | DnaJ heat shock protein family (Hsp40) member A3 | −0.661 | 0.033 |
| down | Strap | Q5XIG8 | STRAP_RAT | Serine-threonine kinase receptor-associated protein (UNR-interacting protein) | −0.552 | 0.033 |
| down | Epdr1 | Q5XII0 | EPDR1_RAT | Mammalian ependymin-related protein 1 (MERP-1) | −1.473 | 0.034 |
| down | Scrn3 | A0A8I6A9K3 | A0A8I6A9K3_RAT | Secernin 3 | −2.151 | 0.034 |
| down | Stoml2 | Q4FZT0 | STML2_RAT | Stomatin-like protein 2, mitochondrial (SLP-2) | −2.015 | 0.034 |
| down | Phyhip | Q568Z9 | PHYIP_RAT | Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1) | −1.086 | 0.034 |
| down | Pmm1 | A6HT35 | A6HT35_RAT | Phosphomannomutase (EC 5.4.2.8) | −0.983 | 0.034 |
| down | Mapk10 | P49187 | MK10_RAT | Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta) | −0.551 | 0.035 |
| down | Rpl9-ps6 | NA | NA | NA | −1.428 | 0.035 |
| down | Ap2b1 | P62944 | AP2B1_RAT | AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) | −0.919 | 0.035 |
| down | Otub1 | B2RYG6 | OTUB1_RAT | Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (Ubiquitin-specific-processing protease OTUB1) | −0.585 | 0.035 |
| down | Cyrib | A0A0G2JXI6 | A0A0G2JXI6_RAT | CYFIP related Rac1 interactor B | −0.511 | 0.035 |
| down | Prxl2a | Q6AXX6 | PXL2A_RAT | Peroxiredoxin-like 2A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) (Redox-regulatory protein FAM213A) (Sperm head protein 1) | −1.292 | 0.035 |
| down | Prkce | P09216 | KPCE_RAT | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | −0.589 | 0.035 |
| down | Hspa2 | P14659 | HSP72_RAT | Heat shock-related 70 kDa protein 2 (Heat shock protein 70.2) (Testis-specific heat shock protein-related) (HST) | −0.648 | 0.036 |
| down | Get3 | G3V9T7 | GET3_RAT | ATPase Get3 (EC 3.6.4.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) | −0.545 | 0.036 |
| down | Sfxn5 | Q8CFD0 | SFXN5_RAT | Sideroflexin-5 (Tricarboxylate carrier BBG-TCC) | −0.487 | 0.036 |
| down | Ndufa11 | Q80W89 | NDUAB_RAT | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7) | −0.611 | 0.036 |
| down | Fabp5 | P55053 | FABP5_RAT | Fatty acid-binding protein 5 (Cutaneous fatty acid-binding protein) (C-FABP) (DA11) (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein, epidermal) | −0.754 | 0.036 |
| down | Rgs14 | O08773 | RGS14_RAT | Regulator of G-protein signaling 14 (RGS14) | −0.495 | 0.036 |
| down | Hnrnpa0 | F1M3H8 | F1M3H8_RAT | Heterogeneous nuclear ribonucleoprotein A0 | −1.937 | 0.037 |
| down | Tmem11 | B0BN86 | TMM11_RAT | Transmembrane protein 11, mitochondrial | −2.430 | 0.037 |
| down | Exoc6b | A0A0G2JYR1 | A0A0G2JYR1_RAT | Exocyst complex component | −1.837 | 0.037 |
| down | Rps10 | P63326 | RS10_RAT | Small ribosomal subunit protein eS10 (40S ribosomal protein S10) | −1.595 | 0.037 |
| down | Dnajc11 | A6IUF7 | A6IUF7_RAT | DnaJ homolog subfamily C member 11 | −1.443 | 0.037 |
| down | Hacd3 | D4ABI7 | D4ABI7_RAT | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) | −1.390 | 0.037 |
| down | Ppp2r5d | A0A8I6A6K6 | A0A8I6A6K6_RAT | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit | −1.154 | 0.037 |
| down | Acat1 | P17764 | THIL_RAT | Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) | −0.774 | 0.037 |
| down | Rasal1 | D3ZHY9 | D3ZHY9_RAT | RAS protein activator like 1 | −0.757 | 0.037 |
| down | Dhx9 | A0A8I6ABZ7 | A0A8I6ABZ7_RAT | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) | −0.741 | 0.037 |
| down | Etfa | P13803 | ETFA_RAT | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | −0.723 | 0.037 |
| down | Dars1 | P15178 | SYDC_RAT | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) | −0.686 | 0.037 |
| down | Rab18 | Q5EB77 | RAB18_RAT | Ras-related protein Rab-18 (EC 3.6.5.2) | −0.646 | 0.037 |
| down | Itpa | D3ZW55 | ITPA_RAT | Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.66) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (XTP/dITP diphosphatase) | −0.624 | 0.037 |
| down | Lgi1 | Q8K4Y5 | LGI1_RAT | Leucine-rich glioma-inactivated protein 1 | −0.535 | 0.037 |
| down | Phyhipl | Q6AYN4 | PHIPL_RAT | Phytanoyl-CoA hydroxylase-interacting protein-like | −0.501 | 0.037 |
| down | Rhoa | P61589 | RHOA_RAT | Transforming protein RhoA (EC 3.6.5.2) | −4.109 | 0.037 |
| down | Prdx2 | P35704 | PRDX2_RAT | Peroxiredoxin-2 (EC 1.11.1.24) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) | −1.986 | 0.037 |
| down | C1qb | P31721 | C1QB_RAT | Complement C1q subcomponent subunit B | −0.834 | 0.037 |
| down | Pcmt1 | P22062 | PIMT_RAT | Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) | −0.826 | 0.037 |
| down | Ndrg1 | Q6JE36 | NDRG1_RAT | Protein NDRG1 (N-myc downstream-regulated gene 1 protein) (Protein Ndr1) | −0.764 | 0.037 |
| down | Rpn2 | P25235 | RPN2_RAT | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2) | −0.757 | 0.037 |
| down | Rab1b | P10536 | RAB1B_RAT | Ras-related protein Rab-1B (EC 3.6.5.2) | −0.724 | 0.037 |
| down | Sptbn2 | Q9QWN8 | SPTN2_RAT | Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41) | −0.635 | 0.037 |
| down | Braf | A0A8I6ATH0 | A0A8I6ATH0_RAT | non-specific serine/threonine protein kinase (EC 2.7.11.1) | −0.628 | 0.037 |
| down | Bcat1 | P54690 | BCAT1_RAT | Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) | −0.589 | 0.037 |
| down | Prkcg | P63319 | KPCG_RAT | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | −0.571 | 0.037 |
| down | Ehd1 | Q641Z6 | EHD1_RAT | EH domain-containing protein 1 | −0.557 | 0.037 |
| down | Actr2 | Q5M7U6 | ARP2_RAT | Actin-related protein 2 (Actin-like protein 2) | −0.497 | 0.037 |
| down | Stam | B5DF55 | B5DF55_RAT | Signal transducing adaptor molecule | −0.731 | 0.037 |
| down | Sort1 | O54861 | SORT_RAT | Sortilin (Glycoprotein 110) (Gp110) (Neurotensin receptor 3) (NTR3) | −0.719 | 0.037 |
| down | Ogdh | Q5XI78 | ODO1_RAT | 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) | −0.963 | 0.038 |
| down | Psmc3 | Q63569 | PRS6A_RAT | 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA) (Tat-binding protein 1) (TBP-1) | −0.493 | 0.038 |
| down | Aldoa | P05065 | ALDOA_RAT | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Muscle-type aldolase) | −0.735 | 0.038 |
| down | Rap1gap | F1LV89 | F1LV89_RAT | Rap1 GTPase-activating protein | −0.779 | 0.038 |
| down | Ganab | D3ZAN3 | D3ZAN3_RAT | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | −0.777 | 0.038 |
| down | Hnrnpm | Q62826 | HNRPM_RAT | Heterogeneous nuclear ribonucleoprotein M (hnRNP M) (M4 protein) | −0.602 | 0.038 |
| down | Kifbp | Q4G074 | KBP_RAT | KIF-binding protein (KIF1-binding protein) | −1.474 | 0.039 |
| down | Got2 | P00507 | AATM_RAT | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | −0.580 | 0.039 |
| down | Ppm1h | Q5M821 | PPM1H_RAT | Protein phosphatase 1H (EC 3.1.3.16) | −0.909 | 0.039 |
| down | Prmt5 | A0A8I5ZP89 | A0A8I5ZP89_RAT | Protein arginine N-methyltransferase 5 (EC 2.1.1.320) | −1.181 | 0.039 |
| down | Syn2 | Q63537 | SYN2_RAT | Synapsin-2 (Synapsin II) | −0.919 | 0.039 |
| down | Slc25a18 | Q505J6 | GHC2_RAT | Mitochondrial glutamate carrier 2 (GC-2) (Glutamate/H(+) symporter 2) (Solute carrier family 25 member 18) | −0.722 | 0.039 |
| down | Cdk5 | Q03114 | CDK5_RAT | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | −0.579 | 0.039 |
| down | Dpysl2 | P47942 | DPYL2_RAT | Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (Turned on after division 64 kDa protein) (TOAD-64) | −0.468 | 0.039 |
| down | Vps45 | O08700 | VPS45_RAT | Vacuolar protein sorting-associated protein 45 (rVps45) | −2.372 | 0.039 |
| down | Capn2 | Q07009 | CAN2_RAT | Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) | −0.962 | 0.040 |
| down | Atp6v1a | D4A133 | D4A133_RAT | V-type proton ATPase catalytic subunit A (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha) | −0.552 | 0.040 |
| down | Slc8a1 | Q01728 | NAC1_RAT | Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) | −1.147 | 0.040 |
| down | Septin6 | B5DFG5 | B5DFG5_RAT | Septin | −0.739 | 0.040 |
| down | Atp6v1e1 | Q6PCU2 | VATE1_RAT | V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (Vacuolar proton pump subunit E 1) | −0.584 | 0.040 |
| down | Sar1b | Q5HZY2 | SAR1B_RAT | Small COPII coat GTPase SAR1B (EC 3.6.5.2) | −2.153 | 0.041 |
| down | Ubfd1 | G3V8E4 | G3V8E4_RAT | Ubiquitin domain-containing protein UBFD1 | −0.790 | 0.041 |
| down | Madd | O08873 | MADD_RAT | MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (RabGEP) | −0.649 | 0.041 |
| down | Cdc5l | O08837 | CDC5L_RAT | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe Cdc5-related protein) | −0.860 | 0.041 |
| down | Actr1a | P85515 | ACTZ_RAT | Alpha-centractin (Centractin) | −0.796 | 0.041 |
| down | Pde2a | Q01062 | PDE2A_RAT | cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) | −0.782 | 0.041 |
| down | Atl1 | Q6PST4 | ATLA1_RAT | Atlastin-1 (EC 3.6.5.-) (Spastic paraplegia 3A homolog) | −0.729 | 0.041 |
| down | Slc3a2 | Q794F9 | 4F2_RAT | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98) | −1.291 | 0.041 |
| down | Cdc42 | Q8CFN2 | CDC42_RAT | Cell division control protein 42 homolog (EC 3.6.5.2) | −0.589 | 0.042 |
| down | Bpnt2 | D4AD37 | IMPA3_RAT | Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (Golgi-resident PAP phosphatase) (gPAPP) (EC 3.1.3.7) (3'(2'), 5'-bisphosphate nucleotidase 2) (Inositol monophosphatase domain-containing protein 1) (Myo-inositol monophosphatase A3) (Phosphoadenosine phosphate 3'-nucleotidase) | −2.167 | 0.042 |
| down | Sec13 | Q5XFW8 | SEC13_RAT | Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) | −1.937 | 0.042 |
| down | Cacybp | Q6AYK6 | CYBP_RAT | Calcyclin-binding protein (CacyBP) | −0.558 | 0.042 |
| down | Aco1 | Q63270 | ACOHC_RAT | Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) | −1.551 | 0.042 |
| down | Ptbp2 | Q66H20 | PTBP2_RAT | Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (PTB-like protein) | −2.493 | 0.042 |
| down | Pef1 | Q641Z8 | PEF1_RAT | Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) | −2.356 | 0.042 |
| down | Nlgn3 | Q62889 | NLGN3_RAT | Neuroligin-3 (Gliotactin homolog) | −0.721 | 0.042 |
| down | Rps3 | P62909 | RS3_RAT | Small ribosomal subunit protein uS3 (EC 4.2.99.18) (40S ribosomal protein S3) | −0.558 | 0.042 |
| down | Agap3 | A0A0G2K2D4 | A0A0G2K2D4_RAT | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (CRAM-associated GTPase) (Centaurin-gamma-3) (MR1-interacting protein) | −0.546 | 0.042 |
| down | Cct7 | A0A8I6AR12 | A0A8I6AR12_RAT | T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) | −0.537 | 0.042 |
| down | Cdipt | P70500 | CDIPT_RAT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase) | −0.698 | 0.043 |
| down | Dpysl4 | Q62951 | DPYL4_RAT | Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) | −0.518 | 0.043 |
| down | Grin2b | Q00960 | NMDE2_RAT | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) | −0.913 | 0.043 |
| down | Hnrnpr | Q566E4 | Q566E4_RAT | Heterogeneous nuclear ribonucleoprotein Q (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) | −1.533 | 0.043 |
| down | Sec14l2 | Q99MS0 | S14L2_RAT | SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (Squalene transfer protein) (Supernatant protein factor) (SPF) | −1.273 | 0.043 |
| down | Olfm1 | Q62609 | NOE1_RAT | Noelin (1B426B) (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) (Pancortin) | −1.032 | 0.043 |
| down | Camk2b | P08413 | KCC2B_RAT | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | −0.793 | 0.043 |
| down | Rheb | Q62639 | RHEB_RAT | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | −0.781 | 0.043 |
| down | Gsk3b | P18266 | GSK3B_RAT | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | −0.653 | 0.043 |
| down | Ncdn | O35095 | NCDN_RAT | Neurochondrin (Neurite outgrowth-related protein from the rat brain) (Norbin) | −0.600 | 0.043 |
| down | Hspa4l | P83581 | HS74L_RAT | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) | −0.501 | 0.043 |
| down | Prpsap2 | O08618 | KPRB_RAT | Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41) | −0.810 | 0.044 |
| down | Abat | P50554 | GABT_RAT | 4-aminobutyrate aminotransferase, mitochondrial (beta-AlaAT I) (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT) [Cleaved into: 4-aminobutyrate aminotransferase, brain isoform; 4-aminobutyrate aminotransferase, liver isoform] | −0.647 | 0.044 |
| down | Purg | D3ZYS1 | D3ZYS1_RAT | Purine-rich element binding protein G | −1.717 | 0.044 |
| down | Gabbr1 | Q9Z0U4 | GABR1_RAT | Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) | −1.661 | 0.044 |
| down | Prmt1 | Q63009 | ANM1_RAT | Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) | −1.116 | 0.044 |
| down | Tpp1 | Q9EQV6 | TPP1_RAT | Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I) | −1.533 | 0.045 |
| down | Ndufs6 | P52504 | NDUS6_RAT | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit) | −2.486 | 0.045 |
| down | Cap2 | P52481 | CAP2_RAT | Adenylyl cyclase-associated protein 2 (CAP 2) | −0.449 | 0.045 |
| down | Ndufa13 | F1LZC5 | F1LZC5_RAT | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | −3.370 | 0.045 |
| down | Mpst | P97532 | THTM_RAT | 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) | −0.763 | 0.045 |
| down | Ywhag | P61983 | 1433G_RAT | 14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed] | −0.727 | 0.045 |
| down | Prickle2 | F1M0J7 | F1M0J7_RAT | Prickle planar cell polarity protein 2 | −1.186 | 0.045 |
| down | Gapdh | P04797 | G3P_RAT | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | −0.465 | 0.045 |
| down | Atp5mj | NA | NA | NA | −1.459 | 0.046 |
| down | Ewsr1 | A0A0G2K850 | A0A0G2K850_RAT | RNA-binding protein EWS | −1.295 | 0.046 |
| down | Aldh7a1 | Q64057 | AL7A1_RAT | Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) | −0.942 | 0.046 |
| down | Tardbp | A6IU83 | A6IU83_RAT | TAR DNA-binding protein 43 | −0.653 | 0.047 |
| down | Adss2 | D4AEP0 | D4AEP0_RAT | Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) | −0.542 | 0.047 |
| down | Gas7 | O55148 | GAS7_RAT | Growth arrest-specific protein 7 (GAS-7) | −1.286 | 0.047 |
| down | Tmem132b | A0A0G2K3D9 | A0A0G2K3D9_RAT | Transmembrane protein 132B | −1.204 | 0.047 |
| down | Fbxo2 | A0A8I6A9Y7 | A0A8I6A9Y7_RAT | F-box protein 2 | −0.660 | 0.047 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.853 | 0.047 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.853 | 0.047 |
| down | Arl15 | A0A8I5ZSX7 | A0A8I5ZSX7_RAT | ADP-ribosylation factor-like protein 15 | −0.862 | 0.047 |
| down | Nudt3 | Q566C7 | NUDT3_RAT | Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59) | −1.507 | 0.048 |
| down | Cd34 | B1PLB1 | B1PLB1_RAT | CD34 antigen isoform 2 (CD34 molecule) | −2.014 | 0.050 |
| down | Ahcyl1 | B5DFN2 | SAHH2_RAT | S-adenosylhomocysteine hydrolase-like protein 1 (IP3R-binding protein released with inositol 1,4,5-trisphosphate) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | −0.567 | 0.050 |
| down | Diras1 | D4A304 | D4A304_RAT | DIRAS family GTPase 1 | −1.308 | 0.050 |
| down | Srsf5 | Q09167 | SRSF5_RAT | Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Insulin-induced growth response protein CL-4) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) | −1.113 | 0.050 |
| down | Dcps | Q8K4F7 | DCPS_RAT | m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) | −1.097 | 0.050 |
| down | Acad9 | B1WC61 | ACAD9_RAT | Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) | −0.858 | 0.050 |
| down | Glul | P09606 | GLNA_RAT | Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) | −0.669 | 0.050 |
| down | Lonp1 | Q924S5 | LONM_RAT | Lon protease homolog, mitochondrial (EC 3.4.21.53) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) | −0.472 | 0.050 |
| down | Ruvbl1 | P60123 | RUVB1_RAT | RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (DNA helicase p50) (Pontin 52) (TIP49a) | −0.645 | 0.050 |
| down | Eif4a3 | Q3B8Q2 | IF4A3_RAT | Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] | −0.870 | 0.050 |
| down | Gabrb3 | P63079 | GBRB3_RAT | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3) | −0.814 | 0.050 |
# EE VS SH (Yold)
# gt 3 - by fold change direction & pvalue
lit_review_proteomics_sig |>
dplyr::ungroup() |>
dplyr:: filter(Condition == "old") %>%
#dplyr::select(-(c(`Av. Ratio`, ))) |>
dplyr::select(c(Condition, In_EE, Gene_name, Entry, Entry.Name,
Protein.names, Fold_change, adj.P.Val)) |>
dplyr::arrange(desc(In_EE), adj.P.Val, Fold_change) |>
gt(
groupname_col = "Condition",
rowname_col = "In_EE"
) |>
fmt_number(decimals = 3) |>
tab_header(
title = "Old - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only)",
subtitle = "2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by old)"
) |>
tab_options(table.font.size=11.5,
stub.font.weight = "bold",
row_group.font.weight = "bold",
row_group.font.size = 12.5,
column_labels.font.size = 12.5,
column_labels.font.weight = "bold")
| Old - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only) | ||||||
| 2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by old) | ||||||
| Gene_name | Entry | Entry.Name | Protein.names | Fold_change | adj.P.Val | |
|---|---|---|---|---|---|---|
| old | ||||||
| up | Nfu1 | D3ZA85 | D3ZA85_RAT | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5) | 1.672 | 0.004 |
| up | Atp5pf | P21571 | ATP5J_RAT | ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) | 1.692 | 0.006 |
| up | Efhd2 | Q4FZY0 | EFHD2_RAT | EF-hand domain-containing protein D2 (Swiprosin-1) | 2.123 | 0.006 |
| up | Slc9a1 | P26431 | SL9A1_RAT | Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) | 0.949 | 0.006 |
| up | Bsn | O88778 | BSN_RAT | Protein bassoon | 0.977 | 0.006 |
| up | Pgrmc1 | P70580 | PGRC1_RAT | Membrane-associated progesterone receptor component 1 (mPR) (25-DX) (Acidic 25 kDa protein) (Ventral midline antigen) (VEMA) | 1.030 | 0.006 |
| up | Cdkn1b | O08769 | O08769_RAT | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | 1.039 | 0.006 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.073 | 0.006 |
| up | Eif4b | A0ABK0LP36 | A0ABK0LP36_RAT | Eukaryotic translation initiation factor 4B | 1.153 | 0.006 |
| up | Sparcl1 | P24054 | SPRL1_RAT | SPARC-like protein 1 (Matrix glycoprotein Sc1) | 1.165 | 0.006 |
| up | Ptprn2 | Q63475 | PTPR2_RAT | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (PTP NE-6) (PTPNE6) (Phogrin) [Cleaved into: IA-2beta60] | 1.182 | 0.006 |
| up | Amph | O08838 | AMPH_RAT | Amphiphysin | 1.234 | 0.006 |
| up | Btf3 | F7EZE5 | F7EZE5_RAT | Transcription factor BTF3 | 1.243 | 0.006 |
| up | Clta | P08081 | CLCA_RAT | Clathrin light chain A (Lca) | 1.244 | 0.006 |
| up | Txn | P11232 | THIO_RAT | Thioredoxin (Trx) | 1.267 | 0.006 |
| up | Akap12 | Q5QD51 | AKA12_RAT | A-kinase anchor protein 12 (AKAP-12) | 1.272 | 0.006 |
| up | Psip1 | Q812D1 | PSIP1_RAT | PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) | 1.294 | 0.006 |
| up | Ythdf3 | A0A8I6ACC2 | A0A8I6ACC2_RAT | YTH domain-containing family protein | 1.306 | 0.006 |
| up | Chchd4 | Q5BJN5 | MIA40_RAT | Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) | 1.346 | 0.006 |
| up | Tmpo | Q62733 | LAP2_RAT | Lamina-associated polypeptide 2, isoform beta (Thymopoietin isoform beta) (TP beta) | 1.358 | 0.006 |
| up | Hnrnpd | Q9JJ54 | HNRPD_RAT | Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) | 1.387 | 0.006 |
| up | Sod1 | P07632 | SODC_RAT | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) | 1.388 | 0.006 |
| up | Alb | P02770 | ALBU_RAT | Albumin | 1.391 | 0.006 |
| up | Tceal5 | A0ABK0KXI7 | A0ABK0KXI7_RAT | Transcription elongation factor A like 5 | 1.399 | 0.006 |
| up | Ppp1r11 | Q6MFY6 | PP1RB_RAT | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Protein phosphatase 1 regulatory subunit 11) | 1.404 | 0.006 |
| up | Ndufv3 | Q6PCU8 | NDUV3_RAT | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) | 1.450 | 0.006 |
| up | Atp5if1 | Q03344 | ATIF1_RAT | ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) | 1.468 | 0.006 |
| up | Bag3 | A6IA08 | A6IA08_RAT | BAG family molecular chaperone regulator 3 (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) | 1.469 | 0.006 |
| up | Cbx1 | A0A8I5ZM96 | A0A8I5ZM96_RAT | Chromobox 1 | 1.587 | 0.006 |
| up | Atox1 | Q9WUC4 | ATOX1_RAT | Copper transport protein ATOX1 (ATX1 homolog protein Rah1) (Metal transport protein ATX1) | 1.609 | 0.006 |
| up | Zfp428 | A0A0G2K1B1 | A0A0G2K1B1_RAT | Zinc finger protein 428 | 1.623 | 0.006 |
| up | Ndufab1 | D3ZF13 | D3ZF13_RAT | Acyl carrier protein | 1.628 | 0.006 |
| up | Timm8a1 | A6IVF6 | A6IVF6_RAT | Mitochondrial import inner membrane translocase subunit | 1.633 | 0.006 |
| up | Hnrnpab | A6HE59 | A6HE59_RAT | Heterogeneous nuclear ribonucleoprotein A/B | 1.650 | 0.006 |
| up | Hspe1 | P26772 | CH10_RAT | 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) | 1.675 | 0.006 |
| up | Rad23b | Q4KMA2 | RD23B_RAT | UV excision repair protein RAD23 homolog B | 1.676 | 0.006 |
| up | Chmp5 | Q4QQV8 | CHMP5_RAT | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) | 1.693 | 0.006 |
| up | Prrt2 | D3ZFB6 | PRRT2_RAT | Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3) | 1.800 | 0.006 |
| up | Pym1 | A0A8I6GKW1 | A0A8I6GKW1_RAT | PYM homolog 1, exon junction complex associated factor | 1.846 | 0.006 |
| up | Rplp2 | P02401 | RLA2_RAT | Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) | 1.971 | 0.006 |
| up | Sncb | Q63754 | SYUB_RAT | Beta-synuclein (Phosphoneuroprotein 14) (PNP 14) | 2.095 | 0.006 |
| up | Ptms | P04550 | PTMS_RAT | Parathymosin (Zinc-binding 11.5 kDa protein) | 2.224 | 0.006 |
| up | Hdgf | Q8VHK7 | HDGF_RAT | Hepatoma-derived growth factor (HDGF) | 2.237 | 0.006 |
| up | Stmn1 | P13668 | STMN1_RAT | Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Pr22 protein) (Prosolin) (pp17) | 2.242 | 0.006 |
