Perez 2024 - multiomics EE x aging (hippocampus mice)

Nice study! :)

from (Perez et al., 2024) A multiomic atlas of the aging hippocampus reveals molecular changes in response to environmental enrichment [nature communications] https://doi.org/10.1038/s41467-024-49608-z

Proteomics

Set up

library(tidyverse)
## ── Attaching core tidyverse packages ──────────────────────── tidyverse 2.0.0 ──
## ✔ dplyr     1.1.4     ✔ readr     2.1.5
## ✔ forcats   1.0.1     ✔ stringr   1.5.2
## ✔ ggplot2   4.0.0     ✔ tibble    3.3.0
## ✔ lubridate 1.9.4     ✔ tidyr     1.3.1
## ✔ purrr     1.1.0     
## ── Conflicts ────────────────────────────────────────── tidyverse_conflicts() ──
## ✖ purrr::%||%()   masks base::%||%()
## ✖ dplyr::filter() masks stats::filter()
## ✖ dplyr::lag()    masks stats::lag()
## ℹ Use the conflicted package (<http://conflicted.r-lib.org/>) to force all conflicts to become errors
library(readxl)
library(writexl)
library(ggrepel) #  for geom_text_repel()
library(gt)
library(ggh4x) # facet_nested

Read in proteomics sheets

prot_df_EEall <- read_excel("input/Perez_2024_EE_age_proteomics_sds20_41467_2024_49608_MOESM23_ESM.xlsx",
                             sheet = "EEall")

prot_df_EEyng <- read_excel("input/Perez_2024_EE_age_proteomics_sds20_41467_2024_49608_MOESM23_ESM.xlsx",
                             sheet = "EEyng")

prot_df_EEold <- read_excel("input/Perez_2024_EE_age_proteomics_sds20_41467_2024_49608_MOESM23_ESM.xlsx",
                             sheet = "EEold")

Bind into a master file

prot_df <- bind_rows(list(all = prot_df_EEall,
                          young = prot_df_EEyng,
                          old = prot_df_EEold),
                     .id = "proteomics_id")

Uniprot dataframes

# load in uniprot df
load(file = "input/mouse_ref_proteome_2025_12_13_54864x295.rda")
load(file = "input/rat_ref_proteome_2025_12_13_51872x295.rda")
load(file = "input/rat_other_proteome_2025_12_15_39538x295.rda")
# cols I want from uniprot

#colnames(mouse_ref_proteome_2025_12_13)

my_cols <- c("Entry", "Entry.Name", "Protein.names", "Gene.Names..primary.",
             "Gene.Names", "Gene.Names..synonym.",  "Annotation", "Reviewed",
             "Protein.existence", "Protein.families", "Length", "Organism",
             "Keywords", "Keyword.ID", "Function..CC.", "Miscellaneous..CC.", "Pathway",
             "GeneID", "Ensembl",
             "Gene.Ontology..GO.", "Gene.Ontology..cellular.component.",
             "Gene.Ontology..molecular.function.", "Gene.Ontology..biological.process.",
             "Gene.Ontology.IDs", "KEGG", "Reactome", "STRING",
             "Entry.version", "Date.of.creation", "Date.of.last.modification",
             "Date.of.last.sequence.modification"
             )

Adding additional metrics to the UniProt dataframes

The code below adds additional metrics to the uniprot dataframe including a calculation score for protein existence ranked from highest (evidence at the protein level) & and occupied metric that measures the number of NA values per row. These scoring metrics are useful to break ties when there are multiple instances of a mapping (see later …).

Stepwise process includes…

  1. Selecting desired columns (based on the my_cols list above)

  2. Make a Protein.existence column with assigned rankings. For example, Protein.existence == "Evidence at protein level" ~ 5 will allow it to try to keep the highest scoring observation when using slice_max() down the line (see https://www.uniprot.org/help/protein_existence for more info).

  3. Calculating NAs per row. this metric will allow keeping the row with the most info (is partially covered by the existing annotation column that is supplied by uniprot but still useful to break further ties at the end).

    1. Note: some blank entries have NA but some are "" (just blank) (which makes them automatically chr class btw), to convert them to all NA without disturbing other columns use na_if() from dplyr (https://dplyr.tidyverse.org/reference/na_if.html) & then mutate across where is.character (see below).

    2. Afterwards then the next computed column occupied will correctly count the NA across the row using baseR rowSums

# https://www.uniprot.org/help/protein_existence - see rankings 
unique(rat_ref_proteome_2025_12_13$Protein.existence) 
## [1] "Evidence at protein level"    "Evidence at transcript level"
## [3] "Inferred from homology"       "Uncertain"                   
## [5] "Predicted"
# MOUSE REF PROTEOME
mouse_ref <- mouse_ref_proteome_2025_12_13 %>% 
  dplyr::select(all_of(my_cols)) %>%
  mutate(existence_ranking = case_when( # ranking level of evidence
    Protein.existence == "Evidence at protein level" ~ 5,
    Protein.existence == "Evidence at transcript level" ~ 4,
    Protein.existence == "Inferred from homology" ~ 3, 
    Protein.existence == "Predicted" ~ 2, 
    Protein.existence == "Uncertain" ~ 1
    ), .after = Protein.existence) %>%
  mutate(across(where(is.character), ~ na_if(.x, ""))) 


# need to run in separate line as mouse ref is input (otheriwise object not found )
mouse_ref <- mouse_ref %>% 
  mutate(occupied = rowSums(!is.na(mouse_ref)))

# 2025_12_15 - NOTE DID NOT GET MOUSE OTHER PROTEOME FROM UNIPROT BECAUSE IT SAYS CONTAIMINATED!
# RAT REF PROTEOME
rat_ref <- rat_ref_proteome_2025_12_13 %>% 
  dplyr::select(all_of(my_cols)) %>%
  mutate(existence_ranking = case_when( # ranking level of evidence
    Protein.existence == "Evidence at protein level" ~ 5,
    Protein.existence == "Evidence at transcript level" ~ 4,
    Protein.existence == "Inferred from homology" ~ 3, 
    Protein.existence == "Predicted" ~ 2, 
    Protein.existence == "Uncertain" ~ 1
    ), .after = Protein.existence) %>%
  mutate(across(where(is.character), ~ na_if(.x, ""))) 

rat_ref <- rat_ref %>%
  mutate(occupied = rowSums(!is.na(rat_ref)))
# RAT OTHER PROTEOME 
rat_other <- other_rat_proteome_2025_12_15 %>%
    dplyr::select(all_of(my_cols)) %>%
    mutate(existence_ranking = case_when( # ranking level of evidence
    Protein.existence == "Evidence at protein level" ~ 5,
    Protein.existence == "Evidence at transcript level" ~ 4,
    Protein.existence == "Inferred from homology" ~ 3, 
    Protein.existence == "Predicted" ~ 2, 
    Protein.existence == "Uncertain" ~ 1
    ), .after = Protein.existence) %>%
  mutate(across(where(is.character), ~ na_if(.x, ""))) 

rat_other <- rat_other %>%
  mutate(occupied = rowSums(!is.na(rat_other)))

Mapping

Mice: Map provided UniProt accession ➝ Gene names & other UP info

,Map uniprot accessions provided by perez to uniprot mice df to get primary gene names etc

Note: occasionally some uniprot ids are 2 in 1 row, sep by ; must unnest. So need to mutate a new column by string_split to recognize the ; when multiple entires are in one Perez’s UNIPROT column. Then use tidyr unnest() to split & expand.

Side note: just unnest UNIPROT (ignore UNIPROT_DB since the other df has this info anyway.) otherwise Error in tidyr::unnest(): ! In row 279, can’t recycle input of size 3 to size 2.

Join join provided df to uniprot mouse df (left_join keeps all of x (original df))

#  String split & unnest to deal with 2 in 1 accessions in cells
prot_df_unnested <- prot_df %>%
  mutate(split_UNIPROT = str_split(UNIPROT, ";"),
         .after = UNIPROT) %>%
  tidyr::unnest(split_UNIPROT) # goes from 6750 to 6849 rows
# Join Perez df to mouse_ref by uniprot accession. 
prot_df_mouse <- left_join(prot_df_unnested, mouse_ref,
                           by = join_by(UNIPROT == Entry))

sum(is.na(prot_df_mouse$Entry.Name)) # check unmapped | 291 of 6558 unmapped
## [1] 291
#sum(!(is.na(prot_df_mouse$Entry.Name))) # 6558

Rat

Rat 1 - Map uniprot rat (primary genes) to mice primary genes

Now with the mapped mouse df. Use the prot_df_mouse, select cols of interest, rename those that will duplicate (to avoid .x at the end when joining, & then join.

Probably could have just mutated .x to .m, but oh well.

#colnames(prot_df_mouse)

prot_df_map_rat_1 <- prot_df_mouse %>%
  dplyr::select(proteomics_id:Gene.Names, Annotation:Protein.existence,
                Protein.families:Length, GeneID:Ensembl) %>% # 24 cols
  rename(entry.name.m = Entry.Name, # new = old
         protein.names.m = Protein.names,
         gene.names.primary.m = Gene.Names..primary.,
         gene.names.m =  Gene.Names,
         annotation.m = Annotation,
         reviewed.m = Reviewed,
         protein.existence.m = Protein.existence,
         protein.families.m = Protein.families,
         length.m = Length,
         GeneID.m = GeneID,
         Ensembl.m = Ensembl) %>%
  # group_by(proteomics_id) %>%
  left_join(rat_ref, # many to many warning
            by = join_by(gene.names.primary.m == Gene.Names..primary.))
## Warning in left_join(., rat_ref, by = join_by(gene.names.primary.m == Gene.Names..primary.)): Detected an unexpected many-to-many relationship between `x` and `y`.
## ℹ Row 1 of `x` matches multiple rows in `y`.
## ℹ Row 923 of `y` matches multiple rows in `x`.
## ℹ If a many-to-many relationship is expected, set `relationship =
##   "many-to-many"` to silence this warning.
# gives many to many warning (fine?) but why 337629 (prev 24513) 
# unique entries are the same though

Rat map 2 - trim multi entries (by group!!!)

Make sure to group by proteomics_id so it doesn’t delete adjacent groups! (e.g. EEold).

Takes prot_df_map_rat_1 then filters out any NAs enties (so unable to map by primary gene name), then groups by proteomics_id (so EEyoung, EEold, EEall), then gene names & then UNIPROT id (provided by Perez) (this is to deal with any gene ids that get dealt to multiple unique uniprot accession entries). Afterwards, the filtering begins - swissprot reviewed > best annotation score > existence ranking > occupied (least NAs).

# informs grouping.
length(unique(prot_df_map_rat_1$proteomics_id)) # 3
## [1] 3
length(unique(prot_df_map_rat_1$gene.names.primary.m)) # 2186
## [1] 2186
length(unique(prot_df_map_rat_1$split_UNIPROT)) # 8040
## [1] 2283
length(unique(prot_df_map_rat_1$Entry)) # 8040
## [1] 8040
# take non empty entries & then group & filter any with multiples
# based on reviewed > annotation score > protein existence

prot_df_map_rat_2 <- prot_df_map_rat_1 %>% #24513 | 337629
  group_by(proteomics_id, gene.names.primary.m, split_UNIPROT) %>% # group by
    # 1 - remove NAs
  filter(!(is.na(Entry))) %>% #24117 | 337524
    # 2 - keep reviewed/swissprot entries
  # or maybe group by just proteomics_id, gene - since rat map is based on gene???
  filter(if(any(Reviewed == "reviewed", na.rm = TRUE)) {
     Reviewed == "reviewed" # if reviewed = keep,
   } else {TRUE}) %>% #10278|44907 - if none, keep unreviewed ones, & filter below
    # 3
  slice_max(Annotation, n = 1) %>% #8445|10773
    # 4 # keep entry with least NAs
  slice_max(existence_ranking, n = 1) %>% #7905|9942
    # 5 - keep entry with least NAs
  slice_max(occupied, n = 1) %>% # |7017 
  
  # still 216 with duplicate entries 
    # 6 - final 
  mutate(id_priority = case_when(
    !is.na(GeneID) & !is.na(Ensembl) & !is.na(KEGG) ~ 6, # has geneID & ensembl & KEGG!
    !is.na(GeneID) & !is.na(Ensembl) ~ 5, # has both geneID & ensembl!
    !is.na(GeneID) ~ 4, # has only gene ID
    !is.na(Ensembl) ~ 3, # has only Ensembl
    !is.na(KEGG) ~ 2, # has only KEGG
    TRUE ~ 0 # all others (if all above were FALSE, then TRUE - so it writes 0)
  )) %>%
  slice_max(id_priority, n = 1, with_ties = FALSE) %>% 
  dplyr::select(-id_priority) %>%
  ungroup() # good practice?

# 1st 6849 (geneID & ensembl - still has duplicates -> 153)
# 2nd 6924? (geneID & ensembl & kegg - still has duplicates -> 129)
# note varying combos of Gene.ID.m, Ensembl.m,  Reactome, STRING, 
# also tried go_id_count - did not resolve - seems to be isoforms? i think
# # 216 with duplicate entries | after (GeneID & Ensembl trim) = 153 
# # 129 KEGG,GeneID& Ensembl| 0 eeny meeny miny moe then with_ties 
# 
# # for checking duplicate entries trimming (see case_when in the chunk above)
# prot_df_map_rat_2_dups <- prot_df_map_rat_2 %>%
#   count(gene.names.primary.m) %>%
#   filter(n > 1) 
# 
# prot_df_maps_rat_2_inspect <- prot_df_map_rat_2 %>%
#   filter(gene.names.primary.m %in% prot_df_map_rat_2_dups$gene.names.primary.m)
# dropped a bit due to removing the NA values ?
length(unique(prot_df_map_rat_2$gene.names.primary.m)) # 2151
## [1] 2151
length(unique(prot_df_map_rat_2$split_UNIPROT)) # 2248
## [1] 2248
length(unique(prot_df_map_rat_2$Entry)) # 2151
## [1] 2151

Rat map 3 - map nas with gene synonyms

Filter NA Entries (no rat accession), then select & peel back columns (to avoid duplicating in subsequent join), then filter out non NAs in the gene.names.primary.m col otherwise remaps & results in >3mil cols

prot_df_map_rat_1_na <- prot_df_map_rat_1 %>%
  filter(is.na(Entry)) %>% #396|105 obs?
  dplyr::select(proteomics_id:Ensembl.m) %>% # peel back to 24 cols
  filter(!is.na(gene.names.primary.m)) # filter out non NAs otherwise maps >3 mil below
# Prep rat_ref_split df 
rat_ref_split <- rat_ref %>% #51872 to 55829
  mutate(split_synonyms = str_split(Gene.Names..synonym., " ")) %>% #sep split by space
  tidyr::unnest(split_synonyms)

Recovered Sh3bgrl, Tceal3, Mtco2, Mtnd1, Mtnd5, Eif2s3x (gene synonyms that match mouse primary). No duplicates here so no need to rank.

# note filtered NAs in gene.names.primary.m (otherwise maps 3 million as NA to NA)
# results in 18 of 105 recovered (or 6 proteins (since 3 groups))
prot_df_map_rat_3 <- left_join(prot_df_map_rat_1_na, rat_ref_split,
                               by = join_by(gene.names.primary.m == split_synonyms))

sum(is.na(prot_df_map_rat_3$Entry)) # still 87 NA
## [1] 87
# many of those NAs see either too specific or too general or non reference prote.
# e.g.  Histone H3,  RIKEN cDNA 2900026A02 gene, etc unmapped
prot_df_map_rat_3_filtered <- prot_df_map_rat_3 %>%
  filter(!is.na(Entry))

Rat map 4 - map remaining missing values to other rat proteome

prot_df_map_rat_3_na <- prot_df_map_rat_3 %>%
  filter(is.na(Entry)) %>% #|87
  dplyr::select(proteomics_id:Ensembl.m) %>% # peel back to 24 cols
  filter(!is.na(gene.names.primary.m)) # filter out non NAs otherwise maps >3 mil below
prot_df_map_rat_4 <- left_join(prot_df_map_rat_3_na, rat_other,
                               by = join_by(
                                 gene.names.primary.m == Gene.Names..primary.)) %>%
  # recovered Grcc10, Timm8a1, H3f3a, Phpt1, Vbp1 
  group_by(proteomics_id, gene.names.primary.m, split_UNIPROT) %>%
  filter(if(any(Reviewed == "reviewed", na.rm = TRUE)) {
     Reviewed == "reviewed"
   } else {TRUE}) %>%
  slice_max(Annotation, n = 1) %>%
  slice_max(existence_ranking, n = 1) %>%
  slice_max(occupied, n = 1) %>% # from 90 entries to 87 - only drops dup of Grcc10
  ungroup() # good practice?
## Warning in left_join(prot_df_map_rat_3_na, rat_other, by = join_by(gene.names.primary.m == : Detected an unexpected many-to-many relationship between `x` and `y`.
## ℹ Row 14 of `x` matches multiple rows in `y`.
## ℹ Row 14754 of `y` matches multiple rows in `x`.
## ℹ If a many-to-many relationship is expected, set `relationship =
##   "many-to-many"` to silence this warning.
sum(is.na(prot_df_map_rat_4$Entry)) # still 72 NA (or 24 missing?)
## [1] 72
# Note: deleted rat_other_split with synonyms as it did not further recover any IDs. 
# hence combining this chunk
# note the join has 90 entries & follow up filter drops it to 3 (so only removes the 3)

Combine rat maps

prot_df_map_rat_combined <- bind_rows(list(
  by_ref_primary_gene = prot_df_map_rat_2,
  by_ref_synonym = prot_df_map_rat_3_filtered, 
  by_other_primary_gene = prot_df_map_rat_4),
  .id = "map_method_df") %>%
  arrange(proteomics_id, desc(dir), gene.names.primary.m) 
  
dim(prot_df_map_rat_combined) # 6849 x 58 | still some duplicates?
## [1] 6849   58
# # export
# write_excel_csv(prot_df_map_rat_combined,
#                 "output/2025_12_16_Perez_2024_proteomics_map_rat_combined_v1.csv")

# # export | with ungroup() added ? not sure if it matters -> check
# write_excel_csv(prot_df_map_rat_combined,
#                 "output/2025_12_27_Perez_2024_proteomics_map_rat_combined_v1.csv")

Proteomics Lit Review file

plot(prot_df_map_rat_combined$logFC)

# for lit review table | Note - duplicates have not been removed - to do manually
lit_review_proteomics <- prot_df_map_rat_combined %>%
  mutate(
    Year = 2024,
    Author = 'Perez',
    Animal = 'Mice',
    Condition = proteomics_id,
    Region = 'Hippocampus',
    Whole = 'Yes',
    Exp_type = 'Protein',
    Method = 'PROTEOMICS_LCMS_LFQ_DIA_OS',
    Used_name = SYMBOL,
    Mod = " ",
    Mod_type = " ",
    Gene_name = `gene.names.primary.m`, # genename used to map mouse 1° to rat gene
    Comparison = 2,
    In_EE = dir,
    Fold_change = logFC, # prob the same as log2FC?
    Arrows = case_when( # dplyr case when, instead of ifelse
      logFC > 2.5 ~ '+++',
      logFC > 1 ~ '++',
      logFC > .05 ~ '+',
      logFC > -.05 ~ '=',
      logFC > -1 ~ '-',
      logFC > -2.5 ~ '--',
      logFC <= -2.5 ~ '---',
      ),
    Significant = ifelse(adj.P.Val <= 0.05, 'yes', 'no'),
    pvalue = adj.P.Val,
    N_tested = ' ',
    Stats_adj = 'adjusted',
    Note = ' ',
    Full_name = Protein.names,
    Uniprot_rat_accession = Entry,
    Uniprot_entry_name = Entry.Name,
    Uniprot_link = ifelse(!is.na(Entry),
                          paste0('https://www.uniprot.org/uniprotkb/', Entry,'/entry'),
                          ' '),
    Wikipedia_link = ifelse(!is.na(Entry),
                            paste0('https://en.wikipedia.org/wiki/',
                                   `gene.names.primary.m`), ' '),
    
    Curation_method = case_when(
      Reviewed == "reviewed" & map_method_df == "by_ref_primary_gene"
        ~ "auto - ref & reviewed (primary gene name)",
      
      Reviewed == "unreviewed" & map_method_df == "by_ref_primary_gene"
        ~ "auto - ref & unreviewed (primary gene name)",
      
      Reviewed == "reviewed" & map_method_df == "by_ref_synonym"
        ~ "auto - ref & reviewed (synonym)",
      
      Reviewed == "unreviewed" & map_method_df == "by_ref_synonym"
        ~ "auto - ref proteome (synonym)",
      
      Reviewed == "reviewed" & map_method_df == "by_other_primary_gene"
        ~ "auto - other & reviewed (primary gene name)",
      
      is.na(Entry.Name)
        ~ "manual - na"),
    
    Class_group = ' ',
    Other_link = ' ',
    Other_comments = 'misc shows combined gene_uniprot_ensembl info from their df',
    misc = paste0(SYMBOL, '_', UNIPROT, '_',  GENEID)
  )

Write excel

https://r4ds.hadley.nz/spreadsheets.html#sec-writing-to-excel

# results in 3 x [2283 x 89] df
split_prot_df_map_rat <- split(lit_review_proteomics,
                               lit_review_proteomics$proteomics_id)

# then add the combined one at the end 
split_prot_df_map_rat$combined <- lit_review_proteomics
# #writes out by sheet (using writexl package)
# write_xlsx(split_prot_df_map_rat,
#            path = "output/2025_12_16_Perez_2024_proteomics_lit_review_all_v1.xlsx")

# #writes out by sheet (using writexl package) | with ungroup?
# write_xlsx(split_prot_df_map_rat,
#            path = "output/2025_12_27_Perez_2024_proteomics_lit_review_all_v1.xlsx")

Significant Only

lit_review_proteomics_sig <- lit_review_proteomics %>%
  filter(adj.P.Val <= 0.05) #6936 to 2015

split_prot_df_map_rat_sig <- split(lit_review_proteomics_sig,
                                   lit_review_proteomics_sig$proteomics_id)

split_prot_df_map_rat_sig$combined <- lit_review_proteomics_sig
# write_xlsx(split_prot_df_map_rat_sig,
#            path = "output/2025_12_16_Perez_2024_proteomics_lit_review_sig_v1.xlsx")
prot_df_map_rat_sig <- prot_df_map_rat_combined  %>%
  filter(adj.P.Val <= 0.05) # 2097 entries!

Plots

Volcano plot

# color coding doesn't work!?!?
volcano_pv <- lit_review_proteomics_sig %>%
  ungroup() %>%
  ggplot(aes(x = logFC, y = -log2(adj.P.Val),
                         label = Gene_name)) +
  geom_point(aes(color = case_when(
    adj.P.Val < 0.05 & logFC > 0.05 ~ "Upregulated (adj.p<0.05)",
    adj.P.Val < 0.05 & logFC < -0.05 ~ "Downregulated (adj.p<0.05)",
                                   TRUE ~ "Not Significant")),
            alpha = 1, size = 1, shape = 1) +
  # xlim(-8,12) +
  geom_vline(xintercept = 0, linetype = "dashed",
             color = "grey40", linewidth = .5) +
  scale_color_manual(values = c("firebrick3", 
                                "royalblue4", 
                                 "grey80"),
                     breaks = c("Upregulated (adj.p<0.05)", 
                                "Downregulated (adj.p<0.05)", 
                                "Not Significant"),
                     labels = c("Upregulated Proteins (p<0.05)", 
                                "Downregulated Proteins (p<0.05)", 
                                "Not Significant")) +
  
  geom_text_repel(label.size = .1) +
  facet_wrap(~proteomics_id, ncol = 1,
             scales = "free_y") +
  labs(
    title = "Perez 2024 - Proteomics - Hippocampus (Mice) - Aging x EE (2025_12_16/17)",
    subtitle = "lit_review_proteomics_sig df - map up mouse (provided) 2 up mouse gene 2 up rat gene",
       x = "Log2 Signal",
       y = "-Log2(adj.p-value)",
       color = "mRNA Regulation") +
  theme_bw() +
  theme(legend.position = "bottom",
        strip.text = element_text(size = 12))
## Warning in geom_text_repel(label.size = 0.1): Ignoring unknown parameters:
## `label.size`
volcano_pv
## Warning: Removed 59 rows containing missing values or values outside the scale range
## (`geom_text_repel()`).
## Warning: ggrepel: 872 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
## Warning: ggrepel: 498 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
## Warning: ggrepel: 410 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps

gt tables

ignore

NA  Q6LED0  H31_RAT Histone H3.1

gt 1 - All (EE vs SH)

# EE VS SH (ALL)
# gt 1 - by fold change direction & pvalue
lit_review_proteomics_sig |> 
  dplyr::ungroup() |>
  dplyr:: filter(Condition == "all") %>%
  #dplyr::select(-(c(`Av. Ratio`, ))) |>
  dplyr::select(c(Condition, In_EE, Gene_name, Entry, Entry.Name,
                  Protein.names, Fold_change, adj.P.Val)) |>
  dplyr::arrange(desc(In_EE), adj.P.Val, Fold_change) |>
  gt(
    groupname_col = "Condition",
    rowname_col = "In_EE"
  ) |>
  fmt_number(decimals = 3) |>
    tab_header(
    title = "All - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only)",
    subtitle = "2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by all)"
    ) |>
    tab_options(table.font.size=11.5,
                stub.font.weight = "bold",
                row_group.font.weight = "bold",
                row_group.font.size = 12.5,
                column_labels.font.size = 12.5,
                column_labels.font.weight = "bold")
All - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only)
2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by all)
Gene_name Entry Entry.Name Protein.names Fold_change adj.P.Val
all
up Slc9a1 P26431 SL9A1_RAT Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) 0.908 0.001
up H1-0 P43278 H10_RAT Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] 0.972 0.001
up Map6 Q63560 MAP6_RAT Microtubule-associated protein 6 (MAP-6) (145-kDa STOP) (STOP145) (Stable tubule-only polypeptide) (STOP) 0.997 0.001
up Tsr2 A0A8I5ZLR7 A0A8I5ZLR7_RAT Pre-rRNA-processing protein TSR2 homolog 1.030 0.001
up Ptprn2 Q63475 PTPR2_RAT Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (PTP NE-6) (PTPNE6) (Phogrin) [Cleaved into: IA-2beta60] 1.138 0.001
up Psip1 Q812D1 PSIP1_RAT PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) 1.197 0.001
up Txn P11232 THIO_RAT Thioredoxin (Trx) 1.212 0.001
up Chchd4 Q5BJN5 MIA40_RAT Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) 1.224 0.001
up Wasl O08816 WASL_RAT Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) 1.248 0.001
up Tceal5 A0ABK0KXI7 A0ABK0KXI7_RAT Transcription elongation factor A like 5 1.311 0.001
up Sod1 P07632 SODC_RAT Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) 1.346 0.001
up Hdgfl3 Q923W4 HDGR3_RAT Hepatoma-derived growth factor-related protein 3 (HRP-3) 1.349 0.001
up Bag3 A6IA08 A6IA08_RAT BAG family molecular chaperone regulator 3 (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) 1.379 0.001
up Atp5pf P21571 ATP5J_RAT ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) 1.447 0.001
up Rph3a P47709 RP3A_RAT Rabphilin-3A (Exophilin-1) 0.899 0.001
up NA Q6LED0 H31_RAT Histone H3.1 0.929 0.001
up Akap12 Q5QD51 AKA12_RAT A-kinase anchor protein 12 (AKAP-12) 1.071 0.001
up Cdkn1b O08769 O08769_RAT Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) 0.859 0.001
up Basp1 Q05175 BASP1_RAT Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) 0.921 0.001
up Slc32a1 O35458 VIAAT_RAT Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (rGVAT) (rat UNC-47 homolog) (RUNC-47) 1.017 0.001
up Ythdf3 A0A8I6ACC2 A0A8I6ACC2_RAT YTH domain-containing family protein 1.135 0.001
up Nfu1 D3ZA85 D3ZA85_RAT NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5) 1.257 0.001
up Cltb P08082 CLCB_RAT Clathrin light chain B (Lcb) 1.272 0.001
up Bsn O88778 BSN_RAT Protein bassoon 0.853 0.001
up Fabp3 P07483 FABPH_RAT Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) 0.864 0.001
up Vgf P20156 VGF_RAT Neurosecretory protein VGF (VGF8a protein) [Cleaved into: VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-11; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-30; VGF-derived peptide TLQP-62; VGF-derived peptide HFHH-10; VGF-derived peptide AQEE-30; VGF-derived peptide LQEQ-19] 1.213 0.001
up Clta P08081 CLCA_RAT Clathrin light chain A (Lca) 1.052 0.001
up Amph O08838 AMPH_RAT Amphiphysin 1.055 0.001
up Ppp1r11 Q6MFY6 PP1RB_RAT E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Protein phosphatase 1 regulatory subunit 11) 1.157 0.001
up Map1a P34926 MAP1A_RAT Microtubule-associated protein 1A (MAP-1A) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] 1.106 0.001
up Ppp1r1b Q6J4I0 PPR1B_RAT Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) 1.160 0.001
up Pclo Q9JKS6 PCLO_RAT Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) 1.048 0.001
up Bod1 Q6AYJ2 BOD1_RAT Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) 1.122 0.001
up Gap43 P07936 NEUM_RAT Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Protein F1) 1.128 0.002
up Rbmx Q4V898 RBMX_RAT RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) (RNA-binding motif protein, X chromosome retrogene) (RNA-binding motif protein, X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] 0.805 0.002
up Gfer Q63042 ALR_RAT FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) 1.158 0.002
up Efhd2 Q4FZY0 EFHD2_RAT EF-hand domain-containing protein D2 (Swiprosin-1) 1.592 0.002
up Fam169a D3ZKX8 D3ZKX8_RAT Family with sequence similarity 169, member A 0.796 0.002
up Sarnp Q498U4 SARNP_RAT SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1) 1.043 0.002
up Tppp3 Q5PPN5 TPPP3_RAT Tubulin polymerization-promoting protein family member 3 1.141 0.002
up Hspe1 P26772 CH10_RAT 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) 1.325 0.002
up Tsc22d1 P62501 T22D1_RAT TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) 1.303 0.002
up Eif4b A0ABK0LP36 A0ABK0LP36_RAT Eukaryotic translation initiation factor 4B 0.942 0.002
up Zfp428 A0A0G2K1B1 A0A0G2K1B1_RAT Zinc finger protein 428 1.316 0.002
up Gprin1 A0A8I6AJM0 A0A8I6AJM0_RAT G protein-regulated inducer of neurite outgrowth 1 1.456 0.002
up Wipf3 Q9Z0G8 WIPF3_RAT WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16) 1.002 0.002
up Glrx5 D4ADD7 D4ADD7_RAT Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5) 0.867 0.002
up Polr2m Q91XQ4 GRL1A_RAT DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) 1.209 0.002
up Fkbp3 G3V6L9 G3V6L9_RAT peptidylprolyl isomerase (EC 5.2.1.8) 0.635 0.002
up Naca M0R9L0 M0R9L0_RAT Nascent polypeptide associated complex subunit alpha 0.898 0.002
up Tmpo Q62733 LAP2_RAT Lamina-associated polypeptide 2, isoform beta (Thymopoietin isoform beta) (TP beta) 0.985 0.002
up Rgs10 P49806 RGS10_RAT Regulator of G-protein signaling 10 (RGS10) 1.180 0.002
up Marcks P30009 MARCS_RAT Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein) 1.210 0.002
up Atp6v1g1 A0A8I6B3N3 A0A8I6B3N3_RAT V-type proton ATPase subunit G 0.696 0.002
up Pdap1 Q62785 HAP28_RAT 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) 1.085 0.002
up Rad23b Q4KMA2 RD23B_RAT UV excision repair protein RAD23 homolog B 1.217 0.002
up Chgb O35314 SCG1_RAT Secretogranin-1 (Chromogranin-B) (CgB) (Glucagonoma peptide) (Secretogranin-I) (SgI) [Cleaved into: PE-11; CCB peptide short form; CCB peptide long form] 1.230 0.002
up Zdhhc5 Q2THW7 ZDHC5_RAT Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) 1.668 0.002
up Lmtk3 F1LSB5 F1LSB5_RAT non-specific serine/threonine protein kinase (EC 2.7.11.1) 0.871 0.002
up Slc39a10 A0A1W2Q626 A0A1W2Q626_RAT Solute carrier family 39 member 10 1.073 0.002
up Nherf1 Q9JJ19 NHRF1_RAT Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) 1.157 0.002
up Cplx2 P84087 CPLX2_RAT Complexin-2 (Complexin II) (CPX II) (Synaphin-1) 0.920 0.002
up Habp4 A1L1K8 HABP4_RAT Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) 0.595 0.002
up Bola1 Q06C60 Q06C60_RAT BolA-like protein 1 0.760 0.002
up Atp5if1 Q03344 ATIF1_RAT ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) 1.143 0.002
up Cttn Q66HL2 SRC8_RAT Src substrate cortactin 0.835 0.002
up Nsfl1c O35987 NSF1C_RAT NSFL1 cofactor p47 (XY body-associated protein XY40) (p97 cofactor p47) 0.873 0.003
up Ensa P60841 ENSA_RAT Alpha-endosulfine (ARPP-19e) 1.225 0.003
up Ndufv3 Q6PCU8 NDUV3_RAT NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) 1.120 0.003
up Ubap2l A0A8I5ZUK2 A0A8I5ZUK2_RAT Ubiquitin associated protein 2-like 0.950 0.003
up Abl2 F1M0N1 F1M0N1_RAT Tyrosine-protein kinase (EC 2.7.10.2) 1.060 0.003
up Serbp1 Q6AXS5 SERB1_RAT SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) (RDA288) 0.869 0.003
up Map1b P15205 MAP1B_RAT Microtubule-associated protein 1B (MAP-1B) (Neuraxin) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] 0.926 0.003
up Smap NA NA NA 1.591 0.003
up 2900026A02Rik NA NA NA 0.612 0.003
up Eif3j1 NA NA NA 0.811 0.003
up Rplp2 P02401 RLA2_RAT Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) 1.473 0.003
up Txndc17 A0ABK0M2Q2 A0ABK0M2Q2_RAT Thioredoxin domain containing 17 2.030 0.003
up Scg2 P10362 SCG2_RAT Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] 1.071 0.003
up Gm2a A0A8I6A5G9 A0A8I6A5G9_RAT Ganglioside GM2 activator 1.107 0.003
up Ubqln1 Q9JJP9 UBQL1_RAT Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) 1.142 0.003
up Stmn1 P13668 STMN1_RAT Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Pr22 protein) (Prosolin) (pp17) 1.681 0.003
up Ndufab1 D3ZF13 D3ZF13_RAT Acyl carrier protein 1.190 0.003
up Prrt2 D3ZFB6 PRRT2_RAT Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3) 1.310 0.003
up Srrm2 A0A8I6A2Y2 A0A8I6A2Y2_RAT Serine/arginine repetitive matrix 2 1.060 0.003
up Ybx1 P62961 YBOX1_RAT Y-box-binding protein 1 (YB-1) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) 1.303 0.003
up NA Q6LED0 H31_RAT Histone H3.1 0.706 0.004
up NA Q6LED0 H31_RAT Histone H3.1 0.706 0.004
up Snca P37377 SYUA_RAT Alpha-synuclein 0.909 0.004
up Dek Q6AXS3 DEK_RAT Protein DEK 0.683 0.004
up Lbh A0ABK0L5J9 A0ABK0L5J9_RAT LBH regulator of WNT signaling pathway 1.557 0.004
up Psmd9 Q9WTV5 PSMD9_RAT 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) (Transactivating protein Bridge-1) 0.716 0.004
up Oxsr1 A0A8I5ZNK2 OXSR1_RAT Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) 0.722 0.004
up Sf1 F1LM37 F1LM37_RAT Splicing factor 1 0.934 0.004
up Tpm1 P04692 TPM1_RAT Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) 1.189 0.004
up Mical3 D3ZGN7 D3ZGN7_RAT F-actin monooxygenase (EC 1.14.13.225) 0.857 0.004
up Fkbp2 A0A8I6GH88 A0A8I6GH88_RAT peptidylprolyl isomerase (EC 5.2.1.8) 0.707 0.004
up NA Q6LED0 H31_RAT Histone H3.1 0.849 0.004
up Hdgfl2 Q925G1 HDGR2_RAT Hepatoma-derived growth factor-related protein 2 (HRP-2) (Hepatoma-derived growth factor 3) (HDGF-3) 0.720 0.004
up Calb2 P47728 CALB2_RAT Calretinin (CR) 0.981 0.004
up Ptpn23 O88902 PTN23_RAT Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) 0.982 0.004
up Cnpy3 A0A8I6A0W3 A0A8I6A0W3_RAT Protein canopy homolog 3 0.978 0.004
up Washc2 Q80X08 WASC2_RAT WASH complex subunit 2 0.669 0.004
up Lrpap1 Q99068 AMRP_RAT Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Gp330-binding 45 kDa protein) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) 0.796 0.004
up Cfdp1 Q75UQ2 CFDP1_RAT Craniofacial development protein 1 (Bucentaur) 0.911 0.004
up Fabp7 P55051 FABP7_RAT Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) 1.535 0.004
up Tppp D3ZQL7 TPPP_RAT Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p25-alpha) 0.557 0.004
up Drap1 A0JPP1 NC2A_RAT Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) 0.781 0.004
up Tpm4 P09495 TPM4_RAT Tropomyosin alpha-4 chain (Tropomyosin-4) (TM-4) 0.837 0.004
up Pcnp Q7TP40 PCNP_RAT PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) (Liver regeneration-related protein LRRG084) 1.118 0.005
up Rims1 Q9JIR4 RIMS1_RAT Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) 0.541 0.005
up Prrt3 D3ZWQ0 D3ZWQ0_RAT Proline-rich transmembrane protein 3 0.799 0.005
up Gcsh Q5I0P2 GCSH_RAT Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein) 1.190 0.005
up Sdc4 P34901 SDC4_RAT Syndecan-4 (SYND4) (Ryudocan core protein) 0.995 0.005
up Endod1 D3ZIP8 D3ZIP8_RAT Endonuclease domain containing 1 0.610 0.005
up Larp1 A0A8I6GJC3 A0A8I6GJC3_RAT La ribonucleoprotein 1, translational regulator 0.977 0.005
up Alb P02770 ALBU_RAT Albumin 0.979 0.005
up Mapre1 Q66HR2 MARE1_RAT Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) 0.590 0.005
up Scp2 P11915 SCP2_RAT Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (Sterol carrier protein X) (SCP-X) 0.596 0.005
up Hcn1 Q9JKB0 HCN1_RAT Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 0.777 0.005
up Prkcsh A0A8I6G8K5 A0A8I6G8K5_RAT Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) 0.647 0.005
up Hgs Q9JJ50 HGS_RAT Hepatocyte growth factor-regulated tyrosine kinase substrate (SNAP-25-interacting protein Hrs-2) 0.680 0.005
up Lasp1 Q99MZ8 LASP1_RAT LIM and SH3 domain protein 1 (LASP-1) 0.748 0.005
up Rabl6 D3ZKQ4 D3ZKQ4_RAT Rab-like protein 6 (GTP-binding protein Parf) (Rab-like protein 1) 1.159 0.005
up Bcas1 Q3ZB98 BCAS1_RAT Breast carcinoma-amplified sequence 1 homolog (Protein whose mRNA is enriched in synaptosomes 2) (Pmes-2) 0.796 0.005
up Prrc2c A0A8I5Y7A0 A0A8I5Y7A0_RAT Proline-rich coiled-coil 2C 0.873 0.005
up Chmp5 Q4QQV8 CHMP5_RAT Charged multivesicular body protein 5 (Chromatin-modifying protein 5) 1.164 0.005
up Cstf2 B4F7F1 B4F7F1_RAT Cleavage stimulation factor subunit 2 (Cstf2 protein) 0.827 0.005
up Stip1 O35814 STIP1_RAT Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) 0.625 0.005
up Cd99l2 Q8R1R5 C99L2_RAT CD99 antigen-like protein 2 (MIC2-like protein 1) (Rhombencephalic expression protein 40 kDa) (Protein rhombex-40) (CD antigen CD99) 0.751 0.005
up Hmgn5 B4F777 HMGN5_RAT High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1) 0.960 0.005
up H1-4 P15865 H14_RAT Histone H1.4 (H1d) 1.005 0.005
up Pcsk1n Q9QXU9 PCS1N_RAT ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; PEN-20; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] 1.525 0.005
up Zbed5 D3ZTR5 D3ZTR5_RAT Zinc finger BED-type containing 5 1.107 0.006
up Acin1 E9PST5 E9PST5_RAT Apoptotic chromatin condensation inducer in the nucleus 0.870 0.006
up Btf3 F7EZE5 F7EZE5_RAT Transcription factor BTF3 0.830 0.006
up Vsnl1 P62762 VISL1_RAT Visinin-like protein 1 (VILIP) (21 kDa CABP) (Neural visinin-like protein 1) (NVL-1) (NVP-1) 0.847 0.006
up Ermn Q5RJL0 ERMIN_RAT Ermin (Juxtanodin) (JN) 1.067 0.006
up Mrpl12 D3ZXF9 D3ZXF9_RAT Large ribosomal subunit protein bL12m (39S ribosomal protein L12, mitochondrial) 1.353 0.007
up Fgf12 P61150 FGF12_RAT Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) 0.746 0.007
up NA Q6LED0 H31_RAT Histone H3.1 0.766 0.007
up NA Q6LED0 H31_RAT Histone H3.1 0.766 0.007
up NA Q6LED0 H31_RAT Histone H3.1 0.766 0.007
up Cst3 P14841 CYTC_RAT Cystatin-C (Cystatin-3) 0.559 0.007
up Lin7a Q9Z250 LIN7A_RAT Protein lin-7 homolog A (Lin-7A) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1) 0.581 0.007
up C1qbp O35796 C1QBP_RAT Complement component 1 Q subcomponent-binding protein, mitochondrial (GC1q-R protein) (Glycoprotein gC1qBP) (C1qBP) 0.797 0.007
up NA Q6LED0 H31_RAT Histone H3.1 1.196 0.007
up NA Q6LED0 H31_RAT Histone H3.1 1.196 0.007
up Snap25 P60881 SNP25_RAT Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) 0.570 0.008
up Rbm3 Q925G0 RBM3_RAT RNA-binding protein 3 (RNA-binding motif protein 3) 0.663 0.008
up Myl6 Q64119 MYL6_RAT Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) 0.629 0.008
up Fkbp1a Q62658 FKB1A_RAT Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) 0.547 0.008
up Scg3 P47868 SCG3_RAT Secretogranin-3 (1B1075) (Secretogranin III) (SgIII) 0.727 0.008
up Timm8a1 A6IVF6 A6IVF6_RAT Mitochondrial import inner membrane translocase subunit 1.052 0.008
up Tfg Q4R1A4 Q4R1A4_RAT TRK-fused gene protein (Trafficking from ER to golgi regulator) 0.466 0.008
up Tcea1 Q4KLL0 TCEA1_RAT Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) 0.623 0.008
up Ndufs8 A0A8I6AL00 A0A8I6AL00_RAT NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) 0.641 0.008
up Npc2 A0A8I6AWS0 A0A8I6AWS0_RAT NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) 0.728 0.008
up Tbc1d10b D3ZSY8 D3ZSY8_RAT TBC1 domain family, member 10b 0.587 0.009
up Uqcrh Q5M9I5 QCR6_RAT Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein) 0.722 0.009
up Fubp1 Q32PX7 FUBP1_RAT Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) 1.121 0.009
up Sparcl1 P24054 SPRL1_RAT SPARC-like protein 1 (Matrix glycoprotein Sc1) 0.740 0.009
up Mrrf Q5RKI9 RRFM_RAT Ribosome-recycling factor, mitochondrial (RRF) (Ribosome-releasing factor, mitochondrial) 0.799 0.009
up Epn1 O88339 EPN1_RAT Epsin-1 (EPS-15-interacting protein 1) 0.518 0.009
up Syn3 O70441 SYN3_RAT Synapsin-3 (Synapsin III) 0.688 0.010
up Tceal3 M0RBL8 M0RBL8_RAT Transcription elongation factor A like 3 (Transcription elongation factor A like 6) 0.896 0.010
up Pafah1b2 O35264 PA1B2_RAT Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) (Platelet-activating factor acetylhydrolase alpha 2 subunit) (PAF-AH alpha 2) 0.898 0.010
up Pnpo O88794 PNPO_RAT Pyridoxine-5'-phosphate oxidase (EC 1.4.3.5) (Pyridoxamine-phosphate oxidase) 0.419 0.010
up Dctn2 Q6AYH5 DCTN2_RAT Dynactin subunit 2 0.409 0.010
up Chmp1a A0A8I6GLB8 A0A8I6GLB8_RAT Charged multivesicular body protein 1A 0.790 0.010
up Dbi P11030 ACBP_RAT Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) [Cleaved into: Triakontatetraneuropeptide (TTN); Octadecaneuropeptide (ODN)] 1.549 0.011
up Apoe P02650 APOE_RAT Apolipoprotein E (Apo-E) 0.736 0.011
up Elob P62870 ELOB_RAT Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) 0.430 0.011
up Dnajc5 P60905 DNJC5_RAT DnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP) 0.564 0.011
up Gpc1 P35053 GPC1_RAT Glypican-1 (HSPG M12) [Cleaved into: Secreted glypican-1] 0.523 0.011
up Camk2n1 Q9JI15 CK2N1_RAT Calcium/calmodulin-dependent protein kinase II inhibitor 1 (calcium/calmodulin-dependent protein kinase II inhibitor alpha) (CaM-KIINalpha) (CaMKIINalpha) 0.923 0.011
up Khdrbs3 Q9JLP1 KHDR3_RAT KH domain-containing, RNA-binding, signal transduction-associated protein 3 (Sam68-like mammalian protein 2) (SLM-2) (rSLM-2) 0.581 0.011
up Cnst A0A8I5ZKG8 A0A8I5ZKG8_RAT Consortin, connexin sorting protein 0.907 0.011
up Mbp P02688 MBP_RAT Myelin basic protein (MBP) 0.758 0.011
up Rida P52759 RIDA_RAT 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Liver perchloric acid-soluble protein) (L-PSP) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (UK114 antigen homolog) (rp14.5) 0.593 0.012
up Zyx A0A8I6AV84 A0A8I6AV84_RAT Zyxin 1.211 0.012
up Set Q63945 SET_RAT Protein SET (Liver regeneration-related protein LRRGR00002) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) 1.030 0.012
up Ndel1 Q78PB6 NDEL1_RAT Nuclear distribution protein nudE-like 1 (Protein Nudel) 1.070 0.012
up Lgals1 P11762 LEG1_RAT Galectin-1 (Gal-1) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (RL 14.5) (S-Lac lectin 1) 0.765 0.012
up Ppp1r2 P50411 IPP2_RAT Protein phosphatase inhibitor 2 (IPP-2) 0.862 0.012
up Trmt112 B2RYS9 B2RYS9_RAT Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) 0.545 0.012
up Tom1l2 A0A8I5ZP70 A0A8I5ZP70_RAT Target of myb1 like 2 membrane trafficking protein 0.522 0.013
up Epb41l2 A0A0G2K162 A0A0G2K162_RAT Erythrocyte membrane protein band 4.1-like 2 0.621 0.013
up Lsm3 D4A7U6 D4A7U6_RAT U6 snRNA-associated Sm-like protein LSm3 0.555 0.013
up Homer3 Q9Z2X5 HOME3_RAT Homer protein homolog 3 (Homer-3) (VASP/Ena-related gene up-regulated during seizure and LTP 3) (Vesl-3) 0.469 0.013
up Rps18-ps6 NA NA NA 0.511 0.013
up Omg F7EYB9 F7EYB9_RAT Oligodendrocyte-myelin glycoprotein 0.576 0.013
up Hnrnpab A6HE59 A6HE59_RAT Heterogeneous nuclear ribonucleoprotein A/B 0.993 0.013
up Rps25 P62853 RS25_RAT Small ribosomal subunit protein eS25 (40S ribosomal protein S25) 0.841 0.013
up Pex14 Q642G4 PEX14_RAT Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) 1.005 0.013
up Cdv3 Q5XIM5 CDV3_RAT Protein CDV3 homolog 1.017 0.013
up Pgrmc1 P70580 PGRC1_RAT Membrane-associated progesterone receptor component 1 (mPR) (25-DX) (Acidic 25 kDa protein) (Ventral midline antigen) (VEMA) 0.627 0.013
up Bnip3l A6K6N6 A6K6N6_RAT BCL2 interacting protein 3 like (BCL2/adenovirus E1B interacting protein 3-like) 1.187 0.013
up Gpr158 D4A6L0 MGLYR_RAT Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158) 0.581 0.013
up Ahnak A0A0G2JUA5 A0A0G2JUA5_RAT AHNAK nucleoprotein 0.865 0.013
up Shfl Q5RJN4 SHFL_RAT Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog (SHFL) (Repressor of yield of DENV protein homolog) (RyDEN) 0.692 0.013
up Nebl D4A164 D4A164_RAT Nebulette 0.618 0.014
up Cul4b D3ZK73 D3ZK73_RAT Cullin-4B 0.906 0.014
up Abraxas2 D4A415 D4A415_RAT Abraxas 2, BRISC complex subunit 1.196 0.014
up Eif4h Q5XI72 IF4H_RAT Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein homolog) 0.964 0.014
up Atxn2l A0A0G2JYE0 A0A0G2JYE0_RAT Ataxin 2-like 0.770 0.014
up Reps1 A0A0G2JZY3 A0A0G2JZY3_RAT RALBP1 associated Eps domain containing 1 0.788 0.014
up Alyref M0RBB1 M0RBB1_RAT Aly/REF export factor 0.458 0.014
up Marcksl1 Q9EPH2 MRP_RAT MARCKS-related protein (Brain protein F52) (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) 1.472 0.014
up Rad23a F7FJT3 F7FJT3_RAT UV excision repair protein RAD23 0.757 0.014
up Negr1 Q9Z0J8 NEGR1_RAT Neuronal growth regulator 1 (Kindred of IgLON) (Kilon) 0.422 0.014
up Evl O08719 EVL_RAT Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) 1.174 0.015
up Ube2n Q9EQX9 UBE2N_RAT Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) 0.365 0.015
up Dtd1 A0A8I6A4Q0 A0A8I6A4Q0_RAT D-aminoacyl-tRNA deacylase (EC 3.1.1.96) 0.624 0.015
up Dbndd2 A0ABK0LCG8 A0ABK0LCG8_RAT Uncharacterized protein 0.897 0.015
up Cnot3 D3ZUV9 D3ZUV9_RAT CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) 0.927 0.015
up Ndufs4 Q5XIF3 NDUS4_RAT NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial (Complex I-18 kDa) (CI-18 kDa) (NADH-ubiquinone oxidoreductase 18 kDa subunit) 0.442 0.015
up Caprin1 Q5M9G3 CAPR1_RAT Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (RNA granule protein 105) 0.663 0.015
up Atp6v1f P50408 VATF_RAT V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F) 0.525 0.015
up Ppp1r12a Q10728 MYPT1_RAT Protein phosphatase 1 regulatory subunit 12A (MBSP) (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) (Protein phosphatase subunit 1M) (PP-1M) (Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110) 0.578 0.015
up Tpd52l2 Q6PCT3 TPD54_RAT Tumor protein D54 (Tumor protein D52-like 2) 0.515 0.015
up Sgtb Q80W98 SGTB_RAT Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) 0.559 0.015
up Cacna1b Q02294 CAC1B_RAT Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) 0.656 0.016
up Clip2 O55156 CLIP2_RAT CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) 0.581 0.016
up Tjp1 A0A0G2K2P5 ZO1_RAT Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1) 0.741 0.016
up Carmil2 D3ZC15 D3ZC15_RAT Capping protein regulator and myosin 1 linker 2 0.464 0.016
up Tpm3-rs7 NA NA NA 1.875 0.016
up Tpm3 Q63610 TPM3_RAT Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) 1.110 0.016
up Chchd6 D4A7N1 MIC25_RAT MICOS complex subunit Mic25 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) 0.650 0.016
up Cbx1 A0A8I5ZM96 A0A8I5ZM96_RAT Chromobox 1 0.936 0.017
up Znf207 NA NA NA 1.004 0.019
up Sh3bgrl3 B2RZ27 SH3L3_RAT SH3 domain-binding glutamic acid-rich-like protein 3 (TNF inhibitory protein B1) (TIP-B1) 1.155 0.019
up Map1s P0C5W1 MAP1S_RAT Microtubule-associated protein 1S (MAP-1S) [Cleaved into: MAP1S heavy chain; MAP1S light chain] 0.847 0.019
up Lnpk A0JN29 A0JN29_RAT Endoplasmic reticulum junction formation protein lunapark 0.418 0.019
up NA Q6LED0 H31_RAT Histone H3.1 0.435 0.019
up NA Q6LED0 H31_RAT Histone H3.1 0.435 0.019
up Ogfrl1 Q4KLH3 OGRL1_RAT Opioid growth factor receptor-like protein 1 0.696 0.020
up Ubqln2 D4AA63 D4AA63_RAT Ubiquilin 2 0.899 0.020
up Lrrc59 Q5RJR8 LRC59_RAT Leucine-rich repeat-containing protein 59 (Protein p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] 0.459 0.020
up Khsrp Q99PF5 FUBP2_RAT Far upstream element-binding protein 2 (FUSE-binding protein 2) (KH type-splicing regulatory protein) (KSRP) (MAP2 RNA trans-acting protein 1) (MARTA1) 0.381 0.020
up Fam131b Q568Z1 F131B_RAT Protein FAM131B 0.720 0.020
up Isca2 D4A4L5 D4A4L5_RAT Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1) 0.539 0.020
up Pacsin1 Q9Z0W5 PACN1_RAT Protein kinase C and casein kinase substrate in neurons protein 1 (Dynamin proline-rich domain-interacting protein) (Dynamin PRD-interacting protein) (Synaptic, dynamin-associated protein I) (Syndapin-1) (Syndapin-I) (SdpI) 0.452 0.020
up Bag4 A0ABZ3NN99 A0ABZ3NN99_RAT BAG cochaperone 4 0.481 0.020
up Trp53bp1 NA NA NA 0.513 0.021
up Mast1 Q810W7 MAST1_RAT Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) 0.949 0.021
up Fgf1 P61149 FGF1_RAT Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Heparin-binding growth factor 1) (HBGF-1) 0.377 0.021
up Safb O88453 SAFB1_RAT Scaffold attachment factor B1 (SAF-B) (SAF-B1) 0.404 0.021
up Zc3h4 D3ZVW3 D3ZVW3_RAT Zinc finger CCCH domain-containing protein 4 1.322 0.022
up Sgta O70593 SGTA_RAT Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 1) 0.416 0.022
up Atp5f1d P35434 ATPD_RAT ATP synthase F(1) complex subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit) 1.219 0.022
up Cyb5a P00173 CYB5_RAT Cytochrome b5 0.734 0.022
up 4833439L19Rik NA NA NA 0.778 0.022
up Tpr F1MA98 TPR_RAT Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein) 0.655 0.023
up Pym1 A0A8I6GKW1 A0A8I6GKW1_RAT PYM homolog 1, exon junction complex associated factor 1.022 0.023
up Wipf2 D3ZUD3 D3ZUD3_RAT WAS/WASL interacting protein family, member 2 0.645 0.023
up Pea15 Q5U318 PEA15_RAT Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) 0.591 0.023
up Shank2 Q9QX74 SHAN2_RAT SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3) 0.417 0.024
up Coa7 D4AC65 D4AC65_RAT Cytochrome c oxidase assembly factor 7 1.009 0.024
up Asap1 Q1AAU6 ASAP1_RAT Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) 0.884 0.024
up Nenf Q6IUR5 NENF_RAT Neudesin (Neuron-derived neurotrophic factor) (SCIRP10-related protein) (Spinal cord injury-related protein 10) 0.969 0.024
up Hyou1 Q63617 HYOU1_RAT Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) 0.524 0.024
up Srsf1 D4A9L2 D4A9L2_RAT Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1) 0.429 0.024
up Map7 A0A0G2KB52 A0A0G2KB52_RAT Microtubule-associated protein 7 0.583 0.024
up Pebp1 P31044 PEBP1_RAT Phosphatidylethanolamine-binding protein 1 (PEBP-1) (23 kDa morphine-binding protein) (HCNPpp) (P23K) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] 0.350 0.025
up Dmtn A0A8I5ZXT2 A0A8I5ZXT2_RAT Dematin (Dematin actin-binding protein) (Erythrocyte membrane protein band 4.9) 0.355 0.025
up Cspg5 Q9ERQ6 CSPG5_RAT Chondroitin sulfate proteoglycan 5 (Acidic leucine-rich EGF-like domain-containing brain protein) (Neuroglycan C) 0.377 0.025
up Uqcrb B2RYS2 B2RYS2_RAT Cytochrome b-c1 complex subunit 7 0.808 0.025
up Rbm8a Q27W01 RBM8A_RAT RNA-binding protein 8A (RNA-binding motif protein 8A) (Ribonucleoprotein RBM8A) 0.983 0.026
up Pde4a P54748 PDE4A_RAT 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (cAMP-specific phosphodiesterase 4A) 0.761 0.026
up Sumo2 P61959 SUMO2_RAT Small ubiquitin-related modifier 2 (SUMO-2) (SMT3 homolog 2) (Sentrin-2) (Ubiquitin-like protein SMT3A) (Smt3A) 1.260 0.026
up Arpin D4A1B2 D4A1B2_RAT Arpin 0.984 0.027
up Saa1 NA NA NA 1.485 0.027
up Ptms P04550 PTMS_RAT Parathymosin (Zinc-binding 11.5 kDa protein) 1.186 0.027
up NA Q6LED0 H31_RAT Histone H3.1 0.565 0.028
up Ppp4r2 D4A8H5 D4A8H5_RAT Protein phosphatase 4, regulatory subunit 2 0.955 0.029
up Fxn D3ZYW7 FRDA_RAT Frataxin, mitochondrial (Fxn) (EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form; Extramitochondrial frataxin] 0.906 0.029
up Rps19 P17074 RS19_RAT Small ribosomal subunit protein eS19 (40S ribosomal protein S19) 1.091 0.031
up Lysmd2 A0A0G2K146 A0A0G2K146_RAT LysM domain containing 2 0.690 0.031
up Map7d2 D4A4L4 MA7D2_RAT MAP7 domain-containing protein 2 (Brain-enriched E-MAP-115-like protein) 0.822 0.031
up Csnk1a1 P97633 KC1A_RAT Casein kinase I isoform alpha (CKI-alpha) (EC 2.7.11.1) (CK1) 1.128 0.032
up Ndufa7 A9UMV9 A9UMV9_RAT NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 (Complex I-B14.5a) (NADH-ubiquinone oxidoreductase subunit B14.5a) 0.342 0.032
up Arfgap1 Q62848 ARFG1_RAT ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) 0.343 0.033
up Ap1m1 Q32Q06 AP1M1_RAT AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) 0.657 0.033
up Apod P23593 APOD_RAT Apolipoprotein D (Apo-D) (ApoD) 0.747 0.034
up Nol3 Q62881 NOL3_RAT Nucleolar protein 3 (Apoptosis repressor with CARD) 0.774 0.034
up Coq8a Q5BJQ0 COQ8A_RAT Atypical kinase COQ8A, mitochondrial (EC 2.7.-.-) (Chaperone activity of bc1 complex-like) (Chaperone-ABC1-like) (Coenzyme Q protein 8A) (aarF domain-containing protein kinase 3) 0.420 0.034
up Ggt7 Q99MZ4 GGT7_RAT Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain] 0.422 0.036
up Cbx3 Q5RJK5 Q5RJK5_RAT Chromobox 3 (Chromobox homolog 3 (HP1 gamma homolog, Drosophila)) 0.534 0.036
up Bcam Q9ESS6 BCAM_RAT Basal cell adhesion molecule (B-CAM cell surface glycoprotein) (Lutheran antigen) (CD antigen CD239) 0.576 0.037
up Psap P10960 SAP_RAT Prosaposin (Sulfated glycoprotein 1) (SGP-1) [Cleaved into: Saposin-A; Saposin-B-Val; Saposin-B; Saposin-C; Saposin-D] 0.944 0.037
up Plcl2 F1M324 F1M324_RAT Phosphoinositide phospholipase C (EC 3.1.4.11) 0.519 0.038
up Cx3cl1 O55145 X3CL1_RAT Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine] 0.618 0.038
up Cmpk1 Q4KM73 KCY_RAT UMP-CMP kinase (EC 2.7.4.14) (Deoxycytidylate kinase) (CK) (dCMP kinase) (Nucleoside-diphosphate kinase) (EC 2.7.4.6) (Uridine monophosphate/cytidine monophosphate kinase) (UMP/CMP kinase) (UMP/CMPK) 0.760 0.038
up Rwdd1 Q99ND9 RWDD1_RAT RWD domain-containing protein 1 (Small androgen receptor-interacting protein) 0.919 0.038
up Baiap2 Q6GMN2 BAIP2_RAT BAR/IMD domain-containing adapter protein 2 (Brain-specific angiogenesis inhibitor 1-associated protein 2) (BAI-associated protein 2) (BAI1-associated protein 2) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53) (Insulin receptor tyrosine kinase substrate protein p53) 0.317 0.038
up Spock2 A0A8I5ZQG2 A0A8I5ZQG2_RAT Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2) 0.817 0.038
up Thrap3 Q5M7V8 TR150_RAT Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) 0.458 0.038
up Mtdh Q9Z1W6 LYRIC_RAT Protein LYRIC (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) 0.564 0.040
up Lbhd2 D3ZC31 D3ZC31_RAT LBH domain containing 2 1.151 0.041
up Ubqln4 D4A3P1 D4A3P1_RAT Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) 0.689 0.041
up Hnrnpd Q9JJ54 HNRPD_RAT Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) 0.709 0.041
up Itgb1 P49134 ITB1_RAT Integrin beta-1 (Beta oligodendroglia) (Beta OL) (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) 0.498 0.042
up Akt1s1 A0A8I5ZRQ9 A0A8I5ZRQ9_RAT AKT1 substrate 1 1.384 0.042
up Hmgb3 F7EWK1 F7EWK1_RAT High mobility group protein B3 (High mobility group protein 2a) (High mobility group protein 4) 1.039 0.042
up Acyp2 P35745 ACYP2_RAT Acylphosphatase-2 (EC 3.6.1.7) (Acylphosphatase, muscle type isozyme) (Acylphosphate phosphohydrolase 2) 0.359 0.043
up Ndufb3 A0A8I5Y9A4 A0A8I5Y9A4_RAT NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 (Complex I-B12) (NADH-ubiquinone oxidoreductase B12 subunit) 0.404 0.044
up Hopx Q78ZR5 HOP_RAT Homeodomain-only protein (Global ischemia-induced gene 15B protein) (GIIg15b) (Odd homeobox protein 1) 0.742 0.044
up Fam219a D4AAI7 D4AAI7_RAT Family with sequence similarity 219, member A 0.875 0.044
up Fus Q5PQK2 Q5PQK2_RAT RNA-binding protein FUS 0.425 0.044
up Cnpy2 A0JN30 A0JN30_RAT Canopy FGF signaling regulator 2 0.468 0.044
up Slc39a6 Q4V887 S39A6_RAT Zinc transporter ZIP6 (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6) 0.614 0.045
up Ppib P24368 PPIB_RAT Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) 0.299 0.045
up Akap5 P24587 AKAP5_RAT A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 150 kDa) (AKAP 150) (P150) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) 0.446 0.045
up NA Q6LED0 H31_RAT Histone H3.1 0.293 0.046
up NA Q6LED0 H31_RAT Histone H3.1 0.293 0.046
up Opcml P32736 OPCM_RAT Opioid-binding protein/cell adhesion molecule (OBCAM) (OPCML) (Opioid-binding cell adhesion molecule) 0.372 0.046
up Clu P05371 CLUS_RAT Clusterin (Dimeric acid glycoprotein) (DAG) (Sulfated glycoprotein 2) (SGP-2) (Testosterone repressed prostate message 2) (TRPM-2) [Cleaved into: Clusterin beta chain; Clusterin alpha chain] 0.316 0.047
up Nudc Q63525 NUDC_RAT Nuclear migration protein nudC (Nuclear distribution protein C homolog) (c15) 0.465 0.047
up Rpl23a P62752 RL23A_RAT Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) 0.383 0.048
up U2af2 F2Z3T9 F2Z3T9_RAT Splicing factor U2AF subunit (U2 snRNP auxiliary factor large subunit) 1.428 0.048
up NA Q6LED0 H31_RAT Histone H3.1 0.820 0.048
up NA Q6LED0 H31_RAT Histone H3.1 0.820 0.048
up Mtpn P62775 MTPN_RAT Myotrophin (Granule cell differentiation protein) (Protein V-1) 0.734 0.049
up Wnk2 A0A0G2KAS8 A0A0G2KAS8_RAT non-specific serine/threonine protein kinase (EC 2.7.11.1) 0.758 0.049
up Snrpa Q5U214 Q5U214_RAT U1 small nuclear ribonucleoprotein A 0.557 0.049
up Kalrn P97924 KALRN_RAT Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (PAM COOH-terminal interactor protein 10) (P-CIP10) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) 0.632 0.049
up Wnk1 Q9JIH7 WNK1_RAT Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) 0.521 0.050
up Gng2 A0ABK0LUW9 A0ABK0LUW9_RAT G protein subunit gamma 2 0.402 0.050
down Drg2 A0A8I5ZWK0 A0A8I5ZWK0_RAT Developmentally-regulated GTP-binding protein 2 (Translation factor GTPase DRG2) −1.045 0.001
down NA Q6LED0 H31_RAT Histone H3.1 −0.893 0.001
down Cyb5r1 Q5EB81 NB5R1_RAT NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) −1.195 0.001
down Unc13a Q62768 UN13A_RAT Protein unc-13 homolog A (Munc13-1) −1.345 0.001
down Shisa6 D4A4M0 D4A4M0_RAT Shisa family member 6 −0.812 0.001
down Acadl P15650 ACADL_RAT Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8) −0.798 0.001
down Rab3a P63012 RAB3A_RAT Ras-related protein Rab-3A (EC 3.6.5.2) −0.699 0.002
down Ap1b1 P52303 AP1B1_RAT AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) −0.818 0.002
down Eipr1 Q5PPK9 EIPR1_RAT EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) −0.894 0.002
down Dlg3 Q62936 DLG3_RAT Disks large homolog 3 (PSD-95/SAP90-related protein 1) (Synapse-associated protein 102) (SAP-102) (SAP102) −0.872 0.002
down Rab6a Q9WVB1 RAB6A_RAT Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) −1.234 0.002
down Xpo7 F1LQM9 F1LQM9_RAT Exportin 7 −1.164 0.002
down Actr3b A0A8I6GL35 A0A8I6GL35_RAT Actin related protein 3B −1.012 0.002
down Ppp1cb P62142 PP1B_RAT Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53) −0.780 0.002
down Kctd12 A0A8I5Y7I2 A0A8I5Y7I2_RAT Potassium channel tetramerization domain containing 12 −0.706 0.002
down C1qb P31721 C1QB_RAT Complement C1q subcomponent subunit B −1.236 0.002
down Padi2 P20717 PADI2_RAT Protein-arginine deiminase type-2 (EC 3.5.3.15) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) −0.818 0.002
down Grin2a Q00959 NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) −1.375 0.002
down Sptbn2 Q9QWN8 SPTN2_RAT Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41) −0.808 0.002
down Prkcg P63319 KPCG_RAT Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) −0.735 0.002
down Ptk2b P70600 FAK2_RAT Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) −0.628 0.002
down Ddx5 Q6AYI1 Q6AYI1_RAT Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) −0.628 0.002
down Twf1 Q5RJR2 TWF1_RAT Twinfilin-1 −0.851 0.002
down Crym Q9QYU4 CRYM_RAT Ketimine reductase mu-crystallin (EC 1.5.1.25) (1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase) (P2C/Pyr2C reductase) (EC 1.5.1.1) (CDK108) (NADP-regulated thyroid-hormone-binding protein) −0.591 0.002
down Hsp90aa1 P82995 HS90A_RAT Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) −0.857 0.003
down Camk2b P08413 KCC2B_RAT Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) −1.046 0.003
down Agap3 A0A0G2K2D4 A0A0G2K2D4_RAT Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (CRAM-associated GTPase) (Centaurin-gamma-3) (MR1-interacting protein) −0.718 0.003
down Pdk3 A6IPZ9 A6IPZ9_RAT Protein-serine/threonine kinase (EC 2.7.11.-) −0.593 0.003
down Ganab D3ZAN3 D3ZAN3_RAT Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) −0.910 0.003
down Opa3 A0A8I6AQX4 A0A8I6AQX4_RAT Outer mitochondrial membrane lipid metabolism regulator OPA3 −0.900 0.003
down Actr2 Q5M7U6 ARP2_RAT Actin-related protein 2 (Actin-like protein 2) −0.583 0.003
down Gnb1 P54311 GBB1_RAT Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) −0.674 0.003
down Slc2a1 P11167 GTR1_RAT Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) −0.663 0.003
down Lgi1 Q8K4Y5 LGI1_RAT Leucine-rich glioma-inactivated protein 1 −0.601 0.003
down Sfxn5 Q8CFD0 SFXN5_RAT Sideroflexin-5 (Tricarboxylate carrier BBG-TCC) −0.541 0.003
down Rps16 P62250 RS16_RAT Small ribosomal subunit protein uS9 (40S ribosomal protein S16) −0.716 0.003
down Atp6v1c1 Q5FVI6 VATC1_RAT V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) −0.745 0.003
down Ckap5 F1M949 F1M949_RAT Cytoskeleton-associated protein 5 −0.869 0.003
down Igsf8 A0A8I6ANQ3 A0A8I6ANQ3_RAT Immunoglobulin superfamily member 8 (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (Prostaglandin regulatory-like protein) −0.675 0.003
down Prep O70196 PPCE_RAT Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) (rPop) −0.667 0.003
down Atp5f1c P35435 ATPG_RAT ATP synthase F(1) complex subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit) −1.185 0.004
down Pfkp P47860 PFKAP_RAT ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) −0.872 0.004
down Hnrnpl F1LQ48 HNRPL_RAT Heterogeneous nuclear ribonucleoprotein L (hnRNP L) −0.652 0.004
down Phyhip Q568Z9 PHYIP_RAT Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1) −1.075 0.004
down Dpysl4 Q62951 DPYL4_RAT Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) −0.590 0.004
down Tspan7 B0BNE7 B0BNE7_RAT Tetraspanin −1.073 0.004
down Prepl Q5HZA6 PPCEL_RAT Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) −0.795 0.004
down Adss2 D4AEP0 D4AEP0_RAT Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) −0.624 0.004
down Dars1 P15178 SYDC_RAT Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) −0.693 0.004
down Gria1 P19490 GRIA1_RAT Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) −0.717 0.004
down Hspa2 P14659 HSP72_RAT Heat shock-related 70 kDa protein 2 (Heat shock protein 70.2) (Testis-specific heat shock protein-related) (HST) −0.646 0.004
down Cct7 A0A8I6AR12 A0A8I6AR12_RAT T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) −0.582 0.004
down Rgs14 O08773 RGS14_RAT Regulator of G-protein signaling 14 (RGS14) −0.499 0.004
down Bdh1 P29147 BDH_RAT D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) −0.921 0.004
down Mapk10 P49187 MK10_RAT Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta) −0.540 0.004
down Rab5b A1L1J8 A1L1J8_RAT small monomeric GTPase (EC 3.6.5.2) −0.909 0.004
down Slc6a7 P28573 SC6A7_RAT Sodium-dependent proline transporter (Solute carrier family 6 member 7) −0.717 0.004
down Pfkl P30835 PFKAL_RAT ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase) −0.686 0.004
down Hspa4l P83581 HS74L_RAT Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) −0.546 0.004
down Ahcyl1 B5DFN2 SAHH2_RAT S-adenosylhomocysteine hydrolase-like protein 1 (IP3R-binding protein released with inositol 1,4,5-trisphosphate) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) −0.641 0.004
down Anks1b P0C6S7 ANS1B_RAT Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) −0.615 0.004
down Septin8 B0BNF1 SEPT8_RAT Septin-8 −0.953 0.004
down Pspc1 Q4KLH4 PSPC1_RAT Paraspeckle component 1 −0.828 0.004
down Exoc4 Q62824 EXOC4_RAT Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8) −0.658 0.004
down Stum A0ABK0LZH3 A0ABK0LZH3_RAT Uncharacterized protein −1.157 0.004
down Inpp4a Q62784 INP4A_RAT Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) −0.754 0.004
down Ppfia3 Q91Z79 LIPA3_RAT Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) −0.610 0.004
down Rheb Q62639 RHEB_RAT GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) −0.821 0.004
down Ca4 P48284 CAH4_RAT Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV) −1.558 0.005
down Prkce P09216 KPCE_RAT Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) −0.564 0.005
down Dlgap1 P97836 DLGP1_RAT Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (rGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) −1.628 0.005
down Etfa P13803 ETFA_RAT Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) −0.704 0.005
down Pygm P09812 PYGM_RAT Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) −0.732 0.005
down Gapdh P04797 G3P_RAT Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) −0.498 0.005
down Fkbp8 Q3B7U9 FKBP8_RAT Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (FK506-binding protein 8) (FKBP-8) (Rotamase) −1.771 0.005
down Cdipt P70500 CDIPT_RAT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase) −0.717 0.005
down Ap2m1 P84092 AP2M1_RAT AP-2 complex subunit mu (AP-2 mu chain) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) −0.647 0.005
down Pdha1 P26284 ODPA_RAT Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) −0.697 0.005
down Aifm1 Q9JM53 AIFM1_RAT Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) −0.671 0.005
down Cops4 Q68FS2 CSN4_RAT COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) −0.643 0.005
down Dhx9 A0A8I6ABZ7 A0A8I6ABZ7_RAT ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) −0.710 0.005
down Mpp2 D3ZAA9 MPP2_RAT MAGUK p55 subfamily member 2 (Protein MPP2) −0.730 0.005
down Glul P09606 GLNA_RAT Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) −0.714 0.005
down Strap Q5XIG8 STRAP_RAT Serine-threonine kinase receptor-associated protein (UNR-interacting protein) −0.508 0.005
down Rab14 P61107 RAB14_RAT Ras-related protein Rab-14 (EC 3.6.5.2) −0.765 0.005
down Rps11 P62282 RS11_RAT Small ribosomal subunit protein uS17 (40S ribosomal protein S11) −0.690 0.005
down Pcx NA NA NA −0.542 0.005
down Prpsap1 Q63468 KPRA_RAT Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) −1.264 0.005
down Trim2 D3ZQG6 TRIM2_RAT Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2) −0.591 0.005
down Syngap1 Q9QUH6 SYGP1_RAT Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (p135 SynGAP) −0.599 0.005
down Cct6a F7ELS2 F7ELS2_RAT T-complex protein 1 subunit zeta −0.637 0.005
down Actr3 Q4V7C7 ARP3_RAT Actin-related protein 3 (Actin-like protein 3) −0.515 0.005
down Rpl11 P62914 RL11_RAT Large ribosomal subunit protein uL5 (60S ribosomal protein L11) −1.979 0.005
down Scrn3 A0A8I6A9K3 A0A8I6A9K3_RAT Secernin 3 −1.929 0.005
down Prmt1 Q63009 ANM1_RAT Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) −1.109 0.005
down Gsk3b P18266 GSK3B_RAT Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) −0.649 0.005
down Atp6v1a D4A133 D4A133_RAT V-type proton ATPase catalytic subunit A (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha) −0.537 0.005
down Arpc1a Q99PD4 ARC1A_RAT Actin-related protein 2/3 complex subunit 1A −0.546 0.005
down Mtmr1 A0A0G2JUZ0 A0A0G2JUZ0_RAT phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) −0.791 0.005
down Actr1a P85515 ACTZ_RAT Alpha-centractin (Centractin) −0.769 0.005
down Acadvl P45953 ACADV_RAT Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) −0.612 0.005
down Rab18 Q5EB77 RAB18_RAT Ras-related protein Rab-18 (EC 3.6.5.2) −0.600 0.005
down Ddx1 Q641Y8 DDX1_RAT ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) −1.343 0.006
down Grin1 P35439 NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) −0.701 0.006
down Cpne6 D4ACG7 D4ACG7_RAT Copine-6 (Copine VI) −0.606 0.006
down Fasn P12785 FAS_RAT Fatty acid synthase (EC 2.3.1.85) (Type I FAS) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] −0.663 0.006
down Tnr Q05546 TENR_RAT Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) −0.494 0.006
down Cpne4 F1M0Z3 F1M0Z3_RAT Copine-4 (Copine IV) −1.066 0.006
down Rps3 P62909 RS3_RAT Small ribosomal subunit protein uS3 (EC 4.2.99.18) (40S ribosomal protein S3) −0.546 0.006
down Tmx3 M0R402 M0R402_RAT Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) −0.940 0.006
down Rab3c P62824 RAB3C_RAT Ras-related protein Rab-3C (EC 3.6.5.2) −0.645 0.006
down Wdr7 Q9ERH3 WDR7_RAT WD repeat-containing protein 7 (TGF-beta resistance-associated protein TRAG) −0.648 0.006
down Dync1h1 P38650 DYHC1_RAT Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) (MAP 1C) −0.683 0.006
down Eif3b Q4G061 EIF3B_RAT Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta) −0.671 0.006
down Rps8 P62243 RS8_RAT Small ribosomal subunit protein eS8 (40S ribosomal protein S8) −0.732 0.006
down Svop Q9Z2I7 SVOP_RAT Synaptic vesicle 2-related protein (SV2-related protein) −1.279 0.006
down Atp2b2 P11506 AT2B2_RAT Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) −0.561 0.006
down Rock2 Q62868 ROCK2_RAT Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (RhoA-binding kinase 2) (p150 ROK-alpha) (ROKalpha) (p164 ROCK-2) −0.636 0.006
down Hnrnpm Q62826 HNRPM_RAT Heterogeneous nuclear ribonucleoprotein M (hnRNP M) (M4 protein) −0.559 0.006
down Ewsr1 A0A0G2K850 A0A0G2K850_RAT RNA-binding protein EWS −1.258 0.006
down Rab7a P09527 RAB7A_RAT Ras-related protein Rab-7a (EC 3.6.5.2) (Ras-related protein BRL-RAS) (Ras-related protein p23) −0.629 0.006
down Gdap1l1 B4F774 B4F774_RAT Ganglioside-induced differentiation-associated protein 1-like 1 −0.620 0.006
down Eef2 P05197 EF2_RAT Elongation factor 2 (EF-2) (EC 3.6.5.-) −0.492 0.006
down Nckap1 P55161 NCKP1_RAT Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) −0.746 0.006
down Gmps Q4V7C6 GUAA_RAT GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) −0.570 0.006
down Srr Q76EQ0 SRR_RAT Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) −0.483 0.006
down Ogt P56558 OGT1_RAT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) −0.636 0.007
down Cct3 Q6P502 TCPG_RAT T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) −0.518 0.007
down Cltc P11442 CLH1_RAT Clathrin heavy chain 1 −0.637 0.007
down Xpnpep1 O54975 XPP1_RAT Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) −0.553 0.007
down Septin9 Q9QZR6 SEPT9_RAT Septin-9 (Eighth septin) (Eseptin) (Septin-like protein) (SLP) −0.536 0.007
down Ugp2 Q4V8I9 Q4V8I9_RAT UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) −0.553 0.007
down Slc8a2 P48768 NAC2_RAT Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) −0.534 0.007
down Hnrnpul2 D4ABT8 D4ABT8_RAT Heterogeneous nuclear ribonucleoprotein U-like protein 2 −0.483 0.007
down Naxd D4AAT7 NNRD_RAT ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase) −0.622 0.007
down Madd O08873 MADD_RAT MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (RabGEP) −0.601 0.007
down Phyhipl Q6AYN4 PHIPL_RAT Phytanoyl-CoA hydroxylase-interacting protein-like −0.449 0.007
down Slc6a1 P23978 SC6A1_RAT Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) −0.634 0.007
down Got2 P00507 AATM_RAT Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) −0.529 0.007
down Tpp2 Q64560 TPP2_RAT Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) −0.841 0.007
down Pde2a Q01062 PDE2A_RAT cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) −0.719 0.007
down Stxbp1 P61765 STXB1_RAT Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) (rbSec1) −0.534 0.007
down Sbf1 M0RAP5 M0RAP5_RAT SET binding factor 1 −0.540 0.007
down Auh F1LU71 AUHM_RAT Methylglutaconyl-CoA hydratase, mitochondrial (3-MG-CoA hydratase) (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (Itaconyl-CoA hydratase) (EC 4.2.1.56) −0.519 0.007
down Get3 G3V9T7 GET3_RAT ATPase Get3 (EC 3.6.4.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) −0.481 0.007
down Kcnma1 Q62976 KCMA1_RAT Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) −1.533 0.007
down Ctsb P00787 CATB_RAT Cathepsin B (EC 3.4.22.1) (Cathepsin B1) (RSG-2) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] −1.054 0.007
down Gnb2 P54313 GBB2_RAT Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) −0.906 0.007
down Itpka P17105 IP3KA_RAT Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A) −0.553 0.007
down Pls3 Q63598 PLST_RAT Plastin-3 (T-plastin) −0.539 0.007
down Ppm1h Q5M821 PPM1H_RAT Protein phosphatase 1H (EC 3.1.3.16) −0.814 0.007
down Ap2a2 P18484 AP2A2_RAT AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) −0.608 0.007
down Psma6 P60901 PSA6_RAT Proteasome subunit alpha type-6 (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1) −0.783 0.007
down Acly P16638 ACLY_RAT ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme) −0.655 0.007
down Ndufv1 Q5XIH3 Q5XIH3_RAT NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 7.1.1.2) −0.603 0.007
down Lrrc57 Q5FVI3 LRC57_RAT Leucine-rich repeat-containing protein 57 −0.939 0.007
down Hnrnpr Q566E4 Q566E4_RAT Heterogeneous nuclear ribonucleoprotein Q (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) −1.408 0.007
down NA Q6LED0 H31_RAT Histone H3.1 −1.163 0.007
down NA Q6LED0 H31_RAT Histone H3.1 −1.163 0.007
down Mapk3 P21708 MK03_RAT Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1) −0.598 0.007