| up | Glrx5 | D4ADD7 | D4ADD7_RAT | Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5) | 1.069 | 0.007 |
| up | Tsr2 | A0A8I5ZLR7 | A0A8I5ZLR7_RAT | Pre-rRNA-processing protein TSR2 homolog | 1.085 | 0.007 |
| up | Srrm2 | A0A8I6A2Y2 | A0A8I6A2Y2_RAT | Serine/arginine repetitive matrix 2 | 1.409 | 0.007 |
| up | Bola1 | Q06C60 | Q06C60_RAT | BolA-like protein 1 | 0.953 | 0.007 |
| up | Fabp3 | P07483 | FABPH_RAT | Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) | 0.970 | 0.007 |
| up | Lasp1 | Q99MZ8 | LASP1_RAT | LIM and SH3 domain protein 1 (LASP-1) | 1.049 | 0.007 |
| up | Cnpy3 | A0A8I6A0W3 | A0A8I6A0W3_RAT | Protein canopy homolog 3 | 1.322 | 0.007 |
| up | Ppp1r1b | Q6J4I0 | PPR1B_RAT | Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) | 1.348 | 0.007 |
| up | Nherf1 | Q9JJ19 | NHRF1_RAT | Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) | 1.456 | 0.007 |
| up | Try10 | A0A8I6APH4 | A0A8I6APH4_RAT | trypsin (EC 3.4.21.4) | 1.638 | 0.007 |
| up | Gtf2i | Q5U2Y1 | GTF2I_RAT | General transcription factor II-I (GTFII-I) (TFII-I) | 2.441 | 0.007 |
| up | Isca2 | D4A4L5 | D4A4L5_RAT | Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1) | 0.917 | 0.007 |
| up | Gfer | Q63042 | ALR_RAT | FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) | 1.347 | 0.007 |
| up | Ensa | P60841 | ENSA_RAT | Alpha-endosulfine (ARPP-19e) | 1.556 | 0.007 |
| up | Mllt11 | Q5M971 | AF1Q_RAT | Protein AF1q | 2.568 | 0.007 |
| up | Chgb | O35314 | SCG1_RAT | Secretogranin-1 (Chromogranin-B) (CgB) (Glucagonoma peptide) (Secretogranin-I) (SgI) [Cleaved into: PE-11; CCB peptide short form; CCB peptide long form] | 1.520 | 0.007 |
| up | Ubqln1 | Q9JJP9 | UBQL1_RAT | Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) | 1.482 | 0.007 |
| up | Vsnl1 | P62762 | VISL1_RAT | Visinin-like protein 1 (VILIP) (21 kDa CABP) (Neural visinin-like protein 1) (NVL-1) (NVP-1) | 1.209 | 0.007 |
| up | Vgf | P20156 | VGF_RAT | Neurosecretory protein VGF (VGF8a protein) [Cleaved into: VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-11; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-30; VGF-derived peptide TLQP-62; VGF-derived peptide HFHH-10; VGF-derived peptide AQEE-30; VGF-derived peptide LQEQ-19] | 1.327 | 0.007 |
| up | Cltb | P08082 | CLCB_RAT | Clathrin light chain B (Lcb) | 1.386 | 0.007 |
| up | Ndel1 | Q78PB6 | NDEL1_RAT | Nuclear distribution protein nudE-like 1 (Protein Nudel) | 1.672 | 0.007 |
| up | Wasl | O08816 | WASL_RAT | Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) | 1.073 | 0.007 |
| up | H1-0 | P43278 | H10_RAT | Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] | 0.865 | 0.007 |
| up | Map6 | Q63560 | MAP6_RAT | Microtubule-associated protein 6 (MAP-6) (145-kDa STOP) (STOP145) (Stable tubule-only polypeptide) (STOP) | 0.967 | 0.007 |
| up | Atp5f1d | P35434 | ATPD_RAT | ATP synthase F(1) complex subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit) | 2.087 | 0.007 |
| up | Cbx3 | Q5RJK5 | Q5RJK5_RAT | Chromobox 3 (Chromobox homolog 3 (HP1 gamma homolog, Drosophila)) | 0.978 | 0.007 |
| up | Cttn | Q66HL2 | SRC8_RAT | Src substrate cortactin | 1.017 | 0.007 |
| up | Hdgfl3 | Q923W4 | HDGR3_RAT | Hepatoma-derived growth factor-related protein 3 (HRP-3) | 1.296 | 0.007 |
| up | Mtpn | P62775 | MTPN_RAT | Myotrophin (Granule cell differentiation protein) (Protein V-1) | 1.410 | 0.007 |
| up | Pcnp | Q7TP40 | PCNP_RAT | PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) (Liver regeneration-related protein LRRG084) | 1.496 | 0.007 |
| up | Ermn | Q5RJL0 | ERMIN_RAT | Ermin (Juxtanodin) (JN) | 1.501 | 0.007 |
| up | Fxn | D3ZYW7 | FRDA_RAT | Frataxin, mitochondrial (Fxn) (EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form; Extramitochondrial frataxin] | 1.608 | 0.007 |
| up | Tppp3 | Q5PPN5 | TPPP3_RAT | Tubulin polymerization-promoting protein family member 3 | 1.297 | 0.007 |
| up | Nsfl1c | O35987 | NSF1C_RAT | NSFL1 cofactor p47 (XY body-associated protein XY40) (p97 cofactor p47) | 1.047 | 0.009 |
| up | Npc2 | A0A8I6AWS0 | A0A8I6AWS0_RAT | NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) | 1.051 | 0.009 |
| up | Tom1l2 | A0A8I5ZP70 | A0A8I5ZP70_RAT | Target of myb1 like 2 membrane trafficking protein | 0.794 | 0.010 |
| up | Rph3a | P47709 | RP3A_RAT | Rabphilin-3A (Exophilin-1) | 0.829 | 0.010 |
| up | Cfdp1 | Q75UQ2 | CFDP1_RAT | Craniofacial development protein 1 (Bucentaur) | 1.177 | 0.010 |
| up | Polr2m | Q91XQ4 | GRL1A_RAT | DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) | 1.394 | 0.010 |
| up | Myl6 | Q64119 | MYL6_RAT | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | 0.888 | 0.010 |
| up | Sarnp | Q498U4 | SARNP_RAT | SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1) | 1.147 | 0.010 |
| up | Rwdd1 | Q99ND9 | RWDD1_RAT | RWD domain-containing protein 1 (Small androgen receptor-interacting protein) | 1.663 | 0.010 |
| up | Pfdn2 | B0BN18 | PFD2_RAT | Prefoldin subunit 2 | 1.786 | 0.010 |
| up | Map1a | P34926 | MAP1A_RAT | Microtubule-associated protein 1A (MAP-1A) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] | 1.166 | 0.010 |
| up | Psap | P10960 | SAP_RAT | Prosaposin (Sulfated glycoprotein 1) (SGP-1) [Cleaved into: Saposin-A; Saposin-B-Val; Saposin-B; Saposin-C; Saposin-D] | 1.700 | 0.010 |
| up | Lrpap1 | Q99068 | AMRP_RAT | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Gp330-binding 45 kDa protein) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | 1.016 | 0.010 |
| up | Fkbp3 | G3V6L9 | G3V6L9_RAT | peptidylprolyl isomerase (EC 5.2.1.8) | 0.718 | 0.010 |
| up | Pclo | Q9JKS6 | PCLO_RAT | Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) | 1.105 | 0.010 |
| up | Naca | M0R9L0 | M0R9L0_RAT | Nascent polypeptide associated complex subunit alpha | 1.016 | 0.011 |
| up | Epn1 | O88339 | EPN1_RAT | Epsin-1 (EPS-15-interacting protein 1) | 0.743 | 0.011 |
| up | Cplx2 | P84087 | CPLX2_RAT | Complexin-2 (Complexin II) (CPX II) (Synaphin-1) | 1.066 | 0.011 |
| up | Slc32a1 | O35458 | VIAAT_RAT | Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (rGVAT) (rat UNC-47 homolog) (RUNC-47) | 0.980 | 0.011 |
| up | C1qbp | O35796 | C1QBP_RAT | Complement component 1 Q subcomponent-binding protein, mitochondrial (GC1q-R protein) (Glycoprotein gC1qBP) (C1qBP) | 1.100 | 0.011 |
| up | Wipf3 | Q9Z0G8 | WIPF3_RAT | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16) | 1.103 | 0.011 |
| up | Gcsh | Q5I0P2 | GCSH_RAT | Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein) | 1.527 | 0.011 |
| up | Npm1 | P13084 | NPM_RAT | Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) | 2.297 | 0.011 |
| up | Atp6v1g1 | A0A8I6B3N3 | A0A8I6B3N3_RAT | V-type proton ATPase subunit G | 0.783 | 0.011 |
| up | Serbp1 | Q6AXS5 | SERB1_RAT | SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) (RDA288) | 1.020 | 0.011 |
| up | Map1b | P15205 | MAP1B_RAT | Microtubule-associated protein 1B (MAP-1B) (Neuraxin) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] | 1.095 | 0.011 |
| up | Ap1m1 | Q32Q06 | AP1M1_RAT | AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) | 1.144 | 0.011 |
| up | Calb2 | P47728 | CALB2_RAT | Calretinin (CR) | 1.222 | 0.011 |
| up | Slc39a10 | A0A1W2Q626 | A0A1W2Q626_RAT | Solute carrier family 39 member 10 | 1.223 | 0.011 |
| up | Abracl | A0ABK0LMJ6 | A0ABK0LMJ6_RAT | ABRA C-terminal like | 1.275 | 0.011 |
| up | Marcksl1 | Q9EPH2 | MRP_RAT | MARCKS-related protein (Brain protein F52) (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) | 2.264 | 0.011 |
| up | Pafah1b2 | O35264 | PA1B2_RAT | Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) (Platelet-activating factor acetylhydrolase alpha 2 subunit) (PAF-AH alpha 2) | 1.294 | 0.011 |
| up | Camk2n1 | Q9JI15 | CK2N1_RAT | Calcium/calmodulin-dependent protein kinase II inhibitor 1 (calcium/calmodulin-dependent protein kinase II inhibitor alpha) (CaM-KIINalpha) (CaMKIINalpha) | 1.344 | 0.011 |
| up | Gprin1 | A0A8I6AJM0 | A0A8I6AJM0_RAT | G protein-regulated inducer of neurite outgrowth 1 | 1.579 | 0.011 |
| up | Lbh | A0ABK0L5J9 | A0ABK0L5J9_RAT | LBH regulator of WNT signaling pathway | 1.896 | 0.011 |
| up | Gpr158 | D4A6L0 | MGLYR_RAT | Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158) | 0.873 | 0.012 |
| up | Gap43 | P07936 | NEUM_RAT | Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Protein F1) | 1.146 | 0.012 |
| up | Set | Q63945 | SET_RAT | Protein SET (Liver regeneration-related protein LRRGR00002) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) | 1.512 | 0.012 |
| up | Basp1 | Q05175 | BASP1_RAT | Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) | 0.804 | 0.012 |
| up | Ndufs8 | A0A8I6AL00 | A0A8I6AL00_RAT | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) | 0.887 | 0.012 |
| up | Snca | P37377 | SYUA_RAT | Alpha-synuclein | 1.087 | 0.012 |
| up | Ubqln4 | D4A3P1 | D4A3P1_RAT | Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) | 1.224 | 0.012 |
| up | Eif4h | Q5XI72 | IF4H_RAT | Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein homolog) | 1.454 | 0.012 |
| up | Cdv3 | Q5XIM5 | CDV3_RAT | Protein CDV3 homolog | 1.515 | 0.012 |
| up | Tpm1 | P04692 | TPM1_RAT | Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) | 1.437 | 0.012 |
| up | Hdgfl2 | Q925G1 | HDGR2_RAT | Hepatoma-derived growth factor-related protein 2 (HRP-2) (Hepatoma-derived growth factor 3) (HDGF-3) | 0.871 | 0.012 |
| up | Marcks | P30009 | MARCS_RAT | Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein) | 1.323 | 0.012 |
| up | Tsc22d1 | P62501 | T22D1_RAT | TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) | 1.345 | 0.012 |
| up | Habp4 | A1L1K8 | HABP4_RAT | Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) | 0.654 | 0.013 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.018 | 0.013 |
| up | Stoml2 | Q4FZT0 | STML2_RAT | Stomatin-like protein 2, mitochondrial (SLP-2) | 2.506 | 0.013 |
| up | Fam169a | D3ZKX8 | D3ZKX8_RAT | Family with sequence similarity 169, member A | 0.790 | 0.013 |
| up | Bod1 | Q6AYJ2 | BOD1_RAT | Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) | 1.087 | 0.013 |
| up | Tpd52 | A0A0G2K865 | A0A0G2K865_RAT | Tumor protein D52 | 1.025 | 0.013 |
| up | Sumo2 | P61959 | SUMO2_RAT | Small ubiquitin-related modifier 2 (SUMO-2) (SMT3 homolog 2) (Sentrin-2) (Ubiquitin-like protein SMT3A) (Smt3A) | 2.075 | 0.013 |
| up | Fgf12 | P61150 | FGF12_RAT | Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) | 0.982 | 0.014 |
| up | Fkbp2 | A0A8I6GH88 | A0A8I6GH88_RAT | peptidylprolyl isomerase (EC 5.2.1.8) | 0.832 | 0.014 |
| up | Rbmx | Q4V898 | RBMX_RAT | RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) (RNA-binding motif protein, X chromosome retrogene) (RNA-binding motif protein, X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] | 0.767 | 0.014 |
| up | Tpm4 | P09495 | TPM4_RAT | Tropomyosin alpha-4 chain (Tropomyosin-4) (TM-4) | 1.010 | 0.014 |
| up | Dbi | P11030 | ACBP_RAT | Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) [Cleaved into: Triakontatetraneuropeptide (TTN); Octadecaneuropeptide (ODN)] | 2.179 | 0.014 |
| up | Fubp1 | Q32PX7 | FUBP1_RAT | Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) | 1.518 | 0.014 |
| up | Tpm3-rs7 | NA | NA | NA | 2.822 | 0.015 |
| up | Ubqln2 | D4AA63 | D4AA63_RAT | Ubiquilin 2 | 1.389 | 0.015 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.470 | 0.015 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.470 | 0.015 |
| up | Zbed5 | D3ZTR5 | D3ZTR5_RAT | Zinc finger BED-type containing 5 | 1.389 | 0.015 |
| up | Abl2 | F1M0N1 | F1M0N1_RAT | Tyrosine-protein kinase (EC 2.7.10.2) | 1.166 | 0.015 |
| up | Ppp1r2 | P50411 | IPP2_RAT | Protein phosphatase inhibitor 2 (IPP-2) | 1.219 | 0.016 |
| up | Hnrnpk | P61980 | HNRPK_RAT | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (dC stretch-binding protein) (CSBP) | 3.650 | 0.016 |
| up | H2ax | A0ABK0LP06 | A0ABK0LP06_RAT | H2A.X variant histone | 1.210 | 0.016 |
| up | Ppp3r1 | P63100 | CANB1_RAT | Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) | 1.065 | 0.016 |
| up | Rbm8a | Q27W01 | RBM8A_RAT | RNA-binding protein 8A (RNA-binding motif protein 8A) (Ribonucleoprotein RBM8A) | 1.580 | 0.016 |
| up | Zdhhc5 | Q2THW7 | ZDHC5_RAT | Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) | 1.733 | 0.016 |
| up | Smap | NA | NA | NA | 1.728 | 0.017 |
| up | Washc2 | Q80X08 | WASC2_RAT | WASH complex subunit 2 | 0.768 | 0.017 |
| up | Arpin | D4A1B2 | D4A1B2_RAT | Arpin | 1.579 | 0.017 |
| up | Pdap1 | Q62785 | HAP28_RAT | 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) | 1.103 | 0.017 |
| up | Rida | P52759 | RIDA_RAT | 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Liver perchloric acid-soluble protein) (L-PSP) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (UK114 antigen homolog) (rp14.5) | 0.817 | 0.018 |
| up | Tpd52l2 | Q6PCT3 | TPD54_RAT | Tumor protein D54 (Tumor protein D52-like 2) | 0.746 | 0.018 |
| up | Hyou1 | Q63617 | HYOU1_RAT | Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) | 0.820 | 0.018 |
| up | Gm2a | A0A8I6A5G9 | A0A8I6A5G9_RAT | Ganglioside GM2 activator | 1.214 | 0.018 |
| up | Pcsk1n | Q9QXU9 | PCS1N_RAT | ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; PEN-20; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] | 1.842 | 0.018 |
| up | Gm49948 | NA | NA | NA | 1.439 | 0.019 |
| up | Reep2 | A0A0G2K1L5 | A0A0G2K1L5_RAT | Receptor expression-enhancing protein | 1.122 | 0.020 |
| up | Nucb1 | Q63083 | NUCB1_RAT | Nucleobindin-1 (Bone 63 kDa calcium-binding protein) (CALNUC) | 1.430 | 0.020 |
| up | Ptpn23 | O88902 | PTN23_RAT | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | 1.096 | 0.020 |
| up | Eef1b | NA | NA | NA | 1.212 | 0.020 |
| up | Dtna | D4A772 | D4A772_RAT | Dystrobrevin | 0.612 | 0.020 |
| up | Dek | Q6AXS3 | DEK_RAT | Protein DEK | 0.736 | 0.020 |
| up | Lin7a | Q9Z250 | LIN7A_RAT | Protein lin-7 homolog A (Lin-7A) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1) | 0.719 | 0.021 |
| up | Drap1 | A0JPP1 | NC2A_RAT | Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) | 0.876 | 0.021 |
| up | Hpca | P84076 | HPCA_RAT | Neuron-specific calcium-binding protein hippocalcin (P23K) | 1.089 | 0.021 |
| up | Rbm3 | Q925G0 | RBM3_RAT | RNA-binding protein 3 (RNA-binding motif protein 3) | 0.826 | 0.021 |
| up | Acin1 | E9PST5 | E9PST5_RAT | Apoptotic chromatin condensation inducer in the nucleus | 1.042 | 0.021 |
| up | 2900026A02Rik | NA | NA | NA | 0.623 | 0.022 |
| up | Mapre1 | Q66HR2 | MARE1_RAT | Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) | 0.668 | 0.022 |
| up | Bin1 | O08839 | BIN1_RAT | Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1) | 1.549 | 0.022 |
| up | Scp2 | P11915 | SCP2_RAT | Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (Sterol carrier protein X) (SCP-X) | 0.670 | 0.022 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.739 | 0.022 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.739 | 0.022 |
| up | Lsm3 | D4A7U6 | D4A7U6_RAT | U6 snRNA-associated Sm-like protein LSm3 | 0.747 | 0.022 |
| up | Eif3j1 | NA | NA | NA | 0.827 | 0.022 |
| up | Ppp1r1a | P19103 | PPR1A_RAT | Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1) | 1.604 | 0.022 |
| up | Ncs1 | P62168 | NCS1_RAT | Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein) | 1.080 | 0.022 |
| up | Sgtb | Q80W98 | SGTB_RAT | Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) | 0.782 | 0.022 |
| up | Map1lc3a | Q6XVN8 | MLP3A_RAT | Microtubule-associated protein 1 light chain 3 alpha (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (Microtubule-associated proteins 1A/1B light chain 3A) (MAP1A/MAP1B LC3 A) (MAP1A/MAP1B light chain 3 A) | 0.618 | 0.023 |
| up | Psmd9 | Q9WTV5 | PSMD9_RAT | 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) (Transactivating protein Bridge-1) | 0.747 | 0.023 |
| up | Lmtk3 | F1LSB5 | F1LSB5_RAT | non-specific serine/threonine protein kinase (EC 2.7.11.1) | 0.821 | 0.023 |
| up | Cdc42ep4 | B1WC33 | B1WC33_RAT | CDC42 effector protein 4 | 0.957 | 0.023 |
| up | Ncl | P13383 | NUCL_RAT | Nucleolin (Protein C23) | 0.978 | 0.023 |
| up | Abraxas2 | D4A415 | D4A415_RAT | Abraxas 2, BRISC complex subunit | 1.642 | 0.023 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.919 | 0.023 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.919 | 0.023 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 0.919 | 0.023 |
| up | Scg2 | P10362 | SCG2_RAT | Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] | 1.094 | 0.023 |
| up | Mrrf | Q5RKI9 | RRFM_RAT | Ribosome-recycling factor, mitochondrial (RRF) (Ribosome-releasing factor, mitochondrial) | 1.006 | 0.024 |
| up | Cst3 | P14841 | CYTC_RAT | Cystatin-C (Cystatin-3) | 0.665 | 0.024 |
| up | Prkcsh | A0A8I6G8K5 | A0A8I6G8K5_RAT | Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) | 0.715 | 0.024 |
| up | Rad23a | F7FJT3 | F7FJT3_RAT | UV excision repair protein RAD23 | 1.039 | 0.024 |
| up | Elob | P62870 | ELOB_RAT | Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) | 0.547 | 0.024 |
| up | Atp6v1e1 | Q6PCU2 | VATE1_RAT | V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (Vacuolar proton pump subunit E 1) | 0.647 | 0.025 |
| up | Gorasp2 | Q9R064 | GORS2_RAT | Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) | 0.886 | 0.025 |
| up | Selenom | A0A0G2JZZ4 | A0A0G2JZZ4_RAT | Selenoprotein M | 1.813 | 0.025 |
| up | Ybx1 | P62961 | YBOX1_RAT | Y-box-binding protein 1 (YB-1) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) | 1.322 | 0.025 |
| up | Asap1 | Q1AAU6 | ASAP1_RAT | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) | 1.315 | 0.026 |
| up | Carmil2 | D3ZC15 | D3ZC15_RAT | Capping protein regulator and myosin 1 linker 2 | 0.638 | 0.026 |
| up | Pacsin1 | Q9Z0W5 | PACN1_RAT | Protein kinase C and casein kinase substrate in neurons protein 1 (Dynamin proline-rich domain-interacting protein) (Dynamin PRD-interacting protein) (Synaptic, dynamin-associated protein I) (Syndapin-1) (Syndapin-I) (SdpI) | 0.643 | 0.026 |
| up | Fkbp1a | Q62658 | FKB1A_RAT | Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) | 0.651 | 0.026 |
| up | Cd99l2 | Q8R1R5 | C99L2_RAT | CD99 antigen-like protein 2 (MIC2-like protein 1) (Rhombencephalic expression protein 40 kDa) (Protein rhombex-40) (CD antigen CD99) | 0.838 | 0.026 |
| up | Caprin1 | Q5M9G3 | CAPR1_RAT | Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (RNA granule protein 105) | 0.900 | 0.026 |
| up | Znf207 | NA | NA | NA | 1.419 | 0.026 |
| up | Dbndd2 | A0ABK0LCG8 | A0ABK0LCG8_RAT | Uncharacterized protein | 1.217 | 0.026 |
| up | Pea15 | Q5U318 | PEA15_RAT | Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) | 0.865 | 0.027 |
| up | Trmt112 | B2RYS9 | B2RYS9_RAT | Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) | 0.705 | 0.027 |
| up | Zyx | A0A8I6AV84 | A0A8I6AV84_RAT | Zyxin | 1.567 | 0.027 |
| up | Tfg | Q4R1A4 | Q4R1A4_RAT | TRK-fused gene protein (Trafficking from ER to golgi regulator) | 0.551 | 0.027 |
| up | Pex14 | Q642G4 | PEX14_RAT | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | 1.319 | 0.027 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.411 | 0.027 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.411 | 0.027 |
| up | Tpm3 | Q63610 | TPM3_RAT | Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) | 1.523 | 0.027 |
| up | Ubap2l | A0A8I5ZUK2 | A0A8I5ZUK2_RAT | Ubiquitin associated protein 2-like | 0.869 | 0.028 |
| up | Nme1 | Q05982 | NDKA_RAT | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Metastasis inhibition factor NM23) (Tumor metastatic process-associated protein) | 0.636 | 0.028 |
| up | Stip1 | O35814 | STIP1_RAT | Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) | 0.676 | 0.029 |
| up | Sf1 | F1LM37 | F1LM37_RAT | Splicing factor 1 | 0.924 | 0.029 |
| up | Fam131b | Q568Z1 | F131B_RAT | Protein FAM131B | 1.010 | 0.029 |
| up | Cyb5a | P00173 | CYB5_RAT | Cytochrome b5 | 1.053 | 0.029 |
| up | Lysmd2 | A0A0G2K146 | A0A0G2K146_RAT | LysM domain containing 2 | 1.046 | 0.029 |
| up | Sh3bgrl3 | B2RZ27 | SH3L3_RAT | SH3 domain-binding glutamic acid-rich-like protein 3 (TNF inhibitory protein B1) (TIP-B1) | 1.605 | 0.029 |
| up | Rgs10 | P49806 | RGS10_RAT | Regulator of G-protein signaling 10 (RGS10) | 0.943 | 0.030 |
| up | Apoe | P02650 | APOE_RAT | Apolipoprotein E (Apo-E) | 0.911 | 0.030 |
| up | Psmd11 | F1LMZ8 | PSD11_RAT | 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) | 1.072 | 0.030 |
| up | Crkl | Q5U2U2 | CRKL_RAT | Crk-like protein | 0.538 | 0.030 |
| up | Lnpk | A0JN29 | A0JN29_RAT | Endoplasmic reticulum junction formation protein lunapark | 0.571 | 0.031 |
| up | Alyref | M0RBB1 | M0RBB1_RAT | Aly/REF export factor | 0.593 | 0.031 |
| up | Sgta | O70593 | SGTA_RAT | Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 1) | 0.582 | 0.031 |
| up | Tceal3 | M0RBL8 | M0RBL8_RAT | Transcription elongation factor A like 3 (Transcription elongation factor A like 6) | 1.075 | 0.031 |
| up | Fabp7 | P55051 | FABP7_RAT | Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) | 1.526 | 0.031 |
| up | Rps28 | P62859 | RS28_RAT | Small ribosomal subunit protein eS28 (40S ribosomal protein S28) | 0.510 | 0.032 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.323 | 0.032 |
| up | NA | Q6LED0 | H31_RAT | Histone H3.1 | 1.323 | 0.032 |
| up | Cap1 | Q08163 | CAP1_RAT | Adenylyl cyclase-associated protein 1 (CAP 1) | 0.602 | 0.033 |
| up | Dctn2 | Q6AYH5 | DCTN2_RAT | Dynactin subunit 2 | 0.482 | 0.033 |
| up | Hmgn5 | B4F777 | HMGN5_RAT | High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1) | 1.011 | 0.033 |
| up | Dynlrb1 | P62628 | DLRB1_RAT | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (robl/LC7-like protein) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) | 1.081 | 0.033 |
| up | Fam219a | D4AAI7 | D4AAI7_RAT | Family with sequence similarity 219, member A | 1.380 | 0.033 |
| up | Oxsr1 | A0A8I5ZNK2 | OXSR1_RAT | Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) | 0.666 | 0.033 |
| up | Tcea1 | Q4KLL0 | TCEA1_RAT | Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) | 0.706 | 0.034 |
| up | Nol3 | Q62881 | NOL3_RAT | Nucleolar protein 3 (Apoptosis repressor with CARD) | 1.156 | 0.035 |
| up | Endod1 | D3ZIP8 | D3ZIP8_RAT | Endonuclease domain containing 1 | 0.598 | 0.035 |
| up | Homer3 | Q9Z2X5 | HOME3_RAT | Homer protein homolog 3 (Homer-3) (VASP/Ena-related gene up-regulated during seizure and LTP 3) (Vesl-3) | 0.574 | 0.035 |
| up | Mrpl12 | D3ZXF9 | D3ZXF9_RAT | Large ribosomal subunit protein bL12m (39S ribosomal protein L12, mitochondrial) | 1.470 | 0.035 |
| up | Lgals1 | P11762 | LEG1_RAT | Galectin-1 (Gal-1) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (RL 14.5) (S-Lac lectin 1) | 0.931 | 0.036 |
| up | Safb | O88453 | SAFB1_RAT | Scaffold attachment factor B1 (SAF-B) (SAF-B1) | 0.545 | 0.036 |
| up | Akap5 | P24587 | AKAP5_RAT | A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 150 kDa) (AKAP 150) (P150) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) | 0.696 | 0.036 |
| up | Pnma8b | D3ZQN3 | D3ZQN3_RAT | PNMA family member 8B | 2.469 | 0.036 |
| up | Gabarapl2 | P60522 | GBRL2_RAT | Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) | 0.560 | 0.037 |
| up | Cox6b1 | P80430 | CX6B1_RAT | Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1) | 0.980 | 0.038 |
| up | Lrrc59 | Q5RJR8 | LRC59_RAT | Leucine-rich repeat-containing protein 59 (Protein p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] | 0.606 | 0.038 |
| up | Akt1s1 | A0A8I5ZRQ9 | A0A8I5ZRQ9_RAT | AKT1 substrate 1 | 2.115 | 0.038 |
| up | Nap1l1 | Q9Z2G8 | NP1L1_RAT | Nucleosome assembly protein 1-like 1 (NAP-1-related protein) | 0.597 | 0.039 |
| up | Snrpa | Q5U214 | Q5U214_RAT | U1 small nuclear ribonucleoprotein A | 0.873 | 0.039 |
| up | Clip2 | O55156 | CLIP2_RAT | CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) | 0.733 | 0.039 |
| up | Wipf2 | D3ZUD3 | D3ZUD3_RAT | WAS/WASL interacting protein family, member 2 | 0.877 | 0.039 |
| up | Txndc17 | A0ABK0M2Q2 | A0ABK0M2Q2_RAT | Thioredoxin domain containing 17 | 1.680 | 0.039 |
| up | Larp1 | A0A8I6GJC3 | A0A8I6GJC3_RAT | La ribonucleoprotein 1, translational regulator | 0.933 | 0.040 |
| up | Ramac | D4AD33 | D4AD33_RAT | RNA guanine-7 methyltransferase activating subunit | 1.645 | 0.040 |
| up | Chmp1a | A0A8I6GLB8 | A0A8I6GLB8_RAT | Charged multivesicular body protein 1A | 0.905 | 0.040 |
| up | Uqcrb | B2RYS2 | B2RYS2_RAT | Cytochrome b-c1 complex subunit 7 | 1.108 | 0.041 |
| up | Rtn4 | Q9JK11 | RTN4_RAT | Reticulon-4 (Foocen) (Glut4 vesicle 20 kDa protein) (Neurite outgrowth inhibitor) (Nogo protein) | 0.482 | 0.042 |
| up | Cul4b | D3ZK73 | D3ZK73_RAT | Cullin-4B | 1.096 | 0.042 |
| up | Sdc4 | P34901 | SDC4_RAT | Syndecan-4 (SYND4) (Ryudocan core protein) | 0.925 | 0.043 |
| up | Rps18-ps6 | NA | NA | NA | 0.601 | 0.043 |
| up | Ak1 | P39069 | KAD1_RAT | Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.4) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) | 0.486 | 0.043 |
| up | Sh3glb2 | Q5PPJ9 | SHLB2_RAT | Endophilin-B2 (SH3 domain-containing GRB2-like protein B2) | 1.018 | 0.043 |
| up | Msn | O35763 | MOES_RAT | Moesin (Membrane-organizing extension spike protein) | 1.556 | 0.044 |
| up | Arid1a | A0A8I6AJE2 | A0A8I6AJE2_RAT | AT-rich interaction domain 1A | 1.848 | 0.044 |
| up | Hmgb3 | F7EWK1 | F7EWK1_RAT | High mobility group protein B3 (High mobility group protein 2a) (High mobility group protein 4) | 1.549 | 0.044 |
| up | Kif5b | Q2PQA9 | KINH_RAT | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | 0.762 | 0.044 |
| up | Bag4 | A0ABZ3NN99 | A0ABZ3NN99_RAT | BAG cochaperone 4 | 0.618 | 0.044 |
| up | Map7 | A0A0G2KB52 | A0A0G2KB52_RAT | Microtubule-associated protein 7 | 0.780 | 0.044 |
| up | Tppp | D3ZQL7 | TPPP_RAT | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p25-alpha) | 0.483 | 0.044 |
| up | Ggt7 | Q99MZ4 | GGT7_RAT | Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain] | 0.605 | 0.044 |
| up | Srsf1 | D4A9L2 | D4A9L2_RAT | Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1) | 0.568 | 0.045 |
| up | App | P08592 | A4_RAT | Amyloid-beta precursor protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31] | 0.776 | 0.045 |
| up | Rcn2 | Q62703 | RCN2_RAT | Reticulocalbin-2 (Calcium-binding protein ERC-55) (Taipoxin-associated calcium-binding protein 49) (TCBP-49) | 1.083 | 0.045 |
| up | Cstf2 | B4F7F1 | B4F7F1_RAT | Cleavage stimulation factor subunit 2 (Cstf2 protein) | 0.775 | 0.046 |
| up | Ciapin1 | Q5XID1 | CPIN1_RAT | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | 0.542 | 0.046 |
| up | Rabl6 | D3ZKQ4 | D3ZKQ4_RAT | Rab-like protein 6 (GTP-binding protein Parf) (Rab-like protein 1) | 1.067 | 0.047 |
| up | Prrt3 | D3ZWQ0 | D3ZWQ0_RAT | Proline-rich transmembrane protein 3 | 0.697 | 0.048 |
| up | Bcas1 | Q3ZB98 | BCAS1_RAT | Breast carcinoma-amplified sequence 1 homolog (Protein whose mRNA is enriched in synaptosomes 2) (Pmes-2) | 0.729 | 0.048 |
| up | 4833439L19Rik | NA | NA | NA | 1.005 | 0.048 |
| up | Ube2n | Q9EQX9 | UBE2N_RAT | Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) | 0.425 | 0.049 |
| up | Umad1 | NA | NA | NA | 1.268 | 0.049 |
| up | Add1 | Q63028 | ADDA_RAT | Alpha-adducin (Erythrocyte adducin subunit alpha) | 2.529 | 0.049 |
| up | Pkia | P63249 | IPKA_RAT | cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) | 2.160 | 0.050 |
| down | Dlgap1 | P97836 | DLGP1_RAT | Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (rGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) | −2.294 | 0.006 |
| down | C1qb | P31721 | C1QB_RAT | Complement C1q subcomponent subunit B | −1.637 | 0.006 |
| down | Unc13a | Q62768 | UN13A_RAT | Protein unc-13 homolog A (Munc13-1) | −1.532 | 0.006 |
| down | Ppp3cb | P20651 | PP2BB_RAT | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) | −0.802 | 0.006 |
| down | Tpp2 | Q64560 | TPP2_RAT | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) | −1.233 | 0.007 |
| down | Flot1 | Q9Z1E1 | FLOT1_RAT | Flotillin-1 (Reggie-2) (REG-2) | −1.083 | 0.007 |
| down | Uso1 | P41542 | USO1_RAT | General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) | −0.954 | 0.007 |
| down | Pip4k2b | O88377 | PI42B_RAT | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (Phosphatidylinositol-phosphate kinase IIgamma) (PIPKIIgamma) (PtdIns(5)P-4-kinase isoform 2-beta) | −1.284 | 0.007 |
| down | Prkcg | P63319 | KPCG_RAT | Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) | −0.899 | 0.007 |
| down | Mtmr1 | A0A0G2JUZ0 | A0A0G2JUZ0_RAT | phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) | −1.107 | 0.007 |
| down | Iqsec1 | A0A0G2JUG7 | IQEC1_RAT | IQ motif and SEC7 domain-containing protein 1 | −1.106 | 0.007 |
| down | Prps1l3 | A0A0G2JSV3 | A0A0G2JSV3_RAT | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase I) | −0.688 | 0.007 |
| down | Cyb5r1 | Q5EB81 | NB5R1_RAT | NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) | −1.236 | 0.007 |
| down | Sptbn2 | Q9QWN8 | SPTN2_RAT | Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41) | −0.981 | 0.007 |
| down | Agap3 | A0A0G2K2D4 | A0A0G2K2D4_RAT | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (CRAM-associated GTPase) (Centaurin-gamma-3) (MR1-interacting protein) | −0.890 | 0.007 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.845 | 0.007 |
| down | Camk2b | P08413 | KCC2B_RAT | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) | −1.298 | 0.007 |
| down | Tmx3 | M0R402 | M0R402_RAT | Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) | −1.308 | 0.007 |
| down | Exoc4 | Q62824 | EXOC4_RAT | Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8) | −0.870 | 0.007 |
| down | Cntnap1 | P97846 | CNTP1_RAT | Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (Paranodin) (p190) | −0.888 | 0.008 |
| down | Drg2 | A0A8I5ZWK0 | A0A8I5ZWK0_RAT | Developmentally-regulated GTP-binding protein 2 (Translation factor GTPase DRG2) | −0.895 | 0.010 |
| down | Anks1b | P0C6S7 | ANS1B_RAT | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) | −0.786 | 0.010 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.997 | 0.010 |
| down | Armc1 | B0BN83 | B0BN83_RAT | Armadillo repeat-containing protein 1 | −0.912 | 0.010 |
| down | Gria1 | P19490 | GRIA1_RAT | Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) | −0.905 | 0.011 |
| down | Psma4 | P21670 | PSA4_RAT | Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) | −0.811 | 0.011 |
| down | Cnksr2 | Q9Z1T4 | CNKR2_RAT | Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) (Membrane-associated guanylate kinase-interacting protein) (Maguin) | −1.017 | 0.011 |
| down | Grin1 | P35439 | NMDZ1_RAT | Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) | −0.928 | 0.011 |
| down | Ppfia3 | Q91Z79 | LIPA3_RAT | Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) | −0.776 | 0.011 |
| down | Ppp3ca | P63329 | PP2BA_RAT | Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) | −0.588 | 0.011 |
| down | Psmd1 | O88761 | PSMD1_RAT | 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) | −1.370 | 0.011 |
| down | Rps11 | P62282 | RS11_RAT | Small ribosomal subunit protein uS17 (40S ribosomal protein S11) | −0.897 | 0.011 |
| down | Eif3b | Q4G061 | EIF3B_RAT | Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta) | −0.894 | 0.011 |
| down | Lap3 | Q68FS4 | AMPL_RAT | Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (LAP) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) | −0.661 | 0.011 |
| down | Abr | A0A0G2JTR4 | ABR_RAT | Active breakpoint cluster region-related protein | −1.004 | 0.011 |
| down | Rab3c | P62824 | RAB3C_RAT | Ras-related protein Rab-3C (EC 3.6.5.2) | −0.846 | 0.012 |
| down | Slc8a2 | P48768 | NAC2_RAT | Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) | −0.714 | 0.012 |
| down | Actr2 | Q5M7U6 | ARP2_RAT | Actin-related protein 2 (Actin-like protein 2) | −0.668 | 0.012 |
| down | Mal2 | Q7TPB7 | Q7TPB7_RAT | MAL2A (Mal, T-cell differentiation protein 2) | −0.647 | 0.012 |
| down | Pfn2 | Q9EPC6 | PROF2_RAT | Profilin-2 (Profilin II) | −0.764 | 0.012 |
| down | Ganab | D3ZAN3 | D3ZAN3_RAT | Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) | −1.043 | 0.012 |
| down | Cltc | P11442 | CLH1_RAT | Clathrin heavy chain 1 | −0.845 | 0.012 |
| down | Ap1b1 | P52303 | AP1B1_RAT | AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) | −0.837 | 0.012 |
| down | Pafah1b1 | P63004 | LIS1_RAT | Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) | −0.903 | 0.012 |
| down | Acadl | P15650 | ACADL_RAT | Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8) | −0.761 | 0.012 |
| down | Shisa6 | D4A4M0 | D4A4M0_RAT | Shisa family member 6 | −0.720 | 0.013 |
| down | Ablim1 | A0A8I5Y6A1 | A0A8I5Y6A1_RAT | Actin-binding LIM protein 1 | −0.662 | 0.013 |
| down | Stum | A0ABK0LZH3 | A0ABK0LZH3_RAT | Uncharacterized protein | −1.422 | 0.013 |
| down | Plppr2 | Q6W5G4 | PLPR2_RAT | Phospholipid phosphatase-related protein type 2 (Inactive phospholipid phosphatase PLPPR2) (Lipid phosphate phosphatase-related protein type 2) (Plasticity-related gene 4 protein) (PRG-4) | −2.004 | 0.013 |
| down | Ap2a2 | P18484 | AP2A2_RAT | AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) | −0.805 | 0.013 |
| down | Slc6a7 | P28573 | SC6A7_RAT | Sodium-dependent proline transporter (Solute carrier family 6 member 7) | −0.864 | 0.013 |
| down | Ddx5 | Q6AYI1 | Q6AYI1_RAT | Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) | −0.667 | 0.013 |
| down | Nsf | Q9QUL6 | NSF_RAT | Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) | −0.646 | 0.013 |
| down | Ptk2b | P70600 | FAK2_RAT | Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) | −0.668 | 0.014 |
| down | Ap2a1 | A0A8I6A4J2 | A0A8I6A4J2_RAT | AP-2 complex subunit alpha | −0.786 | 0.014 |
| down | Cpne6 | D4ACG7 | D4ACG7_RAT | Copine-6 (Copine VI) | −0.767 | 0.014 |
| down | Maoa | P21396 | AOFA_RAT | Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) | −0.696 | 0.014 |
| down | Glrx3 | Q9JLZ1 | GLRX3_RAT | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) | −0.964 | 0.014 |
| down | Gabbr2 | O88871 | GABR2_RAT | Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) | −0.775 | 0.014 |
| down | Septin9 | Q9QZR6 | SEPT9_RAT | Septin-9 (Eighth septin) (Eseptin) (Septin-like protein) (SLP) | −0.692 | 0.014 |
| down | Actr3 | Q4V7C7 | ARP3_RAT | Actin-related protein 3 (Actin-like protein 3) | −0.639 | 0.014 |
| down | Lgi1 | Q8K4Y5 | LGI1_RAT | Leucine-rich glioma-inactivated protein 1 | −0.667 | 0.014 |
| down | Pals2 | B5DFE0 | B5DFE0_RAT | MAGUK p55 subfamily member 2 (Protein MPP2) | −0.621 | 0.014 |
| down | Crym | Q9QYU4 | CRYM_RAT | Ketimine reductase mu-crystallin (EC 1.5.1.25) (1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase) (P2C/Pyr2C reductase) (EC 1.5.1.1) (CDK108) (NADP-regulated thyroid-hormone-binding protein) | −0.623 | 0.014 |
| down | Sfxn5 | Q8CFD0 | SFXN5_RAT | Sideroflexin-5 (Tricarboxylate carrier BBG-TCC) | −0.594 | 0.014 |
| down | Aldh1b1 | Q66HF8 | AL1B1_RAT | Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase family 1 member B1) | −0.958 | 0.015 |
| down | Eipr1 | Q5PPK9 | EIPR1_RAT | EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) | −0.871 | 0.015 |
| down | Svop | Q9Z2I7 | SVOP_RAT | Synaptic vesicle 2-related protein (SV2-related protein) | −1.632 | 0.015 |
| down | Arpc1a | Q99PD4 | ARC1A_RAT | Actin-related protein 2/3 complex subunit 1A | −0.676 | 0.015 |
| down | Ap2m1 | P84092 | AP2M1_RAT | AP-2 complex subunit mu (AP-2 mu chain) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) | −0.782 | 0.015 |
| down | Coro1c | A0A8I6GLR9 | A0A8I6GLR9_RAT | Coronin | −0.728 | 0.016 |
| down | Rac1 | Q6RUV5 | RAC1_RAT | Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1) | −0.657 | 0.016 |
| down | Fasn | P12785 | FAS_RAT | Fatty acid synthase (EC 2.3.1.85) (Type I FAS) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] | −0.820 | 0.016 |
| down | Nbea | A0A8I6AB61 | A0A8I6AB61_RAT | Neurobeachin (Lysosomal-trafficking regulator 2) | −0.741 | 0.016 |
| down | Pcyt2 | O88637 | PCY2_RAT | Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) | −1.120 | 0.016 |
| down | Ap3b2 | A0ABK0LE23 | A0ABK0LE23_RAT | Adaptor related protein complex 3 subunit beta 2 | −0.689 | 0.016 |
| down | Dpysl4 | Q62951 | DPYL4_RAT | Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) | −0.662 | 0.016 |
| down | Xpo7 | F1LQM9 | F1LQM9_RAT | Exportin 7 | −1.157 | 0.016 |
| down | Htt | P51111 | HD_RAT | Huntingtin (Huntington disease protein homolog) (HD protein homolog) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] | −1.186 | 0.017 |
| down | Naxd | D4AAT7 | NNRD_RAT | ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase) | −0.784 | 0.017 |
| down | Adss2 | D4AEP0 | D4AEP0_RAT | Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) | −0.705 | 0.017 |
| down | Lta4h | P30349 | LKHA4_RAT | Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) | −0.607 | 0.018 |
| down | Prpsap1 | Q63468 | KPRA_RAT | Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) | −1.523 | 0.018 |
| down | Kif2a | Q9WV63 | KIF2A_RAT | Kinesin-like protein KIF2A (Kinesin-2) | −0.686 | 0.018 |
| down | Nomo1 | D3ZSA9 | D3ZSA9_RAT | Nodal modulator 1 | −0.804 | 0.018 |
| down | Slc6a1 | P23978 | SC6A1_RAT | Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) | −0.795 | 0.018 |
| down | Cct6a | F7ELS2 | F7ELS2_RAT | T-complex protein 1 subunit zeta | −0.764 | 0.018 |
| down | Rab3a | P63012 | RAB3A_RAT | Ras-related protein Rab-3A (EC 3.6.5.2) | −0.610 | 0.018 |
| down | Myo5a | Q9QYF3 | MYO5A_RAT | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) | −0.638 | 0.018 |
| down | Plec | P30427 | PLEC_RAT | Plectin (PCN) (PLTN) (Plectin-1) | −0.685 | 0.018 |
| down | Psma5 | P34064 | PSA5_RAT | Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) | −0.616 | 0.018 |
| down | Myh10 | Q9JLT0 | MYH10_RAT | Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) | −0.698 | 0.018 |
| down | Nptn | P97546 | NPTN_RAT | Neuroplastin (Glycoprotein 55/65) (gp55/65) (Stromal cell-derived receptor 1) (SDR-1) | −0.545 | 0.019 |
| down | Mtnd5 | P11661 | NU5M_RAT | NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) (NADH dehydrogenase subunit 5) | −1.557 | 0.020 |
| down | Rab5b | A1L1J8 | A1L1J8_RAT | small monomeric GTPase (EC 3.6.5.2) | −1.031 | 0.020 |
| down | Bdh1 | P29147 | BDH_RAT | D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) | −1.037 | 0.020 |
| down | Ppp1cb | P62142 | PP1B_RAT | Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53) | −0.729 | 0.020 |
| down | Ugp2 | Q4V8I9 | Q4V8I9_RAT | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | −0.676 | 0.020 |
| down | Camk4 | P13234 | KCC4_RAT | Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) (Calspermin) | −0.870 | 0.020 |
| down | Nckap1 | P55161 | NCKP1_RAT | Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) | −0.907 | 0.021 |
| down | Ahcyl1 | B5DFN2 | SAHH2_RAT | S-adenosylhomocysteine hydrolase-like protein 1 (IP3R-binding protein released with inositol 1,4,5-trisphosphate) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | −0.715 | 0.021 |
| down | Rpl7a | P62425 | RL7A_RAT | Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) | −0.719 | 0.021 |
| down | Syngap1 | Q9QUH6 | SYGP1_RAT | Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (p135 SynGAP) | −0.694 | 0.021 |
| down | Pcx | NA | NA | NA | −0.623 | 0.021 |
| down | Cul3 | B5DF89 | CUL3_RAT | Cullin-3 | −1.003 | 0.021 |
| down | Uba1 | Q5U300 | UBA1_RAT | Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) | −0.649 | 0.022 |
| down | Adap1 | O88768 | O88768_RAT | ArfGAP with dual PH domains 1 (IP4/PIP3 binding protein) | −1.817 | 0.022 |
| down | Kctd12 | A0A8I5Y7I2 | A0A8I5Y7I2_RAT | Potassium channel tetramerization domain containing 12 | −0.634 | 0.022 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.961 | 0.022 |
| down | Snx15 | Q4V896 | SNX15_RAT | Sorting nexin-15 | −1.026 | 0.022 |
| down | Rhot1 | A1L1L6 | MIRO1_RAT | Mitochondrial Rho GTPase (MIRO-1) (EC 3.6.5.-) (Ras homolog gene family member T1) | −0.942 | 0.022 |
| down | Epha4 | D3ZZK3 | D3ZZK3_RAT | receptor protein-tyrosine kinase (EC 2.7.10.1) | −0.865 | 0.022 |
| down | Cyfip2 | A0A8I6AHL8 | A0A8I6AHL8_RAT | Cytoplasmic FMR1-interacting protein | −0.710 | 0.022 |
| down | Atp2b3 | Q64568 | AT2B3_RAT | Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) | −0.636 | 0.022 |
| down | Nae1 | Q9Z1A5 | ULA1_RAT | NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) | −0.629 | 0.022 |
| down | Hspa4l | P83581 | HS74L_RAT | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) | −0.591 | 0.022 |
| down | Dynll1 | P63170 | DYL1_RAT | Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) | −0.474 | 0.022 |
| down | Cct7 | A0A8I6AR12 | A0A8I6AR12_RAT | T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) | −0.627 | 0.022 |
| down | Maob | P19643 | AOFB_RAT | Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) | −0.847 | 0.022 |
| down | Slc4a4 | Q9JI66 | S4A4_RAT | Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (NBC-like protein) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) | −0.641 | 0.022 |
| down | Pdha1 | P26284 | ODPA_RAT | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | −0.782 | 0.022 |
| down | Fbxl16 | Q5MJ12 | FXL16_RAT | F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) (Spinal cord injury and regeneration-related protein 1) | −0.755 | 0.023 |
| down | Slc4a7 | Q9R1N3 | S4A7_RAT | Sodium bicarbonate cotransporter 3 (Electroneutral sodium bicarbonate cotransporter 1) (NBC-like protein) (Solute carrier family 4 member 7) | −1.958 | 0.023 |
| down | Iars2 | A0A0G2K261 | A0A0G2K261_RAT | Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) | −0.805 | 0.023 |
| down | Dlg3 | Q62936 | DLG3_RAT | Disks large homolog 3 (PSD-95/SAP90-related protein 1) (Synapse-associated protein 102) (SAP-102) (SAP102) | −0.709 | 0.023 |
| down | Psmc2 | Q63347 | PRS7_RAT | 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) | −0.690 | 0.023 |
| down | Eif4g1 | D4AD15 | D4AD15_RAT | Eukaryotic translation initiation factor 4 gamma 1 | −0.659 | 0.023 |
| down | Cct3 | Q6P502 | TCPG_RAT | T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) | −0.609 | 0.023 |
| down | Slc24a2 | O54701 | NCKX2_RAT | Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2) | −0.907 | 0.023 |
| down | Vdac2 | P81155 | VDAC2_RAT | Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (B36-VDAC) (Outer mitochondrial membrane protein porin 2) | −0.919 | 0.024 |
| down | Rock2 | Q62868 | ROCK2_RAT | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (RhoA-binding kinase 2) (p150 ROK-alpha) (ROKalpha) (p164 ROCK-2) | −0.738 | 0.024 |
| down | Tcp1 | P28480 | TCPA_RAT | T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) | −0.488 | 0.024 |
| down | Slc7a14 | A0A0G2K1G8 | A0A0G2K1G8_RAT | Solute carrier family 7, member 14 | −1.190 | 0.024 |
| down | Rap2a | A0ABK0M907 | A0ABK0M907_RAT | Uncharacterized protein | −0.577 | 0.025 |
| down | Cldn11 | Q99P82 | CLD11_RAT | Claudin-11 | −0.888 | 0.026 |
| down | Atp8a1 | F1LUT4 | F1LUT4_RAT | Phospholipid-transporting ATPase (EC 7.6.2.1) | −1.179 | 0.026 |
| down | Rps16 | P62250 | RS16_RAT | Small ribosomal subunit protein uS9 (40S ribosomal protein S16) | −0.695 | 0.026 |