down Ppp3cb P20651 PP2BB_RAT Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) −0.534 0.007
down Adam23 A0A8I6A4T9 A0A8I6A4T9_RAT ADAM metallopeptidase domain 23 −1.254 0.008
down Arcn1 Q66H80 COPD_RAT Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) −0.613 0.008
down Gdi1 P50398 GDIA_RAT Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) −0.471 0.008
down Pfn2 Q9EPC6 PROF2_RAT Profilin-2 (Profilin II) −0.559 0.008
down Ogdh Q5XI78 ODO1_RAT 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) −0.837 0.008
down Add3 Q62847 ADDG_RAT Gamma-adducin (Adducin-like protein 70) (Protein kinase C-binding protein 35H) −0.438 0.008
down Slc24a2 O54701 NCKX2_RAT Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2) −0.741 0.008
down Exoc8 O54924 EXOC8_RAT Exocyst complex component 8 (Exocyst complex 84 kDa subunit) −0.489 0.008
down Ctnna2 A0A0G2JYF7 A0A0G2JYF7_RAT Catenin alpha-2 (Alpha N-catenin) −0.486 0.008
down Braf A0A8I6ATH0 A0A8I6ATH0_RAT non-specific serine/threonine protein kinase (EC 2.7.11.1) −0.546 0.008
down Mlc1 D4ABB2 D4ABB2_RAT Modulator of VRAC current 1 −1.162 0.008
down NA Q6LED0 H31_RAT Histone H3.1 −0.705 0.008
down Gabbr1 Q9Z0U4 GABR1_RAT Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) −1.504 0.008
down Sirt2 Q5RJQ4 SIR2_RAT NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) −0.431 0.008
down Sfxn3 Q9JHY2 SFXN3_RAT Sideroflexin-3 −0.572 0.008
down Lrrc47 F1LT49 F1LT49_RAT Leucine-rich repeat-containing protein 47 −0.684 0.008
down Tardbp A6IU83 A6IU83_RAT TAR DNA-binding protein 43 −0.605 0.008
down Naxe B0BNM1 NNRE_RAT NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) −0.655 0.008
down Ppp3ca P63329 PP2BA_RAT Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) −0.422 0.008
down Prmt5 A0A8I5ZP89 A0A8I5ZP89_RAT Protein arginine N-methyltransferase 5 (EC 2.1.1.320) −1.024 0.008
down Bpnt1 Q9Z1N4 BPNT1_RAT 3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57) (RnPIP) (scHAL2 analogous 3) −0.727 0.008
down Atp5f1a P15999 ATPA_RAT ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) −0.415 0.008
down Rab11b O35509 RB11B_RAT Ras-related protein Rab-11B (EC 3.6.5.2) −0.596 0.008
down Prkca P05696 KPCA_RAT Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) −0.675 0.009
down Mpst P97532 THTM_RAT 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) −0.689 0.009
down Aco2 Q9ER34 ACON_RAT Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) −0.478 0.009
down Cand1 P97536 CAND1_RAT Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1) −0.483 0.009
down Vars1 Q04462 SYVC_RAT Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) −0.614 0.009
down Atp1b2 P13638 AT1B2_RAT Sodium/potassium-transporting ATPase subunit beta-2 (Sodium/potassium-dependent ATPase subunit beta-2) −1.031 0.009
down Nae1 Q9Z1A5 ULA1_RAT NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) −0.499 0.009
down Slc25a12 F1LX07 S2512_RAT Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Solute carrier family 25 member 12) −0.497 0.009
down Prrt1 Q6MG82 PRRT1_RAT Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4) −0.708 0.009
down Ivd P12007 IVD_RAT Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4) (Butyryl-CoA dehydrogenase) (EC 1.3.8.1) −0.487 0.009
down Maoa P21396 AOFA_RAT Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) −0.509 0.009
down Mfn2 Q8R500 MFN2_RAT Mitofusin-2 (EC 3.6.5.-) (Mitochondrial transmembrane GTPase FZO1A) (Protein HSG) (Transmembrane GTPase MFN2) −1.596 0.009
down Coro2b F1LMV9 F1LMV9_RAT Coronin −0.606 0.009
down Gnao1 P59215 GNAO_RAT Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) −0.393 0.009
down Rab1a A0A8I6AJ88 A0A8I6AJ88_RAT small monomeric GTPase (EC 3.6.5.2) −0.479 0.009
down Nsf Q9QUL6 NSF_RAT Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) −0.471 0.009
down Rap1gap F1LV89 F1LV89_RAT Rap1 GTPase-activating protein −0.661 0.009
down Rhot1 A1L1L6 MIRO1_RAT Mitochondrial Rho GTPase (MIRO-1) (EC 3.6.5.-) (Ras homolog gene family member T1) −0.736 0.009
down Adam11 A0A1W2Q6C2 A0A1W2Q6C2_RAT ADAM metallopeptidase domain 11 −0.714 0.009
down Mcu A0A0G2K059 A0A0G2K059_RAT Calcium uniporter protein −0.647 0.009
down Cyfip2 A0A8I6AHL8 A0A8I6AHL8_RAT Cytoplasmic FMR1-interacting protein −0.556 0.009
down Tst P24329 THTR_RAT Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) −0.521 0.009
down Kif2a Q9WV63 KIF2A_RAT Kinesin-like protein KIF2A (Kinesin-2) −0.518 0.009
down Uba1 Q5U300 UBA1_RAT Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) −0.506 0.009
down Rac1 Q6RUV5 RAC1_RAT Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1) −0.489 0.009
down Mtfp1 A6IKE5 A6IKE5_RAT Mitochondrial fission process protein 1 (Mitochondrial 18 kDa protein) −1.170 0.010
down Dpp10 Q6Q629 DPP10_RAT Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase X) (DPP X) (Kv4 potassium channel auxiliary subunit) −0.911 0.010
down Cntnap2 A0A8I6GH02 A0A8I6GH02_RAT Contactin associated protein 2 −0.869 0.010
down Nomo1 D3ZSA9 D3ZSA9_RAT Nodal modulator 1 −0.601 0.010
down Sar1a Q6AY18 Q6AY18_RAT small monomeric GTPase (EC 3.6.5.2) −0.546 0.010
down Diras2 A0A8I5ZKR8 A0A8I5ZKR8_RAT DIRAS family GTPase 2 −1.286 0.010
down Pip4k2b O88377 PI42B_RAT Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (Phosphatidylinositol-phosphate kinase IIgamma) (PIPKIIgamma) (PtdIns(5)P-4-kinase isoform 2-beta) −0.845 0.010
down Mdh2 P04636 MDHM_RAT Malate dehydrogenase, mitochondrial (EC 1.1.1.37) −0.586 0.010
down Akr7a2 Q8CG45 ARK72_RAT Aflatoxin B1 aldehyde reductase member 2 (rAFAR2) (EC 1.1.1.n11) (Succinic semialdehyde reductase) (SSA reductase) −0.831 0.010
down NA Q6LED0 H31_RAT Histone H3.1 −0.791 0.010
down Pfas D4AB17 D4AB17_RAT Phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (Formylglycinamide ribotide amidotransferase) −0.560 0.010
down Adh5 P12711 ADHX_RAT Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase B2) (ADH-B2) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) −0.524 0.010
down Cdk5 Q03114 CDK5_RAT Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) −0.491 0.010
down Otub1 B2RYG6 OTUB1_RAT Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (Ubiquitin-specific-processing protease OTUB1) −0.475 0.010
down Slc12a5 Q63633 S12A5_RAT Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Furosemide-sensitive K-Cl cotransporter) (K-Cl cotransporter 2) (rKCC2) (Neuronal K-Cl cotransporter) −0.491 0.010
down Aldh6a1 Q02253 MMSA_RAT Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) −0.603 0.010
down Pdhb P49432 ODPB_RAT Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) −0.420 0.010
down Vdac2 P81155 VDAC2_RAT Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (B36-VDAC) (Outer mitochondrial membrane protein porin 2) −0.717 0.010
down Fscn1 P85845 FSCN1_RAT Fascin −0.694 0.010
down Nptn P97546 NPTN_RAT Neuroplastin (Glycoprotein 55/65) (gp55/65) (Stromal cell-derived receptor 1) (SDR-1) −0.412 0.010
down Acat1 P17764 THIL_RAT Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) −0.630 0.010
down Sec13 Q5XFW8 SEC13_RAT Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) −1.638 0.010
down Nf1 P97526 NF1_RAT Neurofibromin (Neurofibromatosis-related protein NF-1) −1.069 0.010
down Nfs1 Q99P39 NFS1_RAT Cysteine desulfurase (EC 2.8.1.7) −0.659 0.010
down Cct8 A0A8I6AAR4 A0A8I6AAR4_RAT T-complex protein 1 subunit theta (CCT-theta) −0.504 0.010
down Gnb5 P62882 GNB5_RAT Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5) −1.416 0.010
down Ndufs1 Q66HF1 NDUS1_RAT NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (EC 7.1.1.2) −0.517 0.010
down Lxn Q64361 LXN_RAT Latexin (Endogenous carboxypeptidase inhibitor) (ECI) (Tissue carboxypeptidase inhibitor) (TCI) −0.814 0.011
down Grin2b Q00960 NMDE2_RAT Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) −0.776 0.011
down Hnrnph1 Q8VHV7 HNRH1_RAT Heterogeneous nuclear ribonucleoprotein H (hnRNP H) (Ratsg1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] −0.508 0.011
down Slc25a18 Q505J6 GHC2_RAT Mitochondrial glutamate carrier 2 (GC-2) (Glutamate/H(+) symporter 2) (Solute carrier family 25 member 18) −0.600 0.011
down Psmd3 A6HIT6 A6HIT6_RAT 26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58) −0.465 0.011
down Ppp2r5a D3ZDI7 D3ZDI7_RAT Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit −0.620 0.011
down Syncrip Q7TP47 HNRPQ_RAT Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Liver regeneration-related protein LRRG077) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) −0.625 0.011
down Dpysl2 P47942 DPYL2_RAT Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (Turned on after division 64 kDa protein) (TOAD-64) −0.392 0.011
down Gclc P19468 GSH1_RAT Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase) −0.500 0.011
down Cul3 B5DF89 CUL3_RAT Cullin-3 −0.751 0.011
down Pgm2l1 D3Z955 D3Z955_RAT Phosphoglucomutase 2-like 1 −0.403 0.011
down Pip4k2c O88370 PI42C_RAT Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) −0.540 0.011
down Eif3a Q1JU68 EIF3A_RAT Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) −0.657 0.011
down Rapgef2 F1M386 RPGF2_RAT Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1) −0.508 0.011
down Atic O35567 PUR9_RAT Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)] −0.560 0.012
down Arf6 P62332 ARF6_RAT ADP-ribosylation factor 6 (EC 3.6.5.2) −0.458 0.012
down Septin6 B5DFG5 B5DFG5_RAT Septin −0.606 0.012
down Nbea A0A8I6AB61 A0A8I6AB61_RAT Neurobeachin (Lysosomal-trafficking regulator 2) −0.531 0.012
down Faah P97612 FAAH1_RAT Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidase) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1) −1.519 0.012
down Rnpep O09175 AMPB_RAT Aminopeptidase B (AP-B) (EC 3.4.11.6) (Arginine aminopeptidase) (Arginyl aminopeptidase) (Cytosol aminopeptidase IV) −1.086 0.012
down Snx15 Q4V896 SNX15_RAT Sorting nexin-15 −0.764 0.012
down Adam22 F1M542 F1M542_RAT ADAM metallopeptidase domain 22 −0.592 0.012
down Psmc2 Q63347 PRS7_RAT 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) −0.521 0.012
down Git1 Q9Z272 GIT1_RAT ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (GRK-interactor 1) −0.467 0.012
down Dnm3 Q08877 DYN3_RAT Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) −0.720 0.012
down Gsr P70619 GSHR_RAT Glutathione reductase (GR) (GRase) (EC 1.8.1.7) −0.637 0.012
down Ogdhl D3ZQD3 OGDHL_RAT 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) −0.489 0.012
down Dgkg P49620 DGKG_RAT Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (88 kDa diacylglycerol kinase) (DGK-III) (Diglyceride kinase gamma) (DGK-gamma) −0.762 0.012
down Uqcrc2 P32551 QCR2_RAT Cytochrome b-c1 complex subunit 2, mitochondrial (Complex III subunit 2) (Core protein II) (Ubiquinol-cytochrome-c reductase complex core protein 2) −0.384 0.012
down Hacd3 D4ABI7 D4ABI7_RAT Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) −1.096 0.012
down Rps10 P63326 RS10_RAT Small ribosomal subunit protein eS10 (40S ribosomal protein S10) −1.254 0.012
down Dmxl2 F1M3W5 F1M3W5_RAT Dmx-like 2 −0.674 0.012
down Tkt P50137 TKT_RAT Transketolase (TK) (EC 2.2.1.1) −0.386 0.012
down Dpp6 P46101 DPP6_RAT A-type potassium channel modulatory protein DPP6 (DPPX) (Dipeptidyl aminopeptidase-like protein 6) (Dipeptidyl aminopeptidase-related protein) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl peptidase VI) (DPP VI) −0.518 0.012
down Ap1g1 A0A8I6ARE9 A0A8I6ARE9_RAT AP-1 complex subunit gamma −0.678 0.013
down Micu3 A0A8I6A2H6 MICU3_RAT Calcium uptake protein 3, mitochondrial −0.790 0.013
down Idh3g P41565 IDHG1_RAT Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) −0.769 0.013
down Cct5 Q68FQ0 TCPE_RAT T-complex protein 1 subunit epsilon (TCP-1-epsilon) (EC 3.6.1.-) (CCT-epsilon) −0.674 0.013
down Tollip A2RUW1 TOLIP_RAT Toll-interacting protein −0.540 0.013
down Rab2a P05712 RAB2A_RAT Ras-related protein Rab-2A (EC 3.6.5.2) −0.520 0.013
down NA Q6LED0 H31_RAT Histone H3.1 −1.158 0.013
down NA Q6LED0 H31_RAT Histone H3.1 −1.158 0.013
down Acad9 B1WC61 ACAD9_RAT Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) −0.727 0.013
down Flot1 Q9Z1E1 FLOT1_RAT Flotillin-1 (Reggie-2) (REG-2) −0.683 0.013
down Pygb P53534 PYGB_RAT Glycogen phosphorylase, brain form (EC 2.4.1.1) −0.442 0.013
down Atp6v1h A0A8I6ACJ2 A0A8I6ACJ2_RAT V-type proton ATPase subunit H −0.700 0.013
down Wars1 Q6P7B0 SYWC_RAT Tryptophan--tRNA ligase, cytoplasmic (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) [Cleaved into: T1-TrpRS; T2-TrpRS] −0.646 0.013
down Cntnap1 P97846 CNTP1_RAT Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (Paranodin) (p190) −0.573 0.013
down Slc25a3 P16036 S25A3_RAT Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) (PTP) −0.428 0.013
down Echdc1 Q6AYG5 ECHD1_RAT Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) −0.777 0.013
down Rab1b P10536 RAB1B_RAT Ras-related protein Rab-1B (EC 3.6.5.2) −0.570 0.013
down Rab21 Q6AXT5 RAB21_RAT Ras-related protein Rab-21 (EC 3.6.5.2) −0.512 0.013
down Hspa12a D3ZC55 D3ZC55_RAT Heat shock 70 kDa protein 12A −0.443 0.013
down Gabrb3 P63079 GBRB3_RAT Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3) −0.686 0.013
down Gnaq P82471 GNAQ_RAT Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) −0.622 0.013
down Rack1 P63245 RACK1_RAT Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) (Receptor of activated protein kinase C 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Receptor of activated protein C kinase 1, N-terminally processed)] −0.601 0.013
down Rpn2 P25235 RPN2_RAT Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2) −0.593 0.013
down Ndufa11 Q80W89 NDUAB_RAT NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7) −0.474 0.013
down Atp2b3 Q64568 AT2B3_RAT Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) −0.469 0.013
down Psma5 P34064 PSA5_RAT Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) −0.442 0.013
down Cntn1 Q63198 CNTN1_RAT Contactin-1 (Neural cell surface protein F3) −0.436 0.013
down NA Q6LED0 H31_RAT Histone H3.1 −0.412 0.013
down Park7 O88767 PARK7_RAT Parkinson disease protein 7 homolog (Contraception-associated protein 1) (Protein CAP1) (Fertility protein SP22) (Maillard deglycase) (Parkinsonism-associated deglycase) (Protein DJ-1) (DJ-1) (Protein/nucleic acid deglycase DJ-1) (EC 3.1.2.-, EC 3.5.1.-, EC 3.5.1.124) −0.356 0.013
down Aldh7a1 Q64057 AL7A1_RAT Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) −0.776 0.013
down Farp1 F1LYQ8 FARP1_RAT FERM, ARHGEF and pleckstrin domain-containing protein 1 (FERM, RhoGEF and pleckstrin domain-containing protein 1) −0.624 0.013
down Capza2 Q3T1K5 CAZA2_RAT F-actin-capping protein subunit alpha-2 (CapZ alpha-2) −0.550 0.013
down Tmed10 Q63584 TMEDA_RAT Transmembrane emp24 domain-containing protein 10 (Protein Tmed10) (21 kDa transmembrane-trafficking protein) (Transmembrane protein Tmp21) (p24 family protein delta-1) (p24delta1) −1.135 0.013
down Tuba4a Q5XIF6 TBA4A_RAT Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 4) (Tubulin alpha-4 chain) −0.743 0.013
down Sdcbp Q9JI92 SDCB1_RAT Syntenin-1 (Syndecan-binding protein 1) −0.563 0.013
down Rpn1 P07153 RPN1_RAT Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) −0.534 0.013
down Uso1 P41542 USO1_RAT General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) −0.599 0.013
down Gnai2 P04897 GNAI2_RAT Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) −0.673 0.013
down Pfn1 P62963 PROF1_RAT Profilin-1 (Profilin I) −0.926 0.014
down Atp1a3 P06687 AT1A3_RAT Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) −0.439 0.014
down Mtch1 B0BN30 B0BN30_RAT Mitochondrial carrier homolog 1 −0.938 0.014
down Ruvbl1 P60123 RUVB1_RAT RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (DNA helicase p50) (Pontin 52) (TIP49a) −0.540 0.014
down Pfkm P47858 PFKAM_RAT ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase) −0.534 0.014
down Mif P30904 MIF_RAT Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glutathione-binding 13 kDa protein) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) −0.478 0.014
down Psmb1 P18421 PSB1_RAT Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain) (Proteasome subunit beta-6) (beta-6) −0.525 0.014
down Dctn6 A0A8I5Y4I3 A0A8I5Y4I3_RAT Dynactin subunit 6 (Dynactin subunit p27) −1.145 0.014
down Cnksr2 Q9Z1T4 CNKR2_RAT Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) (Membrane-associated guanylate kinase-interacting protein) (Maguin) −0.663 0.014
down Iars2 A0A0G2K261 A0A0G2K261_RAT Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) −0.588 0.014
down Vcp P46462 TERA_RAT Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (15S Mg(2+)-ATPase p97 subunit) (Valosin-containing protein) (VCP) −0.366 0.014
down Slc7a14 A0A0G2K1G8 A0A0G2K1G8_RAT Solute carrier family 7, member 14 −0.876 0.014
down Dusp3 A0A8I6AF61 A0A8I6AF61_RAT Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) −0.507 0.014
down Psmc3 Q63569 PRS6A_RAT 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA) (Tat-binding protein 1) (TBP-1) −0.388 0.014
down Septin7 Q9WVC0 SEPT7_RAT Septin-7 (CDC10 protein homolog) −0.388 0.014
down Ndufa9 Q5BK63 NDUA9_RAT NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (Sperm flagella protein 3) −0.995 0.014
down Ppp2ca P63331 PP2AA_RAT Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) −0.506 0.014
down Nceh1 B2GV54 NCEH1_RAT Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1) −1.029 0.014
down Ap2a1 A0A8I6A4J2 A0A8I6A4J2_RAT AP-2 complex subunit alpha −0.532 0.014
down Tufm P85834 EFTU_RAT Elongation factor Tu, mitochondrial (EC 3.6.5.3) −0.375 0.014
down Ahsa1 B0BN63 B0BN63_RAT Activator of 90 kDa heat shock protein ATPase homolog 1 −0.467 0.014
down Psma3 P18422 PSA3_RAT Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit K) (Proteasome subunit alpha-7) (alpha-7) −0.524 0.014
down Epha4 D3ZZK3 D3ZZK3_RAT receptor protein-tyrosine kinase (EC 2.7.10.1) −0.623 0.014
down Ablim1 A0A8I5Y6A1 A0A8I5Y6A1_RAT Actin-binding LIM protein 1 −0.445 0.014
down NA Q6LED0 H31_RAT Histone H3.1 −0.689 0.014
down Ablim2 Q6KC51 ABLM2_RAT Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2) −0.671 0.014
down Slc1a3 P24942 EAA1_RAT Excitatory amino acid transporter 1 (Glial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST) (GLAST-1) (Solute carrier family 1 member 3) −0.563 0.014
down Slc25a22 A0A0G2K5L2 GHC1_RAT Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) −0.388 0.014
down Oxct1 B2GV06 SCOT1_RAT Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase) −0.441 0.014
down Tecr Q64232 TECR_RAT Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER) −0.721 0.014
down Mthfd1l B2GUZ3 B2GUZ3_RAT Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) −0.709 0.015
down Icam5 D4A435 D4A435_RAT Intercellular adhesion molecule 5 (Telencephalin) −0.440 0.015
down Adcy9 M0R5U4 M0R5U4_RAT Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (Adenylyl cyclase 9) −0.971 0.015
down Smap1 A0A8I5ZQ30 A0A8I5ZQ30_RAT Small ArfGAP 1 −0.522 0.015
down Aldh2 P11884 ALDH2_RAT Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDH1) −0.793 0.015
down Hadha Q64428 ECHA_RAT Trifunctional enzyme subunit alpha, mitochondrial (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] −0.994 0.015
down Kif5c P56536 KIF5C_RAT Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) −0.336 0.015
down Eef1g Q68FR6 EF1G_RAT Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) −0.781 0.015
down Gk Q63060 GLPK_RAT Glycerol kinase (Glycerokinase) (EC 2.7.1.30) (ATP-stimulated glucocorticoid-receptor translocation promoter) (ASTP) (ATP:glycerol 3-phosphotransferase) −0.851 0.015
down Flot2 Q9Z2S9 FLOT2_RAT Flotillin-2 (Reggie-1) (REG-1) −0.988 0.015
down Cct2 Q5XIM9 TCPB_RAT T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) −0.685 0.015
down Coro1c A0A8I6GLR9 A0A8I6GLR9_RAT Coronin −0.495 0.015
down Akr1b1 P07943 ALDR_RAT Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) −0.468 0.015
down Atp8a1 F1LUT4 F1LUT4_RAT Phospholipid-transporting ATPase (EC 7.6.2.1) −0.856 0.016
down Cd82 O70352 CD82_RAT CD82 antigen (Metastasis suppressor Kangai-1 homolog) (CD antigen CD82) −0.403 0.016
down Mthfd1 P27653 C1TC_RAT C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] −0.492 0.016
down Sdha Q920L2 SDHA_RAT Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp) (Malate dehydrogenase [quinone] flavoprotein subunit) (EC 1.1.5.-) −0.442 0.016
down Gabbr2 O88871 GABR2_RAT Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) −0.514 0.016
down Acot13 D3ZA93 D3ZA93_RAT Acyl-coenzyme A thioesterase 13 (EC 3.1.2.2) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (Thioesterase superfamily member 2) −0.352 0.016
down Dlg4 P31016 DLG4_RAT Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90) −0.495 0.016
down Glud1 P10860 DHE3_RAT Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) (Memory-related gene 2 protein) (MRG-2) −0.440 0.016
down Aldh1b1 Q66HF8 AL1B1_RAT Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase family 1 member B1) −0.636 0.016
down Acot7 Q64559 BACH_RAT Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (ACH1) (ACT) (Acyl-CoA thioesterase 7) (Brain acyl-CoA hydrolase) (BACH) (CTE-IIa) (CTE-IIb) (CTE-II) (LACH1) (Long chain acyl-CoA thioester hydrolase) (MTE-II) −0.529 0.016
down Syngr3 D4ABK1 D4ABK1_RAT Synaptogyrin 3 −0.490 0.017
down Mpp3 O88954 MPP3_RAT MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) −0.855 0.017
down Ccdc22 P86182 CCD22_RAT Coiled-coil domain-containing protein 22 −1.363 0.017
down Arl15 A0A8I5ZSX7 A0A8I5ZSX7_RAT ADP-ribosylation factor-like protein 15 −0.679 0.017
down Prkar2a P12368 KAP2_RAT cAMP-dependent protein kinase type II-alpha regulatory subunit −0.585 0.017
down Uba2 A0A8I6A3Z5 A0A8I6A3Z5_RAT SUMO-activating enzyme subunit 2 (EC 2.3.2.-) −0.508 0.017
down Abat P50554 GABT_RAT 4-aminobutyrate aminotransferase, mitochondrial (beta-AlaAT I) (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT) [Cleaved into: 4-aminobutyrate aminotransferase, brain isoform; 4-aminobutyrate aminotransferase, liver isoform] −0.504 0.017
down Sucla2 F1LM47 F1LM47_RAT Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA) −0.345 0.017
down Pafah1b1 P63004 LIS1_RAT Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) −0.583 0.017
down Nedd4 Q62940 NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) −0.705 0.017
down Prkcb P68403 KPCB_RAT Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) −0.436 0.017
down Ptprs Q64605 PTPRS_RAT Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma) −0.744 0.017
down Ezr P31977 EZRI_RAT Ezrin (Cytovillin) (Villin-2) (p81) −0.744 0.018
down Dnm1 P21575 DYN1_RAT Dynamin-1 (EC 3.6.5.5) (B-dynamin) (D100) (Dynamin I) (Dynamin, brain) −0.652 0.018
down Ap3m2 P53678 AP3M2_RAT AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B) −0.550 0.018
down Rps4x P62703 RS4X_RAT Small ribosomal subunit protein eS4 (40S ribosomal protein S4, X isoform) −0.528 0.018
down Pdk1 Q63065 PDK1_RAT [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (PDK p48) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) −0.827 0.018
down Actr1b F7F067 F7F067_RAT Actin related protein 1B −0.504 0.018
down Ndufa12 F1LXA0 F1LXA0_RAT NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 −0.597 0.018
down Camk4 P13234 KCC4_RAT Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) (Calspermin) −0.594 0.018
down Kcnd2 Q63881 KCND2_RAT A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (RK5) (Shal1) (Voltage-gated potassium channel subunit Kv4.2) −0.818 0.018
down Dynll1 P63170 DYL1_RAT Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) −0.332 0.018
down Rgs7 P49803 RGS7_RAT Regulator of G-protein signaling 7 (RGS7) −0.915 0.018
down Idh3b A0A8I6AMM2 A0A8I6AMM2_RAT Isocitrate dehydrogenase [NAD] subunit, mitochondrial −0.435 0.018
down Syp P07825 SYPH_RAT Synaptophysin (Major synaptic vesicle protein p38) −0.385 0.018
down Rpl12 P23358 RL12_RAT Large ribosomal subunit protein uL11 (60S ribosomal protein L12) −0.304 0.018
down Acot2 O55171 ACOT2_RAT Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (ARTISt/p43) (Acyl coenzyme A thioester hydrolase) (MTE-I) (Very-long-chain acyl-CoA thioesterase) −0.475 0.019
down Ap3b2 A0ABK0LE23 A0ABK0LE23_RAT Adaptor related protein complex 3 subunit beta 2 −0.457 0.019
down Stxbp5l D3ZU84 D3ZU84_RAT Syntaxin binding protein 5L −0.839 0.019
down Ptges3 P83868 TEBP_RAT Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) −0.714 0.019
down Uqcrc1 Q68FY0 QCR1_RAT Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) −0.525 0.019
down Rogdi Q4V7D2 ROGDI_RAT Protein rogdi homolog −0.334 0.019
down Ctbp1 Q9Z2F5 CTBP1_RAT C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-) (50 kDa BFA-dependent ADP-ribosylation substrate) (BARS-50) (C-terminal-binding protein 3) (CtBP3) −0.656 0.019
down Atp1a1 P06685 AT1A1_RAT Sodium/potassium-transporting ATPase subunit alpha-1 (Na(+)/K(+) ATPase alpha-1 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-1) −0.373 0.019
down Gsk3a P18265 GSK3A_RAT Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1) −0.688 0.019
down Pgk1 P16617 PGK1_RAT Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) −0.407 0.019
down Cacna1e Q07652 CAC1E_RAT Voltage-dependent R-type calcium channel subunit alpha-1E (BII) (Brain calcium channel II) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (RBE-II) (RBE2) (Voltage-gated calcium channel subunit alpha Cav2.3) −0.721 0.019
down Syn2 Q63537 SYN2_RAT Synapsin-2 (Synapsin II) −0.676 0.019
down Slc2a3 Q07647 GTR3_RAT Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) −0.465 0.019
down Psat1 A0A0G2K931 A0A0G2K931_RAT Phosphoserine aminotransferase (EC 2.6.1.52) −0.453 0.019
down Plppr2 Q6W5G4 PLPR2_RAT Phospholipid phosphatase-related protein type 2 (Inactive phospholipid phosphatase PLPPR2) (Lipid phosphate phosphatase-related protein type 2) (Plasticity-related gene 4 protein) (PRG-4) −1.275 0.019
down Prpf8 G3V6H2 G3V6H2_RAT Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) −0.565 0.019
down Usp5 D3ZVQ0 D3ZVQ0_RAT Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) −0.407 0.019
down Gpd2 P35571 GPDM_RAT Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) −0.667 0.020
down Cops2 P61203 CSN2_RAT COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) −0.594 0.020
down Slc4a7 Q9R1N3 S4A7_RAT Sodium bicarbonate cotransporter 3 (Electroneutral sodium bicarbonate cotransporter 1) (NBC-like protein) (Solute carrier family 4 member 7) −1.337 0.020
down Hadhb Q60587 ECHB_RAT Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] −0.434 0.020
down Rps2 P27952 RS2_RAT Small ribosomal subunit protein uS5 (40S ribosomal protein S2) −0.404 0.020
down Twf2 B0BMY7 B0BMY7_RAT Twinfilin actin-binding protein 2 −0.989 0.020
down Dclk1 O08875 DCLK1_RAT Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Calcium/calmodulin-dependent protein kinase type I-like CPG16) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1) −0.593 0.020
down Agap2 Q8CGU4 AGAP2_RAT Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE) −0.653 0.020
down Lap3 Q68FS4 AMPL_RAT Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (LAP) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) −0.413 0.020
down Tubb3 Q4QRB4 TBB3_RAT Tubulin beta-3 chain (Neuron-specific class III beta-tubulin) −1.201 0.020
down Msra Q923M1 MSRA_RAT Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR) −0.455 0.020
down Cyrib A0A0G2JXI6 A0A0G2JXI6_RAT CYFIP related Rac1 interactor B −0.364 0.020
down Tcp1 P28480 TCPA_RAT T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) −0.341 0.020
down Slc4a4 Q9JI66 S4A4_RAT Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (NBC-like protein) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) −0.438 0.020
down Ppp2r1a Q5XI34 Q5XI34_RAT Protein phosphatase 2 scaffold subunit A alpha −0.549 0.021
down Bcat1 P54690 BCAT1_RAT Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) −0.425 0.021
down Pcbp2 Q6AYU2 Q6AYU2_RAT Poly(rC) binding protein 2 −0.366 0.021
down Acat2 Q5XI22 THIC_RAT Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase) −0.773 0.021
down Ap2s1 P62744 AP2S1_RAT AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma-adaptin 3b) (Sigma2-adaptin) −0.350 0.021
down Hnrnph2 Q6AY09 HNRH2_RAT Heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) (Heterogeneous nuclear ribonucleoprotein H') (hnRNP H') [Cleaved into: Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed] −1.444 0.021
down Cmas P69060 NEUA_RAT N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) −0.661 0.021
down Arpc2 P85970 ARPC2_RAT Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) −0.398 0.021
down Mlf2 A0A0G2K8Z8 A0A0G2K8Z8_RAT Myeloid leukemia factor 2 −0.457 0.021
down Oat P04182 OAT_RAT Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine--oxo-acid aminotransferase) −0.638 0.021
down Chordc1 D4A4T9 CHRD1_RAT Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHP-1) (Morgana) −0.478 0.021
down Cyb5r3 P20070 NB5R3_RAT NADH-cytochrome b5 reductase 3 (B5R) (Cytochrome b5 reductase) (EC 1.6.2.2) (Diaphorase-1) −0.594 0.021
down Sdhc Q641Z9 Q641Z9_RAT Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (Integral membrane protein CII-3) (Malate dehydrogenase [quinone] cytochrome b560 subunit) (QPs-1) −0.533 0.021
down Fbxl16 Q5MJ12 FXL16_RAT F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) (Spinal cord injury and regeneration-related protein 1) −0.510 0.022
down Rap1gap2 A0A0G2K0S7 A0A0G2K0S7_RAT RAP1 GTPase activating protein 2 −1.482 0.022
down Ola1 A0JPJ7 OLA1_RAT Obg-like ATPase 1 −0.473 0.022
down Cbr4 Q7TS56 CBR4_RAT 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) (3-ketoacyl-[acyl-carrier-protein] reductase beta subunit) (KAR beta subunit) (Carbonyl reductase family member 4) (CBR4) (Quinone reductase CBR4) (EC 1.6.5.10) −1.124 0.022
down Syt1 P21707 SYT1_RAT Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) −0.359 0.022
down Slc25a25 Q8K3P6 SCMC2_RAT Mitochondrial adenyl nucleotide antiporter SLC25A25 (Mitochondrial calcium-dependent solute carrier) (Short calcium-binding mitochondrial carrier protein 2) (SCaMC-2) (Solute carrier family 25 member 25) −0.910 0.022
down Nras Q04970 RASN_RAT GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras) −0.324 0.022
down Hsp90ab1 P34058 HS90B_RAT Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84) −1.065 0.022
down Idh2 P56574 IDHP_RAT Isocitrate dehydrogenase [NADP], mitochondrial (IDH) (EC 1.1.1.42) (ICD-M) (IDP) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) −0.433 0.023
down Paics P51583 PUR6_RAT Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)] −0.649 0.023
down Npepps F1M9V7 F1M9V7_RAT Aminopeptidase (EC 3.4.11.-) −0.430 0.023
down Gda Q9WTT6 GUAD_RAT Guanine deaminase (Guanase) (Guanine aminase) (EC 3.5.4.3) (Guanine aminohydrolase) (GAH) −0.415 0.023
down Bri3bp A0A8I6AHD0 A0A8I6AHD0_RAT Bri3 binding protein −1.253 0.023
down Myo5a Q9QYF3 MYO5A_RAT Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) −0.415 0.023
down Ndufs7 F7ELE5 F7ELE5_RAT NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial (EC 7.1.1.2) (Complex I-20kD) (NADH-ubiquinone oxidoreductase 20 kDa subunit) −1.548 0.023
down Acsl6 P33124 ACSL6_RAT Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6) (Long-chain-fatty-acid--CoA ligase, brain isozyme) −1.003 0.023
down Nrxn1 Q63372 NRX1A_RAT Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) −0.407 0.023
down Ppm1e Q80Z30 PPM1E_RAT Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA) −0.369 0.023
down Rps9 P29314 RS9_RAT Small ribosomal subunit protein uS4 (40S ribosomal protein S9) −0.415 0.023
down Ap2b1 P62944 AP2B1_RAT AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) −0.632 0.023
down Ncdn O35095 NCDN_RAT Neurochondrin (Neurite outgrowth-related protein from the rat brain) (Norbin) −0.441 0.023
down Vdac1 Q9Z2L0 VDAC1_RAT Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (rVDAC1) −0.507 0.023
down Adap1 O88768 O88768_RAT ArfGAP with dual PH domains 1 (IP4/PIP3 binding protein) −1.194 0.023
down Cdc42 Q8CFN2 CDC42_RAT Cell division control protein 42 homolog (EC 3.6.5.2) −0.427 0.023
down Napa P54921 SNAA_RAT Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha) −0.417 0.024
down Mal2 Q7TPB7 Q7TPB7_RAT MAL2A (Mal, T-cell differentiation protein 2) −0.396 0.024
down Gnai1 P10824 GNAI1_RAT Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) −0.333 0.024
down Grk2 P26817 ARBK1_RAT Beta-adrenergic receptor kinase 1 (Beta-ARK-1) (EC 2.7.11.15) (G-protein-coupled receptor kinase 2) −0.518 0.024
down Ndufs2 Q641Y2 NDUS2_RAT NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit) −0.433 0.024
down Cs Q8VHF5 CISY_RAT Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase) −0.428 0.024
down Eif3d Q6AYK8 EIF3D_RAT Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) −0.950 0.024
down Mtch2 A0A8I6AK45 A0A8I6AK45_RAT Mitochondrial carrier homolog 2 −0.511 0.024
down Tubb4a A6KQR9 A6KQR9_RAT Tubulin beta chain −1.041 0.024
down Rasal1 D3ZHY9 D3ZHY9_RAT RAS protein activator like 1 −0.525 0.024
down Gak P97874 GAK_RAT Cyclin-G-associated kinase (EC 2.7.11.1) (DnaJ homolog subfamily C member 26) −0.689 0.025
down Rap2b P61227 RAP2B_RAT Ras-related protein Rap-2b (EC 3.6.5.2) −0.663 0.025
down Gpi Q6P6V0 G6PI_RAT Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) −0.412 0.025
down Mtnd1 P03889 NU1M_RAT NADH-ubiquinone oxidoreductase chain 1 (EC 7.1.1.2) (NADH dehydrogenase subunit 1) −0.753 0.025
down Phb1 P67779 PHB1_RAT Prohibitin 1 −0.348 0.025
down Dnaja3 G3V6I5 G3V6I5_RAT DnaJ heat shock protein family (Hsp40) member A3 −0.445 0.025
down Agk D3Z9L0 D3Z9L0_RAT Acylglycerol kinase, mitochondrial (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) −0.741 0.025
down Pcyt2 O88637 PCY2_RAT Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) −0.703 0.025
down Prxl2a Q6AXX6 PXL2A_RAT Peroxiredoxin-like 2A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) (Redox-regulatory protein FAM213A) (Sperm head protein 1) −0.873 0.025
down Cds2 Q91XU8 CDS2_RAT Phosphatidate cytidylyltransferase 2 (EC 2.7.7.41) (CDP-DAG synthase 2) (CDP-DG synthase 2) (CDP-diacylglycerol synthase 2) (CDS 2) (CDP-diglyceride pyrophosphorylase 2) (CDP-diglyceride synthase 2) (CTP:phosphatidate cytidylyltransferase 2) −0.376 0.025
down Rpl23 P62832 RL23_RAT Large ribosomal subunit protein uL14 (60S ribosomal protein L23) −0.934 0.025
down Gars1 Q5I0G4 GARS_RAT Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1) −0.466 0.025
down Diras1 D4A304 D4A304_RAT DIRAS family GTPase 1 −0.960 0.025
down Alg2 G3V6U3 G3V6U3_RAT Alpha-1,3/1,6-mannosyltransferase ALG2 (EC 2.4.1.132) (EC 2.4.1.257) (GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase) −0.672 0.025
down L2hgdh D3ZVS2 D3ZVS2_RAT L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.2) −0.567 0.025
down Esd B0BNE5 ESTD_RAT S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) −0.463 0.025
down Sars1 Q6P799 SYSC_RAT Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) −0.456 0.025
down Sod2 P07895 SODM_RAT Superoxide dismutase [Mn], mitochondrial (EC 1.15.1.1) −0.391 0.025
down Dcps Q8K4F7 DCPS_RAT m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) −0.804 0.026
down Suclg1 P13086 SUCA_RAT Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) −1.586 0.026
down Lta4h P30349 LKHA4_RAT Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) −0.384 0.026
down Ubxn6 A0A0G2K012 A0A0G2K012_RAT UBX domain-containing protein 6 (UBX domain-containing protein 1) −0.448 0.026
down Pcyox1 Q99ML5 PCYOX_RAT Prenylcysteine oxidase 1 (EC 1.8.3.5) (Chloride ion pump-associated 55 kDa protein) −0.605 0.026
down Mpc2 P38718 MPC2_RAT Mitochondrial pyruvate carrier 2 (Brain protein 44) (Protein 0-44) −0.318 0.026
down Capn2 Q07009 CAN2_RAT Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) −0.669 0.026
down Nrxn3 Q07310 NRX3A_RAT Neurexin-3 (Neurexin III-alpha) (Neurexin-3-alpha) −0.438 0.027
down NA Q6LED0 H31_RAT Histone H3.1 −0.530 0.027
down Decr1 Q64591 DECR_RAT 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) −0.602 0.027
down Ldha P04642 LDHA_RAT L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (LDH muscle subunit) (LDH-M) −0.311 0.027
down Atl1 Q6PST4 ATLA1_RAT Atlastin-1 (EC 3.6.5.-) (Spastic paraplegia 3A homolog) −0.509 0.027
down Arf5 P84083 ARF5_RAT ADP-ribosylation factor 5 −0.691 0.028
down Psma4 P21670 PSA4_RAT Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) −0.473 0.028
down Yars1 Q4KM49 SYYC_RAT Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] −0.356 0.028
down Rap1b Q62636 RAP1B_RAT Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B) −0.789 0.029
down Hsd17b10 O70351 HCD2_RAT 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) −0.394 0.029
down Dld Q6P6R2 DLDH_RAT Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) −0.557 0.029
down Gpx4 P36970 GPX4_RAT Phospholipid hydroperoxide glutathione peroxidase (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) (EC 1.11.1.9) −0.527 0.029
down Plxna4 D3ZES7 D3ZES7_RAT Plexin-A4 −0.956 0.030
down Dync1i2 Q62871 DC1I2_RAT Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2) −0.505 0.031
down Spr P18297 SPRE_RAT Sepiapterin reductase (SPR) (EC 1.1.1.153) −0.265 0.031
down Gnaz P19627 GNAZ_RAT Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) −0.504 0.031
down Exoc6b A0A0G2JYR1 A0A0G2JYR1_RAT Exocyst complex component −1.215 0.031
down Acaa2 P13437 THIM_RAT 3-ketoacyl-CoA thiolase, mitochondrial (EC 2.3.1.16) (Acetyl-CoA acetyltransferase) (EC 2.3.1.9) (Acetyl-CoA acyltransferase) (Acyl-CoA hydrolase, mitochondrial) (EC 3.1.2.-, EC 3.1.2.1, EC 3.1.2.2) (Beta-ketothiolase) (Mitochondrial 3-oxoacyl-CoA thiolase) −0.843 0.031
down Nudt3 Q566C7 NUDT3_RAT Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59) −1.062 0.031
down Abr A0A0G2JTR4 ABR_RAT Active breakpoint cluster region-related protein −0.584 0.031
down Ddx39b Q63413 DX39B_RAT Spliceosome RNA helicase Ddx39b (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein Uap56) −0.529 0.031
down Psmc4 Q63570 PRS6B_RAT 26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (Proteasome 26S subunit ATPase 4) (S6 ATPase) (Tat-binding protein 7) (TBP-7) −0.362 0.031
down Mtco2 P00406 COX2_RAT Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II) −0.382 0.032
down Hspa8 P63018 HSP7C_RAT Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) −0.323 0.032
down Kctd16 A0ABK0M5I7 A0ABK0M5I7_RAT Potassium channel tetramerization domain containing 16 −0.833 0.033
down Rpl18 P12001 RL18_RAT Large ribosomal subunit protein eL18 (60S ribosomal protein L18) −0.446 0.033
down Map2k4 S4VP54 S4VP54_RAT Dual specificity mitogen-activated protein kinase kinase 4 (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (SAPK/ERK kinase 1) −0.360 0.033
down Gga1 A0A8I6GLY6 A0A8I6GLY6_RAT Golgi associated, gamma adaptin ear containing, ARF binding protein 1 −0.900 0.033
down Samm50 Q6AXV4 SAM50_RAT Sorting and assembly machinery component 50 homolog −0.670 0.033
down Cnn3 P37397 CNN3_RAT Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform) −0.578 0.033
down Actn1 Q9Z1P2 ACTN1_RAT Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1) −0.370 0.033
down Rps15a P62246 RS15A_RAT Small ribosomal subunit protein uS8 (40S ribosomal protein S15a) −0.378 0.034
down Dnajc11 A6IUF7 A6IUF7_RAT DnaJ homolog subfamily C member 11 −0.946 0.034
down Babam2 Q6P7Q1 BABA2_RAT BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) −1.145 0.034
down Kyat3 Q58FK9 KAT3_RAT Kynurenine--oxoglutarate transaminase 3 (EC 2.6.1.7) (Cysteine-S-conjugate beta-lyase 2) (EC 4.4.1.13) (Kynurenine aminotransferase 3) (Kynurenine aminotransferase III) (KATIII) (Kynurenine--glyoxylate transaminase) (EC 2.6.1.63) (Kynurenine--oxoglutarate transaminase III) −0.742 0.034
down Slc17a7 Q62634 VGLU1_RAT Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7) −0.373 0.034
down Dlg2 Q63622 DLG2_RAT Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) −0.366 0.034
down Celf2 Q792H5 CELF2_RAT CUGBP Elav-like family member 2 (CELF-2) (Bruno-like protein 3) (CUG triplet repeat RNA-binding protein 2) (CUG-BP2) (CUG-BP- and ETR-3-like factor 2) (ELAV-type RNA-binding protein 3) (ETR-3) (Protein ETR-R3) (Neuroblastoma apoptosis-related RNA-binding protein) (rNapor) (RNA-binding protein BRUNOL-3) −0.335 0.034
down Eprs1 Q6TXE9 Q6TXE9_RAT Bifunctional glutamate/proline--tRNA ligase (EC 6.1.1.15) (Bifunctional aminoacyl-tRNA synthetase) −0.670 0.034
down NA Q6LED0 H31_RAT Histone H3.1 −0.716 0.034
down Rhob P62747 RHOB_RAT Rho-related GTP-binding protein RhoB −0.300 0.034
down Cnp P13233 CN37_RAT 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37) −0.314 0.034
down Anxa11 A0A8I6A5R0 A0A8I6A5R0_RAT Annexin −0.581 0.034
down Alcam O35112 CD166_RAT CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166) −0.453 0.034
down Vps35 G3V8A5 G3V8A5_RAT Vacuolar protein sorting-associated protein 35 −0.452 0.034
down Txnrd1 O89049 TRXR1_RAT Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (NADPH-dependent thioredoxin reductase) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1) −0.532 0.035
down Grm3 P31422 GRM3_RAT Metabotropic glutamate receptor 3 (mGluR3) −0.708 0.035
down Myh10 Q9JLT0 MYH10_RAT Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) −0.424 0.035
down Gnas P63095 GNAS2_RAT Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (G-alpha-8) −0.361 0.035
down Rpl4 P50878 RL4_RAT Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) −0.461 0.035
down Arhgef2 Q5FVC2 ARHG2_RAT Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) −0.423 0.035
down Cbx5 B2RYU7 B2RYU7_RAT Cbx5 protein (Chromobox 5) (Chromobox homolog 5 (HP1 alpha homolog, Drosophila)) −0.877 0.036
down Gls P13264 GLSK_RAT Glutaminase kidney isoform, mitochondrial (GLS) (EC 3.5.1.2) (K-glutaminase) (L-glutamine amidohydrolase) [Cleaved into: Glutaminase kidney isoform, mitochondrial 68 kDa chain; Glutaminase kidney isoform, mitochondrial 65 kDa chain] −0.370 0.036
down Rras2 Q5BJU0 Q5BJU0_RAT RAS related 2 −0.790 0.036
down Crmp1 Q62950 DPYL1_RAT Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) −0.675 0.036
down Sec23a B5DFC3 B5DFC3_RAT Protein transport protein SEC23 −1.244 0.036
down Atp6v0d1 A0A8I6AMP1 A0A8I6AMP1_RAT V-type proton ATPase subunit −0.358 0.036
down Hapln1 P03994 HPLN1_RAT Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein) −0.315 0.037
down Ttyh1 P0C5X8 TTYH1_RAT Protein tweety homolog 1 (Volume-regulated anion channel subunit Ttyh1) −0.511 0.037
down Eef1a1 P62630 EF1A1_RAT Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) −1.125 0.038
down Afg3l2 F1LN92 F1LN92_RAT AFG3 like matrix AAA peptidase subunit 2 −0.498 0.038
down Hycc2 Q4V7D4 Q4V7D4_RAT Family with sequence similarity 126, member B (Hyccin PI4KA lipid kinase complex subunit 2) −0.392 0.038
down Rap2a A0ABK0M907 A0ABK0M907_RAT Uncharacterized protein −0.362 0.038
down Acsbg1 Q924N5 ACBG1_RAT Long-chain-fatty-acid--CoA ligase ACSBG1 (EC 6.2.1.3) (Acyl-CoA synthetase bubblegum family member 1) (Gonadotropin-regulated long chain acyl CoA synthetase) (GR-LACS) −0.350 0.038
down Gstp1 P04906 GSTP1_RAT Glutathione S-transferase P (EC 2.5.1.18) (Chain 7) (GST 7-7) (GST class-pi) −0.335 0.038
down Eif3c B5DFC8 EIF3C_RAT Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110) −0.451 0.039
down Opa1 Q2TA68 OPA1_RAT Dynamin-like GTPase OPA1, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1 homolog) [Cleaved into: Dynamin-like GTPase OPA1, long form (L-OPA1); Dynamin-like GTPase OPA1, short form (S-OPA1)] −0.340 0.039
down Pgd P85968 6PGD_RAT 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) −0.366 0.039
down Fkbp4 Q9QVC8 FKBP4_RAT Peptidyl-prolyl cis-trans isomerase FKBP4 (PPIase FKBP4) (EC 5.2.1.8) (52 kDa FK506-binding protein) (52 kDa FKBP) (FKBP-52) (59 kDa immunophilin) (p59) (FK506-binding protein 4) (FKBP-4) (FKBP59) (HSP-binding immunophilin) (HBI) (Immunophilin FKBP52) (Rotamase) [Cleaved into: Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed] −0.322 0.039
down Ilf2 Q7TP98 ILF2_RAT Interleukin enhancer-binding factor 2 (Liver regeneration-related protein LRRG031) −0.486 0.040
down Gstm5 Q9Z1B2 GSTM5_RAT Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) −0.371 0.040
down Camk2g P11730 KCC2G_RAT Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17) −0.695 0.041
down Ddb1 Q9ESW0 DDB1_RAT DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) −0.469 0.041
down Aars1 P50475 SYAC_RAT Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) −0.403 0.041
down Tspan2 Q9JJW1 TSN2_RAT Tetraspanin-2 (Tspan-2) −1.581 0.041
down Usp14 A0A8I5ZY29 A0A8I5ZY29_RAT Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) −0.479 0.041
down Sipa1l3 F1LYG2 F1LYG2_RAT Signal-induced proliferation-associated 1 like 3 −0.493 0.041
down Srm Q99MI5 Q99MI5_RAT Spermidine synthase (EC 2.5.1.16) (Putrescine aminopropyltransferase) −0.441 0.042
down Nars1 F1LPV0 F1LPV0_RAT Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (Asparaginyl-tRNA synthetase 1) −0.517 0.042
down Htt P51111 HD_RAT Huntingtin (Huntington disease protein homolog) (HD protein homolog) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] −0.691 0.042
down Src Q9WUD9 SRC_RAT Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src) −0.806 0.042
down Plpbp A0A8I6AQ45 A0A8I6AQ45_RAT Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) (Proline synthase co-transcribed bacterial homolog protein) −1.392 0.042
down Inpp1 A6INV6 A6INV6_RAT Inositol polyphosphate 1-phosphatase (EC 3.1.3.57) −0.913 0.043
down Lancl2 Q68FQ9 Q68FQ9_RAT LanC-like protein 2 (Testis-specific adriamycin sensitivity protein) −0.490 0.043
down Srgap3 F1M5M9 F1M5M9_RAT SLIT-ROBO Rho GTPase-activating protein 3 (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) −0.395 0.043
down Slc25a5 Q09073 ADT2_RAT ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed] −1.492 0.043
down Rab5a M0RC99 RAB5A_RAT Ras-related protein Rab-5A (EC 3.6.5.2) (Small GTP-binding protein rab5) −0.302 0.043
down Epb41l1 Q9WTP0 E41L1_RAT Band 4.1-like protein 1 (Erythrocyte membrane protein band 4.1-like 1) (Neuronal protein 4.1) (4.1N) −0.330 0.044
down Rhog Q32PX6 Q32PX6_RAT Rho-related GTP-binding protein RhoG −0.530 0.044
down Pi4ka O08662 PI4KA_RAT Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) −0.438 0.044
down Slc25a11 P97700 M2OM_RAT Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) −0.383 0.044
down Rab3b Q63941 RAB3B_RAT Ras-related protein Rab-3B (EC 3.6.5.2) −0.697 0.044
down Vps26a Q6AY86 VP26A_RAT Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) −0.413 0.044
down Snrpd1 A6KNE7 A6KNE7_RAT Small nuclear ribonucleoprotein Sm D1 (snRNP core protein D1) −0.807 0.044
down Aldh1l1 P28037 AL1L1_RAT Cytosolic 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (FDH) (EC 1.5.1.6) (Aldehyde dehydrogenase family 1 member L1) (FBP-CI) −0.549 0.044
down Napb P85969 SNAB_RAT Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta) −0.334 0.045
down Kpnb1 P52296 IMB1_RAT Importin subunit beta-1 (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) −0.322 0.045
down Klc1 P37285 KLC1_RAT Kinesin light chain 1 (KLC 1) −0.279 0.045
down Mat2a P18298 METK2_RAT S-adenosylmethionine synthase isoform type-2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2) (Methionine adenosyltransferase II) (MAT-II) −0.745 0.045
down Cap2 P52481 CAP2_RAT Adenylyl cyclase-associated protein 2 (CAP 2) −0.295 0.045
down Pdxp Q8VD52 PLPP_RAT Chronophin (EC 3.1.3.16) (EC 3.1.3.74) (Pyridoxal phosphate phosphatase) (PLP phosphatase) (Reg I-binding protein 1) −0.308 0.045
down Ndufa10 Q561S0 NDUAA_RAT NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit) −0.319 0.046
down Myadm Q6VBQ5 MYADM_RAT Myeloid-associated differentiation marker (Myeloid up-regulated protein) −1.469 0.046
down Septin4 A0A096MJN4 SEPT4_RAT Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (Arts) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2) −0.434 0.046
down Ppa1 A0A8I6AI23 A0A8I6AI23_RAT inorganic diphosphatase (EC 3.6.1.1) −0.311 0.046
down Slc6a17 P31662 S6A17_RAT Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17) −0.621 0.047
down Ndufa4 A6IDY9 A6IDY9_RAT Cytochrome c oxidase subunit NDUFA4 −0.261 0.047
down Snap47 Q6P6S0 SNP47_RAT Synaptosomal-associated protein 47 (SNAP-47) (Synaptosomal-associated 47 kDa protein) −0.429 0.047
down Nudcd2 Q5M823 NUDC2_RAT NudC domain-containing protein 2 −0.710 0.047
down Rpl6 P21533 RL6_RAT Large ribosomal subunit protein eL6 (60S ribosomal protein L6) (Neoplasm-related protein C140) −0.423 0.048
down Pmm1 A6HT35 A6HT35_RAT Phosphomannomutase (EC 5.4.2.8) −0.591 0.048
down Trim9 Q91ZY8 TRIM9_RAT E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM9) (SNAP-25-interacting RING finger protein) (Tripartite motif-containing protein 9) −0.474 0.048
down Rpl7a P62425 RL7A_RAT Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) −0.416 0.049
down S1pr1 P48303 S1PR1_RAT Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363) −1.402 0.049
down Tomm70 Q75Q39 TOM70_RAT Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70) −0.509 0.049
down Slc7a5 Q63016 LAT1_RAT Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (Integral membrane protein E16) (Protein TA1) (L-type amino acid transporter 1) (LAT-1) (Solute carrier family 7 member 5) −0.349 0.050

gt 2 - Young (EE vs SH)

# EE VS SH (Young)
# gt 2 - by fold change direction & pvalue
lit_review_proteomics_sig |> 
  dplyr::ungroup() |>
  dplyr:: filter(Condition == "young") %>%
  #dplyr::select(-(c(`Av. Ratio`, ))) |>
  dplyr::select(c(Condition, In_EE, Gene_name, Entry, Entry.Name,
                  Protein.names, Fold_change, adj.P.Val)) |>
  dplyr::arrange(desc(In_EE), adj.P.Val, Fold_change) |>
  gt(
    groupname_col = "Condition",
    rowname_col = "In_EE"
  ) |>
  fmt_number(decimals = 3) |>
    tab_header(
    title = "Young - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only)",
    subtitle = "2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by young)"
    ) |>
    tab_options(table.font.size=11.5,
                stub.font.weight = "bold",
                row_group.font.weight = "bold",
                row_group.font.size = 12.5,
                column_labels.font.size = 12.5,
                column_labels.font.weight = "bold")
Young - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only)
2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by young)
Gene_name Entry Entry.Name Protein.names Fold_change adj.P.Val
young
up H1-0 P43278 H10_RAT Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] 1.078 0.007
up Wasl O08816 WASL_RAT Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) 1.423 0.007
up Basp1 Q05175 BASP1_RAT Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) 1.038 0.010
up H1-4 P15865 H14_RAT Histone H1.4 (H1d) 1.450 0.010
up Slc9a1 P26431 SL9A1_RAT Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) 0.866 0.010
up Rph3a P47709 RP3A_RAT Rabphilin-3A (Exophilin-1) 0.968 0.010
up Map6 Q63560 MAP6_RAT Microtubule-associated protein 6 (MAP-6) (145-kDa STOP) (STOP145) (Stable tubule-only polypeptide) (STOP) 1.026 0.010
up Ptprn2 Q63475 PTPR2_RAT Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (PTP NE-6) (PTPNE6) (Phogrin) [Cleaved into: IA-2beta60] 1.095 0.010
up Txn P11232 THIO_RAT Thioredoxin (Trx) 1.157 0.010
up Atp5pf P21571 ATP5J_RAT ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) 1.203 0.010
up Hdgfl3 Q923W4 HDGR3_RAT Hepatoma-derived growth factor-related protein 3 (HRP-3) 1.401 0.010
up Hgs Q9JJ50 HGS_RAT Hepatocyte growth factor-regulated tyrosine kinase substrate (SNAP-25-interacting protein Hrs-2) 0.942 0.010
up Sod1 P07632 SODC_RAT Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) 1.305 0.011
up Dtd1 A0A8I6A4Q0 A0A8I6A4Q0_RAT D-aminoacyl-tRNA deacylase (EC 3.1.1.96) 1.002 0.012
up Syn3 O70441 SYN3_RAT Synapsin-3 (Synapsin III) 1.028 0.012
up Rgs10 P49806 RGS10_RAT Regulator of G-protein signaling 10 (RGS10) 1.417 0.012
up Chchd4 Q5BJN5 MIA40_RAT Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) 1.101 0.012
up Tsr2 A0A8I5ZLR7 A0A8I5ZLR7_RAT Pre-rRNA-processing protein TSR2 homolog 0.975 0.012
up Bag3 A6IA08 A6IA08_RAT BAG family molecular chaperone regulator 3 (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) 1.289 0.012
up Slc32a1 O35458 VIAAT_RAT Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (rGVAT) (rat UNC-47 homolog) (RUNC-47) 1.053 0.012
up Mical3 D3ZGN7 D3ZGN7_RAT F-actin monooxygenase (EC 1.14.13.225) 1.092 0.013
up Psip1 Q812D1 PSIP1_RAT PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) 1.100 0.013
up Tceal5 A0ABK0KXI7 A0ABK0KXI7_RAT Transcription elongation factor A like 5 1.222 0.013
up Scg3 P47868 SCG3_RAT Secretogranin-3 (1B1075) (Secretogranin III) (SgIII) 1.035 0.013
up Mbp P02688 MBP_RAT Myelin basic protein (MBP) 1.132 0.014
up NA Q6LED0 H31_RAT Histone H3.1 0.786 0.014
up Rbmx Q4V898 RBMX_RAT RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) (RNA-binding motif protein, X chromosome retrogene) (RNA-binding motif protein, X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] 0.843 0.015
up Bod1 Q6AYJ2 BOD1_RAT Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) 1.156 0.015
up Rims1 Q9JIR4 RIMS1_RAT Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) 0.683 0.016
up Nfu1 D3ZA85 D3ZA85_RAT NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5) 0.842 0.016
up Cdkn1b O08769 O08769_RAT Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) 0.679 0.017
up Fam169a D3ZKX8 D3ZKX8_RAT Family with sequence similarity 169, member A 0.803 0.017
up Akap12 Q5QD51 AKA12_RAT A-kinase anchor protein 12 (AKAP-12) 0.869 0.017
up Cltb P08082 CLCB_RAT Clathrin light chain B (Lcb) 1.159 0.017
up Txndc17 A0ABK0M2Q2 A0ABK0M2Q2_RAT Thioredoxin domain containing 17 2.379 0.017
up Vgf P20156 VGF_RAT Neurosecretory protein VGF (VGF8a protein) [Cleaved into: VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-11; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-30; VGF-derived peptide TLQP-62; VGF-derived peptide HFHH-10; VGF-derived peptide AQEE-30; VGF-derived peptide LQEQ-19] 1.099 0.017
up Gap43 P07936 NEUM_RAT Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Protein F1) 1.110 0.018
up Ythdf3 A0A8I6ACC2 A0A8I6ACC2_RAT YTH domain-containing family protein 0.965 0.018
up Fabp3 P07483 FABPH_RAT Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) 0.758 0.019
up Map1a P34926 MAP1A_RAT Microtubule-associated protein 1A (MAP-1A) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] 1.046 0.019
up Bsn O88778 BSN_RAT Protein bassoon 0.728 0.019
up Pclo Q9JKS6 PCLO_RAT Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) 0.991 0.019
up Hcn1 Q9JKB0 HCN1_RAT Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 0.955 0.020
up Shroom2 Q7TP36 SHRM2_RAT Protein Shroom2 (Liver regeneration-related protein LRRG167) (Protein Apxl) 1.044 0.020
up Lmtk3 F1LSB5 F1LSB5_RAT non-specific serine/threonine protein kinase (EC 2.7.11.1) 0.922 0.021
up Ube2v2 Q7M767 UB2V2_RAT Ubiquitin-conjugating enzyme E2 variant 2 (Ubiquitin-conjugating enzyme variant MMS2) 2.170 0.021
up Snap25 P60881 SNP25_RAT Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein) 0.743 0.021
up Ubap2l A0A8I5ZUK2 A0A8I5ZUK2_RAT Ubiquitin associated protein 2-like 1.031 0.021
up Tsc22d1 P62501 T22D1_RAT TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) 1.260 0.021
up Clta P08081 CLCA_RAT Clathrin light chain A (Lca) 0.859 0.022
up Glg1 Q62638 GSLG1_RAT Golgi apparatus protein 1 (E-selectin ligand 1) (ESL-1) (Golgi sialoglycoprotein MG-160) 0.598 0.023
up Prrc2c A0A8I5Y7A0 A0A8I5Y7A0_RAT Proline-rich coiled-coil 2C 1.062 0.023
up Amph O08838 AMPH_RAT Amphiphysin 0.876 0.024
up Ppp1r1b Q6J4I0 PPR1B_RAT Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) 0.972 0.024
up Ppp1r11 Q6MFY6 PP1RB_RAT E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Protein phosphatase 1 regulatory subunit 11) 0.911 0.025
up Spock2 A0A8I5ZQG2 A0A8I5ZQG2_RAT Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2) 1.379 0.025
up Tppp D3ZQL7 TPPP_RAT Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p25-alpha) 0.631 0.025
up Sarnp Q498U4 SARNP_RAT SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1) 0.938 0.025
up Efhd2 Q4FZY0 EFHD2_RAT EF-hand domain-containing protein D2 (Swiprosin-1) 1.061 0.025
up Sorbs2 O35413 SRBS2_RAT Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Neural ArgBP2) (nArgBP2) (Sorbin) 1.470 0.025
up Ldah Q5HZX7 LDAH_RAT Lipid droplet-associated hydrolase (EC 3.1.1.13) (Lipid droplet-associated serine hydrolase) 1.742 0.025
up Ppp1r12a Q10728 MYPT1_RAT Protein phosphatase 1 regulatory subunit 12A (MBSP) (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) (Protein phosphatase subunit 1M) (PP-1M) (Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110) 0.831 0.025
up Gfer Q63042 ALR_RAT FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) 0.968 0.026
up Bnip3l A6K6N6 A6K6N6_RAT BCL2 interacting protein 3 like (BCL2/adenovirus E1B interacting protein 3-like) 1.662 0.026
up Pdap1 Q62785 HAP28_RAT 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) 1.066 0.026
up Spart E9PT90 E9PT90_RAT Spartin 1.712 0.026
up Tppp3 Q5PPN5 TPPP3_RAT Tubulin polymerization-promoting protein family member 3 0.985 0.026
up Gprin1 A0A8I6AJM0 A0A8I6AJM0_RAT G protein-regulated inducer of neurite outgrowth 1 1.333 0.026
up Oxsr1 A0A8I5ZNK2 OXSR1_RAT Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) 0.777 0.027
up Wipf3 Q9Z0G8 WIPF3_RAT WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16) 0.901 0.028
up Prrt3 D3ZWQ0 D3ZWQ0_RAT Proline-rich transmembrane protein 3 0.901 0.028
up Zdhhc5 Q2THW7 ZDHC5_RAT Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) 1.603 0.028
up Ahnak A0A0G2JUA5 A0A0G2JUA5_RAT AHNAK nucleoprotein 1.184 0.030
up Hspe1 P26772 CH10_RAT 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) 0.974 0.030
up Fkbp3 G3V6L9 G3V6L9_RAT peptidylprolyl isomerase (EC 5.2.1.8) 0.553 0.032
up 2900026A02Rik NA NA NA 0.601 0.032
up Marcks P30009 MARCS_RAT Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein) 1.097 0.032
up Pacsin2 Q9QY17 PACN2_RAT Protein kinase C and casein kinase substrate in neurons 2 protein (Synaptic dynamin-associated protein II) (Syndapin-2) (Syndapin-II) (SdpII) 0.549 0.032
up Habp4 A1L1K8 HABP4_RAT Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) 0.537 0.033
up Atp6v1g1 A0A8I6B3N3 A0A8I6B3N3_RAT V-type proton ATPase subunit G 0.608 0.033
up Shank2 Q9QX74 SHAN2_RAT SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3) 0.613 0.033
up Eif4b A0ABK0LP36 A0ABK0LP36_RAT Eukaryotic translation initiation factor 4B 0.732 0.033
up Naca M0R9L0 M0R9L0_RAT Nascent polypeptide associated complex subunit alpha 0.779 0.033
up Eif3j1 NA NA NA 0.796 0.033
up Cacna1b Q02294 CAC1B_RAT Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) 0.904 0.033
up Polr2m Q91XQ4 GRL1A_RAT DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) 1.024 0.033
up Zfp428 A0A0G2K1B1 A0A0G2K1B1_RAT Zinc finger protein 428 1.009 0.033
up Sf1 F1LM37 F1LM37_RAT Splicing factor 1 0.945 0.034
up Scg2 P10362 SCG2_RAT Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] 1.048 0.034
up Necab2 F1LQY6 NECA2_RAT N-terminal EF-hand calcium-binding protein 2 (EF-hand calcium-binding protein 2) (Neuronal calcium-binding protein 2) 0.539 0.035
up Glrx5 D4ADD7 D4ADD7_RAT Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5) 0.665 0.035
up Sdc4 P34901 SDC4_RAT Syndecan-4 (SYND4) (Ryudocan core protein) 1.065 0.035
up Ybx1 P62961 YBOX1_RAT Y-box-binding protein 1 (YB-1) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) 1.284 0.035
up Evl O08719 EVL_RAT Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) 1.579 0.035
up Cnst A0A8I5ZKG8 A0A8I5ZKG8_RAT Consortin, connexin sorting protein 1.146 0.035
up Bcas1 Q3ZB98 BCAS1_RAT Breast carcinoma-amplified sequence 1 homolog (Protein whose mRNA is enriched in synaptosomes 2) (Pmes-2) 0.863 0.036
up Slc39a10 A0A1W2Q626 A0A1W2Q626_RAT Solute carrier family 39 member 10 0.923 0.036
up Dnajc5 P60905 DNJC5_RAT DnaJ homolog subfamily C member 5 (Cysteine string protein) (CSP) 0.702 0.036
up Reps1 A0A0G2JZY3 A0A0G2JZY3_RAT RALBP1 associated Eps domain containing 1 1.044 0.036
up Rabl6 D3ZKQ4 D3ZKQ4_RAT Rab-like protein 6 (GTP-binding protein Parf) (Rab-like protein 1) 1.250 0.036
up Tmpo Q62733 LAP2_RAT Lamina-associated polypeptide 2, isoform beta (Thymopoietin isoform beta) (TP beta) 0.613 0.037
up NA Q6LED0 H31_RAT Histone H3.1 0.673 0.037
up NA Q6LED0 H31_RAT Histone H3.1 0.673 0.037
up Psmd9 Q9WTV5 PSMD9_RAT 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) (Transactivating protein Bridge-1) 0.685 0.037
up Cplx2 P84087 CPLX2_RAT Complexin-2 (Complexin II) (CPX II) (Synaphin-1) 0.773 0.037
up Abl2 F1M0N1 F1M0N1_RAT Tyrosine-protein kinase (EC 2.7.10.2) 0.953 0.037
up Larp1 A0A8I6GJC3 A0A8I6GJC3_RAT La ribonucleoprotein 1, translational regulator 1.022 0.037
up Smap NA NA NA 1.454 0.037
up Fabp7 P55051 FABP7_RAT Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) 1.544 0.037
up Saa1 NA NA NA 2.197 0.037
up Pkig A6JX44 A6JX44_RAT cAMP-dependent protein kinase inhibitor 2.399 0.037
up Endod1 D3ZIP8 D3ZIP8_RAT Endonuclease domain containing 1 0.621 0.037
up Cstf2 B4F7F1 B4F7F1_RAT Cleavage stimulation factor subunit 2 (Cstf2 protein) 0.879 0.037
up Khdrbs3 Q9JLP1 KHDR3_RAT KH domain-containing, RNA-binding, signal transduction-associated protein 3 (Sam68-like mammalian protein 2) (SLM-2) (rSLM-2) 0.709 0.038
up Ktn1 A0A8I6A4W2 A0A8I6A4W2_RAT Kinectin 1 1.889 0.038
up Chgb O35314 SCG1_RAT Secretogranin-1 (Chromogranin-B) (CgB) (Glucagonoma peptide) (Secretogranin-I) (SgI) [Cleaved into: PE-11; CCB peptide short form; CCB peptide long form] 0.939 0.038
up Inf2 E9PT22 E9PT22_RAT Inverted formin-2 1.166 0.038
up Shfl Q5RJN4 SHFL_RAT Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog (SHFL) (Repressor of yield of DENV protein homolog) (RyDEN) 0.880 0.039
up Dek Q6AXS3 DEK_RAT Protein DEK 0.631 0.039
up Omg F7EYB9 F7EYB9_RAT Oligodendrocyte-myelin glycoprotein 0.719 0.039
up Rad23b Q4KMA2 RD23B_RAT UV excision repair protein RAD23 homolog B 0.758 0.039
up Gm2a A0A8I6A5G9 A0A8I6A5G9_RAT Ganglioside GM2 activator 1.001 0.039
up Ppp6r3 F1MAH5 F1MAH5_RAT Protein phosphatase 6, regulatory subunit 3 1.094 0.039
up Nsfl1c O35987 NSF1C_RAT NSFL1 cofactor p47 (XY body-associated protein XY40) (p97 cofactor p47) 0.699 0.039
up Cttn Q66HL2 SRC8_RAT Src substrate cortactin 0.653 0.040
up Bola1 Q06C60 Q06C60_RAT BolA-like protein 1 0.567 0.040
up Thrap3 Q5M7V8 TR150_RAT Thyroid hormone receptor-associated protein 3 (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150) 0.696 0.041
up Nherf1 Q9JJ19 NHRF1_RAT Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) 0.858 0.041
up Mast1 Q810W7 MAST1_RAT Microtubule-associated serine/threonine-protein kinase 1 (EC 2.7.11.1) (Syntrophin-associated serine/threonine-protein kinase) 1.300 0.041
up Serbp1 Q6AXS5 SERB1_RAT SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) (RDA288) 0.717 0.041
up Rpl23a P62752 RL23A_RAT Large ribosomal subunit protein uL23 (60S ribosomal protein L23a) 0.601 0.042
up Map1b P15205 MAP1B_RAT Microtubule-associated protein 1B (MAP-1B) (Neuraxin) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] 0.757 0.042
up Atp5if1 Q03344 ATIF1_RAT ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) 0.819 0.042
up Caskin1 Q8VHK2 CSKI1_RAT Caskin-1 (CASK-interacting protein 1) 0.570 0.043
up Ogfrl1 Q4KLH3 OGRL1_RAT Opioid growth factor receptor-like protein 1 0.920 0.044
up Atxn2l A0A0G2JYE0 A0A0G2JYE0_RAT Ataxin 2-like 0.953 0.045
up Zfand2b Q4KLG9 ZFN2B_RAT AN1-type zinc finger protein 2B (Arsenite-inducible RNA-associated protein-like protein) (AIRAP-like protein) 0.693 0.045
up Ensa P60841 ENSA_RAT Alpha-endosulfine (ARPP-19e) 0.894 0.045
up Ndufv3 Q6PCU8 NDUV3_RAT NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) 0.791 0.047
up Plppr3 Q7TMB0 PLPR3_RAT Phospholipid phosphatase-related protein type 3 (Inactive phospholipid phosphatase PLPPR3) (Lipid phosphate phosphatase-related protein type 3) (Plasticity-related gene 2 protein) (PRG-2) 1.250 0.047
up Nebl D4A164 D4A164_RAT Nebulette 0.748 0.047
up Ptpn23 O88902 PTN23_RAT Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) 0.869 0.047
down Reep2 A0A0G2K1L5 A0A0G2K1L5_RAT Receptor expression-enhancing protein −3.433 0.000
down Tubb3 Q4QRB4 TBB3_RAT Tubulin beta-3 chain (Neuron-specific class III beta-tubulin) −2.267 0.001
down Tubb4a A6KQR9 A6KQR9_RAT Tubulin beta chain −2.005 0.001
down Eef1a1 P62630 EF1A1_RAT Elongation factor 1-alpha 1 (EF-1-alpha-1) (EC 3.6.5.-) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) −2.248 0.006
down Lxn Q64361 LXN_RAT Latexin (Endogenous carboxypeptidase inhibitor) (ECI) (Tissue carboxypeptidase inhibitor) (TCI) −1.356 0.007
down Msn O35763 MOES_RAT Moesin (Membrane-organizing extension spike protein) −3.434 0.007
down Ddx1 Q641Y8 DDX1_RAT ATP-dependent RNA helicase DDX1 (EC 3.6.4.13) (DEAD box protein 1) −2.035 0.007
down Adcy9 M0R5U4 M0R5U4_RAT Adenylate cyclase type 9 (EC 4.6.1.1) (ATP pyrophosphate-lyase 9) (Adenylate cyclase type IX) (Adenylyl cyclase 9) −1.651 0.007
down Rab6a Q9WVB1 RAB6A_RAT Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) −1.627 0.007
down Cyb5b P04166 CYB5B_RAT Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform) −1.627 0.007
down Ckap5 F1M949 F1M949_RAT Cytoskeleton-associated protein 5 −1.202 0.007
down Drg2 A0A8I5ZWK0 A0A8I5ZWK0_RAT Developmentally-regulated GTP-binding protein 2 (Translation factor GTPase DRG2) −1.196 0.007
down Hsp90aa1 P82995 HS90A_RAT Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) −1.151 0.007
down Dtna D4A772 D4A772_RAT Dystrobrevin −1.088 0.007
down Grin2a Q00959 NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) −1.786 0.009
down Twf1 Q5RJR2 TWF1_RAT Twinfilin-1 −1.112 0.009
down Tspan7 B0BNE7 B0BNE7_RAT Tetraspanin −1.473 0.009
down Actr3b A0A8I6GL35 A0A8I6GL35_RAT Actin related protein 3B −1.280 0.009
down Dnm1 P21575 DYN1_RAT Dynamin-1 (EC 3.6.5.5) (B-dynamin) (D100) (Dynamin I) (Dynamin, brain) −1.121 0.009
down Arl3 P37996 ARL3_RAT ADP-ribosylation factor-like protein 3 (ARD3) −0.929 0.009
down Tmed2 Q63524 TMED2_RAT Transmembrane emp24 domain-containing protein 2 (COPI-coated vesicle membrane protein p24) (Membrane protein p24A) (RNP21.4) (p24 family protein beta-1) (p24beta1) −1.981 0.010
down NA Q6LED0 H31_RAT Histone H3.1 −0.940 0.010
down Smap1 A0A8I5ZQ30 A0A8I5ZQ30_RAT Small ArfGAP 1 −0.866 0.010
down Hsp90ab1 P34058 HS90B_RAT Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84) −1.850 0.010
down Sh3gl3 O35180 SH3G3_RAT Endophilin-A3 (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) (SH3p13) −1.751 0.010
down Rab14 P61107 RAB14_RAT Ras-related protein Rab-14 (EC 3.6.5.2) −1.071 0.010
down Eif3i B0BNA7 EIF3I_RAT Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (eIF-3-beta) (eIF3 p36) −1.053 0.010
down Padi2 P20717 PADI2_RAT Protein-arginine deiminase type-2 (EC 3.5.3.15) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) −1.022 0.010
down Ppp2r1a Q5XI34 Q5XI34_RAT Protein phosphatase 2 scaffold subunit A alpha −0.940 0.010
down Shisa6 D4A4M0 D4A4M0_RAT Shisa family member 6 −0.904 0.010
down Dlg3 Q62936 DLG3_RAT Disks large homolog 3 (PSD-95/SAP90-related protein 1) (Synapse-associated protein 102) (SAP-102) (SAP102) −1.036 0.010
down Ca4 P48284 CAH4_RAT Carbonic anhydrase 4 (EC 4.2.1.1) (Carbonate dehydratase IV) (Carbonic anhydrase IV) (CA-IV) −2.132 0.011
down Them4 Q566R0 THEM4_RAT Acyl-coenzyme A thioesterase THEM4 (Acyl-CoA thioesterase THEM4) (EC 3.1.2.2) (Thioesterase superfamily member 4) −2.182 0.012
down Dynlrb1 P62628 DLRB1_RAT Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (robl/LC7-like protein) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) −1.733 0.012
down Pfkp P47860 PFKAP_RAT ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase) −1.137 0.012
down Gtf2i Q5U2Y1 GTF2I_RAT General transcription factor II-I (GTFII-I) (TFII-I) −2.330 0.012
down Tspan2 Q9JJW1 TSN2_RAT Tetraspanin-2 (Tspan-2) −2.958 0.012
down Rps7 P62083 RS7_RAT Small ribosomal subunit protein eS7 (40S ribosomal protein S7) (S8) −2.384 0.012
down Atp1b2 P13638 AT1B2_RAT Sodium/potassium-transporting ATPase subunit beta-2 (Sodium/potassium-dependent ATPase subunit beta-2) −1.530 0.012
down Atp5f1c P35435 ATPG_RAT ATP synthase F(1) complex subunit gamma, mitochondrial (ATP synthase F1 subunit gamma) (F-ATPase gamma subunit) −1.525 0.012
down Rab3a P63012 RAB3A_RAT Ras-related protein Rab-3A (EC 3.6.5.2) −0.787 0.012
down Serpina3k P05545 SPA3K_RAT Serine protease inhibitor A3K (Serpin A3K) (CPI-21) (Contrapsin-like protease inhibitor 1) (GHR-P63) (Growth hormone-regulated proteinase inhibitor) (Kallikrein-binding protein) (KBP) (SPI-2.3) (Serine protease inhibitor 2) (SPI-2) (Thyroid hormone-regulated protein) −0.898 0.012
down Arpc5l A1L108 ARP5L_RAT Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2) −1.128 0.012
down Lrrc47 F1LT49 F1LT49_RAT Leucine-rich repeat-containing protein 47 −0.991 0.012
down Rab11b O35509 RB11B_RAT Ras-related protein Rab-11B (EC 3.6.5.2) −0.868 0.012
down Slc2a1 P11167 GTR1_RAT Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) −0.820 0.012
down Rras2 Q5BJU0 Q5BJU0_RAT RAS related 2 −1.435 0.012
down Hadha Q64428 ECHA_RAT Trifunctional enzyme subunit alpha, mitochondrial (Monolysocardiolipin acyltransferase) (MLCL AT) (EC 2.3.1.-) (TP-alpha) [Includes: Long-chain enoyl-CoA hydratase (EC 4.2.1.17); Long chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.211)] −1.584 0.012
down Alcam O35112 CD166_RAT CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166) −0.814 0.012
down Adss1 M0R629 M0R629_RAT Adenylosuccinate synthetase isozyme 1 (AMPSase 1) (AdSS 1) (EC 6.3.4.4) (Adenylosuccinate synthetase, basic isozyme) (Adenylosuccinate synthetase, muscle isozyme) (M-type adenylosuccinate synthetase) (IMP--aspartate ligase 1) −2.156 0.012
down Mapk3 P21708 MK03_RAT Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1) −0.847 0.013
down Gpd2 P35571 GPDM_RAT Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD-M) (GPDH-M) (EC 1.1.5.3) −1.098 0.013
down Pitpnc1 A0A8I5ZSD8 A0A8I5ZSD8_RAT Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (Retinal degeneration B homolog beta) −2.762 0.013
down Armc10 B1WBW4 ARM10_RAT Armadillo repeat-containing protein 10 −1.457 0.013
down Cyb5r1 Q5EB81 NB5R1_RAT NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) −1.154 0.013
down Acadl P15650 ACADL_RAT Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8) −0.834 0.013
down Purb Q68A21 PURB_RAT Transcriptional regulator protein Pur-beta (Purine-rich element-binding protein B) −1.079 0.014
down Gnai2 P04897 GNAI2_RAT Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) −1.034 0.014
down Hint1 P62959 HINT1_RAT Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (17 kDa inhibitor of protein kinase C) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1) −1.702 0.014
down Idh3g P41565 IDHG1_RAT Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) −1.160 0.014
down Dnm3 Q08877 DYN3_RAT Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin) −1.082 0.014
down Gng3 G3V8K2 G3V8K2_RAT Guanine nucleotide-binding protein subunit gamma −0.945 0.014
down Atp6v1c1 Q5FVI6 VATC1_RAT V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) −0.900 0.014
down Pfkl P30835 PFKAL_RAT ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase) −0.873 0.014
down Septin8 B0BNF1 SEPT8_RAT Septin-8 −1.214 0.014
down Pdk3 A6IPZ9 A6IPZ9_RAT Protein-serine/threonine kinase (EC 2.7.11.-) −0.690 0.014
down Ndufv1 Q5XIH3 Q5XIH3_RAT NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (EC 7.1.1.2) −0.832 0.015
down Rgs7 P49803 RGS7_RAT Regulator of G-protein signaling 7 (RGS7) −1.461 0.015
down Kctd12 A0A8I5Y7I2 A0A8I5Y7I2_RAT Potassium channel tetramerization domain containing 12 −0.777 0.015
down Naxe B0BNM1 NNRE_RAT NAD(P)H-hydrate epimerase (EC 5.1.99.6) (Apolipoprotein A-I-binding protein) (AI-BP) (NAD(P)HX epimerase) −0.919 0.015
down Rdx E9PT65 E9PT65_RAT Radixin −1.792 0.016
down Igsf8 A0A8I6ANQ3 A0A8I6ANQ3_RAT Immunoglobulin superfamily member 8 (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (Prostaglandin regulatory-like protein) −0.806 0.016
down Sfxn3 Q9JHY2 SFXN3_RAT Sideroflexin-3 −0.793 0.016
down Mpp3 O88954 MPP3_RAT MAGUK p55 subfamily member 3 (Discs large homolog 3) (Protein MPP3) −1.336 0.016
down Fkbp8 Q3B7U9 FKBP8_RAT Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (FK506-binding protein 8) (FKBP-8) (Rotamase) −2.262 0.017
down Cct2 Q5XIM9 TCPB_RAT T-complex protein 1 subunit beta (TCP-1-beta) (EC 3.6.1.-) (CCT-beta) −1.053 0.017
down Map1lc3b Q62625 MLP3B_RAT Microtubule-associated protein 1 light chain 3 beta (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (Microtubule-associated proteins 1A/1B light chain 3B) (MAP1A/MAP1B LC3 B) (MAP1A/MAP1B light chain 3 B) −1.734 0.017
down Mapk1 P63086 MK01_RAT Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) −1.404 0.017
down Opa3 A0A8I6AQX4 A0A8I6AQX4_RAT Outer mitochondrial membrane lipid metabolism regulator OPA3 −1.032 0.017
down Gnaq P82471 GNAQ_RAT Guanine nucleotide-binding protein G(q) subunit alpha (EC 3.6.5.-) (Guanine nucleotide-binding protein alpha-q) −0.925 0.017
down Sar1a Q6AY18 Q6AY18_RAT small monomeric GTPase (EC 3.6.5.2) −0.773 0.017
down Stxbp1 P61765 STXB1_RAT Syntaxin-binding protein 1 (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67) (rbSec1) −0.715 0.017
down Ctsb P00787 CATB_RAT Cathepsin B (EC 3.4.22.1) (Cathepsin B1) (RSG-2) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] −1.419 0.017
down Ptges3 P83868 TEBP_RAT Prostaglandin E synthase 3 (EC 5.3.99.3) (Cytosolic prostaglandin E2 synthase) (cPGES) (Hsp90 co-chaperone) (Progesterone receptor complex p23) (Telomerase-binding protein p23) −1.122 0.017
down Eipr1 Q5PPK9 EIPR1_RAT EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) −0.918 0.017
down Aifm1 Q9JM53 AIFM1_RAT Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8) −0.844 0.017
down Ppp1cb P62142 PP1B_RAT Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53) −0.831 0.017
down Atp6v1h A0A8I6ACJ2 A0A8I6ACJ2_RAT V-type proton ATPase subunit H −1.029 0.018
down Unc13a Q62768 UN13A_RAT Protein unc-13 homolog A (Munc13-1) −1.157 0.018
down Hnrnpk P61980 HNRPK_RAT Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (dC stretch-binding protein) (CSBP) −3.831 0.019
down Gdi2 P50399 GDIB_RAT Rab GDP dissociation inhibitor beta (Rab GDI beta) (GDI-3) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2) −0.764 0.019
down Syncrip Q7TP47 HNRPQ_RAT Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Liver regeneration-related protein LRRG077) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) −0.887 0.019
down Dgke A0A096UWG9 A0A096UWG9_RAT Diacylglycerol kinase (DAG kinase) (EC 2.7.1.107) −2.713 0.019
down Pgk1 P16617 PGK1_RAT Phosphoglycerate kinase 1 (EC 2.7.11.1) (EC 2.7.2.3) −0.628 0.019
down Dld Q6P6R2 DLDH_RAT Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) −0.926 0.019
down Ndufa9 Q5BK63 NDUA9_RAT NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (Complex I-39kD) (CI-39kD) (NADH-ubiquinone oxidoreductase 39 kDa subunit) (Sperm flagella protein 3) −1.473 0.019
down Ap1b1 P52303 AP1B1_RAT AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) −0.799 0.020
down Tollip A2RUW1 TOLIP_RAT Toll-interacting protein −0.777 0.020
down Mllt11 Q5M971 AF1Q_RAT Protein AF1q −1.998 0.020
down Pygm P09812 PYGM_RAT Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase) −0.892 0.020
down Tst P24329 THTR_RAT Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese) −0.711 0.020
down Acat2 Q5XI22 THIC_RAT Acetyl-CoA acetyltransferase, cytosolic (EC 2.3.1.9) (Cytosolic acetoacetyl-CoA thiolase) −1.208 0.020
down Dusp3 A0A8I6AF61 A0A8I6AF61_RAT Dual specificity protein phosphatase (EC 3.1.3.16) (EC 3.1.3.48) −0.738 0.021
down Pfn1 P62963 PROF1_RAT Profilin-1 (Profilin I) −1.346 0.021
down Mlc1 D4ABB2 D4ABB2_RAT Modulator of VRAC current 1 −1.544 0.021
down Tuba4a Q5XIF6 TBA4A_RAT Tubulin alpha-4A chain (EC 3.6.5.-) (Alpha-tubulin 4) (Tubulin alpha-4 chain) −1.071 0.021
down Rab7a P09527 RAB7A_RAT Ras-related protein Rab-7a (EC 3.6.5.2) (Ras-related protein BRL-RAS) (Ras-related protein p23) −0.798 0.021
down Xpo7 F1LQM9 F1LQM9_RAT Exportin 7 −1.171 0.022
down Cacna1e Q07652 CAC1E_RAT Voltage-dependent R-type calcium channel subunit alpha-1E (BII) (Brain calcium channel II) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (RBE-II) (RBE2) (Voltage-gated calcium channel subunit alpha Cav2.3) −1.100 0.022
down Atxn10 Q9ER24 ATX10_RAT Ataxin-10 (Neuronal beta-catenin-like protein) (Spinocerebellar ataxia type 10 protein homolog) −1.675 0.023
down Rab2a P05712 RAB2A_RAT Ras-related protein Rab-2A (EC 3.6.5.2) −0.732 0.023
down Adam23 A0A8I6A4T9 A0A8I6A4T9_RAT ADAM metallopeptidase domain 23 −1.626 0.023
down Uba2 A0A8I6A3Z5 A0A8I6A3Z5_RAT SUMO-activating enzyme subunit 2 (EC 2.3.2.-) −0.755 0.023
down Gnb1 P54311 GBB1_RAT Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) −0.714 0.024
down Hnrnpl F1LQ48 HNRPL_RAT Heterogeneous nuclear ribonucleoprotein L (hnRNP L) −0.724 0.024
down Pip4k2c O88370 PI42C_RAT Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma) −0.740 0.024
down Nf1 P97526 NF1_RAT Neurofibromin (Neurofibromatosis-related protein NF-1) −1.453 0.024
down Cops4 Q68FS2 CSN4_RAT COP9 signalosome complex subunit 4 (SGN4) (Signalosome subunit 4) (JAB1-containing signalosome subunit 4) −0.759 0.025
down Gnb2 P54313 GBB2_RAT Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (G protein subunit beta-2) (Transducin beta chain 2) −1.151 0.025
down Suclg1 P13086 SUCA_RAT Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) −2.515 0.025
down Kcnma1 Q62976 KCMA1_RAT Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) −1.939 0.025
down Gm49948 NA NA NA −1.447 0.025
down Dlgap2 P97837 DLGP2_RAT Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2) −1.328 0.025
down Aldh1a1 P51647 AL1A1_RAT Aldehyde dehydrogenase 1A1 (EC 1.2.1.19) (EC 1.2.1.28) (EC 1.2.1.3) (EC 1.2.1.36) (3-deoxyglucosone dehydrogenase) (ALDH-E1) (ALHDII) (Aldehyde dehydrogenase family 1 member A1) (Aldehyde dehydrogenase, cytosolic) (Retinal dehydrogenase 1) (RALDH 1) (RalDH1) −1.218 0.025
down Mpp2 D3ZAA9 MPP2_RAT MAGUK p55 subfamily member 2 (Protein MPP2) −0.860 0.025
down Eef2 P05197 EF2_RAT Elongation factor 2 (EF-2) (EC 3.6.5.-) −0.601 0.025
down Zmym3 E9PTE5 E9PTE5_RAT Zinc finger MYM-type containing 3 −1.819 0.025
down Dgkg P49620 DGKG_RAT Diacylglycerol kinase gamma (DAG kinase gamma) (EC 2.7.1.107) (88 kDa diacylglycerol kinase) (DGK-III) (Diglyceride kinase gamma) (DGK-gamma) −1.051 0.025
down Nmt1 Q8K1Q0 NMT1_RAT Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) −1.260 0.025
down Fscn1 P85845 FSCN1_RAT Fascin −0.921 0.026
down Ctnna2 A0A0G2JYF7 A0A0G2JYF7_RAT Catenin alpha-2 (Alpha N-catenin) −0.614 0.026
down NA Q6LED0 H31_RAT Histone H3.1 −1.602 0.026
down NA Q6LED0 H31_RAT Histone H3.1 −1.602 0.026
down Ddx39b Q63413 DX39B_RAT Spliceosome RNA helicase Ddx39b (EC 3.6.4.13) (56 kDa U2AF65-associated protein) (ATP-dependent RNA helicase p47) (DEAD box protein Uap56) −0.851 0.026
down Inpp4a Q62784 INP4A_RAT Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) −0.852 0.027
down Tpi1 P48500 TPIS_RAT Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase) −0.732 0.027
down Tstd3 A0A8I6GJH7 A0A8I6GJH7_RAT Thiosulfate sulfurtransferase like domain containing 3 −1.895 0.027
down Dpp10 Q6Q629 DPP10_RAT Inactive dipeptidyl peptidase 10 (Dipeptidyl peptidase X) (DPP X) (Kv4 potassium channel auxiliary subunit) −1.189 0.027
down Babam2 Q6P7Q1 BABA2_RAT BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) −1.854 0.028
down Cpne4 F1M0Z3 F1M0Z3_RAT Copine-4 (Copine IV) −1.269 0.028
down Eci1 P23965 ECI1_RAT Enoyl-CoA delta isomerase 1, mitochondrial (MECI) (EC 5.3.3.8) (3,2-trans-enoyl-CoA isomerase) (Delta(3),Delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Dodecenoyl-CoA isomerase) −0.774 0.028
down Rps16 P62250 RS16_RAT Small ribosomal subunit protein uS9 (40S ribosomal protein S16) −0.738 0.028
down Prep O70196 PPCE_RAT Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) (rPop) −0.698 0.028
down Ddx5 Q6AYI1 Q6AYI1_RAT Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) −0.588 0.028
down Anxa6 P48037 ANXA6_RAT Annexin A6 (Annexin VI) (Annexin-6) (Calcium-binding protein 65/67) (CBP 65/67) −0.622 0.028
down Ptk2b P70600 FAK2_RAT Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) −0.588 0.028
down Ezr P31977 EZRI_RAT Ezrin (Cytovillin) (Villin-2) (p81) −1.077 0.028
down Rab21 Q6AXT5 RAB21_RAT Ras-related protein Rab-21 (EC 3.6.5.2) −0.697 0.028
down Crym Q9QYU4 CRYM_RAT Ketimine reductase mu-crystallin (EC 1.5.1.25) (1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase) (P2C/Pyr2C reductase) (EC 1.5.1.1) (CDK108) (NADP-regulated thyroid-hormone-binding protein) −0.558 0.028
down Prkar2a P12368 KAP2_RAT cAMP-dependent protein kinase type II-alpha regulatory subunit −0.839 0.028
down Uqcrc1 Q68FY0 QCR1_RAT Cytochrome b-c1 complex subunit 1, mitochondrial (Complex III subunit 1) (Core protein I) (Ubiquinol-cytochrome-c reductase complex core protein 1) −0.761 0.029
down Dstn Q7M0E3 DEST_RAT Destrin (Actin-depolymerizing factor) (ADF) −4.283 0.030
down Serpina1e NA NA NA −1.628 0.030
down Nisch Q4G017 NISCH_RAT Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline-1 receptor) (I1R) −1.750 0.030
down Camkk1 P97756 KKCC1_RAT Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha) −1.121 0.032
down Tmed9 Q5I0E7 TMED9_RAT Transmembrane emp24 domain-containing protein 9 (p24 family protein alpha-2) (p24alpha2) −0.656 0.032
down Ipo5 D4A781 D4A781_RAT Importin-5 (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) −1.646 0.032
down Nars1 F1LPV0 F1LPV0_RAT Asparagine--tRNA ligase, cytoplasmic (EC 6.1.1.22) (Asparaginyl-tRNA synthetase) (Asparaginyl-tRNA synthetase 1) −0.850 0.032
down NA Q6LED0 H31_RAT Histone H3.1 −1.012 0.032
down Rab1a A0A8I6AJ88 A0A8I6AJ88_RAT small monomeric GTPase (EC 3.6.5.2) −0.598 0.032
down Mtfr1l Q5XII9 MFR1L_RAT Mitochondrial fission regulator 1-like −1.770 0.033
down Kcna2 P63142 KCNA2_RAT Potassium voltage-gated channel subfamily A member 2 (RAK) (RBK2) (RCK5) (Voltage-gated potassium channel subunit Kv1.2) −1.713 0.033
down Sez6l D4AD89 D4AD89_RAT Seizure 6-like protein −1.130 0.033
down Crmp1 Q62950 DPYL1_RAT Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) −1.080 0.033
down Ndufa12 F1LXA0 F1LXA0_RAT NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 −0.845 0.033
down Prepl Q5HZA6 PPCEL_RAT Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) −0.826 0.033
down Arcn1 Q66H80 COPD_RAT Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) −0.739 0.033
down Ppa1 A0A8I6AI23 A0A8I6AI23_RAT inorganic diphosphatase (EC 3.6.1.1) −0.516 0.033
down Faah P97612 FAAH1_RAT Fatty-acid amide hydrolase 1 (EC 3.5.1.99) (Anandamide amidase) (Anandamide amidohydrolase 1) (Fatty acid ester hydrolase) (EC 3.1.1.-) (Oleamide hydrolase 1) −1.995 0.033
down Ccdc22 P86182 CCD22_RAT Coiled-coil domain-containing protein 22 −1.911 0.033
down Diras2 A0A8I5ZKR8 A0A8I5ZKR8_RAT DIRAS family GTPase 2 −1.623 0.033
down Dctn6 A0A8I5Y4I3 A0A8I5Y4I3_RAT Dynactin subunit 6 (Dynactin subunit p27) −1.546 0.033
down Rap2b P61227 RAP2B_RAT Ras-related protein Rap-2b (EC 3.6.5.2) −0.989 0.033
down NA Q6LED0 H31_RAT Histone H3.1 −0.911 0.033
down Cnn3 P37397 CNN3_RAT Calponin-3 (Calponin, acidic isoform) (Calponin, non-muscle isoform) −0.908 0.033
down Bpnt1 Q9Z1N4 BPNT1_RAT 3'(2'),5'-bisphosphate nucleotidase 1 (EC 3.1.3.7) (3'-phosphoadenosine 5'-phosphate phosphatase) (PAP phosphatase) (Bisphosphate 3'-nucleotidase 1) (BPntase 1) (Inositol-polyphosphate 1-phosphatase) (EC 3.1.3.57) (RnPIP) (scHAL2 analogous 3) −0.888 0.033
down Pspc1 Q4KLH4 PSPC1_RAT Paraspeckle component 1 −0.884 0.033
down Rps8 P62243 RS8_RAT Small ribosomal subunit protein eS8 (40S ribosomal protein S8) −0.842 0.033
down Rack1 P63245 RACK1_RAT Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-2-like 1) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) (Receptor of activated protein kinase C 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Receptor of activated protein C kinase 1, N-terminally processed)] −0.800 0.033
down Aldh6a1 Q02253 MMSA_RAT Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) −0.760 0.033
down Sirt2 Q5RJQ4 SIR2_RAT NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) −0.516 0.033
down Akr7a2 Q8CG45 ARK72_RAT Aflatoxin B1 aldehyde reductase member 2 (rAFAR2) (EC 1.1.1.n11) (Succinic semialdehyde reductase) (SSA reductase) −1.048 0.033
down Gdap1l1 B4F774 B4F774_RAT Ganglioside-induced differentiation-associated protein 1-like 1 −0.711 0.033
down Dnaja3 G3V6I5 G3V6I5_RAT DnaJ heat shock protein family (Hsp40) member A3 −0.661 0.033
down Strap Q5XIG8 STRAP_RAT Serine-threonine kinase receptor-associated protein (UNR-interacting protein) −0.552 0.033
down Epdr1 Q5XII0 EPDR1_RAT Mammalian ependymin-related protein 1 (MERP-1) −1.473 0.034
down Scrn3 A0A8I6A9K3 A0A8I6A9K3_RAT Secernin 3 −2.151 0.034
down Stoml2 Q4FZT0 STML2_RAT Stomatin-like protein 2, mitochondrial (SLP-2) −2.015 0.034
down Phyhip Q568Z9 PHYIP_RAT Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1) −1.086 0.034
down Pmm1 A6HT35 A6HT35_RAT Phosphomannomutase (EC 5.4.2.8) −0.983 0.034
down Mapk10 P49187 MK10_RAT Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta) −0.551 0.035
down Rpl9-ps6 NA NA NA −1.428 0.035
down Ap2b1 P62944 AP2B1_RAT AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit) −0.919 0.035
down Otub1 B2RYG6 OTUB1_RAT Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (Ubiquitin-specific-processing protease OTUB1) −0.585 0.035
down Cyrib A0A0G2JXI6 A0A0G2JXI6_RAT CYFIP related Rac1 interactor B −0.511 0.035
down Prxl2a Q6AXX6 PXL2A_RAT Peroxiredoxin-like 2A (Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes) (Protein PAMM) (Redox-regulatory protein FAM213A) (Sperm head protein 1) −1.292 0.035
down Prkce P09216 KPCE_RAT Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) −0.589 0.035
down Hspa2 P14659 HSP72_RAT Heat shock-related 70 kDa protein 2 (Heat shock protein 70.2) (Testis-specific heat shock protein-related) (HST) −0.648 0.036
down Get3 G3V9T7 GET3_RAT ATPase Get3 (EC 3.6.4.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) −0.545 0.036
down Sfxn5 Q8CFD0 SFXN5_RAT Sideroflexin-5 (Tricarboxylate carrier BBG-TCC) −0.487 0.036
down Ndufa11 Q80W89 NDUAB_RAT NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 (Complex I-B14.7) (CI-B14.7) (NADH-ubiquinone oxidoreductase subunit B14.7) −0.611 0.036
down Fabp5 P55053 FABP5_RAT Fatty acid-binding protein 5 (Cutaneous fatty acid-binding protein) (C-FABP) (DA11) (Epidermal-type fatty acid-binding protein) (E-FABP) (Fatty acid-binding protein, epidermal) −0.754 0.036
down Rgs14 O08773 RGS14_RAT Regulator of G-protein signaling 14 (RGS14) −0.495 0.036
down Hnrnpa0 F1M3H8 F1M3H8_RAT Heterogeneous nuclear ribonucleoprotein A0 −1.937 0.037
down Tmem11 B0BN86 TMM11_RAT Transmembrane protein 11, mitochondrial −2.430 0.037
down Exoc6b A0A0G2JYR1 A0A0G2JYR1_RAT Exocyst complex component −1.837 0.037
down Rps10 P63326 RS10_RAT Small ribosomal subunit protein eS10 (40S ribosomal protein S10) −1.595 0.037
down Dnajc11 A6IUF7 A6IUF7_RAT DnaJ homolog subfamily C member 11 −1.443 0.037
down Hacd3 D4ABI7 D4ABI7_RAT Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (EC 4.2.1.134) −1.390 0.037
down Ppp2r5d A0A8I6A6K6 A0A8I6A6K6_RAT Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit −1.154 0.037
down Acat1 P17764 THIL_RAT Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) −0.774 0.037
down Rasal1 D3ZHY9 D3ZHY9_RAT RAS protein activator like 1 −0.757 0.037
down Dhx9 A0A8I6ABZ7 A0A8I6ABZ7_RAT ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) −0.741 0.037
down Etfa P13803 ETFA_RAT Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) −0.723 0.037
down Dars1 P15178 SYDC_RAT Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) −0.686 0.037
down Rab18 Q5EB77 RAB18_RAT Ras-related protein Rab-18 (EC 3.6.5.2) −0.646 0.037
down Itpa D3ZW55 ITPA_RAT Inosine triphosphate pyrophosphatase (ITPase) (Inosine triphosphatase) (EC 3.6.1.66) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) (XTP/dITP diphosphatase) −0.624 0.037
down Lgi1 Q8K4Y5 LGI1_RAT Leucine-rich glioma-inactivated protein 1 −0.535 0.037
down Phyhipl Q6AYN4 PHIPL_RAT Phytanoyl-CoA hydroxylase-interacting protein-like −0.501 0.037
down Rhoa P61589 RHOA_RAT Transforming protein RhoA (EC 3.6.5.2) −4.109 0.037
down Prdx2 P35704 PRDX2_RAT Peroxiredoxin-2 (EC 1.11.1.24) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) (Thioredoxin-dependent peroxiredoxin 2) −1.986 0.037
down C1qb P31721 C1QB_RAT Complement C1q subcomponent subunit B −0.834 0.037
down Pcmt1 P22062 PIMT_RAT Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase) −0.826 0.037
down Ndrg1 Q6JE36 NDRG1_RAT Protein NDRG1 (N-myc downstream-regulated gene 1 protein) (Protein Ndr1) −0.764 0.037
down Rpn2 P25235 RPN2_RAT Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (Ribophorin II) (RPN-II) (Ribophorin-2) −0.757 0.037
down Rab1b P10536 RAB1B_RAT Ras-related protein Rab-1B (EC 3.6.5.2) −0.724 0.037
down Sptbn2 Q9QWN8 SPTN2_RAT Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41) −0.635 0.037
down Braf A0A8I6ATH0 A0A8I6ATH0_RAT non-specific serine/threonine protein kinase (EC 2.7.11.1) −0.628 0.037
down Bcat1 P54690 BCAT1_RAT Branched-chain-amino-acid aminotransferase, cytosolic (BCAT(c)) (EC 2.6.1.42) −0.589 0.037
down Prkcg P63319 KPCG_RAT Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) −0.571 0.037
down Ehd1 Q641Z6 EHD1_RAT EH domain-containing protein 1 −0.557 0.037
down Actr2 Q5M7U6 ARP2_RAT Actin-related protein 2 (Actin-like protein 2) −0.497 0.037
down Stam B5DF55 B5DF55_RAT Signal transducing adaptor molecule −0.731 0.037
down Sort1 O54861 SORT_RAT Sortilin (Glycoprotein 110) (Gp110) (Neurotensin receptor 3) (NTR3) −0.719 0.037
down Ogdh Q5XI78 ODO1_RAT 2-oxoglutarate dehydrogenase complex component E1 (E1o) (OGDC-E1) (OGDH-E1) (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Alpha-KGDH-E1) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) −0.963 0.038
down Psmc3 Q63569 PRS6A_RAT 26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Spermatogenic cell/sperm-associated Tat-binding protein homolog SATA) (Tat-binding protein 1) (TBP-1) −0.493 0.038
down Aldoa P05065 ALDOA_RAT Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Muscle-type aldolase) −0.735 0.038
down Rap1gap F1LV89 F1LV89_RAT Rap1 GTPase-activating protein −0.779 0.038
down Ganab D3ZAN3 D3ZAN3_RAT Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) −0.777 0.038
down Hnrnpm Q62826 HNRPM_RAT Heterogeneous nuclear ribonucleoprotein M (hnRNP M) (M4 protein) −0.602 0.038
down Kifbp Q4G074 KBP_RAT KIF-binding protein (KIF1-binding protein) −1.474 0.039
down Got2 P00507 AATM_RAT Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) −0.580 0.039
down Ppm1h Q5M821 PPM1H_RAT Protein phosphatase 1H (EC 3.1.3.16) −0.909 0.039
down Prmt5 A0A8I5ZP89 A0A8I5ZP89_RAT Protein arginine N-methyltransferase 5 (EC 2.1.1.320) −1.181 0.039
down Syn2 Q63537 SYN2_RAT Synapsin-2 (Synapsin II) −0.919 0.039
down Slc25a18 Q505J6 GHC2_RAT Mitochondrial glutamate carrier 2 (GC-2) (Glutamate/H(+) symporter 2) (Solute carrier family 25 member 18) −0.722 0.039
down Cdk5 Q03114 CDK5_RAT Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) −0.579 0.039
down Dpysl2 P47942 DPYL2_RAT Dihydropyrimidinase-related protein 2 (DRP-2) (Collapsin response mediator protein 2) (CRMP-2) (Turned on after division 64 kDa protein) (TOAD-64) −0.468 0.039
down Vps45 O08700 VPS45_RAT Vacuolar protein sorting-associated protein 45 (rVps45) −2.372 0.039
down Capn2 Q07009 CAN2_RAT Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain) −0.962 0.040
down Atp6v1a D4A133 D4A133_RAT V-type proton ATPase catalytic subunit A (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha) −0.552 0.040
down Slc8a1 Q01728 NAC1_RAT Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) −1.147 0.040
down Septin6 B5DFG5 B5DFG5_RAT Septin −0.739 0.040
down Atp6v1e1 Q6PCU2 VATE1_RAT V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (Vacuolar proton pump subunit E 1) −0.584 0.040
down Sar1b Q5HZY2 SAR1B_RAT Small COPII coat GTPase SAR1B (EC 3.6.5.2) −2.153 0.041
down Ubfd1 G3V8E4 G3V8E4_RAT Ubiquitin domain-containing protein UBFD1 −0.790 0.041
down Madd O08873 MADD_RAT MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (RabGEP) −0.649 0.041
down Cdc5l O08837 CDC5L_RAT Cell division cycle 5-like protein (Cdc5-like protein) (Pombe Cdc5-related protein) −0.860 0.041
down Actr1a P85515 ACTZ_RAT Alpha-centractin (Centractin) −0.796 0.041
down Pde2a Q01062 PDE2A_RAT cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE) −0.782 0.041
down Atl1 Q6PST4 ATLA1_RAT Atlastin-1 (EC 3.6.5.-) (Spastic paraplegia 3A homolog) −0.729 0.041
down Slc3a2 Q794F9 4F2_RAT Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (Solute carrier family 3 member 2) (CD antigen CD98) −1.291 0.041
down Cdc42 Q8CFN2 CDC42_RAT Cell division control protein 42 homolog (EC 3.6.5.2) −0.589 0.042
down Bpnt2 D4AD37 IMPA3_RAT Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (Golgi-resident PAP phosphatase) (gPAPP) (EC 3.1.3.7) (3'(2'), 5'-bisphosphate nucleotidase 2) (Inositol monophosphatase domain-containing protein 1) (Myo-inositol monophosphatase A3) (Phosphoadenosine phosphate 3'-nucleotidase) −2.167 0.042
down Sec13 Q5XFW8 SEC13_RAT Protein SEC13 homolog (GATOR2 complex protein SEC13) (SEC13-like protein 1) −1.937 0.042
down Cacybp Q6AYK6 CYBP_RAT Calcyclin-binding protein (CacyBP) −0.558 0.042
down Aco1 Q63270 ACOHC_RAT Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1) −1.551 0.042
down Ptbp2 Q66H20 PTBP2_RAT Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (PTB-like protein) −2.493 0.042
down Pef1 Q641Z8 PEF1_RAT Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1) −2.356 0.042
down Nlgn3 Q62889 NLGN3_RAT Neuroligin-3 (Gliotactin homolog) −0.721 0.042
down Rps3 P62909 RS3_RAT Small ribosomal subunit protein uS3 (EC 4.2.99.18) (40S ribosomal protein S3) −0.558 0.042
down Agap3 A0A0G2K2D4 A0A0G2K2D4_RAT Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (CRAM-associated GTPase) (Centaurin-gamma-3) (MR1-interacting protein) −0.546 0.042
down Cct7 A0A8I6AR12 A0A8I6AR12_RAT T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) −0.537 0.042
down Cdipt P70500 CDIPT_RAT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase) −0.698 0.043
down Dpysl4 Q62951 DPYL4_RAT Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) −0.518 0.043
down Grin2b Q00960 NMDE2_RAT Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) −0.913 0.043
down Hnrnpr Q566E4 Q566E4_RAT Heterogeneous nuclear ribonucleoprotein Q (Synaptotagmin-binding, cytoplasmic RNA-interacting protein) −1.533 0.043
down Sec14l2 Q99MS0 S14L2_RAT SEC14-like protein 2 (Alpha-tocopherol-associated protein) (TAP) (Squalene transfer protein) (Supernatant protein factor) (SPF) −1.273 0.043
down Olfm1 Q62609 NOE1_RAT Noelin (1B426B) (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) (Pancortin) −1.032 0.043
down Camk2b P08413 KCC2B_RAT Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) −0.793 0.043
down Rheb Q62639 RHEB_RAT GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) −0.781 0.043
down Gsk3b P18266 GSK3B_RAT Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) −0.653 0.043
down Ncdn O35095 NCDN_RAT Neurochondrin (Neurite outgrowth-related protein from the rat brain) (Norbin) −0.600 0.043
down Hspa4l P83581 HS74L_RAT Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) −0.501 0.043
down Prpsap2 O08618 KPRB_RAT Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41) −0.810 0.044
down Abat P50554 GABT_RAT 4-aminobutyrate aminotransferase, mitochondrial (beta-AlaAT I) (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT) [Cleaved into: 4-aminobutyrate aminotransferase, brain isoform; 4-aminobutyrate aminotransferase, liver isoform] −0.647 0.044
down Purg D3ZYS1 D3ZYS1_RAT Purine-rich element binding protein G −1.717 0.044
down Gabbr1 Q9Z0U4 GABR1_RAT Gamma-aminobutyric acid type B receptor subunit 1 (GABA-B receptor 1) (GABA-B-R1) (GABA-BR1) (GABABR1) (Gb1) −1.661 0.044
down Prmt1 Q63009 ANM1_RAT Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) −1.116 0.044
down Tpp1 Q9EQV6 TPP1_RAT Tripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I) −1.533 0.045
down Ndufs6 P52504 NDUS6_RAT NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit) −2.486 0.045
down Cap2 P52481 CAP2_RAT Adenylyl cyclase-associated protein 2 (CAP 2) −0.449 0.045
down Ndufa13 F1LZC5 F1LZC5_RAT NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 −3.370 0.045
down Mpst P97532 THTM_RAT 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2) −0.763 0.045
down Ywhag P61983 1433G_RAT 14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed] −0.727 0.045
down Prickle2 F1M0J7 F1M0J7_RAT Prickle planar cell polarity protein 2 −1.186 0.045
down Gapdh P04797 G3P_RAT Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) −0.465 0.045
down Atp5mj NA NA NA −1.459 0.046
down Ewsr1 A0A0G2K850 A0A0G2K850_RAT RNA-binding protein EWS −1.295 0.046
down Aldh7a1 Q64057 AL7A1_RAT Alpha-aminoadipic semialdehyde dehydrogenase (Alpha-AASA dehydrogenase) (EC 1.2.1.31) (Aldehyde dehydrogenase family 7 member A1) (EC 1.2.1.3) (Antiquitin-1) (Betaine aldehyde dehydrogenase) (EC 1.2.1.8) (Delta1-piperideine-6-carboxylate dehydrogenase) (P6c dehydrogenase) −0.942 0.046
down Tardbp A6IU83 A6IU83_RAT TAR DNA-binding protein 43 −0.653 0.047
down Adss2 D4AEP0 D4AEP0_RAT Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) −0.542 0.047
down Gas7 O55148 GAS7_RAT Growth arrest-specific protein 7 (GAS-7) −1.286 0.047
down Tmem132b A0A0G2K3D9 A0A0G2K3D9_RAT Transmembrane protein 132B −1.204 0.047
down Fbxo2 A0A8I6A9Y7 A0A8I6A9Y7_RAT F-box protein 2 −0.660 0.047
down NA Q6LED0 H31_RAT Histone H3.1 −1.853 0.047
down NA Q6LED0 H31_RAT Histone H3.1 −1.853 0.047
down Arl15 A0A8I5ZSX7 A0A8I5ZSX7_RAT ADP-ribosylation factor-like protein 15 −0.862 0.047
down Nudt3 Q566C7 NUDT3_RAT Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP-1) (EC 3.6.1.52) (Diadenosine hexaphosphate hydrolase) (Ap6A hydrolase) (EC 3.6.1.61) (Endopolyphosphatase) (EC 3.6.1.10) (Nucleoside diphosphate-linked moiety X motif 3) (Nudix motif 3) (m7GpppN-mRNA hydrolase) (EC 3.6.1.62) (m7GpppX diphosphatase) (EC 3.6.1.59) −1.507 0.048
down Cd34 B1PLB1 B1PLB1_RAT CD34 antigen isoform 2 (CD34 molecule) −2.014 0.050
down Ahcyl1 B5DFN2 SAHH2_RAT S-adenosylhomocysteine hydrolase-like protein 1 (IP3R-binding protein released with inositol 1,4,5-trisphosphate) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) −0.567 0.050
down Diras1 D4A304 D4A304_RAT DIRAS family GTPase 1 −1.308 0.050
down Srsf5 Q09167 SRSF5_RAT Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Insulin-induced growth response protein CL-4) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5) −1.113 0.050
down Dcps Q8K4F7 DCPS_RAT m7GpppX diphosphatase (EC 3.6.1.59) (DCS-1) (Decapping scavenger enzyme) (Hint-related 7meGMP-directed hydrolase) (Histidine triad nucleotide-binding protein 5) (Histidine triad protein member 5) (HINT-5) (Scavenger mRNA-decapping enzyme DcpS) −1.097 0.050
down Acad9 B1WC61 ACAD9_RAT Complex I assembly factor ACAD9, mitochondrial (Acyl-CoA dehydrogenase family member 9) (ACAD-9) (EC 1.3.8.-) −0.858 0.050
down Glul P09606 GLNA_RAT Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) −0.669 0.050
down Lonp1 Q924S5 LONM_RAT Lon protease homolog, mitochondrial (EC 3.4.21.53) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15) −0.472 0.050
down Ruvbl1 P60123 RUVB1_RAT RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (DNA helicase p50) (Pontin 52) (TIP49a) −0.645 0.050
down Eif4a3 Q3B8Q2 IF4A3_RAT Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic translation initiation factor 4A isoform 3) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed] −0.870 0.050
down Gabrb3 P63079 GBRB3_RAT Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) (GABAAR subunit beta-3) −0.814 0.050

gt 3 - Old (EE vs SH)