| down | Gnb1 | P54311 | GBB1_RAT | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) | −0.633 | 0.026 |
| down | Rps9 | P29314 | RS9_RAT | Small ribosomal subunit protein uS4 (40S ribosomal protein S9) | −0.607 | 0.026 |
| down | Aco2 | Q9ER34 | ACON_RAT | Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) | −0.582 | 0.026 |
| down | Gapdh | P04797 | G3P_RAT | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) | −0.532 | 0.026 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.822 | 0.026 |
| down | Farp1 | F1LYQ8 | FARP1_RAT | FERM, ARHGEF and pleckstrin domain-containing protein 1 (FERM, RhoGEF and pleckstrin domain-containing protein 1) | −0.823 | 0.026 |
| down | Ddb1 | Q9ESW0 | DDB1_RAT | DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) | −0.756 | 0.026 |
| down | Trim2 | D3ZQG6 | TRIM2_RAT | Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2) | −0.646 | 0.027 |
| down | Mlf2 | A0A0G2K8Z8 | A0A0G2K8Z8_RAT | Myeloid leukemia factor 2 | −0.652 | 0.027 |
| down | Rgs14 | O08773 | RGS14_RAT | Regulator of G-protein signaling 14 (RGS14) | −0.503 | 0.028 |
| down | Cyfip1 | A0A0G2K472 | A0A0G2K472_RAT | Cytoplasmic FMR1-interacting protein | −0.976 | 0.028 |
| down | Rheb | Q62639 | RHEB_RAT | GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) | −0.862 | 0.028 |
| down | Ppp2r5a | D3ZDI7 | D3ZDI7_RAT | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit | −0.779 | 0.028 |
| down | Wdr7 | Q9ERH3 | WDR7_RAT | WD repeat-containing protein 7 (TGF-beta resistance-associated protein TRAG) | −0.721 | 0.028 |
| down | Dars1 | P15178 | SYDC_RAT | Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) | −0.701 | 0.028 |
| down | Aars1 | P50475 | SYAC_RAT | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) | −0.643 | 0.028 |
| down | Camkv | Q63092 | CAMKV_RAT | CaM kinase-like vesicle-associated protein (1G5) | −0.487 | 0.028 |
| down | Slc12a5 | Q63633 | S12A5_RAT | Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Furosemide-sensitive K-Cl cotransporter) (K-Cl cotransporter 2) (rKCC2) (Neuronal K-Cl cotransporter) | −0.602 | 0.028 |
| down | Phyhip | Q568Z9 | PHYIP_RAT | Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1) | −1.064 | 0.029 |
| down | Actr3b | A0A8I6GL35 | A0A8I6GL35_RAT | Actin related protein 3B | −0.744 | 0.029 |
| down | Prep | O70196 | PPCE_RAT | Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) (rPop) | −0.636 | 0.029 |
| down | Arpc2 | P85970 | ARPC2_RAT | Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) | −0.560 | 0.029 |
| down | Hnrnpul2 | D4ABT8 | D4ABT8_RAT | Heterogeneous nuclear ribonucleoprotein U-like protein 2 | −0.543 | 0.029 |
| down | Glul | P09606 | GLNA_RAT | Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) | −0.759 | 0.029 |
| down | Arf4 | P61751 | ARF4_RAT | ADP-ribosylation factor 4 | −0.540 | 0.029 |
| down | Hspa2 | P14659 | HSP72_RAT | Heat shock-related 70 kDa protein 2 (Heat shock protein 70.2) (Testis-specific heat shock protein-related) (HST) | −0.644 | 0.029 |
| down | Acot13 | D3ZA93 | D3ZA93_RAT | Acyl-coenzyme A thioesterase 13 (EC 3.1.2.2) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (Thioesterase superfamily member 2) | −0.469 | 0.029 |
| down | Syngr3 | D4ABK1 | D4ABK1_RAT | Synaptogyrin 3 | −0.661 | 0.029 |
| down | Mcu | A0A0G2K059 | A0A0G2K059_RAT | Calcium uniporter protein | −0.782 | 0.029 |
| down | Rab6a | Q9WVB1 | RAB6A_RAT | Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) | −0.842 | 0.029 |
| down | Gmps | Q4V7C6 | GUAA_RAT | GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) | −0.632 | 0.030 |
| down | Nudcd2 | Q5M823 | NUDC2_RAT | NudC domain-containing protein 2 | −1.158 | 0.030 |
| down | Pygb | P53534 | PYGB_RAT | Glycogen phosphorylase, brain form (EC 2.4.1.1) | −0.560 | 0.030 |
| down | Hnrnph1 | Q8VHV7 | HNRH1_RAT | Heterogeneous nuclear ribonucleoprotein H (hnRNP H) (Ratsg1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] | −0.623 | 0.030 |
| down | Cmas | P69060 | NEUA_RAT | N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) | −0.925 | 0.031 |
| down | Mtch2 | A0A8I6AK45 | A0A8I6AK45_RAT | Mitochondrial carrier homolog 2 | −0.733 | 0.031 |
| down | Adh5 | P12711 | ADHX_RAT | Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase B2) (ADH-B2) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) | −0.631 | 0.031 |
| down | Akr1b1 | P07943 | ALDR_RAT | Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) | −0.617 | 0.031 |
| down | Padi2 | P20717 | PADI2_RAT | Protein-arginine deiminase type-2 (EC 3.5.3.15) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) | −0.614 | 0.031 |
| down | Atp1a3 | P06687 | AT1A3_RAT | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | −0.562 | 0.031 |
| down | Mapk10 | P49187 | MK10_RAT | Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta) | −0.529 | 0.031 |
| down | Srr | Q76EQ0 | SRR_RAT | Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) | −0.529 | 0.031 |
| down | Pdk3 | A6IPZ9 | A6IPZ9_RAT | Protein-serine/threonine kinase (EC 2.7.11.-) | −0.496 | 0.031 |
| down | Rpl11 | P62914 | RL11_RAT | Large ribosomal subunit protein uL5 (60S ribosomal protein L11) | −2.118 | 0.031 |
| down | Prkca | P05696 | KPCA_RAT | Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) | −0.789 | 0.031 |
| down | Prepl | Q5HZA6 | PPCEL_RAT | Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) | −0.765 | 0.031 |
| down | Cdipt | P70500 | CDIPT_RAT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase) | −0.735 | 0.031 |
| down | Tnr | Q05546 | TENR_RAT | Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) | −0.525 | 0.031 |
| down | Eif3d | Q6AYK8 | EIF3D_RAT | Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) | −1.361 | 0.032 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.322 | 0.032 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −1.322 | 0.032 |
| down | Dmxl2 | F1M3W5 | F1M3W5_RAT | Dmx-like 2 | −0.844 | 0.032 |
| down | Me3 | F1M5N4 | F1M5N4_RAT | Malic enzyme | −0.645 | 0.032 |
| down | Prkcb | P68403 | KPCB_RAT | Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) | −0.580 | 0.032 |
| down | Pcbp2 | Q6AYU2 | Q6AYU2_RAT | Poly(rC) binding protein 2 | −0.501 | 0.032 |
| down | Rpn1 | P07153 | RPN1_RAT | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | −0.677 | 0.032 |
| down | Opa3 | A0A8I6AQX4 | A0A8I6AQX4_RAT | Outer mitochondrial membrane lipid metabolism regulator OPA3 | −0.768 | 0.032 |
| down | Spart | E9PT90 | E9PT90_RAT | Spartin | −1.462 | 0.032 |
| down | Vdac1 | Q9Z2L0 | VDAC1_RAT | Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (rVDAC1) | −0.714 | 0.032 |
| down | Septin4 | A0A096MJN4 | SEPT4_RAT | Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (Arts) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2) | −0.693 | 0.032 |
| down | Pls3 | Q63598 | PLST_RAT | Plastin-3 (T-plastin) | −0.596 | 0.032 |
| down | Grin2a | Q00959 | NMDE1_RAT | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) | −0.964 | 0.033 |
| down | Cntn1 | Q63198 | CNTN1_RAT | Contactin-1 (Neural cell surface protein F3) | −0.545 | 0.033 |
| down | Acadvl | P45953 | ACADV_RAT | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) | −0.639 | 0.033 |
| down | Hapln1 | P03994 | HPLN1_RAT | Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein) | −0.474 | 0.033 |
| down | Psmb6 | P28073 | PSB6_RAT | Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome chain 5) (Proteasome delta chain) (Proteasome subunit Y) (Proteasome subunit beta-1) (beta-1) | −0.555 | 0.034 |
| down | Arhgef2 | Q5FVC2 | ARHG2_RAT | Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) | −0.634 | 0.034 |
| down | Syp | P07825 | SYPH_RAT | Synaptophysin (Major synaptic vesicle protein p38) | −0.509 | 0.034 |
| down | Gad2 | Q05683 | DCE2_RAT | Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform) | −0.681 | 0.034 |
| down | Tprg1l | A8WCF8 | TPRGL_RAT | Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) | −0.647 | 0.035 |
| down | Twf1 | Q5RJR2 | TWF1_RAT | Twinfilin-1 | −0.590 | 0.035 |
| down | Slc25a12 | F1LX07 | S2512_RAT | Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Solute carrier family 25 member 12) | −0.566 | 0.035 |
| down | Sdcbp | Q9JI92 | SDCB1_RAT | Syntenin-1 (Syndecan-binding protein 1) | −0.699 | 0.035 |
| down | Coro2b | F1LMV9 | F1LMV9_RAT | Coronin | −0.696 | 0.035 |
| down | Ivd | P12007 | IVD_RAT | Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4) (Butyryl-CoA dehydrogenase) (EC 1.3.8.1) | −0.555 | 0.035 |
| down | Ago1 | D4AC38 | D4AC38_RAT | Protein argonaute-1 | −1.375 | 0.035 |
| down | Hnrnpl | F1LQ48 | HNRPL_RAT | Heterogeneous nuclear ribonucleoprotein L (hnRNP L) | −0.580 | 0.035 |
| down | Sdha | Q920L2 | SDHA_RAT | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp) (Malate dehydrogenase [quinone] flavoprotein subunit) (EC 1.1.5.-) | −0.567 | 0.036 |
| down | Arf6 | P62332 | ARF6_RAT | ADP-ribosylation factor 6 (EC 3.6.5.2) | −0.547 | 0.036 |
| down | Icam5 | D4A435 | D4A435_RAT | Intercellular adhesion molecule 5 (Telencephalin) | −0.555 | 0.036 |
| down | Etfa | P13803 | ETFA_RAT | Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) | −0.684 | 0.036 |
| down | Slc2a3 | Q07647 | GTR3_RAT | Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) | −0.616 | 0.036 |
| down | Ogdhl | D3ZQD3 | OGDHL_RAT | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | −0.588 | 0.036 |
| down | Syt1 | P21707 | SYT1_RAT | Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) | −0.485 | 0.037 |
| down | Nrxn1 | Q63372 | NRX1A_RAT | Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) | −0.556 | 0.037 |
| down | Acy1 | A0A8I6ABX8 | A0A8I6ABX8_RAT | N-acyl-aliphatic-L-amino acid amidohydrolase (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) | −0.592 | 0.037 |
| down | Atp5f1a | P15999 | ATPA_RAT | ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) | −0.458 | 0.037 |
| down | Lrrc57 | Q5FVI3 | LRC57_RAT | Leucine-rich repeat-containing protein 57 | −1.026 | 0.037 |
| down | Prkce | P09216 | KPCE_RAT | Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) | −0.538 | 0.037 |
| down | Dync1h1 | P38650 | DYHC1_RAT | Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) (MAP 1C) | −0.703 | 0.038 |
| down | Atp2b2 | P11506 | AT2B2_RAT | Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) | −0.575 | 0.038 |
| down | Rpl8 | P62919 | RL8_RAT | Large ribosomal subunit protein uL2 (60S ribosomal protein L8) | −0.987 | 0.038 |
| down | Coro1a | Q91ZN1 | COR1A_RAT | Coronin-1A (Coronin-like protein A) (Clipin-A) (Tryptophan aspartate-containing coat protein) (TACO) | −0.639 | 0.038 |
| down | Ndufs2 | Q641Y2 | NDUS2_RAT | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit) | −0.590 | 0.039 |
| down | Pspc1 | Q4KLH4 | PSPC1_RAT | Paraspeckle component 1 | −0.772 | 0.039 |
| down | Psma6 | P60901 | PSA6_RAT | Proteasome subunit alpha type-6 (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1) | −0.838 | 0.039 |
| down | Gsk3b | P18266 | GSK3B_RAT | Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) | −0.646 | 0.039 |
| down | Npepps | F1M9V7 | F1M9V7_RAT | Aminopeptidase (EC 3.4.11.-) | −0.578 | 0.039 |
| down | Hsp90aa1 | P82995 | HS90A_RAT | Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) | −0.563 | 0.039 |
| down | Glud1 | P10860 | DHE3_RAT | Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) (Memory-related gene 2 protein) (MRG-2) | −0.555 | 0.039 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.492 | 0.039 |
| down | Exoc8 | O54924 | EXOC8_RAT | Exocyst complex component 8 (Exocyst complex 84 kDa subunit) | −0.524 | 0.040 |
| down | Slc25a4 | Q05962 | ADT1_RAT | ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) | −0.464 | 0.040 |
| down | Prmt1 | Q63009 | ANM1_RAT | Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) | −1.102 | 0.040 |
| down | Slc2a1 | P11167 | GTR1_RAT | Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) | −0.505 | 0.040 |
| down | Tkt | P50137 | TKT_RAT | Transketolase (TK) (EC 2.2.1.1) | −0.452 | 0.040 |
| down | Dhx9 | A0A8I6ABZ7 | A0A8I6ABZ7_RAT | ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) | −0.678 | 0.040 |
| down | Mtch1 | B0BN30 | B0BN30_RAT | Mitochondrial carrier homolog 1 | −1.144 | 0.040 |
| down | Atp6v1c1 | Q5FVI6 | VATC1_RAT | V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) | −0.589 | 0.040 |
| down | Igsf8 | A0A8I6ANQ3 | A0A8I6ANQ3_RAT | Immunoglobulin superfamily member 8 (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (Prostaglandin regulatory-like protein) | −0.544 | 0.041 |
| down | Atp6v1a | D4A133 | D4A133_RAT | V-type proton ATPase catalytic subunit A (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha) | −0.521 | 0.041 |
| down | Rpl4 | P50878 | RL4_RAT | Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) | −0.667 | 0.041 |
| down | Mthfd1 | P27653 | C1TC_RAT | C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] | −0.611 | 0.042 |
| down | Tecr | Q64232 | TECR_RAT | Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER) | −0.887 | 0.042 |
| down | Gnai1 | P10824 | GNAI1_RAT | Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) | −0.443 | 0.042 |
| down | Sbf1 | M0RAP5 | M0RAP5_RAT | SET binding factor 1 | −0.554 | 0.042 |
| down | Rps3 | P62909 | RS3_RAT | Small ribosomal subunit protein uS3 (EC 4.2.99.18) (40S ribosomal protein S3) | −0.534 | 0.043 |
| down | Atp1a2 | P06686 | AT1A2_RAT | Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(+) subunit) (Sodium pump subunit alpha-2) | −0.462 | 0.043 |
| down | Ilf3 | Q9JIL3 | ILF3_RAT | Interleukin enhancer-binding factor 3 | −0.741 | 0.043 |
| down | Gpx4 | P36970 | GPX4_RAT | Phospholipid hydroperoxide glutathione peroxidase (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) (EC 1.11.1.9) | −0.733 | 0.043 |
| down | Sord | P27867 | DHSO_RAT | Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) | −0.538 | 0.044 |
| down | Chrm1 | P08482 | ACM1_RAT | Muscarinic acetylcholine receptor M1 | −1.197 | 0.044 |
| down | Actr1a | P85515 | ACTZ_RAT | Alpha-centractin (Centractin) | −0.742 | 0.044 |
| down | Prpf8 | G3V6H2 | G3V6H2_RAT | Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) | −0.723 | 0.044 |
| down | Rpl14 | Q63507 | RL14_RAT | Large ribosomal subunit protein eL14 (60S ribosomal protein L14) | −0.680 | 0.044 |
| down | Ogt | P56558 | OGT1_RAT | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) | −0.635 | 0.044 |
| down | Auh | F1LU71 | AUHM_RAT | Methylglutaconyl-CoA hydratase, mitochondrial (3-MG-CoA hydratase) (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (Itaconyl-CoA hydratase) (EC 4.2.1.56) | −0.526 | 0.044 |
| down | Rps2 | P27952 | RS2_RAT | Small ribosomal subunit protein uS5 (40S ribosomal protein S2) | −0.515 | 0.044 |
| down | Slc25a22 | A0A0G2K5L2 | GHC1_RAT | Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) | −0.462 | 0.044 |
| down | Rpl18 | P12001 | RL18_RAT | Large ribosomal subunit protein eL18 (60S ribosomal protein L18) | −0.625 | 0.044 |
| down | Xpnpep1 | O54975 | XPP1_RAT | Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) | −0.551 | 0.044 |
| down | Prrt1 | Q6MG82 | PRRT1_RAT | Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4) | −0.761 | 0.044 |
| down | Gdi1 | P50398 | GDIA_RAT | Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) | −0.484 | 0.044 |
| down | Strap | Q5XIG8 | STRAP_RAT | Serine-threonine kinase receptor-associated protein (UNR-interacting protein) | −0.465 | 0.044 |
| down | Myadm | Q6VBQ5 | MYADM_RAT | Myeloid-associated differentiation marker (Myeloid up-regulated protein) | −2.219 | 0.044 |
| down | Sf3b3 | E9PT66 | E9PT66_RAT | Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (Spliceosome-associated protein 130) | −0.969 | 0.044 |
| down | Eif3a | Q1JU68 | EIF3A_RAT | Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) | −0.745 | 0.044 |
| down | Pdk1 | Q63065 | PDK1_RAT | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (PDK p48) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) | −1.035 | 0.045 |
| down | Rps4x | P62703 | RS4X_RAT | Small ribosomal subunit protein eS4 (40S ribosomal protein S4, X isoform) | −0.657 | 0.045 |
| down | Hadhb | Q60587 | ECHB_RAT | Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] | −0.551 | 0.045 |
| down | Pfas | D4AB17 | D4AB17_RAT | Phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (Formylglycinamide ribotide amidotransferase) | −0.611 | 0.045 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.591 | 0.046 |
| down | NA | Q6LED0 | H31_RAT | Histone H3.1 | −0.591 | 0.046 |
| down | Gphn | Q03555 | GEPH_RAT | Gephyrin (Putative glycine receptor-tubulin linker protein) [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] | −0.489 | 0.046 |
| down | Add3 | Q62847 | ADDG_RAT | Gamma-adducin (Adducin-like protein 70) (Protein kinase C-binding protein 35H) | −0.446 | 0.046 |
| down | Wdr37 | A0A8I6AE33 | A0A8I6AE33_RAT | WD repeat-containing protein 37 | −1.268 | 0.046 |
| down | Srgap3 | F1M5M9 | F1M5M9_RAT | SLIT-ROBO Rho GTPase-activating protein 3 (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) | −0.579 | 0.046 |
| down | Pdxp | Q8VD52 | PLPP_RAT | Chronophin (EC 3.1.3.16) (EC 3.1.3.74) (Pyridoxal phosphate phosphatase) (PLP phosphatase) (Reg I-binding protein 1) | −0.453 | 0.046 |
| down | Inpp4a | Q62784 | INP4A_RAT | Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) | −0.655 | 0.047 |
| down | Pgm2l1 | D3Z955 | D3Z955_RAT | Phosphoglucomutase 2-like 1 | −0.445 | 0.047 |
| down | Itpka | P17105 | IP3KA_RAT | Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A) | −0.549 | 0.047 |
| down | Mfn2 | Q8R500 | MFN2_RAT | Mitofusin-2 (EC 3.6.5.-) (Mitochondrial transmembrane GTPase FZO1A) (Protein HSG) (Transmembrane GTPase MFN2) | −1.704 | 0.048 |
| down | Ewsr1 | A0A0G2K850 | A0A0G2K850_RAT | RNA-binding protein EWS | −1.221 | 0.048 |
| down | Gnao1 | P59215 | GNAO_RAT | Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) | −0.409 | 0.048 |
| down | Rab18 | Q5EB77 | RAB18_RAT | Ras-related protein Rab-18 (EC 3.6.5.2) | −0.554 | 0.049 |
| down | Cct8 | A0A8I6AAR4 | A0A8I6AAR4_RAT | T-complex protein 1 subunit theta (CCT-theta) | −0.545 | 0.049 |
| down | Septin7 | Q9WVC0 | SEPT7_RAT | Septin-7 (CDC10 protein homolog) | −0.446 | 0.049 |
| down | Wbp2 | Q8R478 | WBP2_RAT | WW domain-binding protein 2 (WBP-2) | −0.836 | 0.049 |
# prot_df_map_rat_keywords <- prot_df_map_rat_4 %>%
# filter(adj.P.Val <= 0.05) %>% # 2309
# filter(!is.na(Entry)) %>% # 2278
# mutate(hashtags = str_split(Keywords, ";")) %>%
# tidyr::unnest(hashtags) # 22696
# prot_rat_sig_count <- prot_df_map_rat_sig %>%
# #group_by(proteomics_id, dir) %>%
# group_by(proteomics_id) %>%
# filter(hashtags != "Reference proteome") %>%
# count(hashtags, sort = TRUE)
# find_mouse_Q6LED0 <- mouse_ref %>%
# filter(Entry == "Q6LED0")
#
# find_rat_Q6LED0 <- rat_ref %>%
# filter(Entry == "Q6LED0")
#
# find_rat_other_Q6LED0 <- rat_other %>%
# filter(Entry == "Q6LED0")
In their Zenodo readme doc, this data is described as… 2_proteomicsSWATH_phenodata_averagedReplicates.txt: phenodata for the proteomics experiment, having averaged the technical replicates into single biological replicates. (so columns, except ID, equtes to 12 which probably means 12 mice total 6 per group?)
norm_SWATH <- read_tsv("input/Perez_2024_2_proteomicsSWATH_normalized_log2_filtered_averagedReplicates.txt")
## Rows: 2250 Columns: 13
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: "\t"
## chr (1): ID
## dbl (12): s1, s2, s3, s8, s9, s10, s13, s14, s15, s16, s17, s18
##
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
colnames(norm_SWATH)
## [1] "ID" "s1" "s2" "s3" "s8" "s9" "s10" "s13" "s14" "s15" "s16" "s17"
## [13] "s18"
str(norm_SWATH)
## spc_tbl_ [2,250 × 13] (S3: spec_tbl_df/tbl_df/tbl/data.frame)
## $ ID : chr [1:2250] "ENSMUSG00000027254" "ENSMUSG00000018707" "ENSMUSG00000032826" "ENSMUSG00000032589" ...
## $ s1 : num [1:2250] 24 20.1 17 20.9 22 ...
## $ s2 : num [1:2250] 23.4 20.6 16.6 20.4 22.1 ...
## $ s3 : num [1:2250] 23.3 20.7 16.7 20.5 22.2 ...
## $ s8 : num [1:2250] 24.6 20.1 17.1 21.5 22.3 ...
## $ s9 : num [1:2250] 24.7 19.5 17.3 21.2 22.2 ...
## $ s10: num [1:2250] 24.6 19.7 16.8 21.3 22.1 ...
## $ s13: num [1:2250] 23 20.9 16.4 20.2 22.4 ...
## $ s14: num [1:2250] 23.2 20.9 17 20.4 22.4 ...
## $ s15: num [1:2250] 22.7 20.8 16.7 20.1 22.5 ...
## $ s16: num [1:2250] 24.4 20 16.1 21.1 22.1 ...
## $ s17: num [1:2250] 23.7 20.3 16.1 21.1 21.9 ...
## $ s18: num [1:2250] 24.3 20.2 16.2 21.3 22.2 ...
## - attr(*, "spec")=
## .. cols(
## .. ID = col_character(),
## .. s1 = col_double(),
## .. s2 = col_double(),
## .. s3 = col_double(),
## .. s8 = col_double(),
## .. s9 = col_double(),
## .. s10 = col_double(),
## .. s13 = col_double(),
## .. s14 = col_double(),
## .. s15 = col_double(),
## .. s16 = col_double(),
## .. s17 = col_double(),
## .. s18 = col_double()
## .. )
## - attr(*, "problems")=<externalptr>
Just wrote out unique ensembls & searched in uniprot web (a lot faster & easier)
# some NAs in the original df were directly coded as NA
# so need to specify na = "NA" otherwise some get classed as character & cant bind
rna_df_EEall <- read_excel("input/Perez_2024_EE_age_transcriptomics_sds18_41467_2024_49608_MOESM21_ESM.xlsx",
sheet = "EEall",
na = "NA")
rna_df_EEyng <- read_excel("input/Perez_2024_EE_age_transcriptomics_sds18_41467_2024_49608_MOESM21_ESM.xlsx",
sheet = "EEyng",
na = "NA")
rna_df_EEold <- read_excel("input/Perez_2024_EE_age_transcriptomics_sds18_41467_2024_49608_MOESM21_ESM.xlsx",
sheet = "EEold",
na = "NA")
RNA_df <- bind_rows(list(all = rna_df_EEall,
young = rna_df_EEyng,
old = rna_df_EEold),
.id = "transcriptomics_id") %>%
rename(ENSEMBL = GENEID)
RNA_df_map_rat_1 <- left_join(RNA_df, rat_ref,
by = join_by(SYMBOL == Gene.Names..primary.))