# EE VS SH (Yold)
# gt 3 - by fold change direction & pvalue
lit_review_proteomics_sig |> 
  dplyr::ungroup() |>
  dplyr:: filter(Condition == "old") %>%
  #dplyr::select(-(c(`Av. Ratio`, ))) |>
  dplyr::select(c(Condition, In_EE, Gene_name, Entry, Entry.Name,
                  Protein.names, Fold_change, adj.P.Val)) |>
  dplyr::arrange(desc(In_EE), adj.P.Val, Fold_change) |>
  gt(
    groupname_col = "Condition",
    rowname_col = "In_EE"
  ) |>
  fmt_number(decimals = 3) |>
    tab_header(
    title = "Old - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only)",
    subtitle = "2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by old)"
    ) |>
    tab_options(table.font.size=11.5,
                stub.font.weight = "bold",
                row_group.font.weight = "bold",
                row_group.font.size = 12.5,
                column_labels.font.size = 12.5,
                column_labels.font.weight = "bold")
Old - Perez 2024 - Proteomics - Hippocampus (Mice) (adj.p <=0.05 only)
2025_12_17 - lit_review_proteomics_sig - (EE vs SH - by old)
Gene_name Entry Entry.Name Protein.names Fold_change adj.P.Val
old
up Nfu1 D3ZA85 D3ZA85_RAT NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (HIRA-interacting protein 5) 1.672 0.004
up Atp5pf P21571 ATP5J_RAT ATP synthase peripheral stalk subunit F6, mitochondrial (ATPase subunit F6) (ATP synthase peripheral stalk subunit F6) 1.692 0.006
up Efhd2 Q4FZY0 EFHD2_RAT EF-hand domain-containing protein D2 (Swiprosin-1) 2.123 0.006
up Slc9a1 P26431 SL9A1_RAT Sodium/hydrogen exchanger 1 (Na(+)/H(+) exchanger 1) (NHE-1) (Solute carrier family 9 member 1) 0.949 0.006
up Bsn O88778 BSN_RAT Protein bassoon 0.977 0.006
up Pgrmc1 P70580 PGRC1_RAT Membrane-associated progesterone receptor component 1 (mPR) (25-DX) (Acidic 25 kDa protein) (Ventral midline antigen) (VEMA) 1.030 0.006
up Cdkn1b O08769 O08769_RAT Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) 1.039 0.006
up NA Q6LED0 H31_RAT Histone H3.1 1.073 0.006
up Eif4b A0ABK0LP36 A0ABK0LP36_RAT Eukaryotic translation initiation factor 4B 1.153 0.006
up Sparcl1 P24054 SPRL1_RAT SPARC-like protein 1 (Matrix glycoprotein Sc1) 1.165 0.006
up Ptprn2 Q63475 PTPR2_RAT Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (PTP NE-6) (PTPNE6) (Phogrin) [Cleaved into: IA-2beta60] 1.182 0.006
up Amph O08838 AMPH_RAT Amphiphysin 1.234 0.006
up Btf3 F7EZE5 F7EZE5_RAT Transcription factor BTF3 1.243 0.006
up Clta P08081 CLCA_RAT Clathrin light chain A (Lca) 1.244 0.006
up Txn P11232 THIO_RAT Thioredoxin (Trx) 1.267 0.006
up Akap12 Q5QD51 AKA12_RAT A-kinase anchor protein 12 (AKAP-12) 1.272 0.006
up Psip1 Q812D1 PSIP1_RAT PC4 and SFRS1-interacting protein (Lens epithelium-derived growth factor) 1.294 0.006
up Ythdf3 A0A8I6ACC2 A0A8I6ACC2_RAT YTH domain-containing family protein 1.306 0.006
up Chchd4 Q5BJN5 MIA40_RAT Mitochondrial intermembrane space import and assembly protein 40 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 4) 1.346 0.006
up Tmpo Q62733 LAP2_RAT Lamina-associated polypeptide 2, isoform beta (Thymopoietin isoform beta) (TP beta) 1.358 0.006
up Hnrnpd Q9JJ54 HNRPD_RAT Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1) 1.387 0.006
up Sod1 P07632 SODC_RAT Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) 1.388 0.006
up Alb P02770 ALBU_RAT Albumin 1.391 0.006
up Tceal5 A0ABK0KXI7 A0ABK0KXI7_RAT Transcription elongation factor A like 5 1.399 0.006
up Ppp1r11 Q6MFY6 PP1RB_RAT E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Protein phosphatase 1 regulatory subunit 11) 1.404 0.006
up Ndufv3 Q6PCU8 NDUV3_RAT NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial (Complex I-9kD) (CI-9kD) (NADH-ubiquinone oxidoreductase 9 kDa subunit) 1.450 0.006
up Atp5if1 Q03344 ATIF1_RAT ATPase inhibitor, mitochondrial (ATP synthase F1 subunit epsilon) (Inhibitor of F(1)F(o)-ATPase) (IF(1)) (IF1) 1.468 0.006
up Bag3 A6IA08 A6IA08_RAT BAG family molecular chaperone regulator 3 (Bcl-2-associated athanogene 3) (Bcl-2-binding protein Bis) 1.469 0.006
up Cbx1 A0A8I5ZM96 A0A8I5ZM96_RAT Chromobox 1 1.587 0.006
up Atox1 Q9WUC4 ATOX1_RAT Copper transport protein ATOX1 (ATX1 homolog protein Rah1) (Metal transport protein ATX1) 1.609 0.006
up Zfp428 A0A0G2K1B1 A0A0G2K1B1_RAT Zinc finger protein 428 1.623 0.006
up Ndufab1 D3ZF13 D3ZF13_RAT Acyl carrier protein 1.628 0.006
up Timm8a1 A6IVF6 A6IVF6_RAT Mitochondrial import inner membrane translocase subunit 1.633 0.006
up Hnrnpab A6HE59 A6HE59_RAT Heterogeneous nuclear ribonucleoprotein A/B 1.650 0.006
up Hspe1 P26772 CH10_RAT 10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) 1.675 0.006
up Rad23b Q4KMA2 RD23B_RAT UV excision repair protein RAD23 homolog B 1.676 0.006
up Chmp5 Q4QQV8 CHMP5_RAT Charged multivesicular body protein 5 (Chromatin-modifying protein 5) 1.693 0.006
up Prrt2 D3ZFB6 PRRT2_RAT Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3) 1.800 0.006
up Pym1 A0A8I6GKW1 A0A8I6GKW1_RAT PYM homolog 1, exon junction complex associated factor 1.846 0.006
up Rplp2 P02401 RLA2_RAT Large ribosomal subunit protein P2 (60S acidic ribosomal protein P2) 1.971 0.006
up Sncb Q63754 SYUB_RAT Beta-synuclein (Phosphoneuroprotein 14) (PNP 14) 2.095 0.006
up Ptms P04550 PTMS_RAT Parathymosin (Zinc-binding 11.5 kDa protein) 2.224 0.006
up Hdgf Q8VHK7 HDGF_RAT Hepatoma-derived growth factor (HDGF) 2.237 0.006
up Stmn1 P13668 STMN1_RAT Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Pr22 protein) (Prosolin) (pp17) 2.242 0.006
up Glrx5 D4ADD7 D4ADD7_RAT Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5) 1.069 0.007
up Tsr2 A0A8I5ZLR7 A0A8I5ZLR7_RAT Pre-rRNA-processing protein TSR2 homolog 1.085 0.007
up Srrm2 A0A8I6A2Y2 A0A8I6A2Y2_RAT Serine/arginine repetitive matrix 2 1.409 0.007
up Bola1 Q06C60 Q06C60_RAT BolA-like protein 1 0.953 0.007
up Fabp3 P07483 FABPH_RAT Fatty acid-binding protein, heart (Fatty acid-binding protein 3) (Heart-type fatty acid-binding protein) (H-FABP) 0.970 0.007
up Lasp1 Q99MZ8 LASP1_RAT LIM and SH3 domain protein 1 (LASP-1) 1.049 0.007
up Cnpy3 A0A8I6A0W3 A0A8I6A0W3_RAT Protein canopy homolog 3 1.322 0.007
up Ppp1r1b Q6J4I0 PPR1B_RAT Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein) 1.348 0.007
up Nherf1 Q9JJ19 NHRF1_RAT Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1) 1.456 0.007
up Try10 A0A8I6APH4 A0A8I6APH4_RAT trypsin (EC 3.4.21.4) 1.638 0.007
up Gtf2i Q5U2Y1 GTF2I_RAT General transcription factor II-I (GTFII-I) (TFII-I) 2.441 0.007
up Isca2 D4A4L5 D4A4L5_RAT Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1) 0.917 0.007
up Gfer Q63042 ALR_RAT FAD-linked sulfhydryl oxidase ALR (EC 1.8.3.2) (Augmenter of liver regeneration) 1.347 0.007
up Ensa P60841 ENSA_RAT Alpha-endosulfine (ARPP-19e) 1.556 0.007
up Mllt11 Q5M971 AF1Q_RAT Protein AF1q 2.568 0.007
up Chgb O35314 SCG1_RAT Secretogranin-1 (Chromogranin-B) (CgB) (Glucagonoma peptide) (Secretogranin-I) (SgI) [Cleaved into: PE-11; CCB peptide short form; CCB peptide long form] 1.520 0.007
up Ubqln1 Q9JJP9 UBQL1_RAT Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) 1.482 0.007
up Vsnl1 P62762 VISL1_RAT Visinin-like protein 1 (VILIP) (21 kDa CABP) (Neural visinin-like protein 1) (NVL-1) (NVP-1) 1.209 0.007
up Vgf P20156 VGF_RAT Neurosecretory protein VGF (VGF8a protein) [Cleaved into: VGF(24-63); VGF(180-194); VGF(375-407); Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-11; VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-30; VGF-derived peptide TLQP-62; VGF-derived peptide HFHH-10; VGF-derived peptide AQEE-30; VGF-derived peptide LQEQ-19] 1.327 0.007
up Cltb P08082 CLCB_RAT Clathrin light chain B (Lcb) 1.386 0.007
up Ndel1 Q78PB6 NDEL1_RAT Nuclear distribution protein nudE-like 1 (Protein Nudel) 1.672 0.007
up Wasl O08816 WASL_RAT Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP) 1.073 0.007
up H1-0 P43278 H10_RAT Histone H1.0 (Histone H1') (Histone H1(0)) [Cleaved into: Histone H1.0, N-terminally processed] 0.865 0.007
up Map6 Q63560 MAP6_RAT Microtubule-associated protein 6 (MAP-6) (145-kDa STOP) (STOP145) (Stable tubule-only polypeptide) (STOP) 0.967 0.007
up Atp5f1d P35434 ATPD_RAT ATP synthase F(1) complex subunit delta, mitochondrial (ATP synthase F1 subunit delta) (F-ATPase delta subunit) 2.087 0.007
up Cbx3 Q5RJK5 Q5RJK5_RAT Chromobox 3 (Chromobox homolog 3 (HP1 gamma homolog, Drosophila)) 0.978 0.007
up Cttn Q66HL2 SRC8_RAT Src substrate cortactin 1.017 0.007
up Hdgfl3 Q923W4 HDGR3_RAT Hepatoma-derived growth factor-related protein 3 (HRP-3) 1.296 0.007
up Mtpn P62775 MTPN_RAT Myotrophin (Granule cell differentiation protein) (Protein V-1) 1.410 0.007
up Pcnp Q7TP40 PCNP_RAT PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein) (Liver regeneration-related protein LRRG084) 1.496 0.007
up Ermn Q5RJL0 ERMIN_RAT Ermin (Juxtanodin) (JN) 1.501 0.007
up Fxn D3ZYW7 FRDA_RAT Frataxin, mitochondrial (Fxn) (EC 1.16.3.1) [Cleaved into: Frataxin intermediate form; Frataxin mature form; Extramitochondrial frataxin] 1.608 0.007
up Tppp3 Q5PPN5 TPPP3_RAT Tubulin polymerization-promoting protein family member 3 1.297 0.007
up Nsfl1c O35987 NSF1C_RAT NSFL1 cofactor p47 (XY body-associated protein XY40) (p97 cofactor p47) 1.047 0.009
up Npc2 A0A8I6AWS0 A0A8I6AWS0_RAT NPC intracellular cholesterol transporter 2 (Epididymal secretory protein E1) 1.051 0.009
up Tom1l2 A0A8I5ZP70 A0A8I5ZP70_RAT Target of myb1 like 2 membrane trafficking protein 0.794 0.010
up Rph3a P47709 RP3A_RAT Rabphilin-3A (Exophilin-1) 0.829 0.010
up Cfdp1 Q75UQ2 CFDP1_RAT Craniofacial development protein 1 (Bucentaur) 1.177 0.010
up Polr2m Q91XQ4 GRL1A_RAT DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A) 1.394 0.010
up Myl6 Q64119 MYL6_RAT Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) 0.888 0.010
up Sarnp Q498U4 SARNP_RAT SAP domain-containing ribonucleoprotein (Nuclear protein Hcc-1) 1.147 0.010
up Rwdd1 Q99ND9 RWDD1_RAT RWD domain-containing protein 1 (Small androgen receptor-interacting protein) 1.663 0.010
up Pfdn2 B0BN18 PFD2_RAT Prefoldin subunit 2 1.786 0.010
up Map1a P34926 MAP1A_RAT Microtubule-associated protein 1A (MAP-1A) [Cleaved into: MAP1A heavy chain; MAP1 light chain LC2] 1.166 0.010
up Psap P10960 SAP_RAT Prosaposin (Sulfated glycoprotein 1) (SGP-1) [Cleaved into: Saposin-A; Saposin-B-Val; Saposin-B; Saposin-C; Saposin-D] 1.700 0.010
up Lrpap1 Q99068 AMRP_RAT Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Gp330-binding 45 kDa protein) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) 1.016 0.010
up Fkbp3 G3V6L9 G3V6L9_RAT peptidylprolyl isomerase (EC 5.2.1.8) 0.718 0.010
up Pclo Q9JKS6 PCLO_RAT Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) 1.105 0.010
up Naca M0R9L0 M0R9L0_RAT Nascent polypeptide associated complex subunit alpha 1.016 0.011
up Epn1 O88339 EPN1_RAT Epsin-1 (EPS-15-interacting protein 1) 0.743 0.011
up Cplx2 P84087 CPLX2_RAT Complexin-2 (Complexin II) (CPX II) (Synaphin-1) 1.066 0.011
up Slc32a1 O35458 VIAAT_RAT Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (rGVAT) (rat UNC-47 homolog) (RUNC-47) 0.980 0.011
up C1qbp O35796 C1QBP_RAT Complement component 1 Q subcomponent-binding protein, mitochondrial (GC1q-R protein) (Glycoprotein gC1qBP) (C1qBP) 1.100 0.011
up Wipf3 Q9Z0G8 WIPF3_RAT WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16) 1.103 0.011
up Gcsh Q5I0P2 GCSH_RAT Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein) 1.527 0.011
up Npm1 P13084 NPM_RAT Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin) 2.297 0.011
up Atp6v1g1 A0A8I6B3N3 A0A8I6B3N3_RAT V-type proton ATPase subunit G 0.783 0.011
up Serbp1 Q6AXS5 SERB1_RAT SERPINE1 mRNA-binding protein 1 (PAI1 RNA-binding protein 1) (PAI-RBP1) (Plasminogen activator inhibitor 1 RNA-binding protein) (RDA288) 1.020 0.011
up Map1b P15205 MAP1B_RAT Microtubule-associated protein 1B (MAP-1B) (Neuraxin) [Cleaved into: MAP1B heavy chain; MAP1 light chain LC1] 1.095 0.011
up Ap1m1 Q32Q06 AP1M1_RAT AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin) 1.144 0.011
up Calb2 P47728 CALB2_RAT Calretinin (CR) 1.222 0.011
up Slc39a10 A0A1W2Q626 A0A1W2Q626_RAT Solute carrier family 39 member 10 1.223 0.011
up Abracl A0ABK0LMJ6 A0ABK0LMJ6_RAT ABRA C-terminal like 1.275 0.011
up Marcksl1 Q9EPH2 MRP_RAT MARCKS-related protein (Brain protein F52) (MARCKS-like protein 1) (Macrophage myristoylated alanine-rich C kinase substrate) (Mac-MARCKS) (MacMARCKS) 2.264 0.011
up Pafah1b2 O35264 PA1B2_RAT Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta) (Platelet-activating factor acetylhydrolase alpha 2 subunit) (PAF-AH alpha 2) 1.294 0.011
up Camk2n1 Q9JI15 CK2N1_RAT Calcium/calmodulin-dependent protein kinase II inhibitor 1 (calcium/calmodulin-dependent protein kinase II inhibitor alpha) (CaM-KIINalpha) (CaMKIINalpha) 1.344 0.011
up Gprin1 A0A8I6AJM0 A0A8I6AJM0_RAT G protein-regulated inducer of neurite outgrowth 1 1.579 0.011
up Lbh A0ABK0L5J9 A0ABK0L5J9_RAT LBH regulator of WNT signaling pathway 1.896 0.011
up Gpr158 D4A6L0 MGLYR_RAT Metabotropic glycine receptor (mGlyR) (G-protein coupled receptor 158) 0.873 0.012
up Gap43 P07936 NEUM_RAT Neuromodulin (Axonal membrane protein GAP-43) (Growth-associated protein 43) (Protein F1) 1.146 0.012
up Set Q63945 SET_RAT Protein SET (Liver regeneration-related protein LRRGR00002) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) 1.512 0.012
up Basp1 Q05175 BASP1_RAT Brain acid soluble protein 1 (22 kDa neuronal tissue-enriched acidic protein) (Neuronal axonal membrane protein NAP-22) 0.804 0.012
up Ndufs8 A0A8I6AL00 A0A8I6AL00_RAT NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) 0.887 0.012
up Snca P37377 SYUA_RAT Alpha-synuclein 1.087 0.012
up Ubqln4 D4A3P1 D4A3P1_RAT Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) 1.224 0.012
up Eif4h Q5XI72 IF4H_RAT Eukaryotic translation initiation factor 4H (eIF-4H) (Williams-Beuren syndrome chromosomal region 1 protein homolog) 1.454 0.012
up Cdv3 Q5XIM5 CDV3_RAT Protein CDV3 homolog 1.515 0.012
up Tpm1 P04692 TPM1_RAT Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) 1.437 0.012
up Hdgfl2 Q925G1 HDGR2_RAT Hepatoma-derived growth factor-related protein 2 (HRP-2) (Hepatoma-derived growth factor 3) (HDGF-3) 0.871 0.012
up Marcks P30009 MARCS_RAT Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein) 1.323 0.012
up Tsc22d1 P62501 T22D1_RAT TSC22 domain family protein 1 (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein) 1.345 0.012
up Habp4 A1L1K8 HABP4_RAT Intracellular hyaluronan-binding protein 4 (IHABP-4) (IHABP4) (Hyaluronan-binding protein 4) (Ki-1/57 intracellular antigen) 0.654 0.013
up NA Q6LED0 H31_RAT Histone H3.1 1.018 0.013
up Stoml2 Q4FZT0 STML2_RAT Stomatin-like protein 2, mitochondrial (SLP-2) 2.506 0.013
up Fam169a D3ZKX8 D3ZKX8_RAT Family with sequence similarity 169, member A 0.790 0.013
up Bod1 Q6AYJ2 BOD1_RAT Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) 1.087 0.013
up Tpd52 A0A0G2K865 A0A0G2K865_RAT Tumor protein D52 1.025 0.013
up Sumo2 P61959 SUMO2_RAT Small ubiquitin-related modifier 2 (SUMO-2) (SMT3 homolog 2) (Sentrin-2) (Ubiquitin-like protein SMT3A) (Smt3A) 2.075 0.013
up Fgf12 P61150 FGF12_RAT Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) 0.982 0.014
up Fkbp2 A0A8I6GH88 A0A8I6GH88_RAT peptidylprolyl isomerase (EC 5.2.1.8) 0.832 0.014
up Rbmx Q4V898 RBMX_RAT RNA-binding motif protein, X chromosome (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) (RNA-binding motif protein, X chromosome retrogene) (RNA-binding motif protein, X chromosome retrogene-like) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed] 0.767 0.014
up Tpm4 P09495 TPM4_RAT Tropomyosin alpha-4 chain (Tropomyosin-4) (TM-4) 1.010 0.014
up Dbi P11030 ACBP_RAT Acyl-CoA-binding protein (ACBP) (Diazepam-binding inhibitor) (DBI) (Endozepine) (EP) [Cleaved into: Triakontatetraneuropeptide (TTN); Octadecaneuropeptide (ODN)] 2.179 0.014
up Fubp1 Q32PX7 FUBP1_RAT Far upstream element-binding protein 1 (FBP) (FUSE-binding protein 1) 1.518 0.014
up Tpm3-rs7 NA NA NA 2.822 0.015
up Ubqln2 D4AA63 D4AA63_RAT Ubiquilin 2 1.389 0.015
up NA Q6LED0 H31_RAT Histone H3.1 1.470 0.015
up NA Q6LED0 H31_RAT Histone H3.1 1.470 0.015
up Zbed5 D3ZTR5 D3ZTR5_RAT Zinc finger BED-type containing 5 1.389 0.015
up Abl2 F1M0N1 F1M0N1_RAT Tyrosine-protein kinase (EC 2.7.10.2) 1.166 0.015
up Ppp1r2 P50411 IPP2_RAT Protein phosphatase inhibitor 2 (IPP-2) 1.219 0.016
up Hnrnpk P61980 HNRPK_RAT Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (dC stretch-binding protein) (CSBP) 3.650 0.016
up H2ax A0ABK0LP06 A0ABK0LP06_RAT H2A.X variant histone 1.210 0.016
up Ppp3r1 P63100 CANB1_RAT Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1) 1.065 0.016
up Rbm8a Q27W01 RBM8A_RAT RNA-binding protein 8A (RNA-binding motif protein 8A) (Ribonucleoprotein RBM8A) 1.580 0.016
up Zdhhc5 Q2THW7 ZDHC5_RAT Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) 1.733 0.016
up Smap NA NA NA 1.728 0.017
up Washc2 Q80X08 WASC2_RAT WASH complex subunit 2 0.768 0.017
up Arpin D4A1B2 D4A1B2_RAT Arpin 1.579 0.017
up Pdap1 Q62785 HAP28_RAT 28 kDa heat- and acid-stable phosphoprotein (PDGF-associated protein) (PAP) (PDGFA-associated protein 1) (PAP1) 1.103 0.017
up Rida P52759 RIDA_RAT 2-iminobutanoate/2-iminopropanoate deaminase (EC 3.5.99.10) (Liver perchloric acid-soluble protein) (L-PSP) (Reactive intermediate imine deaminase A homolog) (Translation inhibitor L-PSP ribonuclease) (UK114 antigen homolog) (rp14.5) 0.817 0.018
up Tpd52l2 Q6PCT3 TPD54_RAT Tumor protein D54 (Tumor protein D52-like 2) 0.746 0.018
up Hyou1 Q63617 HYOU1_RAT Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) 0.820 0.018
up Gm2a A0A8I6A5G9 A0A8I6A5G9_RAT Ganglioside GM2 activator 1.214 0.018
up Pcsk1n Q9QXU9 PCS1N_RAT ProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; PEN-20; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))] 1.842 0.018
up Gm49948 NA NA NA 1.439 0.019
up Reep2 A0A0G2K1L5 A0A0G2K1L5_RAT Receptor expression-enhancing protein 1.122 0.020
up Nucb1 Q63083 NUCB1_RAT Nucleobindin-1 (Bone 63 kDa calcium-binding protein) (CALNUC) 1.430 0.020
up Ptpn23 O88902 PTN23_RAT Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) 1.096 0.020
up Eef1b NA NA NA 1.212 0.020
up Dtna D4A772 D4A772_RAT Dystrobrevin 0.612 0.020
up Dek Q6AXS3 DEK_RAT Protein DEK 0.736 0.020
up Lin7a Q9Z250 LIN7A_RAT Protein lin-7 homolog A (Lin-7A) (Mammalian lin-seven protein 1) (MALS-1) (Vertebrate lin-7 homolog 1) (Veli-1) 0.719 0.021
up Drap1 A0JPP1 NC2A_RAT Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha) 0.876 0.021
up Hpca P84076 HPCA_RAT Neuron-specific calcium-binding protein hippocalcin (P23K) 1.089 0.021
up Rbm3 Q925G0 RBM3_RAT RNA-binding protein 3 (RNA-binding motif protein 3) 0.826 0.021
up Acin1 E9PST5 E9PST5_RAT Apoptotic chromatin condensation inducer in the nucleus 1.042 0.021
up 2900026A02Rik NA NA NA 0.623 0.022
up Mapre1 Q66HR2 MARE1_RAT Microtubule-associated protein RP/EB family member 1 (APC-binding protein EB1) (End-binding protein 1) (EB1) 0.668 0.022
up Bin1 O08839 BIN1_RAT Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1) 1.549 0.022
up Scp2 P11915 SCP2_RAT Sterol carrier protein 2 (SCP-2) (Acetyl-CoA C-myristoyltransferase) (EC 2.3.1.155) (Non-specific lipid-transfer protein) (NSL-TP) (Propanoyl-CoA C-acyltransferase) (EC 2.3.1.176) (SCP-2/3-oxoacyl-CoA thiolase) (SCP-2/thiolase) (EC 2.3.1.16) (SCP-chi) (Sterol carrier protein X) (SCP-X) 0.670 0.022
up NA Q6LED0 H31_RAT Histone H3.1 0.739 0.022
up NA Q6LED0 H31_RAT Histone H3.1 0.739 0.022
up Lsm3 D4A7U6 D4A7U6_RAT U6 snRNA-associated Sm-like protein LSm3 0.747 0.022
up Eif3j1 NA NA NA 0.827 0.022
up Ppp1r1a P19103 PPR1A_RAT Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1) 1.604 0.022
up Ncs1 P62168 NCS1_RAT Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein) 1.080 0.022
up Sgtb Q80W98 SGTB_RAT Small glutamine-rich tetratricopeptide repeat-containing protein beta (Beta-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 2) 0.782 0.022
up Map1lc3a Q6XVN8 MLP3A_RAT Microtubule-associated protein 1 light chain 3 alpha (Autophagy-related protein LC3 A) (Autophagy-related ubiquitin-like modifier LC3 A) (MAP1 light chain 3-like protein 1) (Microtubule-associated proteins 1A/1B light chain 3A) (MAP1A/MAP1B LC3 A) (MAP1A/MAP1B light chain 3 A) 0.618 0.023
up Psmd9 Q9WTV5 PSMD9_RAT 26S proteasome non-ATPase regulatory subunit 9 (26S proteasome regulatory subunit p27) (Transactivating protein Bridge-1) 0.747 0.023
up Lmtk3 F1LSB5 F1LSB5_RAT non-specific serine/threonine protein kinase (EC 2.7.11.1) 0.821 0.023
up Cdc42ep4 B1WC33 B1WC33_RAT CDC42 effector protein 4 0.957 0.023
up Ncl P13383 NUCL_RAT Nucleolin (Protein C23) 0.978 0.023
up Abraxas2 D4A415 D4A415_RAT Abraxas 2, BRISC complex subunit 1.642 0.023
up NA Q6LED0 H31_RAT Histone H3.1 0.919 0.023
up NA Q6LED0 H31_RAT Histone H3.1 0.919 0.023
up NA Q6LED0 H31_RAT Histone H3.1 0.919 0.023
up Scg2 P10362 SCG2_RAT Secretogranin-2 (Chromogranin-C) (Secretogranin II) (SgII) [Cleaved into: Secretoneurin (SN); Manserin] 1.094 0.023
up Mrrf Q5RKI9 RRFM_RAT Ribosome-recycling factor, mitochondrial (RRF) (Ribosome-releasing factor, mitochondrial) 1.006 0.024
up Cst3 P14841 CYTC_RAT Cystatin-C (Cystatin-3) 0.665 0.024
up Prkcsh A0A8I6G8K5 A0A8I6G8K5_RAT Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) 0.715 0.024
up Rad23a F7FJT3 F7FJT3_RAT UV excision repair protein RAD23 1.039 0.024
up Elob P62870 ELOB_RAT Elongin-B (EloB) (Elongin 18 kDa subunit) (RNA polymerase II transcription factor SIII subunit B) (SIII p18) (Transcription elongation factor B polypeptide 2) 0.547 0.024
up Atp6v1e1 Q6PCU2 VATE1_RAT V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (Vacuolar proton pump subunit E 1) 0.647 0.025
up Gorasp2 Q9R064 GORS2_RAT Golgi reassembly-stacking protein 2 (GRS2) (Golgi reassembly-stacking protein of 55 kDa) (GRASP55) 0.886 0.025
up Selenom A0A0G2JZZ4 A0A0G2JZZ4_RAT Selenoprotein M 1.813 0.025
up Ybx1 P62961 YBOX1_RAT Y-box-binding protein 1 (YB-1) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor) 1.322 0.025
up Asap1 Q1AAU6 ASAP1_RAT Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein) (ADP-ribosylation factor-directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (DEF-1) (Differentiation-enhancing factor 1) (PIP2-dependent ARF1 GAP) 1.315 0.026
up Carmil2 D3ZC15 D3ZC15_RAT Capping protein regulator and myosin 1 linker 2 0.638 0.026
up Pacsin1 Q9Z0W5 PACN1_RAT Protein kinase C and casein kinase substrate in neurons protein 1 (Dynamin proline-rich domain-interacting protein) (Dynamin PRD-interacting protein) (Synaptic, dynamin-associated protein I) (Syndapin-1) (Syndapin-I) (SdpI) 0.643 0.026
up Fkbp1a Q62658 FKB1A_RAT Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase) 0.651 0.026
up Cd99l2 Q8R1R5 C99L2_RAT CD99 antigen-like protein 2 (MIC2-like protein 1) (Rhombencephalic expression protein 40 kDa) (Protein rhombex-40) (CD antigen CD99) 0.838 0.026
up Caprin1 Q5M9G3 CAPR1_RAT Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (RNA granule protein 105) 0.900 0.026
up Znf207 NA NA NA 1.419 0.026
up Dbndd2 A0ABK0LCG8 A0ABK0LCG8_RAT Uncharacterized protein 1.217 0.026
up Pea15 Q5U318 PEA15_RAT Astrocytic phosphoprotein PEA-15 (15 kDa phosphoprotein enriched in astrocytes) 0.865 0.027
up Trmt112 B2RYS9 B2RYS9_RAT Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog) 0.705 0.027
up Zyx A0A8I6AV84 A0A8I6AV84_RAT Zyxin 1.567 0.027
up Tfg Q4R1A4 Q4R1A4_RAT TRK-fused gene protein (Trafficking from ER to golgi regulator) 0.551 0.027
up Pex14 Q642G4 PEX14_RAT Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) 1.319 0.027
up NA Q6LED0 H31_RAT Histone H3.1 1.411 0.027
up NA Q6LED0 H31_RAT Histone H3.1 1.411 0.027
up Tpm3 Q63610 TPM3_RAT Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) 1.523 0.027
up Ubap2l A0A8I5ZUK2 A0A8I5ZUK2_RAT Ubiquitin associated protein 2-like 0.869 0.028
up Nme1 Q05982 NDKA_RAT Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Metastasis inhibition factor NM23) (Tumor metastatic process-associated protein) 0.636 0.028
up Stip1 O35814 STIP1_RAT Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) 0.676 0.029
up Sf1 F1LM37 F1LM37_RAT Splicing factor 1 0.924 0.029
up Fam131b Q568Z1 F131B_RAT Protein FAM131B 1.010 0.029
up Cyb5a P00173 CYB5_RAT Cytochrome b5 1.053 0.029
up Lysmd2 A0A0G2K146 A0A0G2K146_RAT LysM domain containing 2 1.046 0.029
up Sh3bgrl3 B2RZ27 SH3L3_RAT SH3 domain-binding glutamic acid-rich-like protein 3 (TNF inhibitory protein B1) (TIP-B1) 1.605 0.029
up Rgs10 P49806 RGS10_RAT Regulator of G-protein signaling 10 (RGS10) 0.943 0.030
up Apoe P02650 APOE_RAT Apolipoprotein E (Apo-E) 0.911 0.030
up Psmd11 F1LMZ8 PSD11_RAT 26S proteasome non-ATPase regulatory subunit 11 (26S proteasome regulatory subunit RPN6) 1.072 0.030
up Crkl Q5U2U2 CRKL_RAT Crk-like protein 0.538 0.030
up Lnpk A0JN29 A0JN29_RAT Endoplasmic reticulum junction formation protein lunapark 0.571 0.031
up Alyref M0RBB1 M0RBB1_RAT Aly/REF export factor 0.593 0.031
up Sgta O70593 SGTA_RAT Small glutamine-rich tetratricopeptide repeat-containing protein alpha (Alpha-SGT) (Small glutamine-rich protein with tetratricopeptide repeats 1) 0.582 0.031
up Tceal3 M0RBL8 M0RBL8_RAT Transcription elongation factor A like 3 (Transcription elongation factor A like 6) 1.075 0.031
up Fabp7 P55051 FABP7_RAT Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) 1.526 0.031
up Rps28 P62859 RS28_RAT Small ribosomal subunit protein eS28 (40S ribosomal protein S28) 0.510 0.032
up NA Q6LED0 H31_RAT Histone H3.1 1.323 0.032
up NA Q6LED0 H31_RAT Histone H3.1 1.323 0.032
up Cap1 Q08163 CAP1_RAT Adenylyl cyclase-associated protein 1 (CAP 1) 0.602 0.033
up Dctn2 Q6AYH5 DCTN2_RAT Dynactin subunit 2 0.482 0.033
up Hmgn5 B4F777 HMGN5_RAT High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1) 1.011 0.033
up Dynlrb1 P62628 DLRB1_RAT Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (robl/LC7-like protein) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) 1.081 0.033
up Fam219a D4AAI7 D4AAI7_RAT Family with sequence similarity 219, member A 1.380 0.033
up Oxsr1 A0A8I5ZNK2 OXSR1_RAT Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein) 0.666 0.033
up Tcea1 Q4KLL0 TCEA1_RAT Transcription elongation factor A protein 1 (Transcription elongation factor S-II protein 1) 0.706 0.034
up Nol3 Q62881 NOL3_RAT Nucleolar protein 3 (Apoptosis repressor with CARD) 1.156 0.035
up Endod1 D3ZIP8 D3ZIP8_RAT Endonuclease domain containing 1 0.598 0.035
up Homer3 Q9Z2X5 HOME3_RAT Homer protein homolog 3 (Homer-3) (VASP/Ena-related gene up-regulated during seizure and LTP 3) (Vesl-3) 0.574 0.035
up Mrpl12 D3ZXF9 D3ZXF9_RAT Large ribosomal subunit protein bL12m (39S ribosomal protein L12, mitochondrial) 1.470 0.035
up Lgals1 P11762 LEG1_RAT Galectin-1 (Gal-1) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (RL 14.5) (S-Lac lectin 1) 0.931 0.036
up Safb O88453 SAFB1_RAT Scaffold attachment factor B1 (SAF-B) (SAF-B1) 0.545 0.036
up Akap5 P24587 AKAP5_RAT A-kinase anchor protein 5 (AKAP-5) (A-kinase anchor protein 150 kDa) (AKAP 150) (P150) (cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein) 0.696 0.036
up Pnma8b D3ZQN3 D3ZQN3_RAT PNMA family member 8B 2.469 0.036
up Gabarapl2 P60522 GBRL2_RAT Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) 0.560 0.037
up Cox6b1 P80430 CX6B1_RAT Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1) 0.980 0.038
up Lrrc59 Q5RJR8 LRC59_RAT Leucine-rich repeat-containing protein 59 (Protein p34) [Cleaved into: Leucine-rich repeat-containing protein 59, N-terminally processed] 0.606 0.038
up Akt1s1 A0A8I5ZRQ9 A0A8I5ZRQ9_RAT AKT1 substrate 1 2.115 0.038
up Nap1l1 Q9Z2G8 NP1L1_RAT Nucleosome assembly protein 1-like 1 (NAP-1-related protein) 0.597 0.039
up Snrpa Q5U214 Q5U214_RAT U1 small nuclear ribonucleoprotein A 0.873 0.039
up Clip2 O55156 CLIP2_RAT CAP-Gly domain-containing linker protein 2 (Cytoplasmic linker protein 115) (CLIP-115) (Cytoplasmic linker protein 2) 0.733 0.039
up Wipf2 D3ZUD3 D3ZUD3_RAT WAS/WASL interacting protein family, member 2 0.877 0.039
up Txndc17 A0ABK0M2Q2 A0ABK0M2Q2_RAT Thioredoxin domain containing 17 1.680 0.039
up Larp1 A0A8I6GJC3 A0A8I6GJC3_RAT La ribonucleoprotein 1, translational regulator 0.933 0.040
up Ramac D4AD33 D4AD33_RAT RNA guanine-7 methyltransferase activating subunit 1.645 0.040
up Chmp1a A0A8I6GLB8 A0A8I6GLB8_RAT Charged multivesicular body protein 1A 0.905 0.040
up Uqcrb B2RYS2 B2RYS2_RAT Cytochrome b-c1 complex subunit 7 1.108 0.041
up Rtn4 Q9JK11 RTN4_RAT Reticulon-4 (Foocen) (Glut4 vesicle 20 kDa protein) (Neurite outgrowth inhibitor) (Nogo protein) 0.482 0.042
up Cul4b D3ZK73 D3ZK73_RAT Cullin-4B 1.096 0.042
up Sdc4 P34901 SDC4_RAT Syndecan-4 (SYND4) (Ryudocan core protein) 0.925 0.043
up Rps18-ps6 NA NA NA 0.601 0.043
up Ak1 P39069 KAD1_RAT Adenylate kinase isoenzyme 1 (AK 1) (EC 2.7.4.3) (EC 2.7.4.4) (EC 2.7.4.6) (ATP-AMP transphosphorylase 1) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) (Myokinase) 0.486 0.043
up Sh3glb2 Q5PPJ9 SHLB2_RAT Endophilin-B2 (SH3 domain-containing GRB2-like protein B2) 1.018 0.043
up Msn O35763 MOES_RAT Moesin (Membrane-organizing extension spike protein) 1.556 0.044
up Arid1a A0A8I6AJE2 A0A8I6AJE2_RAT AT-rich interaction domain 1A 1.848 0.044
up Hmgb3 F7EWK1 F7EWK1_RAT High mobility group protein B3 (High mobility group protein 2a) (High mobility group protein 4) 1.549 0.044
up Kif5b Q2PQA9 KINH_RAT Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) 0.762 0.044
up Bag4 A0ABZ3NN99 A0ABZ3NN99_RAT BAG cochaperone 4 0.618 0.044
up Map7 A0A0G2KB52 A0A0G2KB52_RAT Microtubule-associated protein 7 0.780 0.044
up Tppp D3ZQL7 TPPP_RAT Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p25-alpha) 0.483 0.044
up Ggt7 Q99MZ4 GGT7_RAT Glutathione hydrolase 7 (EC 3.4.19.13) (Gamma-glutamyltransferase 7) (GGT 7) (EC 2.3.2.2) (Gamma-glutamyltransferase-like 3) (Gamma-glutamyltranspeptidase 7) [Cleaved into: Glutathione hydrolase 7 heavy chain; Glutathione hydrolase 7 light chain] 0.605 0.044
up Srsf1 D4A9L2 D4A9L2_RAT Serine/arginine-rich splicing factor 1 (Splicing factor, arginine/serine-rich 1) 0.568 0.045
up App P08592 A4_RAT Amyloid-beta precursor protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31] 0.776 0.045
up Rcn2 Q62703 RCN2_RAT Reticulocalbin-2 (Calcium-binding protein ERC-55) (Taipoxin-associated calcium-binding protein 49) (TCBP-49) 1.083 0.045
up Cstf2 B4F7F1 B4F7F1_RAT Cleavage stimulation factor subunit 2 (Cstf2 protein) 0.775 0.046
up Ciapin1 Q5XID1 CPIN1_RAT Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) 0.542 0.046
up Rabl6 D3ZKQ4 D3ZKQ4_RAT Rab-like protein 6 (GTP-binding protein Parf) (Rab-like protein 1) 1.067 0.047
up Prrt3 D3ZWQ0 D3ZWQ0_RAT Proline-rich transmembrane protein 3 0.697 0.048
up Bcas1 Q3ZB98 BCAS1_RAT Breast carcinoma-amplified sequence 1 homolog (Protein whose mRNA is enriched in synaptosomes 2) (Pmes-2) 0.729 0.048
up 4833439L19Rik NA NA NA 1.005 0.048
up Ube2n Q9EQX9 UBE2N_RAT Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) 0.425 0.049
up Umad1 NA NA NA 1.268 0.049
up Add1 Q63028 ADDA_RAT Alpha-adducin (Erythrocyte adducin subunit alpha) 2.529 0.049
up Pkia P63249 IPKA_RAT cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform) 2.160 0.050
down Dlgap1 P97836 DLGP1_RAT Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (rGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1) −2.294 0.006
down C1qb P31721 C1QB_RAT Complement C1q subcomponent subunit B −1.637 0.006
down Unc13a Q62768 UN13A_RAT Protein unc-13 homolog A (Munc13-1) −1.532 0.006
down Ppp3cb P20651 PP2BB_RAT Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit beta isoform) (CNA beta) −0.802 0.006
down Tpp2 Q64560 TPP2_RAT Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) −1.233 0.007
down Flot1 Q9Z1E1 FLOT1_RAT Flotillin-1 (Reggie-2) (REG-2) −1.083 0.007
down Uso1 P41542 USO1_RAT General vesicular transport factor p115 (Protein USO1 homolog) (Transcytosis-associated protein) (TAP) (Vesicle-docking protein) −0.954 0.007
down Pip4k2b O88377 PI42B_RAT Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (Phosphatidylinositol-phosphate kinase IIgamma) (PIPKIIgamma) (PtdIns(5)P-4-kinase isoform 2-beta) −1.284 0.007
down Prkcg P63319 KPCG_RAT Protein kinase C gamma type (PKC-gamma) (EC 2.7.11.13) −0.899 0.007
down Mtmr1 A0A0G2JUZ0 A0A0G2JUZ0_RAT phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) −1.107 0.007
down Iqsec1 A0A0G2JUG7 IQEC1_RAT IQ motif and SEC7 domain-containing protein 1 −1.106 0.007
down Prps1l3 A0A0G2JSV3 A0A0G2JSV3_RAT Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase I) −0.688 0.007
down Cyb5r1 Q5EB81 NB5R1_RAT NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) −1.236 0.007
down Sptbn2 Q9QWN8 SPTN2_RAT Spectrin beta chain, non-erythrocytic 2 (Beta SpIII sigma 1) (Beta-III spectrin) (Glutamate transporter EAAT4-associated protein 41) (SPNB-3) (Spectrin-like protein GTRAP41) −0.981 0.007
down Agap3 A0A0G2K2D4 A0A0G2K2D4_RAT Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (CRAM-associated GTPase) (Centaurin-gamma-3) (MR1-interacting protein) −0.890 0.007
down NA Q6LED0 H31_RAT Histone H3.1 −0.845 0.007
down Camk2b P08413 KCC2B_RAT Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) −1.298 0.007
down Tmx3 M0R402 M0R402_RAT Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) −1.308 0.007
down Exoc4 Q62824 EXOC4_RAT Exocyst complex component 4 (Exocyst complex component Sec8) (rSec8) −0.870 0.007
down Cntnap1 P97846 CNTP1_RAT Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (Paranodin) (p190) −0.888 0.008
down Drg2 A0A8I5ZWK0 A0A8I5ZWK0_RAT Developmentally-regulated GTP-binding protein 2 (Translation factor GTPase DRG2) −0.895 0.010
down Anks1b P0C6S7 ANS1B_RAT Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) −0.786 0.010
down NA Q6LED0 H31_RAT Histone H3.1 −0.997 0.010
down Armc1 B0BN83 B0BN83_RAT Armadillo repeat-containing protein 1 −0.912 0.010
down Gria1 P19490 GRIA1_RAT Glutamate receptor 1 (GluR-1) (AMPA-selective glutamate receptor 1) (GluR-A) (GluR-K1) (Glutamate receptor ionotropic, AMPA 1) −0.905 0.011
down Psma4 P21670 PSA4_RAT Proteasome subunit alpha type-4 (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L) (Proteasome subunit alpha-3) (alpha-3) −0.811 0.011
down Cnksr2 Q9Z1T4 CNKR2_RAT Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR 2) (CNK homolog protein 2) (CNK2) (Membrane-associated guanylate kinase-interacting protein) (Maguin) −1.017 0.011
down Grin1 P35439 NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1) −0.928 0.011
down Ppfia3 Q91Z79 LIPA3_RAT Liprin-alpha-3 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3) (PTPRF-interacting protein alpha-3) −0.776 0.011
down Ppp3ca P63329 PP2BA_RAT Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform) −0.588 0.011
down Psmd1 O88761 PSMD1_RAT 26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112) −1.370 0.011
down Rps11 P62282 RS11_RAT Small ribosomal subunit protein uS17 (40S ribosomal protein S11) −0.897 0.011
down Eif3b Q4G061 EIF3B_RAT Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Eukaryotic translation initiation factor 3 subunit 9) (eIF-3-eta) −0.894 0.011
down Lap3 Q68FS4 AMPL_RAT Cytosol aminopeptidase (EC 3.4.11.1) (Cysteinylglycine-S-conjugate dipeptidase) (EC 3.4.13.23) (Leucine aminopeptidase 3) (LAP-3) (Leucyl aminopeptidase) (LAP) (Peptidase S) (Proline aminopeptidase) (EC 3.4.11.5) (Prolyl aminopeptidase) −0.661 0.011
down Abr A0A0G2JTR4 ABR_RAT Active breakpoint cluster region-related protein −1.004 0.011
down Rab3c P62824 RAB3C_RAT Ras-related protein Rab-3C (EC 3.6.5.2) −0.846 0.012
down Slc8a2 P48768 NAC2_RAT Sodium/calcium exchanger 2 (Na(+)/Ca(2+)-exchange protein 2) (Solute carrier family 8 member 2) −0.714 0.012
down Actr2 Q5M7U6 ARP2_RAT Actin-related protein 2 (Actin-like protein 2) −0.668 0.012
down Mal2 Q7TPB7 Q7TPB7_RAT MAL2A (Mal, T-cell differentiation protein 2) −0.647 0.012
down Pfn2 Q9EPC6 PROF2_RAT Profilin-2 (Profilin II) −0.764 0.012
down Ganab D3ZAN3 D3ZAN3_RAT Neutral alpha-glucosidase AB (EC 3.2.1.207) (Alpha-glucosidase 2) (Glucosidase II subunit alpha) −1.043 0.012
down Cltc P11442 CLH1_RAT Clathrin heavy chain 1 −0.845 0.012
down Ap1b1 P52303 AP1B1_RAT AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit) −0.837 0.012
down Pafah1b1 P63004 LIS1_RAT Platelet-activating factor acetylhydrolase IB subunit alpha (Lissencephaly-1 protein) (LIS-1) (PAF acetylhydrolase 45 kDa subunit) (PAF-AH 45 kDa subunit) (PAF-AH alpha) (PAFAH alpha) −0.903 0.012
down Acadl P15650 ACADL_RAT Long-chain specific acyl-CoA dehydrogenase, mitochondrial (LCAD) (EC 1.3.8.8) −0.761 0.012
down Shisa6 D4A4M0 D4A4M0_RAT Shisa family member 6 −0.720 0.013
down Ablim1 A0A8I5Y6A1 A0A8I5Y6A1_RAT Actin-binding LIM protein 1 −0.662 0.013
down Stum A0ABK0LZH3 A0ABK0LZH3_RAT Uncharacterized protein −1.422 0.013
down Plppr2 Q6W5G4 PLPR2_RAT Phospholipid phosphatase-related protein type 2 (Inactive phospholipid phosphatase PLPPR2) (Lipid phosphate phosphatase-related protein type 2) (Plasticity-related gene 4 protein) (PRG-4) −2.004 0.013
down Ap2a2 P18484 AP2A2_RAT AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit) −0.805 0.013
down Slc6a7 P28573 SC6A7_RAT Sodium-dependent proline transporter (Solute carrier family 6 member 7) −0.864 0.013
down Ddx5 Q6AYI1 Q6AYI1_RAT Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) −0.667 0.013
down Nsf Q9QUL6 NSF_RAT Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF) −0.646 0.013
down Ptk2b P70600 FAK2_RAT Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) −0.668 0.014
down Ap2a1 A0A8I6A4J2 A0A8I6A4J2_RAT AP-2 complex subunit alpha −0.786 0.014
down Cpne6 D4ACG7 D4ACG7_RAT Copine-6 (Copine VI) −0.767 0.014
down Maoa P21396 AOFA_RAT Amine oxidase [flavin-containing] A (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type A) (MAO-A) −0.696 0.014
down Glrx3 Q9JLZ1 GLRX3_RAT Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) −0.964 0.014
down Gabbr2 O88871 GABR2_RAT Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) −0.775 0.014
down Septin9 Q9QZR6 SEPT9_RAT Septin-9 (Eighth septin) (Eseptin) (Septin-like protein) (SLP) −0.692 0.014
down Actr3 Q4V7C7 ARP3_RAT Actin-related protein 3 (Actin-like protein 3) −0.639 0.014
down Lgi1 Q8K4Y5 LGI1_RAT Leucine-rich glioma-inactivated protein 1 −0.667 0.014
down Pals2 B5DFE0 B5DFE0_RAT MAGUK p55 subfamily member 2 (Protein MPP2) −0.621 0.014
down Crym Q9QYU4 CRYM_RAT Ketimine reductase mu-crystallin (EC 1.5.1.25) (1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase) (P2C/Pyr2C reductase) (EC 1.5.1.1) (CDK108) (NADP-regulated thyroid-hormone-binding protein) −0.623 0.014
down Sfxn5 Q8CFD0 SFXN5_RAT Sideroflexin-5 (Tricarboxylate carrier BBG-TCC) −0.594 0.014
down Aldh1b1 Q66HF8 AL1B1_RAT Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase family 1 member B1) −0.958 0.015
down Eipr1 Q5PPK9 EIPR1_RAT EARP and GARP complex-interacting protein 1 (Endosome-associated recycling protein-interacting protein) (Golgi-associated retrograde protein-interacting protein) (Tumor-suppressing STF cDNA 1 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein) −0.871 0.015
down Svop Q9Z2I7 SVOP_RAT Synaptic vesicle 2-related protein (SV2-related protein) −1.632 0.015
down Arpc1a Q99PD4 ARC1A_RAT Actin-related protein 2/3 complex subunit 1A −0.676 0.015
down Ap2m1 P84092 AP2M1_RAT AP-2 complex subunit mu (AP-2 mu chain) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) −0.782 0.015
down Coro1c A0A8I6GLR9 A0A8I6GLR9_RAT Coronin −0.728 0.016
down Rac1 Q6RUV5 RAC1_RAT Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1) −0.657 0.016
down Fasn P12785 FAS_RAT Fatty acid synthase (EC 2.3.1.85) (Type I FAS) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] −0.820 0.016
down Nbea A0A8I6AB61 A0A8I6AB61_RAT Neurobeachin (Lysosomal-trafficking regulator 2) −0.741 0.016
down Pcyt2 O88637 PCY2_RAT Ethanolamine-phosphate cytidylyltransferase (EC 2.7.7.14) (CTP:phosphoethanolamine cytidylyltransferase) (Phosphorylethanolamine transferase) −1.120 0.016
down Ap3b2 A0ABK0LE23 A0ABK0LE23_RAT Adaptor related protein complex 3 subunit beta 2 −0.689 0.016
down Dpysl4 Q62951 DPYL4_RAT Dihydropyrimidinase-related protein 4 (DRP-4) (Collapsin response mediator protein 3) (CRMP-3) (UNC33-like phosphoprotein 4) (ULIP-4) −0.662 0.016
down Xpo7 F1LQM9 F1LQM9_RAT Exportin 7 −1.157 0.016
down Htt P51111 HD_RAT Huntingtin (Huntington disease protein homolog) (HD protein homolog) [Cleaved into: Huntingtin, myristoylated N-terminal fragment] −1.186 0.017
down Naxd D4AAT7 NNRD_RAT ATP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.93) (ATP-dependent NAD(P)HX dehydratase) (Carbohydrate kinase domain-containing protein) (NAD(P)HX dehydratase) −0.784 0.017
down Adss2 D4AEP0 D4AEP0_RAT Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2) −0.705 0.017
down Lta4h P30349 LKHA4_RAT Leukotriene A-4 hydrolase (LTA-4 hydrolase) (EC 3.3.2.6) (Leukotriene A(4) hydrolase) (Tripeptide aminopeptidase LTA4H) (EC 3.4.11.4) −0.607 0.018
down Prpsap1 Q63468 KPRA_RAT Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) −1.523 0.018
down Kif2a Q9WV63 KIF2A_RAT Kinesin-like protein KIF2A (Kinesin-2) −0.686 0.018
down Nomo1 D3ZSA9 D3ZSA9_RAT Nodal modulator 1 −0.804 0.018
down Slc6a1 P23978 SC6A1_RAT Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) −0.795 0.018
down Cct6a F7ELS2 F7ELS2_RAT T-complex protein 1 subunit zeta −0.764 0.018
down Rab3a P63012 RAB3A_RAT Ras-related protein Rab-3A (EC 3.6.5.2) −0.610 0.018
down Myo5a Q9QYF3 MYO5A_RAT Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle) −0.638 0.018
down Plec P30427 PLEC_RAT Plectin (PCN) (PLTN) (Plectin-1) −0.685 0.018
down Psma5 P34064 PSA5_RAT Proteasome subunit alpha type-5 (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome subunit alpha-5) (alpha-5) (Proteasome zeta chain) −0.616 0.018
down Myh10 Q9JLT0 MYH10_RAT Myosin-10 (Cellular myosin heavy chain, type B) (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb) (Non-muscle myosin heavy chain B) (NMMHC-B) (Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) −0.698 0.018
down Nptn P97546 NPTN_RAT Neuroplastin (Glycoprotein 55/65) (gp55/65) (Stromal cell-derived receptor 1) (SDR-1) −0.545 0.019
down Mtnd5 P11661 NU5M_RAT NADH-ubiquinone oxidoreductase chain 5 (EC 7.1.1.2) (NADH dehydrogenase subunit 5) −1.557 0.020
down Rab5b A1L1J8 A1L1J8_RAT small monomeric GTPase (EC 3.6.5.2) −1.031 0.020
down Bdh1 P29147 BDH_RAT D-beta-hydroxybutyrate dehydrogenase, mitochondrial (EC 1.1.1.30) (3-hydroxybutyrate dehydrogenase) (BDH) −1.037 0.020
down Ppp1cb P62142 PP1B_RAT Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (EC 3.1.3.16) (EC 3.1.3.53) −0.729 0.020
down Ugp2 Q4V8I9 Q4V8I9_RAT UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) −0.676 0.020
down Camk4 P13234 KCC4_RAT Calcium/calmodulin-dependent protein kinase type IV (CaMK IV) (EC 2.7.11.17) (CaM kinase-GR) (Calspermin) −0.870 0.020
down Nckap1 P55161 NCKP1_RAT Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) −0.907 0.021
down Ahcyl1 B5DFN2 SAHH2_RAT S-adenosylhomocysteine hydrolase-like protein 1 (IP3R-binding protein released with inositol 1,4,5-trisphosphate) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) −0.715 0.021
down Rpl7a P62425 RL7A_RAT Large ribosomal subunit protein eL8 (60S ribosomal protein L7a) −0.719 0.021
down Syngap1 Q9QUH6 SYGP1_RAT Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1) (p135 SynGAP) −0.694 0.021
down Pcx NA NA NA −0.623 0.021
down Cul3 B5DF89 CUL3_RAT Cullin-3 −1.003 0.021
down Uba1 Q5U300 UBA1_RAT Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) −0.649 0.022
down Adap1 O88768 O88768_RAT ArfGAP with dual PH domains 1 (IP4/PIP3 binding protein) −1.817 0.022
down Kctd12 A0A8I5Y7I2 A0A8I5Y7I2_RAT Potassium channel tetramerization domain containing 12 −0.634 0.022
down NA Q6LED0 H31_RAT Histone H3.1 −0.961 0.022
down Snx15 Q4V896 SNX15_RAT Sorting nexin-15 −1.026 0.022
down Rhot1 A1L1L6 MIRO1_RAT Mitochondrial Rho GTPase (MIRO-1) (EC 3.6.5.-) (Ras homolog gene family member T1) −0.942 0.022
down Epha4 D3ZZK3 D3ZZK3_RAT receptor protein-tyrosine kinase (EC 2.7.10.1) −0.865 0.022
down Cyfip2 A0A8I6AHL8 A0A8I6AHL8_RAT Cytoplasmic FMR1-interacting protein −0.710 0.022
down Atp2b3 Q64568 AT2B3_RAT Plasma membrane calcium-transporting ATPase 3 (PMCA3) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 3) (Plasma membrane calcium pump isoform 3) −0.636 0.022
down Nae1 Q9Z1A5 ULA1_RAT NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) −0.629 0.022
down Hspa4l P83581 HS74L_RAT Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) −0.591 0.022
down Dynll1 P63170 DYL1_RAT Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) −0.474 0.022
down Cct7 A0A8I6AR12 A0A8I6AR12_RAT T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) −0.627 0.022
down Maob P19643 AOFB_RAT Amine oxidase [flavin-containing] B (EC 1.4.3.21) (EC 1.4.3.4) (Monoamine oxidase type B) (MAO-B) −0.847 0.022
down Slc4a4 Q9JI66 S4A4_RAT Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (NBC-like protein) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) −0.641 0.022
down Pdha1 P26284 ODPA_RAT Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) −0.782 0.022
down Fbxl16 Q5MJ12 FXL16_RAT F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) (Spinal cord injury and regeneration-related protein 1) −0.755 0.023
down Slc4a7 Q9R1N3 S4A7_RAT Sodium bicarbonate cotransporter 3 (Electroneutral sodium bicarbonate cotransporter 1) (NBC-like protein) (Solute carrier family 4 member 7) −1.958 0.023
down Iars2 A0A0G2K261 A0A0G2K261_RAT Isoleucine--tRNA ligase, mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) −0.805 0.023
down Dlg3 Q62936 DLG3_RAT Disks large homolog 3 (PSD-95/SAP90-related protein 1) (Synapse-associated protein 102) (SAP-102) (SAP102) −0.709 0.023
down Psmc2 Q63347 PRS7_RAT 26S proteasome regulatory subunit 7 (26S proteasome AAA-ATPase subunit RPT1) (Proteasome 26S subunit ATPase 2) −0.690 0.023
down Eif4g1 D4AD15 D4AD15_RAT Eukaryotic translation initiation factor 4 gamma 1 −0.659 0.023
down Cct3 Q6P502 TCPG_RAT T-complex protein 1 subunit gamma (TCP-1-gamma) (EC 3.6.1.-) (CCT-gamma) −0.609 0.023
down Slc24a2 O54701 NCKX2_RAT Sodium/potassium/calcium exchanger 2 (Na(+)/K(+)/Ca(2+)-exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2) −0.907 0.023
down Vdac2 P81155 VDAC2_RAT Non-selective voltage-gated ion channel VDAC2 (VDAC-2) (B36-VDAC) (Outer mitochondrial membrane protein porin 2) −0.919 0.024
down Rock2 Q62868 ROCK2_RAT Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (RhoA-binding kinase 2) (p150 ROK-alpha) (ROKalpha) (p164 ROCK-2) −0.738 0.024
down Tcp1 P28480 TCPA_RAT T-complex protein 1 subunit alpha (TCP-1-alpha) (EC 3.6.1.-) (CCT-alpha) −0.488 0.024
down Slc7a14 A0A0G2K1G8 A0A0G2K1G8_RAT Solute carrier family 7, member 14 −1.190 0.024
down Rap2a A0ABK0M907 A0ABK0M907_RAT Uncharacterized protein −0.577 0.025
down Cldn11 Q99P82 CLD11_RAT Claudin-11 −0.888 0.026
down Atp8a1 F1LUT4 F1LUT4_RAT Phospholipid-transporting ATPase (EC 7.6.2.1) −1.179 0.026
down Rps16 P62250 RS16_RAT Small ribosomal subunit protein uS9 (40S ribosomal protein S16) −0.695 0.026
down Gnb1 P54311 GBB1_RAT Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1) −0.633 0.026
down Rps9 P29314 RS9_RAT Small ribosomal subunit protein uS4 (40S ribosomal protein S9) −0.607 0.026
down Aco2 Q9ER34 ACON_RAT Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) −0.582 0.026
down Gapdh P04797 G3P_RAT Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (38 kDa BFA-dependent ADP-ribosylation substrate) (BARS-38) (Peptidyl-cysteine S-nitrosylase GAPDH) (EC 2.6.99.-) −0.532 0.026
down NA Q6LED0 H31_RAT Histone H3.1 −0.822 0.026
down Farp1 F1LYQ8 FARP1_RAT FERM, ARHGEF and pleckstrin domain-containing protein 1 (FERM, RhoGEF and pleckstrin domain-containing protein 1) −0.823 0.026
down Ddb1 Q9ESW0 DDB1_RAT DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1) −0.756 0.026
down Trim2 D3ZQG6 TRIM2_RAT Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING-type E3 ubiquitin transferase TRIM2) −0.646 0.027
down Mlf2 A0A0G2K8Z8 A0A0G2K8Z8_RAT Myeloid leukemia factor 2 −0.652 0.027
down Rgs14 O08773 RGS14_RAT Regulator of G-protein signaling 14 (RGS14) −0.503 0.028
down Cyfip1 A0A0G2K472 A0A0G2K472_RAT Cytoplasmic FMR1-interacting protein −0.976 0.028
down Rheb Q62639 RHEB_RAT GTP-binding protein Rheb (EC 3.6.5.-) (Ras homolog enriched in brain) −0.862 0.028
down Ppp2r5a D3ZDI7 D3ZDI7_RAT Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit −0.779 0.028
down Wdr7 Q9ERH3 WDR7_RAT WD repeat-containing protein 7 (TGF-beta resistance-associated protein TRAG) −0.721 0.028
down Dars1 P15178 SYDC_RAT Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) −0.701 0.028
down Aars1 P50475 SYAC_RAT Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Protein lactyltransferase AARS1) (EC 6.-.-.-) −0.643 0.028
down Camkv Q63092 CAMKV_RAT CaM kinase-like vesicle-associated protein (1G5) −0.487 0.028
down Slc12a5 Q63633 S12A5_RAT Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (Furosemide-sensitive K-Cl cotransporter) (K-Cl cotransporter 2) (rKCC2) (Neuronal K-Cl cotransporter) −0.602 0.028
down Phyhip Q568Z9 PHYIP_RAT Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1) −1.064 0.029
down Actr3b A0A8I6GL35 A0A8I6GL35_RAT Actin related protein 3B −0.744 0.029
down Prep O70196 PPCE_RAT Prolyl endopeptidase (PE) (EC 3.4.21.26) (Post-proline cleaving enzyme) (rPop) −0.636 0.029
down Arpc2 P85970 ARPC2_RAT Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC) −0.560 0.029
down Hnrnpul2 D4ABT8 D4ABT8_RAT Heterogeneous nuclear ribonucleoprotein U-like protein 2 −0.543 0.029
down Glul P09606 GLNA_RAT Glutamine synthetase (GS) (EC 6.3.1.2) (Glutamate--ammonia ligase) (Palmitoyltransferase GLUL) (EC 2.3.1.225) −0.759 0.029
down Arf4 P61751 ARF4_RAT ADP-ribosylation factor 4 −0.540 0.029
down Hspa2 P14659 HSP72_RAT Heat shock-related 70 kDa protein 2 (Heat shock protein 70.2) (Testis-specific heat shock protein-related) (HST) −0.644 0.029
down Acot13 D3ZA93 D3ZA93_RAT Acyl-coenzyme A thioesterase 13 (EC 3.1.2.2) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (Thioesterase superfamily member 2) −0.469 0.029
down Syngr3 D4ABK1 D4ABK1_RAT Synaptogyrin 3 −0.661 0.029
down Mcu A0A0G2K059 A0A0G2K059_RAT Calcium uniporter protein −0.782 0.029
down Rab6a Q9WVB1 RAB6A_RAT Ras-related protein Rab-6A (Rab-6) (EC 3.6.5.2) −0.842 0.029
down Gmps Q4V7C6 GUAA_RAT GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) −0.632 0.030
down Nudcd2 Q5M823 NUDC2_RAT NudC domain-containing protein 2 −1.158 0.030
down Pygb P53534 PYGB_RAT Glycogen phosphorylase, brain form (EC 2.4.1.1) −0.560 0.030
down Hnrnph1 Q8VHV7 HNRH1_RAT Heterogeneous nuclear ribonucleoprotein H (hnRNP H) (Ratsg1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed] −0.623 0.030
down Cmas P69060 NEUA_RAT N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) −0.925 0.031
down Mtch2 A0A8I6AK45 A0A8I6AK45_RAT Mitochondrial carrier homolog 2 −0.733 0.031
down Adh5 P12711 ADHX_RAT Alcohol dehydrogenase class-3 (EC 1.1.1.1) (Alcohol dehydrogenase 2) (Alcohol dehydrogenase 5) (Alcohol dehydrogenase B2) (ADH-B2) (Alcohol dehydrogenase class-III) (Glutathione-dependent formaldehyde dehydrogenase) (FALDH) (FDH) (GSH-FDH) (EC 1.1.1.-) (S-(hydroxymethyl)glutathione dehydrogenase) (EC 1.1.1.284) −0.631 0.031
down Akr1b1 P07943 ALDR_RAT Aldo-keto reductase family 1 member B1 (EC 1.1.1.21) (EC 1.1.1.300) (EC 1.1.1.372) (EC 1.1.1.54) (Aldehyde reductase) (Aldose reductase) (AR) −0.617 0.031
down Padi2 P20717 PADI2_RAT Protein-arginine deiminase type-2 (EC 3.5.3.15) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) −0.614 0.031
down Atp1a3 P06687 AT1A3_RAT Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) −0.562 0.031
down Mapk10 P49187 MK10_RAT Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (SAPK-beta) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (p54-beta) −0.529 0.031
down Srr Q76EQ0 SRR_RAT Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17) −0.529 0.031
down Pdk3 A6IPZ9 A6IPZ9_RAT Protein-serine/threonine kinase (EC 2.7.11.-) −0.496 0.031
down Rpl11 P62914 RL11_RAT Large ribosomal subunit protein uL5 (60S ribosomal protein L11) −2.118 0.031
down Prkca P05696 KPCA_RAT Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13) −0.789 0.031
down Prepl Q5HZA6 PPCEL_RAT Prolyl endopeptidase-like (EC 3.4.21.-) (Prolylendopeptidase-like) −0.765 0.031
down Cdipt P70500 CDIPT_RAT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PtdIns synthase) −0.735 0.031
down Tnr Q05546 TENR_RAT Tenascin-R (TN-R) (Janusin) (Neural recognition molecule J1-160/180) (Restrictin) −0.525 0.031
down Eif3d Q6AYK8 EIF3D_RAT Eukaryotic translation initiation factor 3 subunit D (eIF3d) (Eukaryotic translation initiation factor 3 subunit 7) (eIF-3-zeta) −1.361 0.032
down NA Q6LED0 H31_RAT Histone H3.1 −1.322 0.032
down NA Q6LED0 H31_RAT Histone H3.1 −1.322 0.032
down Dmxl2 F1M3W5 F1M3W5_RAT Dmx-like 2 −0.844 0.032
down Me3 F1M5N4 F1M5N4_RAT Malic enzyme −0.645 0.032
down Prkcb P68403 KPCB_RAT Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13) −0.580 0.032
down Pcbp2 Q6AYU2 Q6AYU2_RAT Poly(rC) binding protein 2 −0.501 0.032
down Rpn1 P07153 RPN1_RAT Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) −0.677 0.032
down Opa3 A0A8I6AQX4 A0A8I6AQX4_RAT Outer mitochondrial membrane lipid metabolism regulator OPA3 −0.768 0.032
down Spart E9PT90 E9PT90_RAT Spartin −1.462 0.032
down Vdac1 Q9Z2L0 VDAC1_RAT Non-selective voltage-gated ion channel VDAC1 (Outer mitochondrial membrane protein porin 1) (Voltage-dependent anion-selective channel protein 1) (VDAC-1) (rVDAC1) −0.714 0.032
down Septin4 A0A096MJN4 SEPT4_RAT Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (Arts) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2) −0.693 0.032
down Pls3 Q63598 PLST_RAT Plastin-3 (T-plastin) −0.596 0.032
down Grin2a Q00959 NMDE1_RAT Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) −0.964 0.033
down Cntn1 Q63198 CNTN1_RAT Contactin-1 (Neural cell surface protein F3) −0.545 0.033
down Acadvl P45953 ACADV_RAT Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9) −0.639 0.033
down Hapln1 P03994 HPLN1_RAT Hyaluronan and proteoglycan link protein 1 (Cartilage-linking protein 1) (Cartilage-link protein) (Proteoglycan link protein) −0.474 0.033
down Psmb6 P28073 PSB6_RAT Proteasome subunit beta type-6 (EC 3.4.25.1) (Macropain delta chain) (Multicatalytic endopeptidase complex delta chain) (Proteasome chain 5) (Proteasome delta chain) (Proteasome subunit Y) (Proteasome subunit beta-1) (beta-1) −0.555 0.034
down Arhgef2 Q5FVC2 ARHG2_RAT Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) −0.634 0.034
down Syp P07825 SYPH_RAT Synaptophysin (Major synaptic vesicle protein p38) −0.509 0.034
down Gad2 Q05683 DCE2_RAT Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform) −0.681 0.034
down Tprg1l A8WCF8 TPRGL_RAT Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) −0.647 0.035
down Twf1 Q5RJR2 TWF1_RAT Twinfilin-1 −0.590 0.035
down Slc25a12 F1LX07 S2512_RAT Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (Solute carrier family 25 member 12) −0.566 0.035
down Sdcbp Q9JI92 SDCB1_RAT Syntenin-1 (Syndecan-binding protein 1) −0.699 0.035
down Coro2b F1LMV9 F1LMV9_RAT Coronin −0.696 0.035
down Ivd P12007 IVD_RAT Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) (EC 1.3.8.4) (Butyryl-CoA dehydrogenase) (EC 1.3.8.1) −0.555 0.035
down Ago1 D4AC38 D4AC38_RAT Protein argonaute-1 −1.375 0.035
down Hnrnpl F1LQ48 HNRPL_RAT Heterogeneous nuclear ribonucleoprotein L (hnRNP L) −0.580 0.035
down Sdha Q920L2 SDHA_RAT Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp) (Malate dehydrogenase [quinone] flavoprotein subunit) (EC 1.1.5.-) −0.567 0.036
down Arf6 P62332 ARF6_RAT ADP-ribosylation factor 6 (EC 3.6.5.2) −0.547 0.036
down Icam5 D4A435 D4A435_RAT Intercellular adhesion molecule 5 (Telencephalin) −0.555 0.036
down Etfa P13803 ETFA_RAT Electron transfer flavoprotein subunit alpha, mitochondrial (Alpha-ETF) −0.684 0.036
down Slc2a3 Q07647 GTR3_RAT Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3) −0.616 0.036
down Ogdhl D3ZQD3 OGDHL_RAT 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) −0.588 0.036
down Syt1 P21707 SYT1_RAT Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65) −0.485 0.037
down Nrxn1 Q63372 NRX1A_RAT Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha) −0.556 0.037
down Acy1 A0A8I6ABX8 A0A8I6ABX8_RAT N-acyl-aliphatic-L-amino acid amidohydrolase (EC 3.5.1.14) (N-acyl-L-amino-acid amidohydrolase) −0.592 0.037
down Atp5f1a P15999 ATPA_RAT ATP synthase F(1) complex subunit alpha, mitochondrial (ATP synthase F1 subunit alpha) −0.458 0.037
down Lrrc57 Q5FVI3 LRC57_RAT Leucine-rich repeat-containing protein 57 −1.026 0.037
down Prkce P09216 KPCE_RAT Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon) −0.538 0.037
down Dync1h1 P38650 DYHC1_RAT Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic) (MAP 1C) −0.703 0.038
down Atp2b2 P11506 AT2B2_RAT Plasma membrane calcium-transporting ATPase 2 (PMCA2) (EC 7.2.2.10) (Plasma membrane calcium ATPase isoform 2) (Plasma membrane calcium pump isoform 2) −0.575 0.038
down Rpl8 P62919 RL8_RAT Large ribosomal subunit protein uL2 (60S ribosomal protein L8) −0.987 0.038
down Coro1a Q91ZN1 COR1A_RAT Coronin-1A (Coronin-like protein A) (Clipin-A) (Tryptophan aspartate-containing coat protein) (TACO) −0.639 0.038
down Ndufs2 Q641Y2 NDUS2_RAT NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial (EC 7.1.1.2) (Complex I-49kD) (CI-49kD) (NADH-ubiquinone oxidoreductase 49 kDa subunit) −0.590 0.039
down Pspc1 Q4KLH4 PSPC1_RAT Paraspeckle component 1 −0.772 0.039
down Psma6 P60901 PSA6_RAT Proteasome subunit alpha type-6 (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1) −0.838 0.039
down Gsk3b P18266 GSK3B_RAT Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Factor A) (FA) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1) −0.646 0.039
down Npepps F1M9V7 F1M9V7_RAT Aminopeptidase (EC 3.4.11.-) −0.578 0.039
down Hsp90aa1 P82995 HS90A_RAT Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) −0.563 0.039
down Glud1 P10860 DHE3_RAT Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) (Memory-related gene 2 protein) (MRG-2) −0.555 0.039
down NA Q6LED0 H31_RAT Histone H3.1 −0.492 0.039
down Exoc8 O54924 EXOC8_RAT Exocyst complex component 8 (Exocyst complex 84 kDa subunit) −0.524 0.040
down Slc25a4 Q05962 ADT1_RAT ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) −0.464 0.040
down Prmt1 Q63009 ANM1_RAT Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) −1.102 0.040
down Slc2a1 P11167 GTR1_RAT Solute carrier family 2, facilitated glucose transporter member 1 (Glucose transporter type 1, erythrocyte/brain) (GLUT-1) −0.505 0.040
down Tkt P50137 TKT_RAT Transketolase (TK) (EC 2.2.1.1) −0.452 0.040
down Dhx9 A0A8I6ABZ7 A0A8I6ABZ7_RAT ATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (Nuclear DNA helicase II) −0.678 0.040
down Mtch1 B0BN30 B0BN30_RAT Mitochondrial carrier homolog 1 −1.144 0.040
down Atp6v1c1 Q5FVI6 VATC1_RAT V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) −0.589 0.040
down Igsf8 A0A8I6ANQ3 A0A8I6ANQ3_RAT Immunoglobulin superfamily member 8 (CD81 partner 3) (Glu-Trp-Ile EWI motif-containing protein 2) (Prostaglandin regulatory-like protein) −0.544 0.041
down Atp6v1a D4A133 D4A133_RAT V-type proton ATPase catalytic subunit A (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar proton pump subunit alpha) −0.521 0.041
down Rpl4 P50878 RL4_RAT Large ribosomal subunit protein uL4 (60S ribosomal protein L1) (60S ribosomal protein L4) −0.667 0.041
down Mthfd1 P27653 C1TC_RAT C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)] −0.611 0.042
down Tecr Q64232 TECR_RAT Very-long-chain enoyl-CoA reductase (EC 1.3.1.93) (Synaptic glycoprotein SC2) (Trans-2,3-enoyl-CoA reductase) (TER) −0.887 0.042
down Gnai1 P10824 GNAI1_RAT Guanine nucleotide-binding protein G(i) subunit alpha-1 (EC 3.6.5.-) (Adenylate cyclase-inhibiting G alpha protein) −0.443 0.042
down Sbf1 M0RAP5 M0RAP5_RAT SET binding factor 1 −0.554 0.042
down Rps3 P62909 RS3_RAT Small ribosomal subunit protein uS3 (EC 4.2.99.18) (40S ribosomal protein S3) −0.534 0.043
down Atp1a2 P06686 AT1A2_RAT Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(+) subunit) (Sodium pump subunit alpha-2) −0.462 0.043
down Ilf3 Q9JIL3 ILF3_RAT Interleukin enhancer-binding factor 3 −0.741 0.043
down Gpx4 P36970 GPX4_RAT Phospholipid hydroperoxide glutathione peroxidase (PHGPx) (EC 1.11.1.12) (Glutathione peroxidase 4) (GPx-4) (GSHPx-4) (EC 1.11.1.9) −0.733 0.043
down Sord P27867 DHSO_RAT Sorbitol dehydrogenase (SDH) (EC 1.1.1.-) (L-iditol 2-dehydrogenase) (EC 1.1.1.14) (Polyol dehydrogenase) (Xylitol dehydrogenase) (XDH) (EC 1.1.1.9) −0.538 0.044
down Chrm1 P08482 ACM1_RAT Muscarinic acetylcholine receptor M1 −1.197 0.044
down Actr1a P85515 ACTZ_RAT Alpha-centractin (Centractin) −0.742 0.044
down Prpf8 G3V6H2 G3V6H2_RAT Pre-mRNA-processing-splicing factor 8 (Splicing factor Prp8) −0.723 0.044
down Rpl14 Q63507 RL14_RAT Large ribosomal subunit protein eL14 (60S ribosomal protein L14) −0.680 0.044
down Ogt P56558 OGT1_RAT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (EC 2.4.1.255) (O-GlcNAc transferase subunit p110) (O-linked N-acetylglucosamine transferase 110 kDa subunit) (OGT) −0.635 0.044
down Auh F1LU71 AUHM_RAT Methylglutaconyl-CoA hydratase, mitochondrial (3-MG-CoA hydratase) (EC 4.2.1.18) (AU-specific RNA-binding enoyl-CoA hydratase) (AU-binding enoyl-CoA hydratase) (Itaconyl-CoA hydratase) (EC 4.2.1.56) −0.526 0.044
down Rps2 P27952 RS2_RAT Small ribosomal subunit protein uS5 (40S ribosomal protein S2) −0.515 0.044
down Slc25a22 A0A0G2K5L2 GHC1_RAT Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22) −0.462 0.044
down Rpl18 P12001 RL18_RAT Large ribosomal subunit protein eL18 (60S ribosomal protein L18) −0.625 0.044
down Xpnpep1 O54975 XPP1_RAT Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) −0.551 0.044
down Prrt1 Q6MG82 PRRT1_RAT Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4) −0.761 0.044
down Gdi1 P50398 GDIA_RAT Rab GDP dissociation inhibitor alpha (Rab GDI alpha) (Guanosine diphosphate dissociation inhibitor 1) (GDI-1) −0.484 0.044
down Strap Q5XIG8 STRAP_RAT Serine-threonine kinase receptor-associated protein (UNR-interacting protein) −0.465 0.044
down Myadm Q6VBQ5 MYADM_RAT Myeloid-associated differentiation marker (Myeloid up-regulated protein) −2.219 0.044
down Sf3b3 E9PT66 E9PT66_RAT Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (Spliceosome-associated protein 130) −0.969 0.044
down Eif3a Q1JU68 EIF3A_RAT Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 subunit 10) (eIF-3-theta) −0.745 0.044
down Pdk1 Q63065 PDK1_RAT [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (PDK p48) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1) −1.035 0.045
down Rps4x P62703 RS4X_RAT Small ribosomal subunit protein eS4 (40S ribosomal protein S4, X isoform) −0.657 0.045
down Hadhb Q60587 ECHB_RAT Trifunctional enzyme subunit beta, mitochondrial (TP-beta) [Includes: 3-ketoacyl-CoA thiolase (EC 2.3.1.155) (EC 2.3.1.16) (Acetyl-CoA acyltransferase) (Beta-ketothiolase)] −0.551 0.045
down Pfas D4AB17 D4AB17_RAT Phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (Formylglycinamide ribotide amidotransferase) −0.611 0.045
down NA Q6LED0 H31_RAT Histone H3.1 −0.591 0.046
down NA Q6LED0 H31_RAT Histone H3.1 −0.591 0.046
down Gphn Q03555 GEPH_RAT Gephyrin (Putative glycine receptor-tubulin linker protein) [Includes: Molybdopterin adenylyltransferase (MPT adenylyltransferase) (EC 2.7.7.75) (Domain G); Molybdopterin molybdenumtransferase (MPT Mo-transferase) (EC 2.10.1.1) (Domain E)] −0.489 0.046
down Add3 Q62847 ADDG_RAT Gamma-adducin (Adducin-like protein 70) (Protein kinase C-binding protein 35H) −0.446 0.046
down Wdr37 A0A8I6AE33 A0A8I6AE33_RAT WD repeat-containing protein 37 −1.268 0.046
down Srgap3 F1M5M9 F1M5M9_RAT SLIT-ROBO Rho GTPase-activating protein 3 (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) −0.579 0.046
down Pdxp Q8VD52 PLPP_RAT Chronophin (EC 3.1.3.16) (EC 3.1.3.74) (Pyridoxal phosphate phosphatase) (PLP phosphatase) (Reg I-binding protein 1) −0.453 0.046
down Inpp4a Q62784 INP4A_RAT Inositol polyphosphate-4-phosphatase type I A (Inositol polyphosphate 4-phosphatase type I) (Type I inositol 3,4-bisphosphate 4-phosphatase) (EC 3.1.3.66) −0.655 0.047
down Pgm2l1 D3Z955 D3Z955_RAT Phosphoglucomutase 2-like 1 −0.445 0.047
down Itpka P17105 IP3KA_RAT Inositol-trisphosphate 3-kinase A (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase A) (IP3 3-kinase A) (IP3K A) (InsP 3-kinase A) −0.549 0.047
down Mfn2 Q8R500 MFN2_RAT Mitofusin-2 (EC 3.6.5.-) (Mitochondrial transmembrane GTPase FZO1A) (Protein HSG) (Transmembrane GTPase MFN2) −1.704 0.048
down Ewsr1 A0A0G2K850 A0A0G2K850_RAT RNA-binding protein EWS −1.221 0.048
down Gnao1 P59215 GNAO_RAT Guanine nucleotide-binding protein G(o) subunit alpha (EC 3.6.5.-) −0.409 0.048
down Rab18 Q5EB77 RAB18_RAT Ras-related protein Rab-18 (EC 3.6.5.2) −0.554 0.049
down Cct8 A0A8I6AAR4 A0A8I6AAR4_RAT T-complex protein 1 subunit theta (CCT-theta) −0.545 0.049
down Septin7 Q9WVC0 SEPT7_RAT Septin-7 (CDC10 protein homolog) −0.446 0.049
down Wbp2 Q8R478 WBP2_RAT WW domain-binding protein 2 (WBP-2) −0.836 0.049

Extra

# prot_df_map_rat_keywords <- prot_df_map_rat_4 %>%
#   filter(adj.P.Val <= 0.05) %>% # 2309
#   filter(!is.na(Entry)) %>% # 2278
#   mutate(hashtags = str_split(Keywords, ";")) %>%
#   tidyr::unnest(hashtags) # 22696
# prot_rat_sig_count <- prot_df_map_rat_sig %>%
#   #group_by(proteomics_id, dir) %>%
#   group_by(proteomics_id) %>%
#   filter(hashtags != "Reference proteome") %>% 
#   count(hashtags, sort = TRUE) 
# find_mouse_Q6LED0 <- mouse_ref %>%
#   filter(Entry == "Q6LED0")
# 
# find_rat_Q6LED0 <- rat_ref %>%
#   filter(Entry == "Q6LED0")
# 
# find_rat_other_Q6LED0 <- rat_other %>%
#   filter(Entry == "Q6LED0")

2025_12_27 - read in of Zenodo data to check sample size etc

In their Zenodo readme doc, this data is described as… 2_proteomicsSWATH_phenodata_averagedReplicates.txt: phenodata for the proteomics experiment, having averaged the technical replicates into single biological replicates. (so columns, except ID, equtes to 12 which probably means 12 mice total 6 per group?)

norm_SWATH <- read_tsv("input/Perez_2024_2_proteomicsSWATH_normalized_log2_filtered_averagedReplicates.txt")
## Rows: 2250 Columns: 13
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: "\t"
## chr  (1): ID
## dbl (12): s1, s2, s3, s8, s9, s10, s13, s14, s15, s16, s17, s18
## 
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
colnames(norm_SWATH)
##  [1] "ID"  "s1"  "s2"  "s3"  "s8"  "s9"  "s10" "s13" "s14" "s15" "s16" "s17"
## [13] "s18"
str(norm_SWATH)
## spc_tbl_ [2,250 × 13] (S3: spec_tbl_df/tbl_df/tbl/data.frame)
##  $ ID : chr [1:2250] "ENSMUSG00000027254" "ENSMUSG00000018707" "ENSMUSG00000032826" "ENSMUSG00000032589" ...
##  $ s1 : num [1:2250] 24 20.1 17 20.9 22 ...
##  $ s2 : num [1:2250] 23.4 20.6 16.6 20.4 22.1 ...
##  $ s3 : num [1:2250] 23.3 20.7 16.7 20.5 22.2 ...
##  $ s8 : num [1:2250] 24.6 20.1 17.1 21.5 22.3 ...
##  $ s9 : num [1:2250] 24.7 19.5 17.3 21.2 22.2 ...
##  $ s10: num [1:2250] 24.6 19.7 16.8 21.3 22.1 ...
##  $ s13: num [1:2250] 23 20.9 16.4 20.2 22.4 ...
##  $ s14: num [1:2250] 23.2 20.9 17 20.4 22.4 ...
##  $ s15: num [1:2250] 22.7 20.8 16.7 20.1 22.5 ...
##  $ s16: num [1:2250] 24.4 20 16.1 21.1 22.1 ...
##  $ s17: num [1:2250] 23.7 20.3 16.1 21.1 21.9 ...
##  $ s18: num [1:2250] 24.3 20.2 16.2 21.3 22.2 ...
##  - attr(*, "spec")=
##   .. cols(
##   ..   ID = col_character(),
##   ..   s1 = col_double(),
##   ..   s2 = col_double(),
##   ..   s3 = col_double(),
##   ..   s8 = col_double(),
##   ..   s9 = col_double(),
##   ..   s10 = col_double(),
##   ..   s13 = col_double(),
##   ..   s14 = col_double(),
##   ..   s15 = col_double(),
##   ..   s16 = col_double(),
##   ..   s17 = col_double(),
##   ..   s18 = col_double()
##   .. )
##  - attr(*, "problems")=<externalptr>

Transcriptomics

Just wrote out unique ensembls & searched in uniprot web (a lot faster & easier)

Read in mRNA/transcirptomics DEG excel sheets (sup ds 18)

# some NAs in the original df were directly coded as NA
# so need to specify na = "NA" otherwise some get classed as character & cant bind
rna_df_EEall <- read_excel("input/Perez_2024_EE_age_transcriptomics_sds18_41467_2024_49608_MOESM21_ESM.xlsx",
                             sheet = "EEall",
                           na = "NA")

rna_df_EEyng <- read_excel("input/Perez_2024_EE_age_transcriptomics_sds18_41467_2024_49608_MOESM21_ESM.xlsx",
                           sheet = "EEyng",
                           na = "NA")

rna_df_EEold <- read_excel("input/Perez_2024_EE_age_transcriptomics_sds18_41467_2024_49608_MOESM21_ESM.xlsx",
                           sheet = "EEold",
                           na = "NA")
RNA_df <- bind_rows(list(all = rna_df_EEall,
                          young = rna_df_EEyng,
                          old = rna_df_EEold),
                     .id = "transcriptomics_id") %>%
  rename(ENSEMBL = GENEID)

test RNA direct gene symbol map

RNA_df_map_rat_1 <- left_join(RNA_df, rat_ref,
                              by = join_by(SYMBOL == Gene.Names..primary.))
## Warning in left_join(RNA_df, rat_ref, by = join_by(SYMBOL == Gene.Names..primary.)): Detected an unexpected many-to-many relationship between `x` and `y`.
## ℹ Row 1 of `x` matches multiple rows in `y`.
## ℹ Row 923 of `y` matches multiple rows in `x`.
## ℹ If a many-to-many relationship is expected, set `relationship =
##   "many-to-many"` to silence this warning.
RNA_df_map_rat_1_mapped <- RNA_df_map_rat_1 %>%
  filter(!is.na(Entry))
RNA_df_map_rat_2 <- RNA_df_map_rat_1 %>%
  filter(is.na(Entry)) %>%
  select(transcriptomics_id:SYMBOL) %>%
  left_join(rat_ref_split, by = join_by(SYMBOL == split_synonyms))
## Warning in left_join(., rat_ref_split, by = join_by(SYMBOL == split_synonyms)): Detected an unexpected many-to-many relationship between `x` and `y`.
## ℹ Row 2 of `x` matches multiple rows in `y`.
## ℹ Row 35125 of `y` matches multiple rows in `x`.
## ℹ If a many-to-many relationship is expected, set `relationship =
##   "many-to-many"` to silence this warning.
RNA_df_map_rat_combined <- bind_rows(list(
  by_rat_ref_primary_gene = RNA_df_map_rat_1_mapped,
  by_rat_ref_synonym = RNA_df_map_rat_2), 
  .id = "map_method_df") %>%
  group_by(map_method_df, transcriptomics_id, ENSEMBL) %>% 
  filter(if(any(Reviewed == "reviewed", na.rm = TRUE)) {
    Reviewed == "reviewed"
  } else{TRUE}) %>% 
  slice_max(Annotation, n = 1) %>% 
  slice_max(existence_ranking, n =1) %>% 
  slice_max(occupied, n = 1, with_ties = FALSE) %>%
  ungroup()
# # export
# write_excel_csv(RNA_df_map_rat_combined,
#                 "output/2025_12_27_Perez_2024_RNA_map_rat_combined_v1.csv")