## Warning in left_join(RNA_df, rat_ref, by = join_by(SYMBOL == Gene.Names..primary.)): Detected an unexpected many-to-many relationship between `x` and `y`.
## ℹ Row 1 of `x` matches multiple rows in `y`.
## ℹ Row 923 of `y` matches multiple rows in `x`.
## ℹ If a many-to-many relationship is expected, set `relationship =
## "many-to-many"` to silence this warning.
RNA_df_map_rat_1_mapped <- RNA_df_map_rat_1 %>%
filter(!is.na(Entry))
RNA_df_map_rat_2 <- RNA_df_map_rat_1 %>%
filter(is.na(Entry)) %>%
select(transcriptomics_id:SYMBOL) %>%
left_join(rat_ref_split, by = join_by(SYMBOL == split_synonyms))
## Warning in left_join(., rat_ref_split, by = join_by(SYMBOL == split_synonyms)): Detected an unexpected many-to-many relationship between `x` and `y`.
## ℹ Row 2 of `x` matches multiple rows in `y`.
## ℹ Row 35125 of `y` matches multiple rows in `x`.
## ℹ If a many-to-many relationship is expected, set `relationship =
## "many-to-many"` to silence this warning.
RNA_df_map_rat_combined <- bind_rows(list(
by_rat_ref_primary_gene = RNA_df_map_rat_1_mapped,
by_rat_ref_synonym = RNA_df_map_rat_2),
.id = "map_method_df") %>%
group_by(map_method_df, transcriptomics_id, ENSEMBL) %>%
filter(if(any(Reviewed == "reviewed", na.rm = TRUE)) {
Reviewed == "reviewed"
} else{TRUE}) %>%
slice_max(Annotation, n = 1) %>%
slice_max(existence_ranking, n =1) %>%
slice_max(occupied, n = 1, with_ties = FALSE) %>%
ungroup()
# # export
# write_excel_csv(RNA_df_map_rat_combined,
# "output/2025_12_27_Perez_2024_RNA_map_rat_combined_v1.csv")
# to check range of
plot(RNA_df_map_rat_combined$log2FoldChange)
summary(RNA_df_map_rat_combined) # see range
## map_method_df transcriptomics_id baseMean log2FoldChange
## Length:59505 Length:59505 Min. : 0.00 Min. :-9.9049815
## Class :character Class :character 1st Qu.: 64.94 1st Qu.:-0.0987408
## Mode :character Mode :character Median : 753.94 Median :-0.0001025
## Mean : 3820.64 Mean :-0.0074635
## 3rd Qu.: 3244.98 3rd Qu.: 0.0846927
## Max. :408077.48 Max. :22.0071357
## NA's :4
## lfcSE stat pvalue padj
## Min. :0.01819 Min. :-6.869112 Min. :0.0000 Min. :0.0000
## 1st Qu.:0.07592 1st Qu.:-0.643920 1st Qu.:0.2528 1st Qu.:0.9122
## Median :0.12956 Median :-0.000985 Median :0.5218 Median :0.9998
## Mean :0.26108 Mean :-0.007653 Mean :0.5081 Mean :0.9145
## 3rd Qu.:0.34687 3rd Qu.: 0.636321 3rd Qu.:0.7646 3rd Qu.:1.0000
## Max. :3.92611 Max. : 7.965056 Max. :1.0000 Max. :1.0000
## NA's :4 NA's :4 NA's :73 NA's :8515
## dir ENSEMBL SYMBOL Entry
## Length:59505 Length:59505 Length:59505 Length:59505
## Class :character Class :character Class :character Class :character
## Mode :character Mode :character Mode :character Mode :character
##
##
##
##
## Entry.Name Protein.names Gene.Names Gene.Names..synonym.
## Length:59505 Length:59505 Length:59505 Length:59505
## Class :character Class :character Class :character Class :character
## Mode :character Mode :character Mode :character Mode :character
##
##
##
##
## Annotation Reviewed Protein.existence existence_ranking
## Min. :1.000 Length:59505 Length:59505 Min. :1.000
## 1st Qu.:2.000 Class :character Class :character 1st Qu.:3.000
## Median :3.000 Mode :character Mode :character Median :5.000
## Mean :3.335 Mean :4.103
## 3rd Qu.:5.000 3rd Qu.:5.000
## Max. :5.000 Max. :5.000
## NA's :15294 NA's :15294
## Protein.families Length Organism Keywords
## Length:59505 Min. : 8.0 Length:59505 Length:59505
## Class :character 1st Qu.: 294.0 Class :character Class :character
## Mode :character Median : 467.0 Mode :character Mode :character
## Mean : 618.2
## 3rd Qu.: 749.0
## Max. :26931.0
## NA's :15294
## Keyword.ID Function..CC. Miscellaneous..CC. Pathway
## Length:59505 Length:59505 Length:59505 Length:59505
## Class :character Class :character Class :character Class :character
## Mode :character Mode :character Mode :character Mode :character
##
##
##
##
## GeneID Ensembl Gene.Ontology..GO.
## Length:59505 Length:59505 Length:59505
## Class :character Class :character Class :character
## Mode :character Mode :character Mode :character
##
##
##
##
## Gene.Ontology..cellular.component. Gene.Ontology..molecular.function.
## Length:59505 Length:59505
## Class :character Class :character
## Mode :character Mode :character
##
##
##
##
## Gene.Ontology..biological.process. Gene.Ontology.IDs KEGG
## Length:59505 Length:59505 Length:59505
## Class :character Class :character Class :character
## Mode :character Mode :character Mode :character
##
##
##
##
## Reactome STRING Entry.version Date.of.creation
## Length:59505 Length:59505 Min. : 1.0 Length:59505
## Class :character Class :character 1st Qu.: 78.0 Class :character
## Mode :character Mode :character Median :104.0 Mode :character
## Mean :102.2
## 3rd Qu.:136.0
## Max. :257.0
## NA's :15294
## Date.of.last.modification Date.of.last.sequence.modification occupied
## Length:59505 Length:59505 Min. :18.00
## Class :character Class :character 1st Qu.:26.00
## Mode :character Mode :character Median :27.00
## Mean :26.78
## 3rd Qu.:29.00
## Max. :32.00
## NA's :15294
## Gene.Names..primary.
## Length:59505
## Class :character
## Mode :character
##
##
##
##
colnames(RNA_df_map_rat_combined)
## [1] "map_method_df" "transcriptomics_id"
## [3] "baseMean" "log2FoldChange"
## [5] "lfcSE" "stat"
## [7] "pvalue" "padj"
## [9] "dir" "ENSEMBL"
## [11] "SYMBOL" "Entry"
## [13] "Entry.Name" "Protein.names"
## [15] "Gene.Names" "Gene.Names..synonym."
## [17] "Annotation" "Reviewed"
## [19] "Protein.existence" "existence_ranking"
## [21] "Protein.families" "Length"
## [23] "Organism" "Keywords"
## [25] "Keyword.ID" "Function..CC."
## [27] "Miscellaneous..CC." "Pathway"
## [29] "GeneID" "Ensembl"
## [31] "Gene.Ontology..GO." "Gene.Ontology..cellular.component."
## [33] "Gene.Ontology..molecular.function." "Gene.Ontology..biological.process."
## [35] "Gene.Ontology.IDs" "KEGG"
## [37] "Reactome" "STRING"
## [39] "Entry.version" "Date.of.creation"
## [41] "Date.of.last.modification" "Date.of.last.sequence.modification"
## [43] "occupied" "Gene.Names..primary."
# for lit review table
lit_review_transcriptomics <- RNA_df_map_rat_combined %>%
mutate(
Year = 2024,
Author = 'Perez',
Animal = 'Mice',
Condition = transcriptomics_id,
Region = 'Hippocampus',
Whole = 'Yes',
Exp_type = 'mRNA',
Method = 'TRANSCRIPTOMICS_RNAseq',
Used_name = SYMBOL,
Mod = " ",
Mod_type = " ",
Gene_name = SYMBOL, # genename used to map mouse 1° to rat gene
Comparison = 2,
In_EE = dir,
Fold_change = log2FoldChange, # prob the same as log2FC?
Arrows = case_when( # dplyr case when, instead of ifelse
log2FoldChange > 2.5 ~ '+++',
log2FoldChange > 1 ~ '++',
log2FoldChange> .05 ~ '+',
log2FoldChange > -.05 ~ '=',
log2FoldChange > -1 ~ '-',
log2FoldChange > -2.5 ~ '--',
log2FoldChange <= -2.5 ~ '---',
),
Significant = ifelse(padj <= 0.05, 'yes', 'no'),
pvalue = padj,
N_tested = ' ',
Stats_adj = 'adjusted',
Note = ' ',
Full_name = Protein.names,
Uniprot_rat_accession = Entry,
Uniprot_entry_name = Entry.Name,
Uniprot_link = ifelse(!is.na(Entry),
paste0('https://www.uniprot.org/uniprotkb/', Entry,'/entry'),
' '),
Wikipedia_link = ifelse(!is.na(Entry),
paste0('https://en.wikipedia.org/wiki/',
`Gene.Names..primary.`), ' '),
Curation_method = case_when(
Reviewed == "reviewed" & map_method_df == "by_rat_ref_primary_gene"
~ "auto - ref & reviewed (primary gene name)",
Reviewed == "unreviewed" & map_method_df == "by_rat_ref_primary_gene"
~ "auto - ref & unreviewed (primary gene name)",
Reviewed == "reviewed" & map_method_df == "by_rat_ref_synonym"
~ "auto - ref & reviewed (synonym)",
Reviewed == "unreviewed" & map_method_df == "by_rat_ref_synonym"
~ "auto - ref proteome (synonym)",
is.na(Entry.Name) ~ "manual - na"
),
Class_group = ' ',
Other_link = ' ',
Other_comments = 'misc shows combined gene_ensembl info from their df',
misc = paste0(SYMBOL, '_', ENSEMBL)
) %>%
arrange(Condition, desc(In_EE), pvalue, Fold_change)
# split by age (all, young, old) (in prep for sheet write out)
split_RNA_df_map_rat <- split(lit_review_transcriptomics,
lit_review_transcriptomics$transcriptomics_id)
# add combined one back onto it
split_RNA_df_map_rat$combined <- lit_review_transcriptomics
# # write transcriptomics lit review out excel
# write_xlsx(split_RNA_df_map_rat,
# path = "output/2025_12_27_Perez_2024_transcriptomics_lit_review_all_v1.xlsx")
# filter significant only
# purrr meth (loaded with tidyverse?)
split_RNA_df_map_rat_sig <- map(split_RNA_df_map_rat, ~filter(.x, padj <= 0.05))
# #write out sig version
# write_xlsx(split_RNA_df_map_rat,
# path = "output/2025_12_27_Perez_2024_transcriptomics_lit_review_sig_only_v1.xlsx")
split_RNA_df_map_rat_sig$combined |>
dplyr::select(c(Condition, In_EE, Gene_name, Entry, `Entry.Name`,
`Protein.names`, Fold_change, pvalue, Reviewed )) |>
gt(
groupname_col = "Condition",
rowname_col = "In_EE"
) |>
fmt_number(decimals = 3) |>
tab_header(
title = "Perez 2024 - Transcriptomics - Hippocampus Mice - adjp <= 0.05 only",
subtitle = "2025_12_27 - lit_review_transcriptomics/split_RNA_df_map_rat_sig - (EE vs SH split by Age (all (96), young (60), old (36)))"
) |>
tab_options(heading.title.font.size = 16,
table.font.size=11.5,
stub.font.weight = "bold",
row_group.font.weight = "bold",
row_group.font.size = 12.5,
column_labels.font.size = 12.5,
column_labels.font.weight = "bold") #|>
| Perez 2024 - Transcriptomics - Hippocampus Mice - adjp <= 0.05 only | |||||||
| 2025_12_27 - lit_review_transcriptomics/split_RNA_df_map_rat_sig - (EE vs SH split by Age (all (96), young (60), old (36))) | |||||||
| Gene_name | Entry | Entry.Name | Protein.names | Fold_change | pvalue | Reviewed | |
|---|---|---|---|---|---|---|---|
| all | |||||||
| up | Rasl10a | A0A8I6ALJ9 | A0A8I6ALJ9_RAT | small monomeric GTPase (EC 3.6.5.2) | 0.330 | 0.000 | unreviewed |
| up | Dnajb5 | A0A0G2K9H9 | A0A0G2K9H9_RAT | DnaJ heat shock protein family (Hsp40) member B5 | 0.331 | 0.000 | unreviewed |
| up | Egr4 | Q00911 | EGR4_RAT | Early growth response protein 4 (EGR-4) (Early response protein NGFI-C) (Nerve growth factor-induced protein C) (NGFI-C) | 0.343 | 0.000 | reviewed |
| up | Mdc1 | Q5U2M8 | MDC1_RAT | Mediator of DNA damage checkpoint protein 1 | 0.309 | 0.000 | reviewed |
| up | Otub2 | D3ZAR8 | D3ZAR8_RAT | ubiquitinyl hydrolase 1 (EC 3.4.19.12) | 0.263 | 0.000 | unreviewed |
| up | Egr1 | P08154 | EGR1_RAT | Early growth response protein 1 (EGR-1) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor Zif268) (Zinc finger protein Krox-24) | 0.461 | 0.000 | reviewed |
| up | Kctd6 | G3V6Z2 | G3V6Z2_RAT | Potassium channel tetramerization domain containing 6 | 0.275 | 0.000 | unreviewed |
| up | Acvr1c | P70539 | ACV1C_RAT | Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) | 0.494 | 0.000 | reviewed |
| up | Cbfa2t3 | D4A303 | D4A303_RAT | CBFA2/RUNX1 partner transcriptional co-repressor 3 | 0.504 | 0.000 | unreviewed |
| up | Acvr1 | P80201 | ACVR1_RAT | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) | 0.194 | 0.002 | reviewed |
| up | Ighm | F1LN61 | F1LN61_RAT | Immunoglobulin heavy constant epsilon | 0.502 | 0.003 | unreviewed |
| up | Kdm7a | A0A8I6AQU2 | A0A8I6AQU2_RAT | Lysine-specific demethylase 7A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) | 0.336 | 0.003 | unreviewed |
| up | Bmi1 | A6JM95 | A6JM95_RAT | Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) | 0.180 | 0.012 | unreviewed |
| up | Fam53b | D3Z8Z2 | D3Z8Z2_RAT | Family with sequence similarity 53, member B | 0.173 | 0.020 | unreviewed |
| up | Ccdc71l | F1M119 | F1M119_RAT | Coiled-coil domain containing 71-like | 0.192 | 0.020 | unreviewed |
| up | Ier5 | NA | NA | NA | 0.248 | 0.020 | NA |
| up | Plekha2 | A0A8I5ZTX1 | A0A8I5ZTX1_RAT | Pleckstrin homology domain containing A2 | 0.325 | 0.020 | unreviewed |
| up | Cebpb | P21272 | CEBPB_RAT | CCAAT/enhancer-binding protein beta (C/EBP beta) (C/EBP-related protein 2) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched inhibitory protein) (LIP) (Liver-enriched transcriptional activator) (LAP) (Silencer factor B) (SF-B) | 0.188 | 0.020 | reviewed |
| up | Slc35f3 | M0RA35 | M0RA35_RAT | Solute carrier family 35, member F3 | 0.203 | 0.020 | unreviewed |
| up | Arsj | Q32KJ7 | Q32KJ7_RAT | Arylsulfatase family, member J | 0.276 | 0.020 | unreviewed |
| up | Nemp1 | A0A8I6G8B7 | A0A8I6G8B7_RAT | Nuclear envelope integral membrane protein 1 | 0.322 | 0.020 | unreviewed |
| up | Rimbp2 | Q9JIR1 | RIMB2_RAT | RIMS-binding protein 2 (RIM-BP2) | 0.243 | 0.024 | reviewed |
| up | Paqr9 | A0ABK0LBD5 | A0ABK0LBD5_RAT | Uncharacterized protein | 0.177 | 0.024 | unreviewed |
| up | Nfil3 | Q6IMZ0 | NFIL3_RAT | Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) | 0.433 | 0.026 | reviewed |
| up | Dpy19l3 | D4A9G5 | D4A9G5_RAT | Dpy-19 like C-mannosyltransferase 3 | 0.251 | 0.027 | unreviewed |
| up | Usp25 | A0A8I5ZPF8 | A0A8I5ZPF8_RAT | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) | 0.164 | 0.029 | unreviewed |
| up | Kcnk1 | Q9Z2T2 | KCNK1_RAT | Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (rTWIK) (Potassium channel K2P1) | 0.197 | 0.029 | reviewed |
| up | Cdkn1a | Q64315 | Q64315_RAT | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (p21) | 0.379 | 0.029 | unreviewed |
| up | Penk | P04094 | PENK_RAT | Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-185); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(239-260); Met-enkephalin-Arg-Phe] | 0.443 | 0.029 | reviewed |
| up | Serinc2 | Q4FZV1 | Q4FZV1_RAT | Serine incorporator 2 | 0.691 | 0.029 | unreviewed |
| up | Rnf19a | D3ZXM0 | D3ZXM0_RAT | RBR-type E3 ubiquitin transferase (EC 2.3.2.31) | 0.227 | 0.031 | unreviewed |
| up | Cops2 | P61203 | CSN2_RAT | COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) | 0.108 | 0.032 | reviewed |
| up | Dnaja4 | Q4QR73 | Q4QR73_RAT | DnaJ (Hsp40) homolog, subfamily A, member 4 (DnaJ heat shock protein family (Hsp40) member A4) | 0.240 | 0.032 | unreviewed |
| up | Uxs1 | Q5PQX0 | UXS1_RAT | UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) | 0.188 | 0.033 | reviewed |
| up | Hcfc2 | Q5RKG2 | HCFC2_RAT | Host cell factor 2 (HCF-2) (C2 factor) | 0.233 | 0.038 | reviewed |
| up | Arntl | Q9EPW1 | BMAL1_RAT | Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Brain and muscle ARNT-like 1) (Tic) | 0.243 | 0.038 | reviewed |
| up | Rbm45 | Q8CFD1 | RBM45_RAT | RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RNA-binding motif protein 45) | 0.157 | 0.038 | reviewed |
| up | Fam43b | A0ABK0LR17 | A0ABK0LR17_RAT | Family with sequence similarity 43, member B | 0.271 | 0.040 | unreviewed |
| up | Bahd1 | D3ZHT3 | D3ZHT3_RAT | Bromo adjacent homology domain containing 1 | 0.127 | 0.041 | unreviewed |
| up | Bambi | Q91XN4 | BAMBI_RAT | BMP and activin membrane-bound inhibitor homolog (Kinase-deficient TGFbeta superfamily receptor subunit) | 0.269 | 0.041 | reviewed |
| up | Gm20634 | NA | NA | NA | 0.431 | 0.042 | NA |
| up | Egr3 | P43301 | EGR3_RAT | Early growth response protein 3 (EGR-3) | 0.284 | 0.043 | reviewed |
| up | Fosb | D3ZLB7 | FOSB_RAT | Protein FosB (Transcription factor AP-1 subunit FosB) | 0.430 | 0.043 | reviewed |
| up | Htr4 | Q62758 | 5HT4R_RAT | 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) | 0.226 | 0.047 | reviewed |
| up | Npy5r | Q63634 | NPY5R_RAT | Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor) | 0.237 | 0.047 | reviewed |
| up | H4c9 | NA | NA | NA | 0.683 | 0.047 | NA |
| up | Rilpl1 | D3ZUQ0 | RIPL1_RAT | RILP-like protein 1 (GAPDH's competitor of SIAH1 protein enhances life) (GOSPEL) (Rab-interacting lysosomal-like protein 1) | 0.146 | 0.048 | reviewed |
| up | Lyrm7 | B4F7A1 | LYRM7_RAT | Complex III assembly factor LYRM7 (LYR motif-containing protein 7) | 0.325 | 0.049 | reviewed |
| up | Mapk4 | Q63454 | MK04_RAT | Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) (MNK2) | 0.237 | 0.049 | reviewed |
| down | Notch3 | Q9R172 | NOTC3_RAT | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] | −0.368 | 0.000 | reviewed |
| down | Epb41l2 | A0A0G2K162 | A0A0G2K162_RAT | Erythrocyte membrane protein band 4.1-like 2 | −0.198 | 0.001 | unreviewed |
| down | Rhobtb3 | D3ZW90 | D3ZW90_RAT | Rho-related BTB domain-containing protein 3 | −0.213 | 0.004 | unreviewed |
| down | Apcdd1 | F1M5Q7 | F1M5Q7_RAT | Protein APCDD1 | −0.285 | 0.006 | unreviewed |
| down | Scd2 | Q6P7B9 | SCD2_RAT | Stearoyl-CoA desaturase 2 (EC 1.14.19.1) (Acyl-CoA desaturase 2) (Delta(9)-desaturase 2) (Delta-9 desaturase 2) (Fatty acid desaturase 2) | −0.157 | 0.006 | reviewed |
| down | Prkg2 | Q64595 | KGP2_RAT | cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) | −0.844 | 0.007 | reviewed |
| down | Slc9a3r2 | Q920G2 | NHRF2_RAT | Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) | −0.256 | 0.007 | reviewed |
| down | Slc6a11 | P31647 | S6A11_RAT | Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) | −0.247 | 0.010 | reviewed |
| down | Klk6 | P36374 | KLK6_RAT | Prostatic glandular kallikrein-6 (EC 3.4.21.35) (Glandular kallikrein-8) (rGK-8) (P1 kallikrein) (Tissue kallikrein) | −0.893 | 0.010 | reviewed |
| down | Sema6a | D3ZAG0 | D3ZAG0_RAT | Semaphorin-6A (Semaphorin VIA) (Semaphorin-6A-1) | −0.277 | 0.010 | unreviewed |
| down | Sema4d | A0A8I6G5Q1 | A0A8I6G5Q1_RAT | Semaphorin-4D | −0.256 | 0.010 | unreviewed |
| down | Epb41l3 | A6KF70 | A6KF70_RAT | Erythrocyte membrane protein band 4.1-like 3 (Type II brain 4.1) | −0.164 | 0.010 | unreviewed |
| down | Gnai2 | P04897 | GNAI2_RAT | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | −0.121 | 0.010 | reviewed |
| down | Dusp26 | Q5FVI9 | DUS26_RAT | Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) | −0.269 | 0.010 | reviewed |
| down | Gal3st1 | D3ZCT9 | D3ZCT9_RAT | Galactose-3-O-sulfotransferase 1 | −0.304 | 0.011 | unreviewed |
| down | Kcna6 | P17659 | KCNA6_RAT | Potassium voltage-gated channel subfamily A member 6 (RCK2) (Voltage-gated potassium channel subunit Kv1.6) (Voltage-gated potassium channel subunit Kv2) | −0.168 | 0.012 | reviewed |
| down | Atp10a | A0A0G2JWQ8 | A0A0G2JWQ8_RAT | Phospholipid-transporting ATPase (EC 7.6.2.1) | −0.354 | 0.012 | unreviewed |
| down | Scarb2 | P27615 | SCRB2_RAT | Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) | −0.099 | 0.012 | reviewed |
| down | Rassf2 | Q3B7D5 | RASF2_RAT | Ras association domain-containing protein 2 | −0.221 | 0.016 | reviewed |
| down | Unc13c | Q62770 | UN13C_RAT | Protein unc-13 homolog C (Munc13-3) | −0.485 | 0.016 | reviewed |
| down | Glud1 | P10860 | DHE3_RAT | Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) (Memory-related gene 2 protein) (MRG-2) | −0.159 | 0.017 | reviewed |
| down | Mtss2 | D4A3S6 | D4A3S6_RAT | MTSS I-BAR domain containing 2 | −0.174 | 0.018 | unreviewed |
| down | Dbp | P16443 | DBP_RAT | D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (D site albumin promoter-binding protein 1) | −0.442 | 0.020 | reviewed |
| down | Hsdl1 | Q4V8B7 | HSDL1_RAT | Inactive hydroxysteroid dehydrogenase-like protein 1 | −0.167 | 0.020 | reviewed |
| down | Pcdh15 | A0A8I6B3E0 | A0A8I6B3E0_RAT | Protocadherin-15 | −0.405 | 0.020 | unreviewed |
| down | Ldhd | A0A0G2K1W9 | A0A0G2K1W9_RAT | Probable D-lactate dehydrogenase, mitochondrial (EC 1.1.2.4) | −0.284 | 0.020 | unreviewed |
| down | Adcyap1r1 | P32215 | PACR_RAT | Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) | −0.179 | 0.020 | reviewed |
| down | Pcdh10 | F1M6B6 | F1M6B6_RAT | Protocadherin 10 | −0.207 | 0.030 | unreviewed |
| down | Mthfd1l | B2GUZ3 | B2GUZ3_RAT | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) | −0.244 | 0.032 | unreviewed |
| down | Smarcd3 | Q5U3Y2 | Q5U3Y2_RAT | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 | −0.162 | 0.032 | unreviewed |
| down | Slc1a3 | P24942 | EAA1_RAT | Excitatory amino acid transporter 1 (Glial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST) (GLAST-1) (Solute carrier family 1 member 3) | −0.172 | 0.033 | reviewed |
| down | Nr1d2 | Q63504 | NR1D2_RAT | Nuclear receptor subfamily 1 group D member 2 (EAR4) (Rev-erb-beta) | −0.242 | 0.037 | reviewed |
| down | Bcl7c | D3ZUL4 | D3ZUL4_RAT | BAF chromatin remodeling complex subunit BCL7C | −0.212 | 0.038 | unreviewed |
| down | Slc44a2 | B4F795 | CTL2_RAT | Choline transporter-like protein 2 (Solute carrier family 44 member 2) | −0.121 | 0.038 | reviewed |
| down | Serinc5 | Q63175 | SERC5_RAT | Serine incorporator 5 (Developmentally regulated protein TPO1) | −0.165 | 0.040 | reviewed |
| down | Ctu2 | Q3B7U4 | CTU2_RAT | Cytoplasmic tRNA 2-thiolation protein 2 | −0.701 | 0.041 | reviewed |
| down | Itfg2 | A0A8I6AHW3 | A0A8I6AHW3_RAT | Integrin alpha FG-GAP repeat containing 2 | −0.256 | 0.043 | unreviewed |
| down | Myo6 | D4A5I9 | D4A5I9_RAT | Unconventional myosin-VI (Unconventional myosin-6) | −0.170 | 0.043 | unreviewed |
| down | Sirt2 | Q5RJQ4 | SIR2_RAT | NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | −0.139 | 0.043 | reviewed |
| down | Shmt1 | Q6TXG7 | Q6TXG7_RAT | Serine hydroxymethyltransferase (EC 2.1.2.1) | −0.659 | 0.043 | unreviewed |
| down | Tbc1d9b | F1LRL4 | F1LRL4_RAT | TBC1 domain family member 9B | −0.156 | 0.045 | unreviewed |
| down | Igfbp5 | P24594 | IBP5_RAT | Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) | −0.239 | 0.047 | reviewed |
| down | Dip2a | F1LZ43 | F1LZ43_RAT | Disco-interacting protein 2 homolog A | −0.144 | 0.047 | unreviewed |
| down | Clcn6 | D4A3H5 | D4A3H5_RAT | Chloride channel protein | −0.085 | 0.047 | unreviewed |
| down | Doc2a | P70611 | DOC2A_RAT | Double C2-like domain-containing protein alpha (Doc2-alpha) | −0.533 | 0.048 | reviewed |
| old | |||||||
| up | Gm21985 | NA | NA | NA | 9.307 | 0.000 | NA |
| up | Tanc1 | Q6F6B3 | TANC1_RAT | Protein TANC1 (TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1) | 0.290 | 0.000 | reviewed |
| up | Plekha2 | A0A8I5ZTX1 | A0A8I5ZTX1_RAT | Pleckstrin homology domain containing A2 | 0.412 | 0.000 | unreviewed |
| up | Anapc10 | A6IYH7 | A6IYH7_RAT | Anaphase-promoting complex subunit 10 | 0.734 | 0.000 | unreviewed |
| up | Lrp1b | F1M443 | F1M443_RAT | Low-density lipoprotein receptor-related protein 1B (Low-density lipoprotein receptor-related protein-deleted in tumor) | 0.332 | 0.001 | unreviewed |
| up | Iqgap2 | A0A8I6AM38 | A0A8I6AM38_RAT | IQ motif containing GTPase activating protein 2 | 0.395 | 0.001 | unreviewed |
| up | Paqr9 | A0ABK0LBD5 | A0ABK0LBD5_RAT | Uncharacterized protein | 0.238 | 0.003 | unreviewed |
| up | Dusp6 | Q64346 | DUS6_RAT | Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) | 0.371 | 0.003 | reviewed |
| up | Akr1e1 | NA | NA | NA | 0.429 | 0.003 | NA |
| up | Otub2 | D3ZAR8 | D3ZAR8_RAT | ubiquitinyl hydrolase 1 (EC 3.4.19.12) | 0.318 | 0.004 | unreviewed |
| up | Drd1 | P18901 | DRD1_RAT | D(1A) dopamine receptor (Dopamine D1 receptor) | 0.540 | 0.007 | reviewed |
| up | Ncdn | O35095 | NCDN_RAT | Neurochondrin (Neurite outgrowth-related protein from the rat brain) (Norbin) | 0.203 | 0.011 | reviewed |
| up | Rasl10a | A0A8I6ALJ9 | A0A8I6ALJ9_RAT | small monomeric GTPase (EC 3.6.5.2) | 0.313 | 0.016 | unreviewed |
| up | Cntnap5b | Q0V8T5 | CTP5B_RAT | Contactin-associated protein like 5-2 (Cell recognition molecule Caspr5-2) (Cell recognition molecule Caspr5b) (Contactin-associated protein-like 5b) | 0.379 | 0.016 | reviewed |
| up | Med17 | D4ABU0 | D4ABU0_RAT | Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) | 0.385 | 0.016 | unreviewed |
| up | Lct | Q02401 | LPH_RAT | Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)] | 0.398 | 0.016 | reviewed |
| up | Rnf112 | O70418 | RN112_RAT | RING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Zinc finger protein 179) | 0.251 | 0.016 | reviewed |
| up | Lrg1 | M0R8H5 | M0R8H5_RAT | Leucine-rich alpha-2-glycoprotein 1 | 2.565 | 0.024 | unreviewed |
| up | Slc7a14 | A0A0G2K1G8 | A0A0G2K1G8_RAT | Solute carrier family 7, member 14 | 0.180 | 0.037 | unreviewed |
| up | Rbp3 | G3V8Q4 | G3V8Q4_RAT | Retinol-binding protein 3 (Interphotoreceptor retinoid-binding protein) (Interstitial retinol-binding protein) | 3.386 | 0.047 | unreviewed |
| up | C1ql2 | A0A3B0IP42 | A0A3B0IP42_RAT | Complement C1q like 2 | 0.212 | 0.049 | unreviewed |
| up | Bdnf | P23363 | BDNF_RAT | Neurotrophic factor BDNF precursor form (proBDNF) (Brain-derived neurotrophic factor) [Cleaved into: Neurotrophic factor BDNF] | 0.351 | 0.049 | reviewed |
| down | Unc13c | Q62770 | UN13C_RAT | Protein unc-13 homolog C (Munc13-3) | −0.593 | 0.000 | reviewed |
| down | Stard4 | D3Z9I9 | D3Z9I9_RAT | StAR-related lipid transfer protein 4 (START domain-containing protein 4) | −0.479 | 0.001 | unreviewed |
| down | Pcdh11x | A0A8I6AKA9 | A0A8I6AKA9_RAT | Protocadherin 11 X-linked | −0.920 | 0.001 | unreviewed |
| down | Camk2n2 | Q9Z2N6 | CK2N2_RAT | Calcium/calmodulin-dependent protein kinase II inhibitor 2 (CaM-KII inhibitory protein) (CaM-KIIN) (CaM-KIINbeta) | −0.620 | 0.001 | reviewed |
| down | Mfge8 | P70490 | MFGM_RAT | Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (O-acetyl GD3 ganglioside synthase) (AGS) (SED1) | −0.372 | 0.003 | reviewed |
| down | Slc6a11 | P31647 | S6A11_RAT | Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) | −0.305 | 0.003 | reviewed |
| down | Tacr3 | P16177 | NK3R_RAT | Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) | −2.437 | 0.006 | reviewed |
| down | Rapgef3 | Q9Z1C8 | RPGF3_RAT | Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) | −0.358 | 0.019 | reviewed |
| down | Gpsm1 | Q9R080 | GPSM1_RAT | G-protein-signaling modulator 1 (Activator of G-protein signaling 3) | −0.403 | 0.024 | reviewed |
| down | Pcdh15 | A0A8I6B3E0 | A0A8I6B3E0_RAT | Protocadherin-15 | −0.585 | 0.032 | unreviewed |
| down | Slc17a6 | Q9JI12 | VGLU2_RAT | Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6) | −0.836 | 0.032 | reviewed |
| down | Slc35a5 | D4A7S3 | D4A7S3_RAT | Solute carrier family 35, member A5 | −0.222 | 0.043 | unreviewed |
| down | Fxyd6 | Q91XV6 | FXYD6_RAT | FXYD domain-containing ion transport regulator 6 (Phosphohippolin) (Vascular endothelial cell-specific protein 6) (VESP6) | −0.497 | 0.046 | reviewed |
| down | Kitl | P21581 | SCF_RAT | Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)] | −0.443 | 0.049 | reviewed |
| young | |||||||
| up | Acvr1c | P70539 | ACV1C_RAT | Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) | 0.599 | 0.000 | reviewed |
| up | Ttn | A0A8I5ZU83 | A0A8I5ZU83_RAT | Titin (EC 2.7.11.1) (Connectin) | 2.208 | 0.000 | unreviewed |
| up | Dnajb5 | A0A0G2K9H9 | A0A0G2K9H9_RAT | DnaJ heat shock protein family (Hsp40) member B5 | 0.423 | 0.000 | unreviewed |
| up | Gm45234 | NA | NA | NA | 7.907 | 0.000 | NA |
| up | Gm21860 | NA | NA | NA | 7.689 | 0.000 | NA |
| up | Cbfa2t3 | D4A303 | D4A303_RAT | CBFA2/RUNX1 partner transcriptional co-repressor 3 | 0.672 | 0.000 | unreviewed |
| up | Penk | P04094 | PENK_RAT | Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-185); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(239-260); Met-enkephalin-Arg-Phe] | 0.583 | 0.000 | reviewed |
| up | Egr1 | P08154 | EGR1_RAT | Early growth response protein 1 (EGR-1) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor Zif268) (Zinc finger protein Krox-24) | 0.587 | 0.000 | reviewed |
| up | Ddi2 | A0A8J8Y1M0 | A0A8J8Y1M0_RAT | DNA damage inducible 1 homolog 2 | 0.259 | 0.001 | unreviewed |
| up | Fndc3b | D4A0W7 | D4A0W7_RAT | Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37) | 0.435 | 0.001 | unreviewed |
| up | Fras1 | A0A8I6AIZ0 | A0A8I6AIZ0_RAT | Extracellular matrix organizing protein FRAS1 | 0.731 | 0.001 | unreviewed |
| up | Rasl10a | A0A8I6ALJ9 | A0A8I6ALJ9_RAT | small monomeric GTPase (EC 3.6.5.2) | 0.346 | 0.001 | unreviewed |
| up | Ighm | F1LN61 | F1LN61_RAT | Immunoglobulin heavy constant epsilon | 0.527 | 0.002 | unreviewed |
| up | Xlr3a | M0RDK0 | M0RDK0_RAT | X-linked lymphocyte-regulated protein 3A-like | 2.451 | 0.004 | unreviewed |
| up | Fam43b | A0ABK0LR17 | A0ABK0LR17_RAT | Family with sequence similarity 43, member B | 0.364 | 0.004 | unreviewed |
| up | Xlr4a | D4A7L7 | D4A7L7_RAT | X-linked lymphocyte-regulated 4A | 6.617 | 0.005 | unreviewed |
| up | Cdkn1a | Q64315 | Q64315_RAT | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (p21) | 0.532 | 0.008 | unreviewed |
| up | Kctd6 | G3V6Z2 | G3V6Z2_RAT | Potassium channel tetramerization domain containing 6 | 0.357 | 0.011 | unreviewed |
| up | Mga | A0A8I6AGZ4 | A0A8I6AGZ4_RAT | MAX gene-associated protein | 0.271 | 0.013 | unreviewed |
| up | Dnajb1 | D3ZUU5 | D3ZUU5_RAT | DnaJ heat shock protein family (Hsp40) member B1 | 0.311 | 0.017 | unreviewed |
| up | Egr4 | Q00911 | EGR4_RAT | Early growth response protein 4 (EGR-4) (Early response protein NGFI-C) (Nerve growth factor-induced protein C) (NGFI-C) | 0.369 | 0.023 | reviewed |
| up | Uba6 | D4A8H3 | D4A8H3_RAT | Ubiquitin-like modifier-activating enzyme 6 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1-like protein 2) | 0.373 | 0.032 | unreviewed |
| up | Kdm7a | A0A8I6AQU2 | A0A8I6AQU2_RAT | Lysine-specific demethylase 7A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) | 0.404 | 0.032 | unreviewed |
| up | Zmym2 | D4A3R6 | D4A3R6_RAT | Zinc finger MYM-type containing 2 | 0.215 | 0.034 | unreviewed |
| up | Nop58 | Q9QZ86 | NOP58_RAT | Nucleolar protein 58 (Nopp140-associated protein of 65 kDa) (Nucleolar protein 5) | 0.319 | 0.039 | reviewed |
| up | Nqo2 | Q6AY80 | NQO2_RAT | Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) | 0.399 | 0.039 | reviewed |
| up | Egr2 | P51774 | EGR2_RAT | E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20) | 2.084 | 0.042 | reviewed |
| down | Igfbp5 | P24594 | IBP5_RAT | Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) | −0.299 | 0.000 | reviewed |
| down | Kntc1 | A0A8I6G9X6 | A0A8I6G9X6_RAT | Kinetochore associated 1 | −1.345 | 0.000 | unreviewed |
| down | Mllt10 | A0A8I5ZK97 | A0A8I5ZK97_RAT | MLLT10, histone lysine methyltransferase DOT1L cofactor | −0.401 | 0.000 | unreviewed |
| down | Col6a4 | A0A8I6A6Y7 | A0A8I6A6Y7_RAT | Collagen, type VI, alpha 4 | −2.461 | 0.000 | unreviewed |
| down | Ctu2 | Q3B7U4 | CTU2_RAT | Cytoplasmic tRNA 2-thiolation protein 2 | −0.978 | 0.000 | reviewed |
| down | Gm4735 | NA | NA | NA | −7.498 | 0.000 | NA |
| down | Cacng5 | Q8VHW8 | CCG5_RAT | Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5) | −0.631 | 0.001 | reviewed |
| down | Apcdd1 | F1M5Q7 | F1M5Q7_RAT | Protein APCDD1 | −0.388 | 0.001 | unreviewed |
| down | Foxq1 | Q63244 | FOXQ1_RAT | Forkhead box protein Q1 (HNF-3/forkhead-like protein 1) (HFH-1) (Hepatocyte nuclear factor 3 forkhead homolog 1) | −0.618 | 0.001 | reviewed |
| down | Itgad | Q9QYE7 | ITAD_RAT | Integrin alpha-D (CD antigen CD11d) | −3.410 | 0.003 | reviewed |
| down | Ctxn3 | B2GV70 | B2GV70_RAT | Cortexin 3 | −2.226 | 0.003 | unreviewed |
| down | Rapgef4 | Q9Z1C7 | RPGF4_RAT | Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) | −0.187 | 0.003 | reviewed |
| down | Sema6a | D3ZAG0 | D3ZAG0_RAT | Semaphorin-6A (Semaphorin VIA) (Semaphorin-6A-1) | −0.350 | 0.004 | unreviewed |
| down | Olig1 | Q9WUQ3 | OLIG1_RAT | Oligodendrocyte transcription factor 1 (Oligo1) (Olg-1 bHLH protein) | −0.322 | 0.004 | reviewed |
| down | Morf4l1-ps1 | NA | NA | NA | −6.744 | 0.008 | NA |
| down | Ebf2 | D3ZT68 | D3ZT68_RAT | Transcription factor COE2 (Early B-cell factor 2) | −3.729 | 0.012 | unreviewed |
| down | Cadm4 | Q1WIM1 | CADM4_RAT | Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) | −0.265 | 0.016 | reviewed |
| down | Mbp | P02688 | MBP_RAT | Myelin basic protein (MBP) | −0.496 | 0.018 | reviewed |
| down | Gcnt1 | Q64165 | Q64165_RAT | Glucosaminyl (N-acetyl) transferase 1 | −0.606 | 0.019 | unreviewed |
| down | Gm12184 | NA | NA | NA | −2.512 | 0.021 | NA |
| down | Abi3 | Q6AYC6 | Q6AYC6_RAT | ABI gene family member 3 (New molecule including SH3) | −0.793 | 0.025 | unreviewed |
| down | Sgf29 | P0C606 | SGF29_RAT | SAGA-associated factor 29 (rSGF29) (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) | −0.533 | 0.025 | reviewed |
| down | Rassf2 | Q3B7D5 | RASF2_RAT | Ras association domain-containing protein 2 | −0.287 | 0.028 | reviewed |
| down | Ebf3 | D4A274 | D4A274_RAT | Transcription factor COE3 (Early B-cell factor 3) (Olf-1/EBF-like 2) | −1.467 | 0.032 | unreviewed |
| down | Nr1d1 | Q63503 | NR1D1_RAT | Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) | −0.448 | 0.032 | reviewed |
| down | Plekhb1 | Q9WU68 | PKHB1_RAT | Pleckstrin homology domain-containing family B member 1 (PH domain-containing family B member 1) (Evectin-1) | −0.389 | 0.032 | reviewed |
| down | Fam205a1 | NA | NA | NA | −6.066 | 0.033 | NA |
| down | Elp6 | B2RYG8 | ELP6_RAT | Elongator complex protein 6 (Protein TMEM103) | −0.860 | 0.033 | reviewed |
| down | Notch3 | Q9R172 | NOTC3_RAT | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] | −0.409 | 0.033 | reviewed |
| down | 2900052L18Rik | NA | NA | NA | −0.634 | 0.034 | NA |
| down | Gab1 | D3ZAL7 | D3ZAL7_RAT | GRB2-associated binding protein 1 | −0.363 | 0.034 | unreviewed |
| down | Gm29216 | NA | NA | NA | −0.279 | 0.036 | NA |
| down | Abcb1a | Q9JK64 | Q9JK64_RAT | P-type phospholipid transporter (EC 7.6.2.1) | −0.415 | 0.048 | unreviewed |
# opt_stylize(style = 6, color = 'pink') # cute but also ew looks like excel
# opt_stylize(style = 1, color = 'gray', add_row_striping = TRUE)
plot(lit_review_transcriptomics$pvalue) # see distribution of pvalues
plot(lit_review_transcriptomics$Fold_change) # see distribution of fold change
volcano_RNA <- lit_review_transcriptomics %>%
filter(pvalue <= 0.2) %>% # filter otherwise 20000 dots per plot...
ggplot(aes(x = Fold_change, y = -log2(pvalue),
label = Gene_name)) +
geom_point(aes(color = case_when(
pvalue < 0.05 & Fold_change > 0.05 ~ "Upregulated (adj.p<0.05)",
pvalue < 0.05 & Fold_change < -0.05 ~ "Downregulated (adj.p<0.05)",
pvalue < 0.1 & Fold_change > 0.05 ~ "Upregulated (adj.p<0.1)",
pvalue < 0.1 & Fold_change < -0.05 ~ "Downregulated (adj.p<0.1)",
TRUE ~ "Not Significant")),
alpha = 1, size = 1.5, shape = 1) +
# xlim(-8,12) +
geom_vline(xintercept = 0, linetype = "dashed",
color = "grey40", linewidth = .5) +
scale_color_manual(values = c("firebrick3",
"royalblue4",
"lightpink1",
"lightblue3" ,
"grey80"),
breaks = c("Upregulated (adj.p<0.05)",
"Downregulated (adj.p<0.05)",
"Upregulated (adj.p<0.1)",
"Downregulated (adj.p<0.1)",
"Not Significant"),
labels = c("Upregulated mRNA (adj.p<0.05)",
"Downregulated mRNA (adj.p<0.05)",
"Upregulated mRNA (adj.p<0.1)",
"Downregulated mRNA (adj.p<0.1)",
"Not Significant")) +
geom_text_repel() +
facet_wrap(~Condition, ncol = 1,
scales = "free_y") +
labs(
title = "Perez 2024 - Transriptomics - Hippocampus (Mice) - EE x Aging (2025_12_27)",
subtitle = "",
x = "Log2 Signal",
y = "-Log2(adj.p-value)",
color = "mRNA Regulation") +
theme_bw() +
theme(legend.position = "bottom",
strip.text = element_text(size = 12))
volcano_RNA
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_text_repel()`).