RNA Literature Review file

# to check range of 
plot(RNA_df_map_rat_combined$log2FoldChange)

summary(RNA_df_map_rat_combined) # see range
##  map_method_df      transcriptomics_id    baseMean         log2FoldChange      
##  Length:59505       Length:59505       Min.   :     0.00   Min.   :-9.9049815  
##  Class :character   Class :character   1st Qu.:    64.94   1st Qu.:-0.0987408  
##  Mode  :character   Mode  :character   Median :   753.94   Median :-0.0001025  
##                                        Mean   :  3820.64   Mean   :-0.0074635  
##                                        3rd Qu.:  3244.98   3rd Qu.: 0.0846927  
##                                        Max.   :408077.48   Max.   :22.0071357  
##                                                            NA's   :4           
##      lfcSE              stat               pvalue            padj       
##  Min.   :0.01819   Min.   :-6.869112   Min.   :0.0000   Min.   :0.0000  
##  1st Qu.:0.07592   1st Qu.:-0.643920   1st Qu.:0.2528   1st Qu.:0.9122  
##  Median :0.12956   Median :-0.000985   Median :0.5218   Median :0.9998  
##  Mean   :0.26108   Mean   :-0.007653   Mean   :0.5081   Mean   :0.9145  
##  3rd Qu.:0.34687   3rd Qu.: 0.636321   3rd Qu.:0.7646   3rd Qu.:1.0000  
##  Max.   :3.92611   Max.   : 7.965056   Max.   :1.0000   Max.   :1.0000  
##  NA's   :4         NA's   :4           NA's   :73       NA's   :8515    
##      dir              ENSEMBL             SYMBOL             Entry          
##  Length:59505       Length:59505       Length:59505       Length:59505      
##  Class :character   Class :character   Class :character   Class :character  
##  Mode  :character   Mode  :character   Mode  :character   Mode  :character  
##                                                                             
##                                                                             
##                                                                             
##                                                                             
##   Entry.Name        Protein.names       Gene.Names        Gene.Names..synonym.
##  Length:59505       Length:59505       Length:59505       Length:59505        
##  Class :character   Class :character   Class :character   Class :character    
##  Mode  :character   Mode  :character   Mode  :character   Mode  :character    
##                                                                               
##                                                                               
##                                                                               
##                                                                               
##    Annotation      Reviewed         Protein.existence  existence_ranking
##  Min.   :1.000   Length:59505       Length:59505       Min.   :1.000    
##  1st Qu.:2.000   Class :character   Class :character   1st Qu.:3.000    
##  Median :3.000   Mode  :character   Mode  :character   Median :5.000    
##  Mean   :3.335                                         Mean   :4.103    
##  3rd Qu.:5.000                                         3rd Qu.:5.000    
##  Max.   :5.000                                         Max.   :5.000    
##  NA's   :15294                                         NA's   :15294    
##  Protein.families       Length          Organism           Keywords        
##  Length:59505       Min.   :    8.0   Length:59505       Length:59505      
##  Class :character   1st Qu.:  294.0   Class :character   Class :character  
##  Mode  :character   Median :  467.0   Mode  :character   Mode  :character  
##                     Mean   :  618.2                                        
##                     3rd Qu.:  749.0                                        
##                     Max.   :26931.0                                        
##                     NA's   :15294                                          
##   Keyword.ID        Function..CC.      Miscellaneous..CC.   Pathway         
##  Length:59505       Length:59505       Length:59505       Length:59505      
##  Class :character   Class :character   Class :character   Class :character  
##  Mode  :character   Mode  :character   Mode  :character   Mode  :character  
##                                                                             
##                                                                             
##                                                                             
##                                                                             
##     GeneID            Ensembl          Gene.Ontology..GO.
##  Length:59505       Length:59505       Length:59505      
##  Class :character   Class :character   Class :character  
##  Mode  :character   Mode  :character   Mode  :character  
##                                                          
##                                                          
##                                                          
##                                                          
##  Gene.Ontology..cellular.component. Gene.Ontology..molecular.function.
##  Length:59505                       Length:59505                      
##  Class :character                   Class :character                  
##  Mode  :character                   Mode  :character                  
##                                                                       
##                                                                       
##                                                                       
##                                                                       
##  Gene.Ontology..biological.process. Gene.Ontology.IDs      KEGG          
##  Length:59505                       Length:59505       Length:59505      
##  Class :character                   Class :character   Class :character  
##  Mode  :character                   Mode  :character   Mode  :character  
##                                                                          
##                                                                          
##                                                                          
##                                                                          
##    Reactome            STRING          Entry.version   Date.of.creation  
##  Length:59505       Length:59505       Min.   :  1.0   Length:59505      
##  Class :character   Class :character   1st Qu.: 78.0   Class :character  
##  Mode  :character   Mode  :character   Median :104.0   Mode  :character  
##                                        Mean   :102.2                     
##                                        3rd Qu.:136.0                     
##                                        Max.   :257.0                     
##                                        NA's   :15294                     
##  Date.of.last.modification Date.of.last.sequence.modification    occupied    
##  Length:59505              Length:59505                       Min.   :18.00  
##  Class :character          Class :character                   1st Qu.:26.00  
##  Mode  :character          Mode  :character                   Median :27.00  
##                                                               Mean   :26.78  
##                                                               3rd Qu.:29.00  
##                                                               Max.   :32.00  
##                                                               NA's   :15294  
##  Gene.Names..primary.
##  Length:59505        
##  Class :character    
##  Mode  :character    
##                      
##                      
##                      
## 
colnames(RNA_df_map_rat_combined)
##  [1] "map_method_df"                      "transcriptomics_id"                
##  [3] "baseMean"                           "log2FoldChange"                    
##  [5] "lfcSE"                              "stat"                              
##  [7] "pvalue"                             "padj"                              
##  [9] "dir"                                "ENSEMBL"                           
## [11] "SYMBOL"                             "Entry"                             
## [13] "Entry.Name"                         "Protein.names"                     
## [15] "Gene.Names"                         "Gene.Names..synonym."              
## [17] "Annotation"                         "Reviewed"                          
## [19] "Protein.existence"                  "existence_ranking"                 
## [21] "Protein.families"                   "Length"                            
## [23] "Organism"                           "Keywords"                          
## [25] "Keyword.ID"                         "Function..CC."                     
## [27] "Miscellaneous..CC."                 "Pathway"                           
## [29] "GeneID"                             "Ensembl"                           
## [31] "Gene.Ontology..GO."                 "Gene.Ontology..cellular.component."
## [33] "Gene.Ontology..molecular.function." "Gene.Ontology..biological.process."
## [35] "Gene.Ontology.IDs"                  "KEGG"                              
## [37] "Reactome"                           "STRING"                            
## [39] "Entry.version"                      "Date.of.creation"                  
## [41] "Date.of.last.modification"          "Date.of.last.sequence.modification"
## [43] "occupied"                           "Gene.Names..primary."
# for lit review table 
lit_review_transcriptomics <- RNA_df_map_rat_combined %>%
  mutate(
    Year = 2024,
    Author = 'Perez',
    Animal = 'Mice',
    Condition = transcriptomics_id,
    Region = 'Hippocampus',
    Whole = 'Yes',
    Exp_type = 'mRNA',
    Method = 'TRANSCRIPTOMICS_RNAseq',
    Used_name = SYMBOL,
    Mod = " ",
    Mod_type = " ",
    Gene_name = SYMBOL, # genename used to map mouse 1° to rat gene
    Comparison = 2,
    In_EE = dir,
    Fold_change = log2FoldChange, # prob the same as log2FC?
    Arrows = case_when( # dplyr case when, instead of ifelse
      log2FoldChange > 2.5 ~ '+++',
      log2FoldChange > 1 ~ '++',
      log2FoldChange> .05 ~ '+',
      log2FoldChange > -.05 ~ '=',
      log2FoldChange > -1 ~ '-',
      log2FoldChange > -2.5 ~ '--',
      log2FoldChange <= -2.5 ~ '---',
      ),
    Significant = ifelse(padj <= 0.05, 'yes', 'no'),
    pvalue = padj,
    N_tested = ' ',
    Stats_adj = 'adjusted',
    Note = ' ',
    Full_name = Protein.names,
    Uniprot_rat_accession = Entry,
    Uniprot_entry_name = Entry.Name,
    Uniprot_link = ifelse(!is.na(Entry),
                   paste0('https://www.uniprot.org/uniprotkb/', Entry,'/entry'),
                          ' '),
    Wikipedia_link = ifelse(!is.na(Entry),
                            paste0('https://en.wikipedia.org/wiki/',
                                   `Gene.Names..primary.`), ' '),
    
    Curation_method = case_when(
      Reviewed == "reviewed" & map_method_df == "by_rat_ref_primary_gene"
        ~ "auto - ref & reviewed (primary gene name)",
      
      Reviewed == "unreviewed" & map_method_df == "by_rat_ref_primary_gene"
        ~ "auto - ref & unreviewed (primary gene name)",
      
      Reviewed == "reviewed" & map_method_df == "by_rat_ref_synonym"
        ~ "auto - ref & reviewed (synonym)",
      
      Reviewed == "unreviewed" & map_method_df == "by_rat_ref_synonym"
        ~ "auto - ref proteome (synonym)",
      
      is.na(Entry.Name) ~ "manual - na"
      ),
    Class_group = ' ',
    Other_link = ' ',
    Other_comments = 'misc shows combined gene_ensembl info from their df',
    misc = paste0(SYMBOL, '_', ENSEMBL)
  ) %>%
  arrange(Condition, desc(In_EE), pvalue, Fold_change)

All for export

# split by age (all, young, old) (in prep for sheet write out)
split_RNA_df_map_rat <- split(lit_review_transcriptomics,
                              lit_review_transcriptomics$transcriptomics_id)

# add combined one back onto it 
split_RNA_df_map_rat$combined <- lit_review_transcriptomics
# # write transcriptomics lit review out excel 
# write_xlsx(split_RNA_df_map_rat,
#            path = "output/2025_12_27_Perez_2024_transcriptomics_lit_review_all_v1.xlsx")

Significant only for export

# filter significant only 
# purrr meth (loaded with tidyverse?)
split_RNA_df_map_rat_sig  <- map(split_RNA_df_map_rat, ~filter(.x, padj <= 0.05))
# #write out sig version
# write_xlsx(split_RNA_df_map_rat,
#            path = "output/2025_12_27_Perez_2024_transcriptomics_lit_review_sig_only_v1.xlsx")

gt sig mRNA

split_RNA_df_map_rat_sig$combined |> 
  dplyr::select(c(Condition, In_EE, Gene_name, Entry, `Entry.Name`,
                  `Protein.names`, Fold_change, pvalue, Reviewed )) |>
  gt(
    groupname_col = "Condition",
    rowname_col = "In_EE"
  ) |>
  fmt_number(decimals = 3) |>
    tab_header(
    title = "Perez 2024 - Transcriptomics - Hippocampus Mice - adjp <= 0.05 only",
    subtitle = "2025_12_27 - lit_review_transcriptomics/split_RNA_df_map_rat_sig - (EE vs SH split by Age (all (96), young (60), old (36)))"
    ) |>
    tab_options(heading.title.font.size = 16,
                table.font.size=11.5,
                stub.font.weight = "bold",
                row_group.font.weight = "bold",
                row_group.font.size = 12.5,
                column_labels.font.size = 12.5,
                column_labels.font.weight = "bold") #|>
Perez 2024 - Transcriptomics - Hippocampus Mice - adjp <= 0.05 only
2025_12_27 - lit_review_transcriptomics/split_RNA_df_map_rat_sig - (EE vs SH split by Age (all (96), young (60), old (36)))
Gene_name Entry Entry.Name Protein.names Fold_change pvalue Reviewed
all
up Rasl10a A0A8I6ALJ9 A0A8I6ALJ9_RAT small monomeric GTPase (EC 3.6.5.2) 0.330 0.000 unreviewed
up Dnajb5 A0A0G2K9H9 A0A0G2K9H9_RAT DnaJ heat shock protein family (Hsp40) member B5 0.331 0.000 unreviewed
up Egr4 Q00911 EGR4_RAT Early growth response protein 4 (EGR-4) (Early response protein NGFI-C) (Nerve growth factor-induced protein C) (NGFI-C) 0.343 0.000 reviewed
up Mdc1 Q5U2M8 MDC1_RAT Mediator of DNA damage checkpoint protein 1 0.309 0.000 reviewed
up Otub2 D3ZAR8 D3ZAR8_RAT ubiquitinyl hydrolase 1 (EC 3.4.19.12) 0.263 0.000 unreviewed
up Egr1 P08154 EGR1_RAT Early growth response protein 1 (EGR-1) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor Zif268) (Zinc finger protein Krox-24) 0.461 0.000 reviewed
up Kctd6 G3V6Z2 G3V6Z2_RAT Potassium channel tetramerization domain containing 6 0.275 0.000 unreviewed
up Acvr1c P70539 ACV1C_RAT Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) 0.494 0.000 reviewed
up Cbfa2t3 D4A303 D4A303_RAT CBFA2/RUNX1 partner transcriptional co-repressor 3 0.504 0.000 unreviewed
up Acvr1 P80201 ACVR1_RAT Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) 0.194 0.002 reviewed
up Ighm F1LN61 F1LN61_RAT Immunoglobulin heavy constant epsilon 0.502 0.003 unreviewed
up Kdm7a A0A8I6AQU2 A0A8I6AQU2_RAT Lysine-specific demethylase 7A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) 0.336 0.003 unreviewed
up Bmi1 A6JM95 A6JM95_RAT Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) 0.180 0.012 unreviewed
up Fam53b D3Z8Z2 D3Z8Z2_RAT Family with sequence similarity 53, member B 0.173 0.020 unreviewed
up Ccdc71l F1M119 F1M119_RAT Coiled-coil domain containing 71-like 0.192 0.020 unreviewed
up Ier5 NA NA NA 0.248 0.020 NA
up Plekha2 A0A8I5ZTX1 A0A8I5ZTX1_RAT Pleckstrin homology domain containing A2 0.325 0.020 unreviewed
up Cebpb P21272 CEBPB_RAT CCAAT/enhancer-binding protein beta (C/EBP beta) (C/EBP-related protein 2) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched inhibitory protein) (LIP) (Liver-enriched transcriptional activator) (LAP) (Silencer factor B) (SF-B) 0.188 0.020 reviewed
up Slc35f3 M0RA35 M0RA35_RAT Solute carrier family 35, member F3 0.203 0.020 unreviewed
up Arsj Q32KJ7 Q32KJ7_RAT Arylsulfatase family, member J 0.276 0.020 unreviewed
up Nemp1 A0A8I6G8B7 A0A8I6G8B7_RAT Nuclear envelope integral membrane protein 1 0.322 0.020 unreviewed
up Rimbp2 Q9JIR1 RIMB2_RAT RIMS-binding protein 2 (RIM-BP2) 0.243 0.024 reviewed
up Paqr9 A0ABK0LBD5 A0ABK0LBD5_RAT Uncharacterized protein 0.177 0.024 unreviewed
up Nfil3 Q6IMZ0 NFIL3_RAT Nuclear factor interleukin-3-regulated protein (E4 promoter-binding protein 4) 0.433 0.026 reviewed
up Dpy19l3 D4A9G5 D4A9G5_RAT Dpy-19 like C-mannosyltransferase 3 0.251 0.027 unreviewed
up Usp25 A0A8I5ZPF8 A0A8I5ZPF8_RAT Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) 0.164 0.029 unreviewed
up Kcnk1 Q9Z2T2 KCNK1_RAT Potassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (rTWIK) (Potassium channel K2P1) 0.197 0.029 reviewed
up Cdkn1a Q64315 Q64315_RAT Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (p21) 0.379 0.029 unreviewed
up Penk P04094 PENK_RAT Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-185); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(239-260); Met-enkephalin-Arg-Phe] 0.443 0.029 reviewed
up Serinc2 Q4FZV1 Q4FZV1_RAT Serine incorporator 2 0.691 0.029 unreviewed
up Rnf19a D3ZXM0 D3ZXM0_RAT RBR-type E3 ubiquitin transferase (EC 2.3.2.31) 0.227 0.031 unreviewed
up Cops2 P61203 CSN2_RAT COP9 signalosome complex subunit 2 (SGN2) (Signalosome subunit 2) (Alien homolog) (JAB1-containing signalosome subunit 2) (Thyroid receptor-interacting protein 15) (TR-interacting protein 15) (TRIP-15) 0.108 0.032 reviewed
up Dnaja4 Q4QR73 Q4QR73_RAT DnaJ (Hsp40) homolog, subfamily A, member 4 (DnaJ heat shock protein family (Hsp40) member A4) 0.240 0.032 unreviewed
up Uxs1 Q5PQX0 UXS1_RAT UDP-glucuronic acid decarboxylase 1 (EC 4.1.1.35) (UDP-glucuronate decarboxylase 1) (UGD) (UXS-1) 0.188 0.033 reviewed
up Hcfc2 Q5RKG2 HCFC2_RAT Host cell factor 2 (HCF-2) (C2 factor) 0.233 0.038 reviewed
up Arntl Q9EPW1 BMAL1_RAT Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Brain and muscle ARNT-like 1) (Tic) 0.243 0.038 reviewed
up Rbm45 Q8CFD1 RBM45_RAT RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RNA-binding motif protein 45) 0.157 0.038 reviewed
up Fam43b A0ABK0LR17 A0ABK0LR17_RAT Family with sequence similarity 43, member B 0.271 0.040 unreviewed
up Bahd1 D3ZHT3 D3ZHT3_RAT Bromo adjacent homology domain containing 1 0.127 0.041 unreviewed
up Bambi Q91XN4 BAMBI_RAT BMP and activin membrane-bound inhibitor homolog (Kinase-deficient TGFbeta superfamily receptor subunit) 0.269 0.041 reviewed
up Gm20634 NA NA NA 0.431 0.042 NA
up Egr3 P43301 EGR3_RAT Early growth response protein 3 (EGR-3) 0.284 0.043 reviewed
up Fosb D3ZLB7 FOSB_RAT Protein FosB (Transcription factor AP-1 subunit FosB) 0.430 0.043 reviewed
up Htr4 Q62758 5HT4R_RAT 5-hydroxytryptamine receptor 4 (5-HT-4) (5-HT4) (Serotonin receptor 4) 0.226 0.047 reviewed
up Npy5r Q63634 NPY5R_RAT Neuropeptide Y receptor type 5 (NPY5-R) (NPY-Y5 receptor) (NPYY5-R) (Y5 receptor) 0.237 0.047 reviewed
up H4c9 NA NA NA 0.683 0.047 NA
up Rilpl1 D3ZUQ0 RIPL1_RAT RILP-like protein 1 (GAPDH's competitor of SIAH1 protein enhances life) (GOSPEL) (Rab-interacting lysosomal-like protein 1) 0.146 0.048 reviewed
up Lyrm7 B4F7A1 LYRM7_RAT Complex III assembly factor LYRM7 (LYR motif-containing protein 7) 0.325 0.049 reviewed
up Mapk4 Q63454 MK04_RAT Mitogen-activated protein kinase 4 (MAP kinase 4) (MAPK 4) (EC 2.7.11.24) (Extracellular signal-regulated kinase 4) (ERK-4) (MAP kinase isoform p63) (p63-MAPK) (MNK2) 0.237 0.049 reviewed
down Notch3 Q9R172 NOTC3_RAT Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] −0.368 0.000 reviewed
down Epb41l2 A0A0G2K162 A0A0G2K162_RAT Erythrocyte membrane protein band 4.1-like 2 −0.198 0.001 unreviewed
down Rhobtb3 D3ZW90 D3ZW90_RAT Rho-related BTB domain-containing protein 3 −0.213 0.004 unreviewed
down Apcdd1 F1M5Q7 F1M5Q7_RAT Protein APCDD1 −0.285 0.006 unreviewed
down Scd2 Q6P7B9 SCD2_RAT Stearoyl-CoA desaturase 2 (EC 1.14.19.1) (Acyl-CoA desaturase 2) (Delta(9)-desaturase 2) (Delta-9 desaturase 2) (Fatty acid desaturase 2) −0.157 0.006 reviewed
down Prkg2 Q64595 KGP2_RAT cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) −0.844 0.007 reviewed
down Slc9a3r2 Q920G2 NHRF2_RAT Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1) −0.256 0.007 reviewed
down Slc6a11 P31647 S6A11_RAT Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) −0.247 0.010 reviewed
down Klk6 P36374 KLK6_RAT Prostatic glandular kallikrein-6 (EC 3.4.21.35) (Glandular kallikrein-8) (rGK-8) (P1 kallikrein) (Tissue kallikrein) −0.893 0.010 reviewed
down Sema6a D3ZAG0 D3ZAG0_RAT Semaphorin-6A (Semaphorin VIA) (Semaphorin-6A-1) −0.277 0.010 unreviewed
down Sema4d A0A8I6G5Q1 A0A8I6G5Q1_RAT Semaphorin-4D −0.256 0.010 unreviewed
down Epb41l3 A6KF70 A6KF70_RAT Erythrocyte membrane protein band 4.1-like 3 (Type II brain 4.1) −0.164 0.010 unreviewed
down Gnai2 P04897 GNAI2_RAT Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) −0.121 0.010 reviewed
down Dusp26 Q5FVI9 DUS26_RAT Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) −0.269 0.010 reviewed
down Gal3st1 D3ZCT9 D3ZCT9_RAT Galactose-3-O-sulfotransferase 1 −0.304 0.011 unreviewed
down Kcna6 P17659 KCNA6_RAT Potassium voltage-gated channel subfamily A member 6 (RCK2) (Voltage-gated potassium channel subunit Kv1.6) (Voltage-gated potassium channel subunit Kv2) −0.168 0.012 reviewed
down Atp10a A0A0G2JWQ8 A0A0G2JWQ8_RAT Phospholipid-transporting ATPase (EC 7.6.2.1) −0.354 0.012 unreviewed
down Scarb2 P27615 SCRB2_RAT Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36) −0.099 0.012 reviewed
down Rassf2 Q3B7D5 RASF2_RAT Ras association domain-containing protein 2 −0.221 0.016 reviewed
down Unc13c Q62770 UN13C_RAT Protein unc-13 homolog C (Munc13-3) −0.485 0.016 reviewed
down Glud1 P10860 DHE3_RAT Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) (Memory-related gene 2 protein) (MRG-2) −0.159 0.017 reviewed
down Mtss2 D4A3S6 D4A3S6_RAT MTSS I-BAR domain containing 2 −0.174 0.018 unreviewed
down Dbp P16443 DBP_RAT D site-binding protein (Albumin D box-binding protein) (Albumin D-element-binding protein) (D site albumin promoter-binding protein 1) −0.442 0.020 reviewed
down Hsdl1 Q4V8B7 HSDL1_RAT Inactive hydroxysteroid dehydrogenase-like protein 1 −0.167 0.020 reviewed
down Pcdh15 A0A8I6B3E0 A0A8I6B3E0_RAT Protocadherin-15 −0.405 0.020 unreviewed
down Ldhd A0A0G2K1W9 A0A0G2K1W9_RAT Probable D-lactate dehydrogenase, mitochondrial (EC 1.1.2.4) −0.284 0.020 unreviewed
down Adcyap1r1 P32215 PACR_RAT Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor) (PACAP-R-1) (PACAP-R1) −0.179 0.020 reviewed
down Pcdh10 F1M6B6 F1M6B6_RAT Protocadherin 10 −0.207 0.030 unreviewed
down Mthfd1l B2GUZ3 B2GUZ3_RAT Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) −0.244 0.032 unreviewed
down Smarcd3 Q5U3Y2 Q5U3Y2_RAT SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 −0.162 0.032 unreviewed
down Slc1a3 P24942 EAA1_RAT Excitatory amino acid transporter 1 (Glial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST) (GLAST-1) (Solute carrier family 1 member 3) −0.172 0.033 reviewed
down Nr1d2 Q63504 NR1D2_RAT Nuclear receptor subfamily 1 group D member 2 (EAR4) (Rev-erb-beta) −0.242 0.037 reviewed
down Bcl7c D3ZUL4 D3ZUL4_RAT BAF chromatin remodeling complex subunit BCL7C −0.212 0.038 unreviewed
down Slc44a2 B4F795 CTL2_RAT Choline transporter-like protein 2 (Solute carrier family 44 member 2) −0.121 0.038 reviewed
down Serinc5 Q63175 SERC5_RAT Serine incorporator 5 (Developmentally regulated protein TPO1) −0.165 0.040 reviewed
down Ctu2 Q3B7U4 CTU2_RAT Cytoplasmic tRNA 2-thiolation protein 2 −0.701 0.041 reviewed
down Itfg2 A0A8I6AHW3 A0A8I6AHW3_RAT Integrin alpha FG-GAP repeat containing 2 −0.256 0.043 unreviewed
down Myo6 D4A5I9 D4A5I9_RAT Unconventional myosin-VI (Unconventional myosin-6) −0.170 0.043 unreviewed
down Sirt2 Q5RJQ4 SIR2_RAT NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) −0.139 0.043 reviewed
down Shmt1 Q6TXG7 Q6TXG7_RAT Serine hydroxymethyltransferase (EC 2.1.2.1) −0.659 0.043 unreviewed
down Tbc1d9b F1LRL4 F1LRL4_RAT TBC1 domain family member 9B −0.156 0.045 unreviewed
down Igfbp5 P24594 IBP5_RAT Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) −0.239 0.047 reviewed
down Dip2a F1LZ43 F1LZ43_RAT Disco-interacting protein 2 homolog A −0.144 0.047 unreviewed
down Clcn6 D4A3H5 D4A3H5_RAT Chloride channel protein −0.085 0.047 unreviewed
down Doc2a P70611 DOC2A_RAT Double C2-like domain-containing protein alpha (Doc2-alpha) −0.533 0.048 reviewed
old
up Gm21985 NA NA NA 9.307 0.000 NA
up Tanc1 Q6F6B3 TANC1_RAT Protein TANC1 (TPR domain, ankyrin-repeat and coiled-coil domain-containing protein 1) 0.290 0.000 reviewed
up Plekha2 A0A8I5ZTX1 A0A8I5ZTX1_RAT Pleckstrin homology domain containing A2 0.412 0.000 unreviewed
up Anapc10 A6IYH7 A6IYH7_RAT Anaphase-promoting complex subunit 10 0.734 0.000 unreviewed
up Lrp1b F1M443 F1M443_RAT Low-density lipoprotein receptor-related protein 1B (Low-density lipoprotein receptor-related protein-deleted in tumor) 0.332 0.001 unreviewed
up Iqgap2 A0A8I6AM38 A0A8I6AM38_RAT IQ motif containing GTPase activating protein 2 0.395 0.001 unreviewed
up Paqr9 A0ABK0LBD5 A0ABK0LBD5_RAT Uncharacterized protein 0.238 0.003 unreviewed
up Dusp6 Q64346 DUS6_RAT Dual specificity protein phosphatase 6 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3) 0.371 0.003 reviewed
up Akr1e1 NA NA NA 0.429 0.003 NA
up Otub2 D3ZAR8 D3ZAR8_RAT ubiquitinyl hydrolase 1 (EC 3.4.19.12) 0.318 0.004 unreviewed
up Drd1 P18901 DRD1_RAT D(1A) dopamine receptor (Dopamine D1 receptor) 0.540 0.007 reviewed
up Ncdn O35095 NCDN_RAT Neurochondrin (Neurite outgrowth-related protein from the rat brain) (Norbin) 0.203 0.011 reviewed
up Rasl10a A0A8I6ALJ9 A0A8I6ALJ9_RAT small monomeric GTPase (EC 3.6.5.2) 0.313 0.016 unreviewed
up Cntnap5b Q0V8T5 CTP5B_RAT Contactin-associated protein like 5-2 (Cell recognition molecule Caspr5-2) (Cell recognition molecule Caspr5b) (Contactin-associated protein-like 5b) 0.379 0.016 reviewed
up Med17 D4ABU0 D4ABU0_RAT Mediator of RNA polymerase II transcription subunit 17 (Mediator complex subunit 17) 0.385 0.016 unreviewed
up Lct Q02401 LPH_RAT Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)] 0.398 0.016 reviewed
up Rnf112 O70418 RN112_RAT RING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Zinc finger protein 179) 0.251 0.016 reviewed
up Lrg1 M0R8H5 M0R8H5_RAT Leucine-rich alpha-2-glycoprotein 1 2.565 0.024 unreviewed
up Slc7a14 A0A0G2K1G8 A0A0G2K1G8_RAT Solute carrier family 7, member 14 0.180 0.037 unreviewed
up Rbp3 G3V8Q4 G3V8Q4_RAT Retinol-binding protein 3 (Interphotoreceptor retinoid-binding protein) (Interstitial retinol-binding protein) 3.386 0.047 unreviewed
up C1ql2 A0A3B0IP42 A0A3B0IP42_RAT Complement C1q like 2 0.212 0.049 unreviewed
up Bdnf P23363 BDNF_RAT Neurotrophic factor BDNF precursor form (proBDNF) (Brain-derived neurotrophic factor) [Cleaved into: Neurotrophic factor BDNF] 0.351 0.049 reviewed
down Unc13c Q62770 UN13C_RAT Protein unc-13 homolog C (Munc13-3) −0.593 0.000 reviewed
down Stard4 D3Z9I9 D3Z9I9_RAT StAR-related lipid transfer protein 4 (START domain-containing protein 4) −0.479 0.001 unreviewed
down Pcdh11x A0A8I6AKA9 A0A8I6AKA9_RAT Protocadherin 11 X-linked −0.920 0.001 unreviewed
down Camk2n2 Q9Z2N6 CK2N2_RAT Calcium/calmodulin-dependent protein kinase II inhibitor 2 (CaM-KII inhibitory protein) (CaM-KIIN) (CaM-KIINbeta) −0.620 0.001 reviewed
down Mfge8 P70490 MFGM_RAT Lactadherin (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (O-acetyl GD3 ganglioside synthase) (AGS) (SED1) −0.372 0.003 reviewed
down Slc6a11 P31647 S6A11_RAT Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11) −0.305 0.003 reviewed
down Tacr3 P16177 NK3R_RAT Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) −2.437 0.006 reviewed
down Rapgef3 Q9Z1C8 RPGF3_RAT Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI) −0.358 0.019 reviewed
down Gpsm1 Q9R080 GPSM1_RAT G-protein-signaling modulator 1 (Activator of G-protein signaling 3) −0.403 0.024 reviewed
down Pcdh15 A0A8I6B3E0 A0A8I6B3E0_RAT Protocadherin-15 −0.585 0.032 unreviewed
down Slc17a6 Q9JI12 VGLU2_RAT Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6) −0.836 0.032 reviewed
down Slc35a5 D4A7S3 D4A7S3_RAT Solute carrier family 35, member A5 −0.222 0.043 unreviewed
down Fxyd6 Q91XV6 FXYD6_RAT FXYD domain-containing ion transport regulator 6 (Phosphohippolin) (Vascular endothelial cell-specific protein 6) (VESP6) −0.497 0.046 reviewed
down Kitl P21581 SCF_RAT Kit ligand (Hematopoietic growth factor KL) (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)] −0.443 0.049 reviewed
young
up Acvr1c P70539 ACV1C_RAT Activin receptor type-1C (EC 2.7.11.30) (Activin receptor type IC) (ACTR-IC) (Activin receptor-like kinase 7) (ALK-7) 0.599 0.000 reviewed
up Ttn A0A8I5ZU83 A0A8I5ZU83_RAT Titin (EC 2.7.11.1) (Connectin) 2.208 0.000 unreviewed
up Dnajb5 A0A0G2K9H9 A0A0G2K9H9_RAT DnaJ heat shock protein family (Hsp40) member B5 0.423 0.000 unreviewed
up Gm45234 NA NA NA 7.907 0.000 NA
up Gm21860 NA NA NA 7.689 0.000 NA
up Cbfa2t3 D4A303 D4A303_RAT CBFA2/RUNX1 partner transcriptional co-repressor 3 0.672 0.000 unreviewed
up Penk P04094 PENK_RAT Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin (Opioid growth factor) (OGF); PENK(114-133); PENK(143-185); Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(239-260); Met-enkephalin-Arg-Phe] 0.583 0.000 reviewed
up Egr1 P08154 EGR1_RAT Early growth response protein 1 (EGR-1) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor Zif268) (Zinc finger protein Krox-24) 0.587 0.000 reviewed
up Ddi2 A0A8J8Y1M0 A0A8J8Y1M0_RAT DNA damage inducible 1 homolog 2 0.259 0.001 unreviewed
up Fndc3b D4A0W7 D4A0W7_RAT Fibronectin type III domain-containing protein 3B (Factor for adipocyte differentiation 104) (HCV NS5A-binding protein 37) 0.435 0.001 unreviewed
up Fras1 A0A8I6AIZ0 A0A8I6AIZ0_RAT Extracellular matrix organizing protein FRAS1 0.731 0.001 unreviewed
up Rasl10a A0A8I6ALJ9 A0A8I6ALJ9_RAT small monomeric GTPase (EC 3.6.5.2) 0.346 0.001 unreviewed
up Ighm F1LN61 F1LN61_RAT Immunoglobulin heavy constant epsilon 0.527 0.002 unreviewed
up Xlr3a M0RDK0 M0RDK0_RAT X-linked lymphocyte-regulated protein 3A-like 2.451 0.004 unreviewed
up Fam43b A0ABK0LR17 A0ABK0LR17_RAT Family with sequence similarity 43, member B 0.364 0.004 unreviewed
up Xlr4a D4A7L7 D4A7L7_RAT X-linked lymphocyte-regulated 4A 6.617 0.005 unreviewed
up Cdkn1a Q64315 Q64315_RAT Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (p21) 0.532 0.008 unreviewed
up Kctd6 G3V6Z2 G3V6Z2_RAT Potassium channel tetramerization domain containing 6 0.357 0.011 unreviewed
up Mga A0A8I6AGZ4 A0A8I6AGZ4_RAT MAX gene-associated protein 0.271 0.013 unreviewed
up Dnajb1 D3ZUU5 D3ZUU5_RAT DnaJ heat shock protein family (Hsp40) member B1 0.311 0.017 unreviewed
up Egr4 Q00911 EGR4_RAT Early growth response protein 4 (EGR-4) (Early response protein NGFI-C) (Nerve growth factor-induced protein C) (NGFI-C) 0.369 0.023 reviewed
up Uba6 D4A8H3 D4A8H3_RAT Ubiquitin-like modifier-activating enzyme 6 (EC 6.2.1.45) (Ubiquitin-activating enzyme E1-like protein 2) 0.373 0.032 unreviewed
up Kdm7a A0A8I6AQU2 A0A8I6AQU2_RAT Lysine-specific demethylase 7A (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 1D) (Lysine-specific demethylase 7) ([histone H3]-dimethyl-L-lysine9 demethylase 7A) 0.404 0.032 unreviewed
up Zmym2 D4A3R6 D4A3R6_RAT Zinc finger MYM-type containing 2 0.215 0.034 unreviewed
up Nop58 Q9QZ86 NOP58_RAT Nucleolar protein 58 (Nopp140-associated protein of 65 kDa) (Nucleolar protein 5) 0.319 0.039 reviewed
up Nqo2 Q6AY80 NQO2_RAT Ribosyldihydronicotinamide dehydrogenase [quinone] (EC 1.10.5.1) (NRH dehydrogenase [quinone] 2) (NRH:quinone oxidoreductase 2) (Quinone reductase 2) (QR2) 0.399 0.039 reviewed
up Egr2 P51774 EGR2_RAT E3 SUMO-protein ligase EGR2 (EC 2.3.2.-) (E3 SUMO-protein transferase ERG2) (Early growth response protein 2) (EGR-2) (Zinc finger protein Krox-20) 2.084 0.042 reviewed
down Igfbp5 P24594 IBP5_RAT Insulin-like growth factor-binding protein 5 (IBP-5) (IGF-binding protein 5) (IGFBP-5) −0.299 0.000 reviewed
down Kntc1 A0A8I6G9X6 A0A8I6G9X6_RAT Kinetochore associated 1 −1.345 0.000 unreviewed
down Mllt10 A0A8I5ZK97 A0A8I5ZK97_RAT MLLT10, histone lysine methyltransferase DOT1L cofactor −0.401 0.000 unreviewed
down Col6a4 A0A8I6A6Y7 A0A8I6A6Y7_RAT Collagen, type VI, alpha 4 −2.461 0.000 unreviewed
down Ctu2 Q3B7U4 CTU2_RAT Cytoplasmic tRNA 2-thiolation protein 2 −0.978 0.000 reviewed
down Gm4735 NA NA NA −7.498 0.000 NA
down Cacng5 Q8VHW8 CCG5_RAT Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5) −0.631 0.001 reviewed
down Apcdd1 F1M5Q7 F1M5Q7_RAT Protein APCDD1 −0.388 0.001 unreviewed
down Foxq1 Q63244 FOXQ1_RAT Forkhead box protein Q1 (HNF-3/forkhead-like protein 1) (HFH-1) (Hepatocyte nuclear factor 3 forkhead homolog 1) −0.618 0.001 reviewed
down Itgad Q9QYE7 ITAD_RAT Integrin alpha-D (CD antigen CD11d) −3.410 0.003 reviewed
down Ctxn3 B2GV70 B2GV70_RAT Cortexin 3 −2.226 0.003 unreviewed
down Rapgef4 Q9Z1C7 RPGF4_RAT Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII) −0.187 0.003 reviewed
down Sema6a D3ZAG0 D3ZAG0_RAT Semaphorin-6A (Semaphorin VIA) (Semaphorin-6A-1) −0.350 0.004 unreviewed
down Olig1 Q9WUQ3 OLIG1_RAT Oligodendrocyte transcription factor 1 (Oligo1) (Olg-1 bHLH protein) −0.322 0.004 reviewed
down Morf4l1-ps1 NA NA NA −6.744 0.008 NA
down Ebf2 D3ZT68 D3ZT68_RAT Transcription factor COE2 (Early B-cell factor 2) −3.729 0.012 unreviewed
down Cadm4 Q1WIM1 CADM4_RAT Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) −0.265 0.016 reviewed
down Mbp P02688 MBP_RAT Myelin basic protein (MBP) −0.496 0.018 reviewed
down Gcnt1 Q64165 Q64165_RAT Glucosaminyl (N-acetyl) transferase 1 −0.606 0.019 unreviewed
down Gm12184 NA NA NA −2.512 0.021 NA
down Abi3 Q6AYC6 Q6AYC6_RAT ABI gene family member 3 (New molecule including SH3) −0.793 0.025 unreviewed
down Sgf29 P0C606 SGF29_RAT SAGA-associated factor 29 (rSGF29) (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) −0.533 0.025 reviewed
down Rassf2 Q3B7D5 RASF2_RAT Ras association domain-containing protein 2 −0.287 0.028 reviewed
down Ebf3 D4A274 D4A274_RAT Transcription factor COE3 (Early B-cell factor 3) (Olf-1/EBF-like 2) −1.467 0.032 unreviewed
down Nr1d1 Q63503 NR1D1_RAT Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1) −0.448 0.032 reviewed
down Plekhb1 Q9WU68 PKHB1_RAT Pleckstrin homology domain-containing family B member 1 (PH domain-containing family B member 1) (Evectin-1) −0.389 0.032 reviewed
down Fam205a1 NA NA NA −6.066 0.033 NA
down Elp6 B2RYG8 ELP6_RAT Elongator complex protein 6 (Protein TMEM103) −0.860 0.033 reviewed
down Notch3 Q9R172 NOTC3_RAT Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] −0.409 0.033 reviewed
down 2900052L18Rik NA NA NA −0.634 0.034 NA
down Gab1 D3ZAL7 D3ZAL7_RAT GRB2-associated binding protein 1 −0.363 0.034 unreviewed
down Gm29216 NA NA NA −0.279 0.036 NA
down Abcb1a Q9JK64 Q9JK64_RAT P-type phospholipid transporter (EC 7.6.2.1) −0.415 0.048 unreviewed
 
  # opt_stylize(style = 6, color = 'pink') # cute but also ew looks like excel
  # opt_stylize(style = 1, color = 'gray', add_row_striping = TRUE)

Plots

plot(lit_review_transcriptomics$pvalue) # see distribution of pvalues

plot(lit_review_transcriptomics$Fold_change) # see distribution of fold change

Volcano plot

volcano_RNA <- lit_review_transcriptomics %>%
  filter(pvalue <= 0.2) %>% # filter otherwise 20000 dots per plot... 
  ggplot(aes(x = Fold_change, y = -log2(pvalue),
                         label = Gene_name)) +
  geom_point(aes(color = case_when(
    pvalue < 0.05 & Fold_change > 0.05 ~ "Upregulated (adj.p<0.05)",
    pvalue < 0.05 & Fold_change < -0.05 ~ "Downregulated (adj.p<0.05)",
    pvalue < 0.1 & Fold_change > 0.05 ~ "Upregulated (adj.p<0.1)",
    pvalue < 0.1 & Fold_change < -0.05 ~ "Downregulated (adj.p<0.1)",
                                   TRUE ~ "Not Significant")),
            alpha = 1, size = 1.5, shape = 1) +
  # xlim(-8,12) +
  geom_vline(xintercept = 0, linetype = "dashed",
             color = "grey40", linewidth = .5) +
  scale_color_manual(values = c("firebrick3", 
                                "royalblue4", 
                                "lightpink1", 
                                "lightblue3" ,
                                 "grey80"),
                     breaks = c("Upregulated (adj.p<0.05)", 
                                "Downregulated (adj.p<0.05)", 
                                "Upregulated (adj.p<0.1)",
                                "Downregulated (adj.p<0.1)",
                                "Not Significant"),
                     labels = c("Upregulated mRNA (adj.p<0.05)", 
                                "Downregulated mRNA (adj.p<0.05)", 
                                "Upregulated mRNA (adj.p<0.1)", 
                                "Downregulated mRNA (adj.p<0.1)", 
                                "Not Significant")) +
  
  geom_text_repel() +
  facet_wrap(~Condition, ncol = 1,
             scales = "free_y") +
  labs(
    title = "Perez 2024 - Transriptomics - Hippocampus (Mice) - EE x Aging  (2025_12_27)",
    subtitle = "",
       x = "Log2 Signal",
       y = "-Log2(adj.p-value)",
       color = "mRNA Regulation") +
  theme_bw() +
  theme(legend.position = "bottom",
        strip.text = element_text(size = 12))

volcano_RNA
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_text_repel()`).
## Warning: ggrepel: 389 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
## Warning: ggrepel: 83 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps
## Warning: ggrepel: 81 unlabeled data points (too many overlaps). Consider
## increasing max.overlaps