## Warning: ggrepel: 389 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
## Warning: ggrepel: 83 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
## Warning: ggrepel: 81 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
# intersect of observed
intersect(split_prot_df_map_rat$combined$Gene_name,
split_RNA_df_map_rat$combined$Gene_name)
## [1] "2900026A02Rik" "4833439L19Rik" "4931406C07Rik" "Aatk"
## [5] "Abi1" "Abl2" "Abracl" "Abraxas2"
## [9] "Acad8" "Acan" "Acbd3" "Acin1"
## [13] "Acsf2" "Actg1" "Acyp1" "Acyp2"
## [17] "Add1" "Adgrl1" "Adrm1" "Afdn"
## [21] "Agfg1" "Ahnak" "Aimp1" "Aip"
## [25] "Ak1" "Akap12" "Akap5" "Akt1s1"
## [29] "Alyref" "Amer2" "Amph" "Anapc1"
## [33] "Anp32a" "Anxa7" "Ap1m1" "Ap1s1"
## [37] "Ap3s1" "Apba1" "Apoa1" "Apod"
## [41] "Apoe" "App" "Aprt" "Arfgap1"
## [45] "Arfip2" "Arhgap21" "Arhgap23" "Arhgef17"
## [49] "Arhgef6" "Arid1a" "Arl1" "Arpin"
## [53] "Arrb1" "Arsb" "Asap1" "Atox1"
## [57] "Atp2a2" "Atp6v1d" "Atp6v1e1" "Atp6v1f"
## [61] "Atp6v1g1" "Atxn2l" "Bad" "Bag3"
## [65] "Bag4" "Bag6" "Baiap2" "Basp1"
## [69] "Bcam" "Bcan" "Bcas1" "Bcl2l13"
## [73] "Bcl7c" "Bclaf1" "Begain" "Bin1"
## [77] "Bin2" "Blmh" "Bnip3l" "Bod1"
## [81] "Bola1" "Brk1" "Bsn" "Btf3"
## [85] "Bzw1" "C1qbp" "Cacna1a" "Cacna1b"
## [89] "Cacnb1" "Cadm1" "Cadm2" "Cadm3"
## [93] "Calb1" "Calb2" "Calr" "Camk2n1"
## [97] "Camsap2" "Cap1" "Caprin1" "Capza1"
## [101] "Carmil2" "Caskin1" "Cast" "Cavin1"
## [105] "Cbx1" "Cbx3" "Cc2d1a" "Ccar2"
## [109] "Ccsap" "Cd200" "Cd47" "Cd81"
## [113] "Cd99l2" "Cdc37" "Cdc42ep4" "Cdh11"
## [117] "Cdh13" "Cdk14" "Cdkn1b" "Cdv3"
## [121] "Cend1" "Cep170" "Cep170b" "Cfdp1"
## [125] "Chchd3" "Chchd4" "Chchd6" "Chgb"
## [129] "Chmp1a" "Chmp5" "Chtop" "Ciapin1"
## [133] "Cirbp" "Clasp2" "Clic4" "Clint1"
## [137] "Clip1" "Clip2" "Clptm1" "Clta"
## [141] "Cltb" "Clu" "Cmpk1" "Cnot3"
## [145] "Cnpy2" "Cnpy3" "Cnst" "Coa7"
## [149] "Cops8" "Coq8a" "Coq9" "Cox5a"
## [153] "Cox6b1" "Cplx1" "Cplx2" "Crk"
## [157] "Crkl" "Crtc1" "Cryl1" "Cryzl1"
## [161] "Csde1" "Csnk1a1" "Cspg5" "Csrp1"
## [165] "Cst3" "Cstf2" "Ctnnb1" "Ctnnd2"
## [169] "Cttn" "Cttnbp2" "Cul4b" "Cwc15"
## [173] "Cx3cl1" "Cyb5a" "Cygb" "Dag1"
## [177] "Dbi" "Dbndd2" "Dbnl" "Dctn2"
## [181] "Ddx17" "Ddx6" "Dek" "Denr"
## [185] "Dhrs1" "Dip2a" "Dkk3" "Dlgap3"
## [189] "Dlgap4" "Dlst" "Dmtn" "Dnajb6"
## [193] "Dnajc5" "Dnajc8" "Dock9" "Dpysl5"
## [197] "Drap1" "Dtd1" "Dync1li2" "Eci2"
## [201] "Eef1a2" "Eefsec" "Efhd2" "Eftud2"
## [205] "Eif1ax" "Eif3f" "Eif3g" "Eif3j1"
## [209] "Eif4b" "Eif4ebp2" "Eif4g2" "Eif4h"
## [213] "Eif5" "Eif5a" "Eif5b" "Elob"
## [217] "Endod1" "Enpp6" "Ensa" "Epb41l2"
## [221] "Epn1" "Eps15l1" "Erc2" "Ermn"
## [225] "Erp29" "Erp44" "Evl" "Fabp3"
## [229] "Fabp7" "Fah" "Fam114a2" "Fam131b"
## [233] "Fam169a" "Fam219a" "Fdx2" "Fgf1"
## [237] "Fgf12" "Fkbp1a" "Fkbp2" "Fkbp3"
## [241] "Fmn2" "Fmr1" "Fnbp1" "Fubp1"
## [245] "Fus" "Fxn" "Fxyd6" "G3bp1"
## [249] "Gaa" "Gabarapl2" "Gabra1" "Gad1"
## [253] "Galk1" "Gap43" "Gcsh" "Gdpd1"
## [257] "Gfer" "Gga3" "Ggct" "Ggt7"
## [261] "Gipc1" "Gjc2" "Glg1" "Glo1"
## [265] "Glrx5" "Gltp" "Gm2a" "Gmppa"
## [269] "Gng2" "Golga5" "Gorasp2" "Gpc1"
## [273] "Gpc4" "Gpm6a" "Gpm6b" "Gpr158"
## [277] "Gprin1" "Gprin3" "Grb2" "Grcc10"
## [281] "Grm2" "Grm5" "Grpel1" "Gtf2i"
## [285] "H2ax" "Habp4" "Hapln4" "Hcfc1"
## [289] "Hcn1" "Hdac6" "Hdgf" "Hdgfl2"
## [293] "Hdgfl3" "Hectd1" "Hgs" "Hikeshi"
## [297] "Hmga1" "Hmgb3" "Hmgn5" "Hnrnpa1"
## [301] "Hnrnpab" "Hnrnpc" "Hnrnpd" "Hnrnpdl"
## [305] "Hnrnpll" "Homer3" "Hopx" "Hp"
## [309] "Hpca" "Hpcal1" "Hpx" "Hs1bp3"
## [313] "Hspa4" "Hspe1" "Htatsf1" "Huwe1"
## [317] "Hyou1" "Ighm" "Impact" "Inf2"
## [321] "Isca2" "Iscu" "Ist1" "Itgb1"
## [325] "Itsn1" "Jam3" "Jph1" "Jph3"
## [329] "Jpt1" "Kalrn" "Kcnip2" "Khdrbs3"
## [333] "Khsrp" "Kif5b" "Klc2" "Ktn1"
## [337] "L1cam" "Lamp1" "Lamtor1" "Lamtor5"
## [341] "Larp1" "Lasp1" "Lbh" "Lbhd2"
## [345] "Ldah" "Letm1" "Lgals1" "Lgalsl"
## [349] "Lin7a" "Lmnb1" "Lmtk3" "Lnpk"
## [353] "Lrg1" "Lrp1" "Lrpap1" "Lrrc59"
## [357] "Lrrfip2" "Lsm3" "Ly6h" "Lysmd2"
## [361] "M6pr" "Mag" "Map1a" "Map1b"
## [365] "Map1lc3a" "Map1s" "Map6" "Map7"
## [369] "Map7d2" "Mapre1" "Mapre3" "Marcks"
## [373] "Marcksl1" "Mark3" "Mast1" "Mbp"
## [377] "Mccc2" "Mea1" "Mecp2" "Mfsd6"
## [381] "Mical3" "Mindy2" "Mink1" "Mllt11"
## [385] "Mrpl12" "Mrpl40" "Mrps31" "Mrrf"
## [389] "Msrb2" "Mtdh" "Mtpn" "Myl6"
## [393] "Naca" "Nap1l1" "Nap1l4" "Napg"
## [397] "Nav1" "Ncald" "Ncan" "Nckipsd"
## [401] "Ncl" "Ncs1" "Ndel1" "Ndrg2"
## [405] "Ndufa5" "Ndufa6" "Ndufa7" "Ndufab1"
## [409] "Ndufb10" "Ndufb3" "Ndufb6" "Ndufs4"
## [413] "Ndufs5" "Ndufs8" "Ndufv2" "Ndufv3"
## [417] "Nebl" "Necab2" "Nectin1" "Nedd8"
## [421] "Nefh" "Negr1" "Nenf" "Nfu1"
## [425] "Nfya" "Nipa1" "Nme1" "Nol3"
## [429] "Nop56" "Nova1" "Npc2" "Npm1"
## [433] "Nsfl1c" "Nt5dc3" "Ntm" "Nucb1"
## [437] "Nucks1" "Nudc" "Nup62" "Ociad1"
## [441] "Ogfrl1" "Omg" "Opalin" "Opcml"
## [445] "Oplah" "Otud6b" "Oxr1" "Oxsr1"
## [449] "Pacsin1" "Pacsin2" "Pafah1b2" "Pak1"
## [453] "Pak2" "Palmd" "Pclo" "Pcnp"
## [457] "Pcsk1n" "Pdap1" "Pdcd10" "Pde4a"
## [461] "Pdia3" "Pdlim5" "Pebp1" "Pex14"
## [465] "Pfdn2" "Pgam1" "Pgbd5" "Pgrmc1"
## [469] "Phpt1" "Pitpnm1" "Pkia" "Pkig"
## [473] "Pkm" "Plcl2" "Plppr3" "Pnma8b"
## [477] "Pnn" "Pnpo" "Polr2m" "Ppfia4"
## [481] "Ppib" "Ppid" "Ppm1a" "Ppp1r11"
## [485] "Ppp1r12a" "Ppp1r12c" "Ppp1r1a" "Ppp1r1b"
## [489] "Ppp1r2" "Ppp1r7" "Ppp1r9a" "Ppp1r9b"
## [493] "Ppp3r1" "Ppp4r2" "Ppp6c" "Ppp6r1"
## [497] "Ppp6r3" "Pqbp1" "Prdx6" "Prkcsh"
## [501] "Prnp" "Prodh" "Prps2" "Prrc2a"
## [505] "Prrc2c" "Prrt2" "Prrt3" "Psap"
## [509] "Psd" "Psip1" "Psma1" "Psmb3"
## [513] "Psmb7" "Psmc5" "Psmd11" "Psmd13"
## [517] "Psmd14" "Psmd6" "Psmd7" "Psmd8"
## [521] "Psmd9" "Psme1" "Ptgds" "Ptma"
## [525] "Ptms" "Ptpn23" "Ptpn9" "Ptpra"
## [529] "Ptprn2" "Ptprz1" "Puf60" "Pum1"
## [533] "Pym1" "Rab10" "Rab27b" "Rab3gap2"
## [537] "Rabl6" "Rad23a" "Rad23b" "Ralbp1"
## [541] "Ralgapa1" "Ramac" "Ranbp3" "Rbm3"
## [545] "Rbm8a" "Rbmx" "Rcn1" "Rcn2"
## [549] "Rell2" "Reps1" "Reps2" "Rftn2"
## [553] "Rgs10" "Rida" "Rimbp2" "Rims1"
## [557] "Ripor1" "Rmdn3" "Rnh1" "Rnmt"
## [561] "Rph3a" "Rpl10" "Rpl19" "Rpl22"
## [565] "Rpl23a" "Rpl31" "Rpl38" "Rplp1"
## [569] "Rplp2" "Rps13" "Rps15" "Rps17"
## [573] "Rps19" "Rps25" "Rps28" "Rpsa"
## [577] "Rrbp1" "Rrp1" "Rtcb" "Rtn3"
## [581] "Rtn4" "Rwdd1" "S100a16" "Safb"
## [585] "Sarnp" "Scamp3" "Scg2" "Scg3"
## [589] "Scn2a" "Scp2" "Sdc4" "Sec24b"
## [593] "Sec24c" "Sec31a" "Selenom" "Serbp1"
## [597] "Set" "Setd7" "Sf1" "Sf3b4"
## [601] "Sgip1" "Sgta" "Sgtb" "Sh3bgrl3"
## [605] "Sh3gl2" "Sh3glb2" "Sh3kbp1" "Shank1"
## [609] "Shank2" "Shank3" "Shfl" "Shisa7"
## [613] "Shroom2" "Skp1" "Slc12a2" "Slc25a23"
## [617] "Slc27a4" "Slc32a1" "Slc39a10" "Slc39a6"
## [621] "Slc6a11" "Slc6a6" "Slc9a1" "Smarcc2"
## [625] "Snap25" "Snca" "Sncb" "Snrpa"
## [629] "Snx1" "Snx12" "Snx3" "Sod1"
## [633] "Sorbs1" "Sorbs2" "Sparcl1" "Specc1"
## [637] "Spock1" "Spock2" "Sptb" "Sri"
## [641] "Srp19" "Srp72" "Srrm2" "Srrt"
## [645] "Srsf1" "Srsf10" "Srsf2" "Srsf7"
## [649] "Ssb" "Sst" "St13" "Stip1"
## [653] "Stmn1" "Stoml2" "Strn" "Strn3"
## [657] "Stx1b" "Stx7" "Sub1" "Suclg2"
## [661] "Sumo2" "Svip" "Syap1" "Syn1"
## [665] "Syn3" "Synm" "Synrg" "Tacc1"
## [669] "Taf15" "Tagln" "Tagln2" "Tagln3"
## [673] "Tbc1d10b" "Tbcd" "Tcea1" "Tceal3"
## [677] "Tceal5" "Tfg" "Tgoln1" "Thop1"
## [681] "Thrap3" "Timm44" "Timm8a1" "Tjp1"
## [685] "Tmem63b" "Tmod1" "Tmod2" "Tmpo"
## [689] "Tnks1bp1" "Tom1" "Tom1l2" "Tomm34"
## [693] "Tpd52" "Tpd52l1" "Tpd52l2" "Tpm1"
## [697] "Tpm3" "Tpm3-rs7" "Tpm4" "Tppp"
## [701] "Tppp3" "Tpr" "Tpt1" "Trappc3"
## [705] "Trappc8" "Trim28" "Trio" "Trir"
## [709] "Trmt112" "Trp53bp1" "Tsc22d1" "Tsr2"
## [713] "Ttc1" "Ttc7b" "Ttr" "Tubb2b"
## [717] "Txndc17" "U2af2" "Uba3" "Ubap2l"
## [721] "Ube2l3" "Ube2n" "Ube2v2" "Ube3a"
## [725] "Ubqln1" "Ubqln2" "Ubqln4" "Ubr4"
## [729] "Ubtd2" "Uchl1" "Uchl3" "Ufm1"
## [733] "Umad1" "Uqcrb" "Uqcrh" "Uqcrq"
## [737] "Usp7" "Vasp" "Vat1l" "Vcan"
## [741] "Vcl" "Vcpip1" "Vgf" "Vps52"
## [745] "Vps53" "Vsnl1" "Vta1" "Wasf1"
## [749] "Washc2" "Wasl" "Wipf2" "Wipf3"
## [753] "Wnk1" "Wnk2" "Yaf2" "Ybx1"
## [757] "Yjefn3" "Ythdf3" "Zbed5" "Zc2hc1a"
## [761] "Zc3h4" "Zdhhc5" "Zfand2b" "Zfand6"
## [765] "Zfp428" "Zfp512" "Zyx" NA
## [769] "6430548M08Rik" "Aamdc" "Abat" "Abcd3"
## [773] "Abce1" "Abcf2" "Abhd12" "Abi2"
## [777] "Ablim1" "Ablim2" "Abr" "Acaa1a"
## [781] "Acaa2" "Acad9" "Acadl" "Acadm"
## [785] "Acadvl" "Acat1" "Acat2" "Acly"
## [789] "Aco1" "Aco2" "Acot13" "Acot2"
## [793] "Acot7" "Acp1" "Acsbg1" "Acsl3"
## [797] "Acsl6" "Acss1" "Actb" "Actn1"
## [801] "Actr1a" "Actr1b" "Actr2" "Actr3"
## [805] "Actr3b" "Acy1" "Adam11" "Adam22"
## [809] "Adam23" "Adap1" "Adcy9" "Add2"
## [813] "Add3" "Adh5" "Adk" "Ado"
## [817] "Adprh" "Afg3l2" "Agap2" "Agap3"
## [821] "Agfg2" "Agk" "Agl" "Ago1"
## [825] "Agpat1" "Ahcyl1" "Ahcyl2" "Ahsa1"
## [829] "Aifm1" "Ak3" "Ak4" "Ak5"
## [833] "Akr1a1" "Alad" "Alcam" "Aldh1a1"
## [837] "Aldh1b1" "Aldh1l1" "Aldh2" "Aldh4a1"
## [841] "Aldh5a1" "Aldh6a1" "Aldh7a1" "Aldoa"
## [845] "Aldoc" "Alg2" "Anks1b" "Anp32b"
## [849] "Anxa11" "Anxa2" "Anxa6" "Ap1b1"
## [853] "Ap1g1" "Ap2a1" "Ap2a2" "Ap2b1"
## [857] "Ap2m1" "Ap2s1" "Ap3b2" "Ap3d1"
## [861] "Ap3m2" "Apbb1" "Apex1" "Api5"
## [865] "Apmap" "Apoo" "Apool" "Appl1"
## [869] "Aqp4" "Arcn1" "Arf4" "Arf5"
## [873] "Arf6" "Arhgap1" "Arhgap44" "Arhgdia"
## [877] "Arhgef2" "Arl15" "Arl3" "Arl8b"
## [881] "Armc1" "Armc10" "Arpc1a" "Arpc2"
## [885] "Arpc3" "Arpc4" "Arpc5" "Arpc5l"
## [889] "Asah1" "Asl" "Asns" "Aspa"
## [893] "Asph" "Asrgl1" "Ass1" "Astn1"
## [897] "Atad3a" "Atcay" "Atg3" "Atg7"
## [901] "Atic" "Atl1" "Atp1a1" "Atp1a2"
## [905] "Atp1a3" "Atp1b1" "Atp1b2" "Atp1b3"
## [909] "Atp2b2" "Atp2b3" "Atp2b4" "Atp5pb"
## [913] "Atp6ap1" "Atp6v0c" "Atp6v0d1" "Atp6v1a"
## [917] "Atp6v1b2" "Atp6v1c1" "Atp6v1h" "Atp8a1"
## [921] "Atpaf1" "Atxn10" "Auh" "Babam2"
## [925] "Bcat1" "Bdh1" "Blvra" "Blvrb"
## [929] "Bphl" "Bpnt1" "Bpnt2" "Braf"
## [933] "Bri3bp" "Brsk1" "Brsk2" "Bsdc1"
## [937] "Bub3" "C1qb" "C1qc" "C2cd2l"
## [941] "Cab39" "Cacna1e" "Cacna2d3" "Cacnb3"
## [945] "Cacybp" "Cadm4" "Calcoco1" "Camk1d"
## [949] "Camk2b" "Camk2d" "Camk2g" "Camk4"
## [953] "Camkk1" "Camkv" "Cand1" "Canx"
## [957] "Cap2" "Capn2" "Capza2" "Capzb"
## [961] "Carhsp1" "Cask" "Cat" "Cbr1"
## [965] "Cbr3" "Cbr4" "Cbx5" "Ccdc177"
## [969] "Ccdc22" "Ccdc6" "Ccdc85c" "Ccny"
## [973] "Cct2" "Cct3" "Cct4" "Cct5"
## [977] "Cct6a" "Cct7" "Cct8" "Cd34"
## [981] "Cd44" "Cd82" "Cdc42" "Cdc42bpb"
## [985] "Cdc5l" "Cdh10" "Cdh2" "Cdipt"
## [989] "Cdk5" "Cds2" "Celf2" "Cenpv"
## [993] "Cfap36" "Chl1" "Chmp6" "Chordc1"
## [997] "Chrm1" "Ckap4" "Ckap5" "Ckb"
## [1001] "Ckmt1" "Cldn11" "Clic6" "Clpp"
## [1005] "Clstn1" "Cltc" "Clvs1" "Cmas"
## [1009] "Cnbp" "Cndp2" "Cnih2" "Cnksr2"
## [1013] "Cnn3" "Cnp" "Cnrip1" "Cntn1"
## [1017] "Cntn2" "Cntnap1" "Cntnap2" "Comtd1"
## [1021] "Copa" "Copg1" "Cops2" "Cops4"
## [1025] "Cops6" "Cops7a" "Coq3" "Coro1a"
## [1029] "Coro1b" "Coro1c" "Coro2b" "Coro7"
## [1033] "Cotl1" "Cox4i1" "Cox6a1" "Cox7a2"
## [1037] "Cpe" "Cpne1" "Cpne4" "Cpne6"
## [1041] "Cpsf6" "Creb1" "Creld1" "Crip2"
## [1045] "Crmp1" "Cryab" "Crym" "Cryz"
## [1049] "Cs" "Cse1l" "Csnk2a1" "Csnk2a2"
## [1053] "Csnk2b" "Cstb" "Ctbp1" "Ctnna2"
## [1057] "Ctsb" "Ctsd" "Cul1" "Cul2"
## [1061] "Cul3" "Cul5" "Cyb5b" "Cyb5r1"
## [1065] "Cyb5r3" "Cyc1" "Cyfip1" "Cyfip2"
## [1069] "Cyria" "Cyrib" "Dagla" "Dazap1"
## [1073] "Dbt" "Dclk1" "Dclk2" "Dcps"
## [1077] "Dctn1" "Dctn4" "Dctn6" "Ddah1"
## [1081] "Ddb1" "Ddt" "Ddx1" "Ddx19b"
## [1085] "Ddx39b" "Ddx3x" "Ddx42" "Ddx5"
## [1089] "Decr1" "Dgkb" "Dgke" "Dgkg"
## [1093] "Dgkh" "Dgki" "Dgkz" "Dhrs4"
## [1097] "Dhx9" "Diras1" "Diras2" "Dlat"
## [1101] "Dld" "Dlg1" "Dlg2" "Dlg3"
## [1105] "Dlg4" "Dlgap1" "Dlgap2" "Dmxl2"
## [1109] "Dnaja1" "Dnaja2" "Dnaja3" "Dnaja4"
## [1113] "Dnajb4" "Dnajc11" "Dnajc6" "Dnm1"
## [1117] "Dnm3" "Dnpep" "Dpp10" "Dpp3"
## [1121] "Dpp6" "Dpysl2" "Dpysl3" "Dpysl4"
## [1125] "Drg1" "Drg2" "Dstn" "Dtna"
## [1129] "Dusp3" "Dync1h1" "Dync1i2" "Dync1li1"
## [1133] "Dynll1" "Dynll2" "Dynlrb1" "Echdc1"
## [1137] "Echs1" "Eci1" "Eea1" "Eef1a1"
## [1141] "Eef1d" "Eef1g" "Eef2" "Efr3b"
## [1145] "Ehd1" "Ehd3" "Eif1b" "Eif2s2"
## [1149] "Eif2s3x" "Eif3a" "Eif3b" "Eif3c"
## [1153] "Eif3d" "Eif3h" "Eif3i" "Eif4a1"
## [1157] "Eif4a2" "Eif4a3" "Eif4e" "Eif4g1"
## [1161] "Eif4g3" "Eipr1" "Elavl1" "Elavl4"
## [1165] "Elfn2" "Elmo2" "Eloc" "Emd"
## [1169] "Eno2" "Entpd2" "Epb41l1" "Epdr1"
## [1173] "Epha4" "Ephx1" "Ephx2" "Epm2aip1"
## [1177] "Erc1" "Erlin2" "Esd" "Etfa"
## [1181] "Etfb" "Etfdh" "Ethe1" "Ewsr1"
## [1185] "Exoc4" "Exoc5" "Exoc6b" "Exoc8"
## [1189] "Exog" "Ezr" "Faah" "Fabp5"
## [1193] "Faf2" "Fam163b" "Fam98b" "Farp1"
## [1197] "Farsa" "Farsb" "Fasn" "Fbxl16"
## [1201] "Fbxo2" "Fbxo41" "Fermt2" "Fkbp15"
## [1205] "Fkbp4" "Fkbp5" "Fkbp8" "Flna"
## [1209] "Flot1" "Flot2" "Fn3krp" "Fnta"
## [1213] "Frrs1l" "Fscn1" "Fth1" "Fxyd1"
## [1217] "G3bp2" "G6pdx" "Gabbr1" "Gabbr2"
## [1221] "Gabrb3" "Gabrg2" "Gad2" "Gak"
## [1225] "Ganab" "Gapdh" "Gart" "Gas7"
## [1229] "Gatd1" "Gclc" "Gda" "Gdap1"
## [1233] "Gdap1l1" "Gdi1" "Gdi2" "Get3"
## [1237] "Gfap" "Gga1" "Git1" "Gja1"
## [1241] "Gk" "Glod4" "Glrx" "Glrx3"
## [1245] "Gls" "Glud1" "Glul" "Gm20431"
## [1249] "Gmfb" "Gmpr" "Gmps" "Gna11"
## [1253] "Gna13" "Gnai1" "Gnai2" "Gnai3"
## [1257] "Gnao1" "Gnaq" "Gnas" "Gnaz"
## [1261] "Gnb1" "Gnb2" "Gnb5" "Gng12"
## [1265] "Gng3" "Gng4" "Gnl1" "Got1"
## [1269] "Got2" "Gpd1" "Gpd1l" "Gpd2"
## [1273] "Gphn" "Gpr37l1" "Gps1" "Gpx4"
## [1277] "Grhpr" "Gria1" "Gria3" "Grin1"
## [1281] "Grin2a" "Grin2b" "Gripap1" "Grk2"
## [1285] "Grm3" "Gsk3a" "Gsk3b" "Gsn"
## [1289] "Gspt1" "Gsr" "Gstm1" "Gstm5"
## [1293] "Gstp1" "H3f3a" "Hacd3" "Hadha"
## [1297] "Hadhb" "Hagh" "Hapln1" "Hapln2"
## [1301] "Hdhd2" "Hecw2" "Hepacam" "Hexb"
## [1305] "Hexim1" "Hibadh" "Hibch" "Hint1"
## [1309] "Hip1r" "Hk1" "Hmgb1" "Hmgcl"
## [1313] "Hmox2" "Hnrnpa0" "Hnrnpa2b1" "Hnrnpa3"
## [1317] "Hnrnpf" "Hnrnph1" "Hnrnph2" "Hnrnph3"
## [1321] "Hnrnpk" "Hnrnpl" "Hnrnpm" "Hnrnpr"
## [1325] "Hnrnpu" "Hnrnpul2" "Homer1" "Hp1bp3"
## [1329] "Hpcal4" "Hsd17b10" "Hsd17b4" "Hsp90aa1"
## [1333] "Hsp90ab1" "Hsp90b1" "Hspa12a" "Hspa1a"
## [1337] "Hspa2" "Hspa4l" "Hspa5" "Hspa8"
## [1341] "Hspa9" "Hspd1" "Hsph1" "Htra2"
## [1345] "Htt" "Iars2" "Icam5" "Idh1"
## [1349] "Idh2" "Idh3a" "Idh3b" "Idh3g"
## [1353] "Igsf8" "Ilf2" "Ilf3" "Impa1"
## [1357] "Impdh2" "Ina" "Inpp1" "Inpp4a"
## [1361] "Ipo5" "Ipo7" "Ipo9" "Iqgap2"
## [1365] "Iqsec1" "Irgq" "Isoc2a" "Itgb8"
## [1369] "Itm2c" "Itpa" "Itpka" "Itpr1"
## [1373] "Ivd" "Kbtbd11" "Kcna1" "Kcna2"
## [1377] "Kcnab2" "Kcnd2" "Kcnma1" "Kctd12"
## [1381] "Kctd16" "Kif1a" "Kif2a" "Kif5c"
## [1385] "Kifap3" "Kifbp" "Klc1" "Kpna3"
## [1389] "Kpnb1" "Krt2" "Krt5" "Ksr1"
## [1393] "Kyat3" "L2hgdh" "Lancl1" "Lancl2"
## [1397] "Lap3" "Ldha" "Ldhb" "Lgi1"
## [1401] "Lin7c" "Lingo1" "Lmna" "Lmnb2"
## [1405] "Lonp1" "Lrpprc" "Lrrc47" "Lrrc4b"
## [1409] "Lrrc57" "Lrrc7" "Lsm4" "Lta4h"
## [1413] "Luc7l2" "Lxn" "Lypla1" "Lypla2"
## [1417] "Macroh2a1" "Madd" "Magi1" "Mal2"
## [1421] "Maoa" "Maob" "Map1lc3b" "Map2k1"
## [1425] "Map2k4" "Map6d1" "Map7d1" "Mapk1"
## [1429] "Mapk10" "Mapk3" "Mapre2" "Mark2"
## [1433] "Mat2a" "Mat2b" "Matr3" "Mcee"
## [1437] "Mcu" "Mdh1" "Mdh2" "Me1"
## [1441] "Me3" "Mecr" "Mff" "Mfn2"
## [1445] "Mgll" "Mia3" "Micos13" "Micu3"
## [1449] "Mif" "Mlc1" "Mlf2" "Mmut"
## [1453] "Mob4" "Mog" "Mpc2" "Mpdu1"
## [1457] "Mpi" "Mpp2" "Mpp3" "Mpst"
## [1461] "Mras" "Mrpl58" "Msn" "Msra"
## [1465] "Mtarc2" "Mtch1" "Mtch2" "Mtfp1"
## [1469] "Mtfr1l" "Mthfd1" "Mthfd1l" "Mtmr1"
## [1473] "Mtres1" "Mtx1" "Myadm" "Myh10"
## [1477] "Myh9" "Myo18a" "Myo5a" "Nadk2"
## [1481] "Nae1" "Nampt" "Nans" "Napa"
## [1485] "Napb" "Naxd" "Naxe" "Nbea"
## [1489] "Ncam2" "Ncdn" "Nceh1" "Nck2"
## [1493] "Nckap1" "Ndrg1" "Ndrg3" "Ndrg4"
## [1497] "Ndufa10" "Ndufa11" "Ndufa12" "Ndufa13"
## [1501] "Ndufa3" "Ndufa4" "Ndufa8" "Ndufa9"
## [1505] "Ndufb11" "Ndufb4" "Ndufb8" "Ndufb9"
## [1509] "Ndufs1" "Ndufs2" "Ndufs3" "Ndufs6"
## [1513] "Ndufs7" "Ndufv1" "Necap1" "Nedd4"
## [1517] "Nedd4l" "Nefl" "Nefm" "Nf1"
## [1521] "Nfs1" "Nipsnap1" "Nipsnap2" "Nisch"
## [1525] "Nlgn2" "Nlgn3" "Nmt1" "Nolc1"
## [1529] "Nomo1" "Nono" "Npepps" "Nptn"
## [1533] "Nptx1" "Nras" "Nrbp1" "Nrxn1"
## [1537] "Nrxn3" "Nsf" "Nsmf" "Nt5c"
## [1541] "Ntrk2" "Ntrk3" "Nudcd2" "Nudcd3"
## [1545] "Nudt3" "Numbl" "Oat" "Ogdh"
## [1549] "Ogdhl" "Ogt" "Ola1" "Olfm1"
## [1553] "Opa1" "Opa3" "Osbp" "Osbpl1a"
## [1557] "Otub1" "Oxct1" "P4hb" "Pa2g4"
## [1561] "Pabpc1" "Pabpn1" "Pacs1" "Padi2"
## [1565] "Pafah1b1" "Paics" "Pals2" "Park7"
## [1569] "Pcbp1" "Pcbp2" "Pcca" "Pccb"
## [1573] "Pcdh10" "Pcdh9" "Pck2" "Pcmt1"
## [1577] "Pcp4l1" "Pcx" "Pcyox1" "Pcyt2"
## [1581] "Pdcd5" "Pdcd6ip" "Pde1a" "Pde1b"
## [1585] "Pde2a" "Pdha1" "Pdhb" "Pdhx"
## [1589] "Pdia4" "Pdia6" "Pdk1" "Pdk3"
## [1593] "Pdxk" "Pdxp" "Pef1" "Pepd"
## [1597] "Pex19" "Pex5l" "Pfas" "Pfkl"
## [1601] "Pfkm" "Pfkp" "Pfn1" "Pfn2"
## [1605] "Pgd" "Pgk1" "Pgls" "Pgm1"
## [1609] "Pgm2l1" "Pgp" "Phactr1" "Phb2"
## [1613] "Phf24" "Phgdh" "Phyhip" "Phyhipl"
## [1617] "Pi4ka" "Pin1" "Pip4k2a" "Pip4k2b"
## [1621] "Pip4k2c" "Pip5k1c" "Pitpna" "Pitpnc1"
## [1625] "Pkp4" "Plcb1" "Plcl1" "Pld3"
## [1629] "Plec" "Plin3" "Plp1" "Plpbp"
## [1633] "Plpp3" "Plppr2" "Plppr4" "Pls3"
## [1637] "Plxna1" "Plxna4" "Pmm1" "Por"
## [1641] "Ppa1" "Ppa2" "Ppfia3" "Ppia"
## [1645] "Ppm1b" "Ppm1e" "Ppm1h" "Ppme1"
## [1649] "Ppp1cb" "Ppp1r21" "Ppp2ca" "Ppp2r1a"
## [1653] "Ppp2r2a" "Ppp2r5a" "Ppp2r5d" "Ppp2r5e"
## [1657] "Ppp3ca" "Ppp3cb" "Ppp5c" "Ppt1"
## [1661] "Pptc7" "Prdx1" "Prdx2" "Prdx3"
## [1665] "Prdx5" "Prep" "Prepl" "Prickle2"
## [1669] "Prkaca" "Prkacb" "Prkag2" "Prkar1a"
## [1673] "Prkar1b" "Prkar2a" "Prkar2b" "Prkca"
## [1677] "Prkcb" "Prkce" "Prkcg" "Prmt1"
## [1681] "Prmt5" "Prpf19" "Prpf8" "Prps1l3"
## [1685] "Prpsap1" "Prpsap2" "Prrt1" "Prune1"
## [1689] "Prune2" "Prxl2a" "Psat1" "Psd3"
## [1693] "Psma2" "Psma3" "Psma4" "Psma5"
## [1697] "Psma6" "Psma7" "Psmb1" "Psmb4"
## [1701] "Psmb5" "Psmb6" "Psmc1" "Psmc2"
## [1705] "Psmc3" "Psmc4" "Psmc6" "Psmd1"
## [1709] "Psmd12" "Psmd2" "Psmd3" "Psmd4"
## [1713] "Psmd5" "Pspc1" "Psph" "Ptbp2"
## [1717] "Ptges3" "Ptk2b" "Ptn" "Ptpa"
## [1721] "Ptpn11" "Ptprd" "Ptprs" "Pura"
## [1725] "Purb" "Purg" "Pvalb" "Pycr2"
## [1729] "Pygb" "Pygm" "Qdpr" "Rab11b"
## [1733] "Rab12" "Rab14" "Rab18" "Rab1a"
## [1737] "Rab1b" "Rab21" "Rab2a" "Rab35"
## [1741] "Rab3a" "Rab3b" "Rab3c" "Rab5a"
## [1745] "Rab5b" "Rab5c" "Rab6a" "Rab6b"
## [1749] "Rabgap1" "Rabggta" "Rac1" "Rack1"
## [1753] "Rala" "Ran" "Ranbp1" "Rangap1"
## [1757] "Rap1a" "Rap1b" "Rap1gap" "Rap1gap2"
## [1761] "Rap1gds1" "Rap2a" "Rap2b" "Rapgef2"
## [1765] "Rapgef4" "Rasal1" "Rasgrf1" "Rbbp4"
## [1769] "Rbbp9" "Rbm39" "Rdx" "Reep2"
## [1773] "Retreg2" "Rgs14" "Rgs7" "Rgs7bp"
## [1777] "Rheb" "Rhoa" "Rhob" "Rhog"
## [1781] "Rhot1" "Rilpl1" "Rnf214" "Rnpep"
## [1785] "Rock2" "Rogdi" "Rpl10a" "Rpl11"
## [1789] "Rpl12" "Rpl13" "Rpl13a" "Rpl14"
## [1793] "Rpl18" "Rpl23" "Rpl24" "Rpl27a"
## [1797] "Rpl28" "Rpl3" "Rpl30" "Rpl4"
## [1801] "Rpl5" "Rpl6" "Rpl7" "Rpl7a"
## [1805] "Rpl8" "Rpl9-ps6" "Rplp0" "Rpn1"
## [1809] "Rpn2" "Rps10" "Rps11" "Rps14"
## [1813] "Rps15a" "Rps16" "Rps2" "Rps20"
## [1817] "Rps23" "Rps24" "Rps26" "Rps27"
## [1821] "Rps3" "Rps4x" "Rps6" "Rps7"
## [1825] "Rps8" "Rps9" "Rras2" "Rufy3"
## [1829] "Ruvbl1" "Ruvbl2" "S1pr1" "Sae1"
## [1833] "Samm50" "Sar1a" "Sar1b" "Sbf1"
## [1837] "Scai" "Scamp1" "Scamp5" "Scn2b"
## [1841] "Scrn1" "Scrn3" "Sdcbp" "Sdha"
## [1845] "Sdhb" "Sdhc" "Sec13" "Sec14l2"
## [1849] "Sec22b" "Sec23a" "Sema7a" "Septin11"
## [1853] "Septin4" "Septin6" "Septin7" "Septin8"
## [1857] "Septin9" "Serpinb1a" "Serpinb6a" "Sez6l"
## [1861] "Sez6l2" "Sf3b2" "Sf3b3" "Sfpq"
## [1865] "Sfxn1" "Sfxn3" "Sfxn5" "Sh3bgrl"
## [1869] "Sh3bgrl2" "Sh3gl1" "Sh3gl3" "Sh3glb1"
## [1873] "Shisa6" "Sipa1l1" "Sipa1l3" "Sirt2"
## [1877] "Slc12a5" "Slc17a7" "Slc1a3" "Slc1a4"
## [1881] "Slc24a2" "Slc25a11" "Slc25a12" "Slc25a18"
## [1885] "Slc25a22" "Slc25a25" "Slc25a3" "Slc25a4"
## [1889] "Slc25a46" "Slc25a5" "Slc2a1" "Slc2a3"
## [1893] "Slc38a3" "Slc3a2" "Slc43a2" "Slc44a1"
## [1897] "Slc4a10" "Slc4a4" "Slc4a7" "Slc6a1"
## [1901] "Slc6a17" "Slc6a7" "Slc7a14" "Slc7a5"
## [1905] "Slc8a1" "Slc8a2" "Slk" "Smap1"
## [1909] "Smap2" "Smarce1" "Smpd3" "Snap47"
## [1913] "Snd1" "Snph" "Snrnp200" "Snrnp70"
## [1917] "Snrpd1" "Snrpd3" "Snta1" "Snw1"
## [1921] "Snx15" "Snx2" "Snx27" "Sod2"
## [1925] "Sord" "Sort1" "Sparc" "Spr"
## [1929] "Sptan1" "Sptbn1" "Sptbn2" "Sptbn4"
## [1933] "Src" "Srcin1" "Srgap2" "Srgap3"
## [1937] "Srm" "Srpk2" "Srr" "Srsf5"
## [1941] "Stam" "Stim1" "Stim2" "Stk24"
## [1945] "Stk39" "Strap" "Strn4" "Stub1"
## [1949] "Stum" "Stx12" "Stx1a" "Stxbp1"
## [1953] "Stxbp5" "Stxbp5l" "Stxbp6" "Sucla2"
## [1957] "Suclg1" "Sugt1" "Sult4a1" "Sv2a"
## [1961] "Sv2b" "Svop" "Syn2" "Syncrip"
## [1965] "Syngap1" "Syngr3" "Synj1" "Synpo"
## [1969] "Synpr" "Syp" "Syt1" "Syt12"
## [1973] "Syt7" "Taldo1" "Tardbp" "Tbc1d24"
## [1977] "Tceal6" "Tcp1" "Tecpr1" "Tecr"
## [1981] "Tfrc" "Them4" "Thy1" "Tial1"
## [1985] "Tigar" "Timm50" "Tiprl" "Tkt"
## [1989] "Tln1" "Tln2" "Tmed10" "Tmed2"
## [1993] "Tmed9" "Tmem11" "Tmem132b" "Tmem30a"
## [1997] "Tmem65" "Tmx1" "Tmx2" "Tmx3"
## [2001] "Tmx4" "Tnik" "Tnr" "Tollip"
## [2005] "Tomm22" "Tpi1" "Tpp1" "Tpp2"
## [2009] "Trap1" "Trim2" "Trim3" "Trim9"
## [2013] "Trnt1" "Tsfm" "Tsg101" "Tspan2"
## [2017] "Tspan7" "Tst" "Tstd3" "Ttyh1"
## [2021] "Ttyh3" "Tuba1a" "Tuba4a" "Tubb2a"
## [2025] "Tubb3" "Tubb4a" "Tubb4b" "Tubb5"
## [2029] "Tufm" "Twf1" "Twf2" "Txndc5"
## [2033] "Txnl1" "Txnrd1" "Uba1" "Uba2"
## [2037] "Uba52" "Ube2d3" "Ube2h" "Ube2k"
## [2041] "Ube2m" "Ube2o" "Ube2z" "Ubfd1"
## [2045] "Ubl4a" "Ubxn6" "Ubxn7" "Ugp2"
## [2049] "Unc13a" "Uqcr10" "Uqcr11" "Uqcrc1"
## [2053] "Uqcrc2" "Uqcrfs1" "Uso1" "Usp14"
## [2057] "Usp31" "Usp46" "Usp5" "Usp9x"
## [2061] "Vapa" "Vapb" "Vat1" "Vbp1"
## [2065] "Vcp" "Vdac1" "Vdac2" "Vim"
## [2069] "Vps13c" "Vps26a" "Vps26b" "Vps26c"
## [2073] "Vps29" "Vps35" "Vps45" "Vps4a"
## [2077] "Vps50" "Vps51" "Vwa5a" "Wasf3"
## [2081] "Wbp2" "Wdr1" "Wdr13" "Wdr37"
## [2085] "Wdr44" "Wdr47" "Wdr7" "Wdr77"
## [2089] "Wfs1" "Xpnpep1" "Xpo1" "Xpo7"
## [2093] "Ykt6" "Ylpm1" "Ywhab" "Ywhae"
## [2097] "Ywhag" "Ywhah" "Ywhaq" "Ywhaz"
## [2101] "Zmym3"
length(intersect(split_prot_df_map_rat$combined$Gene_name,
split_RNA_df_map_rat$combined$Gene_name)) #2101 (just proteins from)
## [1] 2101
#intersect of significant observed
intersect(split_prot_df_map_rat_sig$combined$Gene_name,
split_RNA_df_map_rat_sig$combined$Gene_name)
## [1] "Epb41l2" "Mbp" "Cops2" "Glud1" "Gnai2" "Mthfd1l" "Ncdn"
## [8] "Sirt2" "Slc1a3" "Slc7a14"
length(intersect(split_prot_df_map_rat_sig$combined$Gene_name,
split_RNA_df_map_rat_sig$combined$Gene_name)) #10
## [1] 10
# # mega df (combining botth lit reviews)
# mega_df <- bind_rows(list(lit_review_proteomics = lit_review_proteomics,
# lit_review_transcriptomics = lit_review_transcriptomics),
# .id = "omics_assay")
# list of common genes/proteins (SYMBOL) observed in both
common_list <- intersect(split_prot_df_map_rat$combined$Gene_name,
split_RNA_df_map_rat$combined$Gene_name)
# make vector of conditions
# conditions <- unique(mega_df$Condition)
conditions <- unique(lit_review_proteomics$Condition)
TO DO: Maybe do a for loop to get the overlapping proteins/genes for each entry? look at their old code?
Quick Key word analysis | based off the one from arroyo
key_annos <- read_excel("input/keywords_all_2025_12_09_uniprot.xlsx")
keywords_df_prot <- lit_review_proteomics_sig %>%
ungroup() %>%
mutate(hashtags = str_split(Keywords, ";")) %>% # splits into list by sep ;
tidyr::unnest(hashtags)
keywords_counts_prot <- keywords_df_prot %>%
group_by(proteomics_id, In_EE) %>%
filter(hashtags != "Reference proteome") %>% # ignore ref
dplyr::count(hashtags, sort = TRUE) %>%
mutate(total = sum(n)) %>% # note is grouped!
mutate(percent = round(n/total * 100, 1)) %>%
mutate(dummy = "1") %>% # needed for input - so it can plot 1 bar
left_join(key_annos, by = join_by(hashtags == Name)) %>%
mutate(In_EE = as.factor(In_EE),
Category = as.factor(Category))
summary(keywords_counts_prot) # percent median .1 & mean.399
## proteomics_id In_EE hashtags n
## Length:1482 down:830 Length:1482 Min. : 1.00
## Class :character up :652 Class :character 1st Qu.: 1.00
## Mode :character Mode :character Median : 3.00
## Mean : 12.69
## 3rd Qu.: 10.75
## Max. :382.00
##
## total percent dummy Keyword ID
## Min. :1145 Min. :0.0000 Length:1482 Length:1482
## 1st Qu.:2313 1st Qu.:0.0000 Class :character Class :character
## Median :3085 Median :0.1000 Mode :character Mode :character
## Mean :3381 Mean :0.3994
## 3rd Qu.:3262 3rd Qu.:0.3000
## Max. :6287 Max. :8.2000
##
## Category Gene Ontologies Definition
## Biological process:466 Length:1482 Length:1482
## Molecular function:322 Class :character Class :character
## Cellular component:226 Mode :character Mode :character
## Ligand :166
## PTM :140
## Domain :116
## (Other) : 46
## Synonyms Links Children Parents
## Length:1482 Length:1482 Length:1482 Length:1482
## Class :character Class :character Class :character Class :character
## Mode :character Mode :character Mode :character Mode :character
##
##
##
##
## Statistics
## Length:1482
## Class :character
## Mode :character
##
##
##
##
plot(keywords_counts_prot$n)
keyplot_prot_1 <- keywords_counts_prot %>%
filter(percent > 1) %>% # 11 keywords
# filter(n > 5) %>%
ggplot(aes(x = n,
y = dummy,
fill = Category)) +
geom_col(position = "fill", color = "grey10", alpha = 0.8) +
facet_nested(proteomics_id~In_EE,
scales = 'free_x',
space = 'free',
# switch = "both"
) +
labs(x = "Uniprot Keyword", y = "Count",
title = "Perez 2024 - Keywords in Significant Proteins",
subtitle = "") +
scale_fill_brewer(palette = "Spectral") +
theme_bw() +
theme(
legend.position = "bottom",
axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.5, # 90, hj1 t/R, vj.5 cent
size = 10, face = 'italic'),
axis.text.y = element_text(hjust = 1, color = "grey20", size = 10), # rota 90 & hjust=1 (top/right)
)
keyplot_prot_1
keyplot_prot_2 <- keywords_counts_prot %>%
# ungroup() %>%
filter(!Category %in% c("Technical term",
"Coding sequence diversity")) %>%
filter(percent > 1) %>% # 11 keywords
# filter(n > 5) %>%
ggplot(aes(x = hashtags,
# x = reorder(Category, n),
y = percent,
# fill = reorder(hashtags, n))
# alpha = hashtags,
color = In_EE,
fill = Category)) +
geom_col(position = position_dodge(
preserve = 'single', width = .7), # so col sam wid
width = .7, alpha = 0.5) +
facet_nested(proteomics_id~Category,
scales = 'free_x',
space = 'free') +
labs(x = "Uniprot Keyword", y = "Count",
title = "Perez 2024 - Keywords in Significant Proteins",
subtitle = "") +
scale_fill_brewer(palette = "Spectral") +
scale_color_manual(values = c("royalblue4", "firebrick3")) +
theme_bw() +
theme(
legend.position = "bottom",
axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.5, # 90, hj1 t/R, vj.5 cent
size = 10, face = 'italic'),
axis.text.y = element_text(hjust = 1, color = "grey20", size = 10), # rota 90 & hjust=1 (top/right)
panel.spacing = unit(0, "cm"), # Removes space between panel
)
keyplot_prot_2
keywords_df_RNA <- lit_review_transcriptomics %>%
ungroup() %>%
filter(padj <= 0.1) %>%
mutate(hashtags = str_split(Keywords, ";")) %>% # splits into list by sep ;
tidyr::unnest(hashtags)
keywords_counts_RNA <- keywords_df_RNA %>%
group_by(transcriptomics_id, In_EE) %>%
filter(hashtags != "Reference proteome") %>% # ignore ref
dplyr::count(hashtags, sort = TRUE) %>%
mutate(total = sum(n)) %>% # note is grouped!
mutate(percent = round(n/total * 100, 1)) %>%
mutate(dummy = "1") %>% # needed for input - so it can plot 1 bar
left_join(key_annos, by = join_by(hashtags == Name)) %>%
mutate(In_EE = as.factor(In_EE),
Category = as.factor(Category))
summary(keywords_counts_RNA) # percent median .4 + mean 0.86
## transcriptomics_id In_EE hashtags n
## Length:691 down:374 Length:691 Min. : 1.000
## Class :character up :317 Class :character 1st Qu.: 1.000
## Mode :character Mode :character Median : 2.000
## Mean : 3.763
## 3rd Qu.: 4.000
## Max. :51.000
##
## total percent dummy Keyword ID
## Min. :167.0 Min. :0.1000 Length:691 Length:691
## 1st Qu.:273.0 1st Qu.:0.2000 Class :character Class :character
## Median :311.0 Median :0.4000 Mode :character Mode :character
## Mean :519.8 Mean :0.8624
## 3rd Qu.:898.0 3rd Qu.:1.0000
## Max. :898.0 Max. :6.6000
##
## Category Gene Ontologies Definition
## Molecular function:157 Length:691 Length:691
## Biological process:153 Class :character Class :character
## Cellular component:112 Mode :character Mode :character
## Ligand : 84
## Domain : 80
## PTM : 76
## (Other) : 29
## Synonyms Links Children Parents
## Length:691 Length:691 Length:691 Length:691
## Class :character Class :character Class :character Class :character
## Mode :character Mode :character Mode :character Mode :character
##
##
##
##
## Statistics
## Length:691
## Class :character
## Mode :character
##
##
##
##
plot(keywords_counts_RNA$n)
keyplot_RNA_1 <- keywords_counts_RNA %>%
filter(percent > 1) %>% # 11 keywords
# filter(n > 5) %>%
ggplot(aes(x = n,
y = dummy,
fill = Category)) +
geom_col(position = "fill", color = "grey10", alpha = 0.8) +
facet_nested(transcriptomics_id~In_EE,
scales = 'free_x',
space = 'free',
# switch = "both"
) +
labs(x = "Uniprot Keyword", y = "Count",
title = "Perez 2024 - Keywords in Significant RNA",
subtitle = "") +
scale_fill_brewer(palette = "Spectral") +
theme_bw() +
theme(
legend.position = "bottom",
axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.5, # 90, hj1 t/R, vj.5 cent
size = 10, face = 'italic'),
axis.text.y = element_text(hjust = 1, color = "grey20", size = 10), # rota 90 & hjust=1 (top/right)
)
keyplot_RNA_1
keyplot_RNA_2 <- keywords_counts_RNA %>%
# ungroup() %>%
filter(!Category %in% c("Technical term",
"Coding sequence diversity")) %>%
filter(percent > .7) %>%
# filter(n > 5) %>%
ggplot(aes(x = hashtags,
# x = reorder(Category, n),
y = percent,
# fill = reorder(hashtags, n))
# alpha = hashtags,
color = In_EE,
fill = Category)) +
geom_col(position = position_dodge(
preserve = 'single', width = .7), # so col sam wid
width = .7, alpha = 0.5) +
facet_nested(transcriptomics_id~Category,
scales = 'free_x',
space = 'free') +
labs(x = "Uniprot Keyword", y = "Count",
title = "Perez 2024 - Keywords in Significant Proteins",
subtitle = "") +
scale_fill_brewer(palette = "Spectral") +
scale_color_manual(values = c("royalblue4", "firebrick3")) +
theme_bw() +
theme(
legend.position = "bottom",
axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.5, # 90, hj1 t/R, vj.5 cent
size = 10, face = 'italic'),
axis.text.y = element_text(hjust = 1, color = "grey20", size = 10), # rota 90 & hjust=1 (top/right)
panel.spacing = unit(0, "cm"), # Removes space between panel
)
keyplot_RNA_2