# intersect of observed 
intersect(split_prot_df_map_rat$combined$Gene_name,
          split_RNA_df_map_rat$combined$Gene_name)
##    [1] "2900026A02Rik" "4833439L19Rik" "4931406C07Rik" "Aatk"         
##    [5] "Abi1"          "Abl2"          "Abracl"        "Abraxas2"     
##    [9] "Acad8"         "Acan"          "Acbd3"         "Acin1"        
##   [13] "Acsf2"         "Actg1"         "Acyp1"         "Acyp2"        
##   [17] "Add1"          "Adgrl1"        "Adrm1"         "Afdn"         
##   [21] "Agfg1"         "Ahnak"         "Aimp1"         "Aip"          
##   [25] "Ak1"           "Akap12"        "Akap5"         "Akt1s1"       
##   [29] "Alyref"        "Amer2"         "Amph"          "Anapc1"       
##   [33] "Anp32a"        "Anxa7"         "Ap1m1"         "Ap1s1"        
##   [37] "Ap3s1"         "Apba1"         "Apoa1"         "Apod"         
##   [41] "Apoe"          "App"           "Aprt"          "Arfgap1"      
##   [45] "Arfip2"        "Arhgap21"      "Arhgap23"      "Arhgef17"     
##   [49] "Arhgef6"       "Arid1a"        "Arl1"          "Arpin"        
##   [53] "Arrb1"         "Arsb"          "Asap1"         "Atox1"        
##   [57] "Atp2a2"        "Atp6v1d"       "Atp6v1e1"      "Atp6v1f"      
##   [61] "Atp6v1g1"      "Atxn2l"        "Bad"           "Bag3"         
##   [65] "Bag4"          "Bag6"          "Baiap2"        "Basp1"        
##   [69] "Bcam"          "Bcan"          "Bcas1"         "Bcl2l13"      
##   [73] "Bcl7c"         "Bclaf1"        "Begain"        "Bin1"         
##   [77] "Bin2"          "Blmh"          "Bnip3l"        "Bod1"         
##   [81] "Bola1"         "Brk1"          "Bsn"           "Btf3"         
##   [85] "Bzw1"          "C1qbp"         "Cacna1a"       "Cacna1b"      
##   [89] "Cacnb1"        "Cadm1"         "Cadm2"         "Cadm3"        
##   [93] "Calb1"         "Calb2"         "Calr"          "Camk2n1"      
##   [97] "Camsap2"       "Cap1"          "Caprin1"       "Capza1"       
##  [101] "Carmil2"       "Caskin1"       "Cast"          "Cavin1"       
##  [105] "Cbx1"          "Cbx3"          "Cc2d1a"        "Ccar2"        
##  [109] "Ccsap"         "Cd200"         "Cd47"          "Cd81"         
##  [113] "Cd99l2"        "Cdc37"         "Cdc42ep4"      "Cdh11"        
##  [117] "Cdh13"         "Cdk14"         "Cdkn1b"        "Cdv3"         
##  [121] "Cend1"         "Cep170"        "Cep170b"       "Cfdp1"        
##  [125] "Chchd3"        "Chchd4"        "Chchd6"        "Chgb"         
##  [129] "Chmp1a"        "Chmp5"         "Chtop"         "Ciapin1"      
##  [133] "Cirbp"         "Clasp2"        "Clic4"         "Clint1"       
##  [137] "Clip1"         "Clip2"         "Clptm1"        "Clta"         
##  [141] "Cltb"          "Clu"           "Cmpk1"         "Cnot3"        
##  [145] "Cnpy2"         "Cnpy3"         "Cnst"          "Coa7"         
##  [149] "Cops8"         "Coq8a"         "Coq9"          "Cox5a"        
##  [153] "Cox6b1"        "Cplx1"         "Cplx2"         "Crk"          
##  [157] "Crkl"          "Crtc1"         "Cryl1"         "Cryzl1"       
##  [161] "Csde1"         "Csnk1a1"       "Cspg5"         "Csrp1"        
##  [165] "Cst3"          "Cstf2"         "Ctnnb1"        "Ctnnd2"       
##  [169] "Cttn"          "Cttnbp2"       "Cul4b"         "Cwc15"        
##  [173] "Cx3cl1"        "Cyb5a"         "Cygb"          "Dag1"         
##  [177] "Dbi"           "Dbndd2"        "Dbnl"          "Dctn2"        
##  [181] "Ddx17"         "Ddx6"          "Dek"           "Denr"         
##  [185] "Dhrs1"         "Dip2a"         "Dkk3"          "Dlgap3"       
##  [189] "Dlgap4"        "Dlst"          "Dmtn"          "Dnajb6"       
##  [193] "Dnajc5"        "Dnajc8"        "Dock9"         "Dpysl5"       
##  [197] "Drap1"         "Dtd1"          "Dync1li2"      "Eci2"         
##  [201] "Eef1a2"        "Eefsec"        "Efhd2"         "Eftud2"       
##  [205] "Eif1ax"        "Eif3f"         "Eif3g"         "Eif3j1"       
##  [209] "Eif4b"         "Eif4ebp2"      "Eif4g2"        "Eif4h"        
##  [213] "Eif5"          "Eif5a"         "Eif5b"         "Elob"         
##  [217] "Endod1"        "Enpp6"         "Ensa"          "Epb41l2"      
##  [221] "Epn1"          "Eps15l1"       "Erc2"          "Ermn"         
##  [225] "Erp29"         "Erp44"         "Evl"           "Fabp3"        
##  [229] "Fabp7"         "Fah"           "Fam114a2"      "Fam131b"      
##  [233] "Fam169a"       "Fam219a"       "Fdx2"          "Fgf1"         
##  [237] "Fgf12"         "Fkbp1a"        "Fkbp2"         "Fkbp3"        
##  [241] "Fmn2"          "Fmr1"          "Fnbp1"         "Fubp1"        
##  [245] "Fus"           "Fxn"           "Fxyd6"         "G3bp1"        
##  [249] "Gaa"           "Gabarapl2"     "Gabra1"        "Gad1"         
##  [253] "Galk1"         "Gap43"         "Gcsh"          "Gdpd1"        
##  [257] "Gfer"          "Gga3"          "Ggct"          "Ggt7"         
##  [261] "Gipc1"         "Gjc2"          "Glg1"          "Glo1"         
##  [265] "Glrx5"         "Gltp"          "Gm2a"          "Gmppa"        
##  [269] "Gng2"          "Golga5"        "Gorasp2"       "Gpc1"         
##  [273] "Gpc4"          "Gpm6a"         "Gpm6b"         "Gpr158"       
##  [277] "Gprin1"        "Gprin3"        "Grb2"          "Grcc10"       
##  [281] "Grm2"          "Grm5"          "Grpel1"        "Gtf2i"        
##  [285] "H2ax"          "Habp4"         "Hapln4"        "Hcfc1"        
##  [289] "Hcn1"          "Hdac6"         "Hdgf"          "Hdgfl2"       
##  [293] "Hdgfl3"        "Hectd1"        "Hgs"           "Hikeshi"      
##  [297] "Hmga1"         "Hmgb3"         "Hmgn5"         "Hnrnpa1"      
##  [301] "Hnrnpab"       "Hnrnpc"        "Hnrnpd"        "Hnrnpdl"      
##  [305] "Hnrnpll"       "Homer3"        "Hopx"          "Hp"           
##  [309] "Hpca"          "Hpcal1"        "Hpx"           "Hs1bp3"       
##  [313] "Hspa4"         "Hspe1"         "Htatsf1"       "Huwe1"        
##  [317] "Hyou1"         "Ighm"          "Impact"        "Inf2"         
##  [321] "Isca2"         "Iscu"          "Ist1"          "Itgb1"        
##  [325] "Itsn1"         "Jam3"          "Jph1"          "Jph3"         
##  [329] "Jpt1"          "Kalrn"         "Kcnip2"        "Khdrbs3"      
##  [333] "Khsrp"         "Kif5b"         "Klc2"          "Ktn1"         
##  [337] "L1cam"         "Lamp1"         "Lamtor1"       "Lamtor5"      
##  [341] "Larp1"         "Lasp1"         "Lbh"           "Lbhd2"        
##  [345] "Ldah"          "Letm1"         "Lgals1"        "Lgalsl"       
##  [349] "Lin7a"         "Lmnb1"         "Lmtk3"         "Lnpk"         
##  [353] "Lrg1"          "Lrp1"          "Lrpap1"        "Lrrc59"       
##  [357] "Lrrfip2"       "Lsm3"          "Ly6h"          "Lysmd2"       
##  [361] "M6pr"          "Mag"           "Map1a"         "Map1b"        
##  [365] "Map1lc3a"      "Map1s"         "Map6"          "Map7"         
##  [369] "Map7d2"        "Mapre1"        "Mapre3"        "Marcks"       
##  [373] "Marcksl1"      "Mark3"         "Mast1"         "Mbp"          
##  [377] "Mccc2"         "Mea1"          "Mecp2"         "Mfsd6"        
##  [381] "Mical3"        "Mindy2"        "Mink1"         "Mllt11"       
##  [385] "Mrpl12"        "Mrpl40"        "Mrps31"        "Mrrf"         
##  [389] "Msrb2"         "Mtdh"          "Mtpn"          "Myl6"         
##  [393] "Naca"          "Nap1l1"        "Nap1l4"        "Napg"         
##  [397] "Nav1"          "Ncald"         "Ncan"          "Nckipsd"      
##  [401] "Ncl"           "Ncs1"          "Ndel1"         "Ndrg2"        
##  [405] "Ndufa5"        "Ndufa6"        "Ndufa7"        "Ndufab1"      
##  [409] "Ndufb10"       "Ndufb3"        "Ndufb6"        "Ndufs4"       
##  [413] "Ndufs5"        "Ndufs8"        "Ndufv2"        "Ndufv3"       
##  [417] "Nebl"          "Necab2"        "Nectin1"       "Nedd8"        
##  [421] "Nefh"          "Negr1"         "Nenf"          "Nfu1"         
##  [425] "Nfya"          "Nipa1"         "Nme1"          "Nol3"         
##  [429] "Nop56"         "Nova1"         "Npc2"          "Npm1"         
##  [433] "Nsfl1c"        "Nt5dc3"        "Ntm"           "Nucb1"        
##  [437] "Nucks1"        "Nudc"          "Nup62"         "Ociad1"       
##  [441] "Ogfrl1"        "Omg"           "Opalin"        "Opcml"        
##  [445] "Oplah"         "Otud6b"        "Oxr1"          "Oxsr1"        
##  [449] "Pacsin1"       "Pacsin2"       "Pafah1b2"      "Pak1"         
##  [453] "Pak2"          "Palmd"         "Pclo"          "Pcnp"         
##  [457] "Pcsk1n"        "Pdap1"         "Pdcd10"        "Pde4a"        
##  [461] "Pdia3"         "Pdlim5"        "Pebp1"         "Pex14"        
##  [465] "Pfdn2"         "Pgam1"         "Pgbd5"         "Pgrmc1"       
##  [469] "Phpt1"         "Pitpnm1"       "Pkia"          "Pkig"         
##  [473] "Pkm"           "Plcl2"         "Plppr3"        "Pnma8b"       
##  [477] "Pnn"           "Pnpo"          "Polr2m"        "Ppfia4"       
##  [481] "Ppib"          "Ppid"          "Ppm1a"         "Ppp1r11"      
##  [485] "Ppp1r12a"      "Ppp1r12c"      "Ppp1r1a"       "Ppp1r1b"      
##  [489] "Ppp1r2"        "Ppp1r7"        "Ppp1r9a"       "Ppp1r9b"      
##  [493] "Ppp3r1"        "Ppp4r2"        "Ppp6c"         "Ppp6r1"       
##  [497] "Ppp6r3"        "Pqbp1"         "Prdx6"         "Prkcsh"       
##  [501] "Prnp"          "Prodh"         "Prps2"         "Prrc2a"       
##  [505] "Prrc2c"        "Prrt2"         "Prrt3"         "Psap"         
##  [509] "Psd"           "Psip1"         "Psma1"         "Psmb3"        
##  [513] "Psmb7"         "Psmc5"         "Psmd11"        "Psmd13"       
##  [517] "Psmd14"        "Psmd6"         "Psmd7"         "Psmd8"        
##  [521] "Psmd9"         "Psme1"         "Ptgds"         "Ptma"         
##  [525] "Ptms"          "Ptpn23"        "Ptpn9"         "Ptpra"        
##  [529] "Ptprn2"        "Ptprz1"        "Puf60"         "Pum1"         
##  [533] "Pym1"          "Rab10"         "Rab27b"        "Rab3gap2"     
##  [537] "Rabl6"         "Rad23a"        "Rad23b"        "Ralbp1"       
##  [541] "Ralgapa1"      "Ramac"         "Ranbp3"        "Rbm3"         
##  [545] "Rbm8a"         "Rbmx"          "Rcn1"          "Rcn2"         
##  [549] "Rell2"         "Reps1"         "Reps2"         "Rftn2"        
##  [553] "Rgs10"         "Rida"          "Rimbp2"        "Rims1"        
##  [557] "Ripor1"        "Rmdn3"         "Rnh1"          "Rnmt"         
##  [561] "Rph3a"         "Rpl10"         "Rpl19"         "Rpl22"        
##  [565] "Rpl23a"        "Rpl31"         "Rpl38"         "Rplp1"        
##  [569] "Rplp2"         "Rps13"         "Rps15"         "Rps17"        
##  [573] "Rps19"         "Rps25"         "Rps28"         "Rpsa"         
##  [577] "Rrbp1"         "Rrp1"          "Rtcb"          "Rtn3"         
##  [581] "Rtn4"          "Rwdd1"         "S100a16"       "Safb"         
##  [585] "Sarnp"         "Scamp3"        "Scg2"          "Scg3"         
##  [589] "Scn2a"         "Scp2"          "Sdc4"          "Sec24b"       
##  [593] "Sec24c"        "Sec31a"        "Selenom"       "Serbp1"       
##  [597] "Set"           "Setd7"         "Sf1"           "Sf3b4"        
##  [601] "Sgip1"         "Sgta"          "Sgtb"          "Sh3bgrl3"     
##  [605] "Sh3gl2"        "Sh3glb2"       "Sh3kbp1"       "Shank1"       
##  [609] "Shank2"        "Shank3"        "Shfl"          "Shisa7"       
##  [613] "Shroom2"       "Skp1"          "Slc12a2"       "Slc25a23"     
##  [617] "Slc27a4"       "Slc32a1"       "Slc39a10"      "Slc39a6"      
##  [621] "Slc6a11"       "Slc6a6"        "Slc9a1"        "Smarcc2"      
##  [625] "Snap25"        "Snca"          "Sncb"          "Snrpa"        
##  [629] "Snx1"          "Snx12"         "Snx3"          "Sod1"         
##  [633] "Sorbs1"        "Sorbs2"        "Sparcl1"       "Specc1"       
##  [637] "Spock1"        "Spock2"        "Sptb"          "Sri"          
##  [641] "Srp19"         "Srp72"         "Srrm2"         "Srrt"         
##  [645] "Srsf1"         "Srsf10"        "Srsf2"         "Srsf7"        
##  [649] "Ssb"           "Sst"           "St13"          "Stip1"        
##  [653] "Stmn1"         "Stoml2"        "Strn"          "Strn3"        
##  [657] "Stx1b"         "Stx7"          "Sub1"          "Suclg2"       
##  [661] "Sumo2"         "Svip"          "Syap1"         "Syn1"         
##  [665] "Syn3"          "Synm"          "Synrg"         "Tacc1"        
##  [669] "Taf15"         "Tagln"         "Tagln2"        "Tagln3"       
##  [673] "Tbc1d10b"      "Tbcd"          "Tcea1"         "Tceal3"       
##  [677] "Tceal5"        "Tfg"           "Tgoln1"        "Thop1"        
##  [681] "Thrap3"        "Timm44"        "Timm8a1"       "Tjp1"         
##  [685] "Tmem63b"       "Tmod1"         "Tmod2"         "Tmpo"         
##  [689] "Tnks1bp1"      "Tom1"          "Tom1l2"        "Tomm34"       
##  [693] "Tpd52"         "Tpd52l1"       "Tpd52l2"       "Tpm1"         
##  [697] "Tpm3"          "Tpm3-rs7"      "Tpm4"          "Tppp"         
##  [701] "Tppp3"         "Tpr"           "Tpt1"          "Trappc3"      
##  [705] "Trappc8"       "Trim28"        "Trio"          "Trir"         
##  [709] "Trmt112"       "Trp53bp1"      "Tsc22d1"       "Tsr2"         
##  [713] "Ttc1"          "Ttc7b"         "Ttr"           "Tubb2b"       
##  [717] "Txndc17"       "U2af2"         "Uba3"          "Ubap2l"       
##  [721] "Ube2l3"        "Ube2n"         "Ube2v2"        "Ube3a"        
##  [725] "Ubqln1"        "Ubqln2"        "Ubqln4"        "Ubr4"         
##  [729] "Ubtd2"         "Uchl1"         "Uchl3"         "Ufm1"         
##  [733] "Umad1"         "Uqcrb"         "Uqcrh"         "Uqcrq"        
##  [737] "Usp7"          "Vasp"          "Vat1l"         "Vcan"         
##  [741] "Vcl"           "Vcpip1"        "Vgf"           "Vps52"        
##  [745] "Vps53"         "Vsnl1"         "Vta1"          "Wasf1"        
##  [749] "Washc2"        "Wasl"          "Wipf2"         "Wipf3"        
##  [753] "Wnk1"          "Wnk2"          "Yaf2"          "Ybx1"         
##  [757] "Yjefn3"        "Ythdf3"        "Zbed5"         "Zc2hc1a"      
##  [761] "Zc3h4"         "Zdhhc5"        "Zfand2b"       "Zfand6"       
##  [765] "Zfp428"        "Zfp512"        "Zyx"           NA             
##  [769] "6430548M08Rik" "Aamdc"         "Abat"          "Abcd3"        
##  [773] "Abce1"         "Abcf2"         "Abhd12"        "Abi2"         
##  [777] "Ablim1"        "Ablim2"        "Abr"           "Acaa1a"       
##  [781] "Acaa2"         "Acad9"         "Acadl"         "Acadm"        
##  [785] "Acadvl"        "Acat1"         "Acat2"         "Acly"         
##  [789] "Aco1"          "Aco2"          "Acot13"        "Acot2"        
##  [793] "Acot7"         "Acp1"          "Acsbg1"        "Acsl3"        
##  [797] "Acsl6"         "Acss1"         "Actb"          "Actn1"        
##  [801] "Actr1a"        "Actr1b"        "Actr2"         "Actr3"        
##  [805] "Actr3b"        "Acy1"          "Adam11"        "Adam22"       
##  [809] "Adam23"        "Adap1"         "Adcy9"         "Add2"         
##  [813] "Add3"          "Adh5"          "Adk"           "Ado"          
##  [817] "Adprh"         "Afg3l2"        "Agap2"         "Agap3"        
##  [821] "Agfg2"         "Agk"           "Agl"           "Ago1"         
##  [825] "Agpat1"        "Ahcyl1"        "Ahcyl2"        "Ahsa1"        
##  [829] "Aifm1"         "Ak3"           "Ak4"           "Ak5"          
##  [833] "Akr1a1"        "Alad"          "Alcam"         "Aldh1a1"      
##  [837] "Aldh1b1"       "Aldh1l1"       "Aldh2"         "Aldh4a1"      
##  [841] "Aldh5a1"       "Aldh6a1"       "Aldh7a1"       "Aldoa"        
##  [845] "Aldoc"         "Alg2"          "Anks1b"        "Anp32b"       
##  [849] "Anxa11"        "Anxa2"         "Anxa6"         "Ap1b1"        
##  [853] "Ap1g1"         "Ap2a1"         "Ap2a2"         "Ap2b1"        
##  [857] "Ap2m1"         "Ap2s1"         "Ap3b2"         "Ap3d1"        
##  [861] "Ap3m2"         "Apbb1"         "Apex1"         "Api5"         
##  [865] "Apmap"         "Apoo"          "Apool"         "Appl1"        
##  [869] "Aqp4"          "Arcn1"         "Arf4"          "Arf5"         
##  [873] "Arf6"          "Arhgap1"       "Arhgap44"      "Arhgdia"      
##  [877] "Arhgef2"       "Arl15"         "Arl3"          "Arl8b"        
##  [881] "Armc1"         "Armc10"        "Arpc1a"        "Arpc2"        
##  [885] "Arpc3"         "Arpc4"         "Arpc5"         "Arpc5l"       
##  [889] "Asah1"         "Asl"           "Asns"          "Aspa"         
##  [893] "Asph"          "Asrgl1"        "Ass1"          "Astn1"        
##  [897] "Atad3a"        "Atcay"         "Atg3"          "Atg7"         
##  [901] "Atic"          "Atl1"          "Atp1a1"        "Atp1a2"       
##  [905] "Atp1a3"        "Atp1b1"        "Atp1b2"        "Atp1b3"       
##  [909] "Atp2b2"        "Atp2b3"        "Atp2b4"        "Atp5pb"       
##  [913] "Atp6ap1"       "Atp6v0c"       "Atp6v0d1"      "Atp6v1a"      
##  [917] "Atp6v1b2"      "Atp6v1c1"      "Atp6v1h"       "Atp8a1"       
##  [921] "Atpaf1"        "Atxn10"        "Auh"           "Babam2"       
##  [925] "Bcat1"         "Bdh1"          "Blvra"         "Blvrb"        
##  [929] "Bphl"          "Bpnt1"         "Bpnt2"         "Braf"         
##  [933] "Bri3bp"        "Brsk1"         "Brsk2"         "Bsdc1"        
##  [937] "Bub3"          "C1qb"          "C1qc"          "C2cd2l"       
##  [941] "Cab39"         "Cacna1e"       "Cacna2d3"      "Cacnb3"       
##  [945] "Cacybp"        "Cadm4"         "Calcoco1"      "Camk1d"       
##  [949] "Camk2b"        "Camk2d"        "Camk2g"        "Camk4"        
##  [953] "Camkk1"        "Camkv"         "Cand1"         "Canx"         
##  [957] "Cap2"          "Capn2"         "Capza2"        "Capzb"        
##  [961] "Carhsp1"       "Cask"          "Cat"           "Cbr1"         
##  [965] "Cbr3"          "Cbr4"          "Cbx5"          "Ccdc177"      
##  [969] "Ccdc22"        "Ccdc6"         "Ccdc85c"       "Ccny"         
##  [973] "Cct2"          "Cct3"          "Cct4"          "Cct5"         
##  [977] "Cct6a"         "Cct7"          "Cct8"          "Cd34"         
##  [981] "Cd44"          "Cd82"          "Cdc42"         "Cdc42bpb"     
##  [985] "Cdc5l"         "Cdh10"         "Cdh2"          "Cdipt"        
##  [989] "Cdk5"          "Cds2"          "Celf2"         "Cenpv"        
##  [993] "Cfap36"        "Chl1"          "Chmp6"         "Chordc1"      
##  [997] "Chrm1"         "Ckap4"         "Ckap5"         "Ckb"          
## [1001] "Ckmt1"         "Cldn11"        "Clic6"         "Clpp"         
## [1005] "Clstn1"        "Cltc"          "Clvs1"         "Cmas"         
## [1009] "Cnbp"          "Cndp2"         "Cnih2"         "Cnksr2"       
## [1013] "Cnn3"          "Cnp"           "Cnrip1"        "Cntn1"        
## [1017] "Cntn2"         "Cntnap1"       "Cntnap2"       "Comtd1"       
## [1021] "Copa"          "Copg1"         "Cops2"         "Cops4"        
## [1025] "Cops6"         "Cops7a"        "Coq3"          "Coro1a"       
## [1029] "Coro1b"        "Coro1c"        "Coro2b"        "Coro7"        
## [1033] "Cotl1"         "Cox4i1"        "Cox6a1"        "Cox7a2"       
## [1037] "Cpe"           "Cpne1"         "Cpne4"         "Cpne6"        
## [1041] "Cpsf6"         "Creb1"         "Creld1"        "Crip2"        
## [1045] "Crmp1"         "Cryab"         "Crym"          "Cryz"         
## [1049] "Cs"            "Cse1l"         "Csnk2a1"       "Csnk2a2"      
## [1053] "Csnk2b"        "Cstb"          "Ctbp1"         "Ctnna2"       
## [1057] "Ctsb"          "Ctsd"          "Cul1"          "Cul2"         
## [1061] "Cul3"          "Cul5"          "Cyb5b"         "Cyb5r1"       
## [1065] "Cyb5r3"        "Cyc1"          "Cyfip1"        "Cyfip2"       
## [1069] "Cyria"         "Cyrib"         "Dagla"         "Dazap1"       
## [1073] "Dbt"           "Dclk1"         "Dclk2"         "Dcps"         
## [1077] "Dctn1"         "Dctn4"         "Dctn6"         "Ddah1"        
## [1081] "Ddb1"          "Ddt"           "Ddx1"          "Ddx19b"       
## [1085] "Ddx39b"        "Ddx3x"         "Ddx42"         "Ddx5"         
## [1089] "Decr1"         "Dgkb"          "Dgke"          "Dgkg"         
## [1093] "Dgkh"          "Dgki"          "Dgkz"          "Dhrs4"        
## [1097] "Dhx9"          "Diras1"        "Diras2"        "Dlat"         
## [1101] "Dld"           "Dlg1"          "Dlg2"          "Dlg3"         
## [1105] "Dlg4"          "Dlgap1"        "Dlgap2"        "Dmxl2"        
## [1109] "Dnaja1"        "Dnaja2"        "Dnaja3"        "Dnaja4"       
## [1113] "Dnajb4"        "Dnajc11"       "Dnajc6"        "Dnm1"         
## [1117] "Dnm3"          "Dnpep"         "Dpp10"         "Dpp3"         
## [1121] "Dpp6"          "Dpysl2"        "Dpysl3"        "Dpysl4"       
## [1125] "Drg1"          "Drg2"          "Dstn"          "Dtna"         
## [1129] "Dusp3"         "Dync1h1"       "Dync1i2"       "Dync1li1"     
## [1133] "Dynll1"        "Dynll2"        "Dynlrb1"       "Echdc1"       
## [1137] "Echs1"         "Eci1"          "Eea1"          "Eef1a1"       
## [1141] "Eef1d"         "Eef1g"         "Eef2"          "Efr3b"        
## [1145] "Ehd1"          "Ehd3"          "Eif1b"         "Eif2s2"       
## [1149] "Eif2s3x"       "Eif3a"         "Eif3b"         "Eif3c"        
## [1153] "Eif3d"         "Eif3h"         "Eif3i"         "Eif4a1"       
## [1157] "Eif4a2"        "Eif4a3"        "Eif4e"         "Eif4g1"       
## [1161] "Eif4g3"        "Eipr1"         "Elavl1"        "Elavl4"       
## [1165] "Elfn2"         "Elmo2"         "Eloc"          "Emd"          
## [1169] "Eno2"          "Entpd2"        "Epb41l1"       "Epdr1"        
## [1173] "Epha4"         "Ephx1"         "Ephx2"         "Epm2aip1"     
## [1177] "Erc1"          "Erlin2"        "Esd"           "Etfa"         
## [1181] "Etfb"          "Etfdh"         "Ethe1"         "Ewsr1"        
## [1185] "Exoc4"         "Exoc5"         "Exoc6b"        "Exoc8"        
## [1189] "Exog"          "Ezr"           "Faah"          "Fabp5"        
## [1193] "Faf2"          "Fam163b"       "Fam98b"        "Farp1"        
## [1197] "Farsa"         "Farsb"         "Fasn"          "Fbxl16"       
## [1201] "Fbxo2"         "Fbxo41"        "Fermt2"        "Fkbp15"       
## [1205] "Fkbp4"         "Fkbp5"         "Fkbp8"         "Flna"         
## [1209] "Flot1"         "Flot2"         "Fn3krp"        "Fnta"         
## [1213] "Frrs1l"        "Fscn1"         "Fth1"          "Fxyd1"        
## [1217] "G3bp2"         "G6pdx"         "Gabbr1"        "Gabbr2"       
## [1221] "Gabrb3"        "Gabrg2"        "Gad2"          "Gak"          
## [1225] "Ganab"         "Gapdh"         "Gart"          "Gas7"         
## [1229] "Gatd1"         "Gclc"          "Gda"           "Gdap1"        
## [1233] "Gdap1l1"       "Gdi1"          "Gdi2"          "Get3"         
## [1237] "Gfap"          "Gga1"          "Git1"          "Gja1"         
## [1241] "Gk"            "Glod4"         "Glrx"          "Glrx3"        
## [1245] "Gls"           "Glud1"         "Glul"          "Gm20431"      
## [1249] "Gmfb"          "Gmpr"          "Gmps"          "Gna11"        
## [1253] "Gna13"         "Gnai1"         "Gnai2"         "Gnai3"        
## [1257] "Gnao1"         "Gnaq"          "Gnas"          "Gnaz"         
## [1261] "Gnb1"          "Gnb2"          "Gnb5"          "Gng12"        
## [1265] "Gng3"          "Gng4"          "Gnl1"          "Got1"         
## [1269] "Got2"          "Gpd1"          "Gpd1l"         "Gpd2"         
## [1273] "Gphn"          "Gpr37l1"       "Gps1"          "Gpx4"         
## [1277] "Grhpr"         "Gria1"         "Gria3"         "Grin1"        
## [1281] "Grin2a"        "Grin2b"        "Gripap1"       "Grk2"         
## [1285] "Grm3"          "Gsk3a"         "Gsk3b"         "Gsn"          
## [1289] "Gspt1"         "Gsr"           "Gstm1"         "Gstm5"        
## [1293] "Gstp1"         "H3f3a"         "Hacd3"         "Hadha"        
## [1297] "Hadhb"         "Hagh"          "Hapln1"        "Hapln2"       
## [1301] "Hdhd2"         "Hecw2"         "Hepacam"       "Hexb"         
## [1305] "Hexim1"        "Hibadh"        "Hibch"         "Hint1"        
## [1309] "Hip1r"         "Hk1"           "Hmgb1"         "Hmgcl"        
## [1313] "Hmox2"         "Hnrnpa0"       "Hnrnpa2b1"     "Hnrnpa3"      
## [1317] "Hnrnpf"        "Hnrnph1"       "Hnrnph2"       "Hnrnph3"      
## [1321] "Hnrnpk"        "Hnrnpl"        "Hnrnpm"        "Hnrnpr"       
## [1325] "Hnrnpu"        "Hnrnpul2"      "Homer1"        "Hp1bp3"       
## [1329] "Hpcal4"        "Hsd17b10"      "Hsd17b4"       "Hsp90aa1"     
## [1333] "Hsp90ab1"      "Hsp90b1"       "Hspa12a"       "Hspa1a"       
## [1337] "Hspa2"         "Hspa4l"        "Hspa5"         "Hspa8"        
## [1341] "Hspa9"         "Hspd1"         "Hsph1"         "Htra2"        
## [1345] "Htt"           "Iars2"         "Icam5"         "Idh1"         
## [1349] "Idh2"          "Idh3a"         "Idh3b"         "Idh3g"        
## [1353] "Igsf8"         "Ilf2"          "Ilf3"          "Impa1"        
## [1357] "Impdh2"        "Ina"           "Inpp1"         "Inpp4a"       
## [1361] "Ipo5"          "Ipo7"          "Ipo9"          "Iqgap2"       
## [1365] "Iqsec1"        "Irgq"          "Isoc2a"        "Itgb8"        
## [1369] "Itm2c"         "Itpa"          "Itpka"         "Itpr1"        
## [1373] "Ivd"           "Kbtbd11"       "Kcna1"         "Kcna2"        
## [1377] "Kcnab2"        "Kcnd2"         "Kcnma1"        "Kctd12"       
## [1381] "Kctd16"        "Kif1a"         "Kif2a"         "Kif5c"        
## [1385] "Kifap3"        "Kifbp"         "Klc1"          "Kpna3"        
## [1389] "Kpnb1"         "Krt2"          "Krt5"          "Ksr1"         
## [1393] "Kyat3"         "L2hgdh"        "Lancl1"        "Lancl2"       
## [1397] "Lap3"          "Ldha"          "Ldhb"          "Lgi1"         
## [1401] "Lin7c"         "Lingo1"        "Lmna"          "Lmnb2"        
## [1405] "Lonp1"         "Lrpprc"        "Lrrc47"        "Lrrc4b"       
## [1409] "Lrrc57"        "Lrrc7"         "Lsm4"          "Lta4h"        
## [1413] "Luc7l2"        "Lxn"           "Lypla1"        "Lypla2"       
## [1417] "Macroh2a1"     "Madd"          "Magi1"         "Mal2"         
## [1421] "Maoa"          "Maob"          "Map1lc3b"      "Map2k1"       
## [1425] "Map2k4"        "Map6d1"        "Map7d1"        "Mapk1"        
## [1429] "Mapk10"        "Mapk3"         "Mapre2"        "Mark2"        
## [1433] "Mat2a"         "Mat2b"         "Matr3"         "Mcee"         
## [1437] "Mcu"           "Mdh1"          "Mdh2"          "Me1"          
## [1441] "Me3"           "Mecr"          "Mff"           "Mfn2"         
## [1445] "Mgll"          "Mia3"          "Micos13"       "Micu3"        
## [1449] "Mif"           "Mlc1"          "Mlf2"          "Mmut"         
## [1453] "Mob4"          "Mog"           "Mpc2"          "Mpdu1"        
## [1457] "Mpi"           "Mpp2"          "Mpp3"          "Mpst"         
## [1461] "Mras"          "Mrpl58"        "Msn"           "Msra"         
## [1465] "Mtarc2"        "Mtch1"         "Mtch2"         "Mtfp1"        
## [1469] "Mtfr1l"        "Mthfd1"        "Mthfd1l"       "Mtmr1"        
## [1473] "Mtres1"        "Mtx1"          "Myadm"         "Myh10"        
## [1477] "Myh9"          "Myo18a"        "Myo5a"         "Nadk2"        
## [1481] "Nae1"          "Nampt"         "Nans"          "Napa"         
## [1485] "Napb"          "Naxd"          "Naxe"          "Nbea"         
## [1489] "Ncam2"         "Ncdn"          "Nceh1"         "Nck2"         
## [1493] "Nckap1"        "Ndrg1"         "Ndrg3"         "Ndrg4"        
## [1497] "Ndufa10"       "Ndufa11"       "Ndufa12"       "Ndufa13"      
## [1501] "Ndufa3"        "Ndufa4"        "Ndufa8"        "Ndufa9"       
## [1505] "Ndufb11"       "Ndufb4"        "Ndufb8"        "Ndufb9"       
## [1509] "Ndufs1"        "Ndufs2"        "Ndufs3"        "Ndufs6"       
## [1513] "Ndufs7"        "Ndufv1"        "Necap1"        "Nedd4"        
## [1517] "Nedd4l"        "Nefl"          "Nefm"          "Nf1"          
## [1521] "Nfs1"          "Nipsnap1"      "Nipsnap2"      "Nisch"        
## [1525] "Nlgn2"         "Nlgn3"         "Nmt1"          "Nolc1"        
## [1529] "Nomo1"         "Nono"          "Npepps"        "Nptn"         
## [1533] "Nptx1"         "Nras"          "Nrbp1"         "Nrxn1"        
## [1537] "Nrxn3"         "Nsf"           "Nsmf"          "Nt5c"         
## [1541] "Ntrk2"         "Ntrk3"         "Nudcd2"        "Nudcd3"       
## [1545] "Nudt3"         "Numbl"         "Oat"           "Ogdh"         
## [1549] "Ogdhl"         "Ogt"           "Ola1"          "Olfm1"        
## [1553] "Opa1"          "Opa3"          "Osbp"          "Osbpl1a"      
## [1557] "Otub1"         "Oxct1"         "P4hb"          "Pa2g4"        
## [1561] "Pabpc1"        "Pabpn1"        "Pacs1"         "Padi2"        
## [1565] "Pafah1b1"      "Paics"         "Pals2"         "Park7"        
## [1569] "Pcbp1"         "Pcbp2"         "Pcca"          "Pccb"         
## [1573] "Pcdh10"        "Pcdh9"         "Pck2"          "Pcmt1"        
## [1577] "Pcp4l1"        "Pcx"           "Pcyox1"        "Pcyt2"        
## [1581] "Pdcd5"         "Pdcd6ip"       "Pde1a"         "Pde1b"        
## [1585] "Pde2a"         "Pdha1"         "Pdhb"          "Pdhx"         
## [1589] "Pdia4"         "Pdia6"         "Pdk1"          "Pdk3"         
## [1593] "Pdxk"          "Pdxp"          "Pef1"          "Pepd"         
## [1597] "Pex19"         "Pex5l"         "Pfas"          "Pfkl"         
## [1601] "Pfkm"          "Pfkp"          "Pfn1"          "Pfn2"         
## [1605] "Pgd"           "Pgk1"          "Pgls"          "Pgm1"         
## [1609] "Pgm2l1"        "Pgp"           "Phactr1"       "Phb2"         
## [1613] "Phf24"         "Phgdh"         "Phyhip"        "Phyhipl"      
## [1617] "Pi4ka"         "Pin1"          "Pip4k2a"       "Pip4k2b"      
## [1621] "Pip4k2c"       "Pip5k1c"       "Pitpna"        "Pitpnc1"      
## [1625] "Pkp4"          "Plcb1"         "Plcl1"         "Pld3"         
## [1629] "Plec"          "Plin3"         "Plp1"          "Plpbp"        
## [1633] "Plpp3"         "Plppr2"        "Plppr4"        "Pls3"         
## [1637] "Plxna1"        "Plxna4"        "Pmm1"          "Por"          
## [1641] "Ppa1"          "Ppa2"          "Ppfia3"        "Ppia"         
## [1645] "Ppm1b"         "Ppm1e"         "Ppm1h"         "Ppme1"        
## [1649] "Ppp1cb"        "Ppp1r21"       "Ppp2ca"        "Ppp2r1a"      
## [1653] "Ppp2r2a"       "Ppp2r5a"       "Ppp2r5d"       "Ppp2r5e"      
## [1657] "Ppp3ca"        "Ppp3cb"        "Ppp5c"         "Ppt1"         
## [1661] "Pptc7"         "Prdx1"         "Prdx2"         "Prdx3"        
## [1665] "Prdx5"         "Prep"          "Prepl"         "Prickle2"     
## [1669] "Prkaca"        "Prkacb"        "Prkag2"        "Prkar1a"      
## [1673] "Prkar1b"       "Prkar2a"       "Prkar2b"       "Prkca"        
## [1677] "Prkcb"         "Prkce"         "Prkcg"         "Prmt1"        
## [1681] "Prmt5"         "Prpf19"        "Prpf8"         "Prps1l3"      
## [1685] "Prpsap1"       "Prpsap2"       "Prrt1"         "Prune1"       
## [1689] "Prune2"        "Prxl2a"        "Psat1"         "Psd3"         
## [1693] "Psma2"         "Psma3"         "Psma4"         "Psma5"        
## [1697] "Psma6"         "Psma7"         "Psmb1"         "Psmb4"        
## [1701] "Psmb5"         "Psmb6"         "Psmc1"         "Psmc2"        
## [1705] "Psmc3"         "Psmc4"         "Psmc6"         "Psmd1"        
## [1709] "Psmd12"        "Psmd2"         "Psmd3"         "Psmd4"        
## [1713] "Psmd5"         "Pspc1"         "Psph"          "Ptbp2"        
## [1717] "Ptges3"        "Ptk2b"         "Ptn"           "Ptpa"         
## [1721] "Ptpn11"        "Ptprd"         "Ptprs"         "Pura"         
## [1725] "Purb"          "Purg"          "Pvalb"         "Pycr2"        
## [1729] "Pygb"          "Pygm"          "Qdpr"          "Rab11b"       
## [1733] "Rab12"         "Rab14"         "Rab18"         "Rab1a"        
## [1737] "Rab1b"         "Rab21"         "Rab2a"         "Rab35"        
## [1741] "Rab3a"         "Rab3b"         "Rab3c"         "Rab5a"        
## [1745] "Rab5b"         "Rab5c"         "Rab6a"         "Rab6b"        
## [1749] "Rabgap1"       "Rabggta"       "Rac1"          "Rack1"        
## [1753] "Rala"          "Ran"           "Ranbp1"        "Rangap1"      
## [1757] "Rap1a"         "Rap1b"         "Rap1gap"       "Rap1gap2"     
## [1761] "Rap1gds1"      "Rap2a"         "Rap2b"         "Rapgef2"      
## [1765] "Rapgef4"       "Rasal1"        "Rasgrf1"       "Rbbp4"        
## [1769] "Rbbp9"         "Rbm39"         "Rdx"           "Reep2"        
## [1773] "Retreg2"       "Rgs14"         "Rgs7"          "Rgs7bp"       
## [1777] "Rheb"          "Rhoa"          "Rhob"          "Rhog"         
## [1781] "Rhot1"         "Rilpl1"        "Rnf214"        "Rnpep"        
## [1785] "Rock2"         "Rogdi"         "Rpl10a"        "Rpl11"        
## [1789] "Rpl12"         "Rpl13"         "Rpl13a"        "Rpl14"        
## [1793] "Rpl18"         "Rpl23"         "Rpl24"         "Rpl27a"       
## [1797] "Rpl28"         "Rpl3"          "Rpl30"         "Rpl4"         
## [1801] "Rpl5"          "Rpl6"          "Rpl7"          "Rpl7a"        
## [1805] "Rpl8"          "Rpl9-ps6"      "Rplp0"         "Rpn1"         
## [1809] "Rpn2"          "Rps10"         "Rps11"         "Rps14"        
## [1813] "Rps15a"        "Rps16"         "Rps2"          "Rps20"        
## [1817] "Rps23"         "Rps24"         "Rps26"         "Rps27"        
## [1821] "Rps3"          "Rps4x"         "Rps6"          "Rps7"         
## [1825] "Rps8"          "Rps9"          "Rras2"         "Rufy3"        
## [1829] "Ruvbl1"        "Ruvbl2"        "S1pr1"         "Sae1"         
## [1833] "Samm50"        "Sar1a"         "Sar1b"         "Sbf1"         
## [1837] "Scai"          "Scamp1"        "Scamp5"        "Scn2b"        
## [1841] "Scrn1"         "Scrn3"         "Sdcbp"         "Sdha"         
## [1845] "Sdhb"          "Sdhc"          "Sec13"         "Sec14l2"      
## [1849] "Sec22b"        "Sec23a"        "Sema7a"        "Septin11"     
## [1853] "Septin4"       "Septin6"       "Septin7"       "Septin8"      
## [1857] "Septin9"       "Serpinb1a"     "Serpinb6a"     "Sez6l"        
## [1861] "Sez6l2"        "Sf3b2"         "Sf3b3"         "Sfpq"         
## [1865] "Sfxn1"         "Sfxn3"         "Sfxn5"         "Sh3bgrl"      
## [1869] "Sh3bgrl2"      "Sh3gl1"        "Sh3gl3"        "Sh3glb1"      
## [1873] "Shisa6"        "Sipa1l1"       "Sipa1l3"       "Sirt2"        
## [1877] "Slc12a5"       "Slc17a7"       "Slc1a3"        "Slc1a4"       
## [1881] "Slc24a2"       "Slc25a11"      "Slc25a12"      "Slc25a18"     
## [1885] "Slc25a22"      "Slc25a25"      "Slc25a3"       "Slc25a4"      
## [1889] "Slc25a46"      "Slc25a5"       "Slc2a1"        "Slc2a3"       
## [1893] "Slc38a3"       "Slc3a2"        "Slc43a2"       "Slc44a1"      
## [1897] "Slc4a10"       "Slc4a4"        "Slc4a7"        "Slc6a1"       
## [1901] "Slc6a17"       "Slc6a7"        "Slc7a14"       "Slc7a5"       
## [1905] "Slc8a1"        "Slc8a2"        "Slk"           "Smap1"        
## [1909] "Smap2"         "Smarce1"       "Smpd3"         "Snap47"       
## [1913] "Snd1"          "Snph"          "Snrnp200"      "Snrnp70"      
## [1917] "Snrpd1"        "Snrpd3"        "Snta1"         "Snw1"         
## [1921] "Snx15"         "Snx2"          "Snx27"         "Sod2"         
## [1925] "Sord"          "Sort1"         "Sparc"         "Spr"          
## [1929] "Sptan1"        "Sptbn1"        "Sptbn2"        "Sptbn4"       
## [1933] "Src"           "Srcin1"        "Srgap2"        "Srgap3"       
## [1937] "Srm"           "Srpk2"         "Srr"           "Srsf5"        
## [1941] "Stam"          "Stim1"         "Stim2"         "Stk24"        
## [1945] "Stk39"         "Strap"         "Strn4"         "Stub1"        
## [1949] "Stum"          "Stx12"         "Stx1a"         "Stxbp1"       
## [1953] "Stxbp5"        "Stxbp5l"       "Stxbp6"        "Sucla2"       
## [1957] "Suclg1"        "Sugt1"         "Sult4a1"       "Sv2a"         
## [1961] "Sv2b"          "Svop"          "Syn2"          "Syncrip"      
## [1965] "Syngap1"       "Syngr3"        "Synj1"         "Synpo"        
## [1969] "Synpr"         "Syp"           "Syt1"          "Syt12"        
## [1973] "Syt7"          "Taldo1"        "Tardbp"        "Tbc1d24"      
## [1977] "Tceal6"        "Tcp1"          "Tecpr1"        "Tecr"         
## [1981] "Tfrc"          "Them4"         "Thy1"          "Tial1"        
## [1985] "Tigar"         "Timm50"        "Tiprl"         "Tkt"          
## [1989] "Tln1"          "Tln2"          "Tmed10"        "Tmed2"        
## [1993] "Tmed9"         "Tmem11"        "Tmem132b"      "Tmem30a"      
## [1997] "Tmem65"        "Tmx1"          "Tmx2"          "Tmx3"         
## [2001] "Tmx4"          "Tnik"          "Tnr"           "Tollip"       
## [2005] "Tomm22"        "Tpi1"          "Tpp1"          "Tpp2"         
## [2009] "Trap1"         "Trim2"         "Trim3"         "Trim9"        
## [2013] "Trnt1"         "Tsfm"          "Tsg101"        "Tspan2"       
## [2017] "Tspan7"        "Tst"           "Tstd3"         "Ttyh1"        
## [2021] "Ttyh3"         "Tuba1a"        "Tuba4a"        "Tubb2a"       
## [2025] "Tubb3"         "Tubb4a"        "Tubb4b"        "Tubb5"        
## [2029] "Tufm"          "Twf1"          "Twf2"          "Txndc5"       
## [2033] "Txnl1"         "Txnrd1"        "Uba1"          "Uba2"         
## [2037] "Uba52"         "Ube2d3"        "Ube2h"         "Ube2k"        
## [2041] "Ube2m"         "Ube2o"         "Ube2z"         "Ubfd1"        
## [2045] "Ubl4a"         "Ubxn6"         "Ubxn7"         "Ugp2"         
## [2049] "Unc13a"        "Uqcr10"        "Uqcr11"        "Uqcrc1"       
## [2053] "Uqcrc2"        "Uqcrfs1"       "Uso1"          "Usp14"        
## [2057] "Usp31"         "Usp46"         "Usp5"          "Usp9x"        
## [2061] "Vapa"          "Vapb"          "Vat1"          "Vbp1"         
## [2065] "Vcp"           "Vdac1"         "Vdac2"         "Vim"          
## [2069] "Vps13c"        "Vps26a"        "Vps26b"        "Vps26c"       
## [2073] "Vps29"         "Vps35"         "Vps45"         "Vps4a"        
## [2077] "Vps50"         "Vps51"         "Vwa5a"         "Wasf3"        
## [2081] "Wbp2"          "Wdr1"          "Wdr13"         "Wdr37"        
## [2085] "Wdr44"         "Wdr47"         "Wdr7"          "Wdr77"        
## [2089] "Wfs1"          "Xpnpep1"       "Xpo1"          "Xpo7"         
## [2093] "Ykt6"          "Ylpm1"         "Ywhab"         "Ywhae"        
## [2097] "Ywhag"         "Ywhah"         "Ywhaq"         "Ywhaz"        
## [2101] "Zmym3"
length(intersect(split_prot_df_map_rat$combined$Gene_name,
          split_RNA_df_map_rat$combined$Gene_name)) #2101 (just proteins from)
## [1] 2101
#intersect of significant observed 
intersect(split_prot_df_map_rat_sig$combined$Gene_name,
          split_RNA_df_map_rat_sig$combined$Gene_name)
##  [1] "Epb41l2" "Mbp"     "Cops2"   "Glud1"   "Gnai2"   "Mthfd1l" "Ncdn"   
##  [8] "Sirt2"   "Slc1a3"  "Slc7a14"
length(intersect(split_prot_df_map_rat_sig$combined$Gene_name,
          split_RNA_df_map_rat_sig$combined$Gene_name)) #10
## [1] 10
# # mega df (combining botth lit reviews)
# mega_df <- bind_rows(list(lit_review_proteomics = lit_review_proteomics,
#                     lit_review_transcriptomics = lit_review_transcriptomics), 
#                     .id = "omics_assay")

# list of common genes/proteins (SYMBOL) observed in both
common_list <- intersect(split_prot_df_map_rat$combined$Gene_name,
                        split_RNA_df_map_rat$combined$Gene_name)

# make vector of conditions
# conditions <- unique(mega_df$Condition)
conditions <- unique(lit_review_proteomics$Condition)

TO DO: Maybe do a for loop to get the overlapping proteins/genes for each entry? look at their old code?

Quick keyword analysis 2025_12_31

Quick Key word analysis | based off the one from arroyo

key_annos <- read_excel("input/keywords_all_2025_12_09_uniprot.xlsx")

Proteomics

keywords_df_prot <- lit_review_proteomics_sig %>%
  ungroup() %>%
  mutate(hashtags = str_split(Keywords, ";")) %>% # splits into list by sep ;
  tidyr::unnest(hashtags)
keywords_counts_prot <- keywords_df_prot %>%
  group_by(proteomics_id, In_EE) %>%
  filter(hashtags != "Reference proteome") %>%  # ignore ref
  dplyr::count(hashtags, sort = TRUE) %>%
  mutate(total = sum(n)) %>% # note is grouped!
  mutate(percent = round(n/total * 100, 1)) %>%
  mutate(dummy = "1") %>%  # needed for input - so it can plot 1 bar
  left_join(key_annos, by = join_by(hashtags == Name)) %>%
  mutate(In_EE = as.factor(In_EE),
         Category = as.factor(Category)) 
summary(keywords_counts_prot) # percent median .1 & mean.399
##  proteomics_id       In_EE       hashtags               n         
##  Length:1482        down:830   Length:1482        Min.   :  1.00  
##  Class :character   up  :652   Class :character   1st Qu.:  1.00  
##  Mode  :character              Mode  :character   Median :  3.00  
##                                                   Mean   : 12.69  
##                                                   3rd Qu.: 10.75  
##                                                   Max.   :382.00  
##                                                                   
##      total         percent          dummy            Keyword ID       
##  Min.   :1145   Min.   :0.0000   Length:1482        Length:1482       
##  1st Qu.:2313   1st Qu.:0.0000   Class :character   Class :character  
##  Median :3085   Median :0.1000   Mode  :character   Mode  :character  
##  Mean   :3381   Mean   :0.3994                                        
##  3rd Qu.:3262   3rd Qu.:0.3000                                        
##  Max.   :6287   Max.   :8.2000                                        
##                                                                       
##                Category   Gene Ontologies     Definition       
##  Biological process:466   Length:1482        Length:1482       
##  Molecular function:322   Class :character   Class :character  
##  Cellular component:226   Mode  :character   Mode  :character  
##  Ligand            :166                                        
##  PTM               :140                                        
##  Domain            :116                                        
##  (Other)           : 46                                        
##    Synonyms            Links             Children           Parents         
##  Length:1482        Length:1482        Length:1482        Length:1482       
##  Class :character   Class :character   Class :character   Class :character  
##  Mode  :character   Mode  :character   Mode  :character   Mode  :character  
##                                                                             
##                                                                             
##                                                                             
##                                                                             
##   Statistics       
##  Length:1482       
##  Class :character  
##  Mode  :character  
##                    
##                    
##                    
## 
plot(keywords_counts_prot$n)

keyplot_prot_1 <- keywords_counts_prot %>%
  filter(percent > 1) %>% # 11 keywords
  # filter(n > 5) %>%
  ggplot(aes(x = n,
             y = dummy,
             fill = Category)) +
  geom_col(position = "fill", color = "grey10", alpha = 0.8) +
    facet_nested(proteomics_id~In_EE, 
             scales = 'free_x',
             space = 'free',
             # switch = "both"
             ) +
  labs(x = "Uniprot Keyword", y = "Count",
       title = "Perez 2024 - Keywords in Significant Proteins",
       subtitle = "") +
  scale_fill_brewer(palette = "Spectral") +
  theme_bw() +
  theme(
    legend.position = "bottom",
     axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.5, # 90, hj1 t/R, vj.5 cent
                               size = 10, face = 'italic'), 
    axis.text.y = element_text(hjust = 1, color = "grey20", size = 10), # rota 90 & hjust=1 (top/right)
    )

keyplot_prot_1

keyplot_prot_2 <- keywords_counts_prot %>%
  
  # ungroup() %>%
  filter(!Category %in% c("Technical term",
                          "Coding sequence diversity")) %>%
  filter(percent > 1) %>% # 11 keywords
  # filter(n > 5) %>%
  
  ggplot(aes(x = hashtags,
             # x = reorder(Category, n),
             y = percent,
             # fill = reorder(hashtags, n))
             # alpha = hashtags, 
             color = In_EE,
             fill = Category)) +
  
  geom_col(position = position_dodge(
    preserve = 'single', width = .7), # so col sam wid
    width = .7, alpha = 0.5) +
  
  facet_nested(proteomics_id~Category, 
             scales = 'free_x',
             space = 'free') +
  
  labs(x = "Uniprot Keyword", y = "Count",
       title = "Perez 2024 - Keywords in Significant Proteins",
       subtitle = "") +
  
  scale_fill_brewer(palette = "Spectral") +
  scale_color_manual(values = c("royalblue4", "firebrick3")) +
  
  theme_bw() +
  theme(
    legend.position = "bottom",
     axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.5, # 90, hj1 t/R, vj.5 cent
                               size = 10, face = 'italic'), 
    axis.text.y = element_text(hjust = 1, color = "grey20", size = 10), # rota 90 & hjust=1 (top/right)
    panel.spacing = unit(0, "cm"),  # Removes space between panel 
    )


keyplot_prot_2

Trancriptomics

keywords_df_RNA <- lit_review_transcriptomics %>%
  ungroup() %>%
  filter(padj <= 0.1) %>%
  mutate(hashtags = str_split(Keywords, ";")) %>% # splits into list by sep ;
  tidyr::unnest(hashtags)
keywords_counts_RNA <- keywords_df_RNA %>%
  group_by(transcriptomics_id, In_EE) %>%
  filter(hashtags != "Reference proteome") %>%  # ignore ref
  dplyr::count(hashtags, sort = TRUE) %>%
  mutate(total = sum(n)) %>% # note is grouped!
  mutate(percent = round(n/total * 100, 1)) %>%
  mutate(dummy = "1") %>%  # needed for input - so it can plot 1 bar
  left_join(key_annos, by = join_by(hashtags == Name)) %>%
  mutate(In_EE = as.factor(In_EE),
         Category = as.factor(Category)) 
summary(keywords_counts_RNA) # percent median .4 + mean 0.86 
##  transcriptomics_id  In_EE       hashtags               n         
##  Length:691         down:374   Length:691         Min.   : 1.000  
##  Class :character   up  :317   Class :character   1st Qu.: 1.000  
##  Mode  :character              Mode  :character   Median : 2.000  
##                                                   Mean   : 3.763  
##                                                   3rd Qu.: 4.000  
##                                                   Max.   :51.000  
##                                                                   
##      total          percent          dummy            Keyword ID       
##  Min.   :167.0   Min.   :0.1000   Length:691         Length:691        
##  1st Qu.:273.0   1st Qu.:0.2000   Class :character   Class :character  
##  Median :311.0   Median :0.4000   Mode  :character   Mode  :character  
##  Mean   :519.8   Mean   :0.8624                                        
##  3rd Qu.:898.0   3rd Qu.:1.0000                                        
##  Max.   :898.0   Max.   :6.6000                                        
##                                                                        
##                Category   Gene Ontologies     Definition       
##  Molecular function:157   Length:691         Length:691        
##  Biological process:153   Class :character   Class :character  
##  Cellular component:112   Mode  :character   Mode  :character  
##  Ligand            : 84                                        
##  Domain            : 80                                        
##  PTM               : 76                                        
##  (Other)           : 29                                        
##    Synonyms            Links             Children           Parents         
##  Length:691         Length:691         Length:691         Length:691        
##  Class :character   Class :character   Class :character   Class :character  
##  Mode  :character   Mode  :character   Mode  :character   Mode  :character  
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##   Statistics       
##  Length:691        
##  Class :character  
##  Mode  :character  
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plot(keywords_counts_RNA$n)

keyplot_RNA_1 <- keywords_counts_RNA %>% 
  filter(percent > 1) %>% # 11 keywords
  # filter(n > 5) %>%
  ggplot(aes(x = n,
             y = dummy,
             fill = Category)) +
  geom_col(position = "fill", color = "grey10", alpha = 0.8) +
    facet_nested(transcriptomics_id~In_EE, 
             scales = 'free_x',
             space = 'free',
             # switch = "both"
             ) +
  labs(x = "Uniprot Keyword", y = "Count",
       title = "Perez 2024 - Keywords in Significant RNA",
       subtitle = "") +
  scale_fill_brewer(palette = "Spectral") +
  theme_bw() +
  theme(
    legend.position = "bottom",
     axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.5, # 90, hj1 t/R, vj.5 cent
                               size = 10, face = 'italic'), 
    axis.text.y = element_text(hjust = 1, color = "grey20", size = 10), # rota 90 & hjust=1 (top/right)
    )

keyplot_RNA_1

keyplot_RNA_2 <- keywords_counts_RNA %>%
  
  # ungroup() %>%
  filter(!Category %in% c("Technical term",
                          "Coding sequence diversity")) %>%
  filter(percent > .7) %>% 
  # filter(n > 5) %>%
  
  ggplot(aes(x = hashtags,
             # x = reorder(Category, n),
             y = percent,
             # fill = reorder(hashtags, n))
             # alpha = hashtags, 
             color = In_EE,
             fill = Category)) +
  
  geom_col(position = position_dodge(
    preserve = 'single', width = .7), # so col sam wid
    width = .7, alpha = 0.5) +
  
  facet_nested(transcriptomics_id~Category, 
             scales = 'free_x',
             space = 'free') +
  
  labs(x = "Uniprot Keyword", y = "Count",
       title = "Perez 2024 - Keywords in Significant Proteins",
       subtitle = "") +
  
  scale_fill_brewer(palette = "Spectral") +
  scale_color_manual(values = c("royalblue4", "firebrick3")) +
  
  theme_bw() +
  theme(
    legend.position = "bottom",
     axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.5, # 90, hj1 t/R, vj.5 cent
                               size = 10, face = 'italic'), 
    axis.text.y = element_text(hjust = 1, color = "grey20", size = 10), # rota 90 & hjust=1 (top/right)
    panel.spacing = unit(0, "cm"),  # Removes space between panel 
    )


keyplot_RNA_2